Research graph
References from Mechanistic Interplay Between Biomechanical Signaling and Epigenetic Regulation: Targeted Therapy Against Tumor Development and Malignant Progression. Local targets link to admitted publications; unresolved targets remain external evidence.
Beyond genetics: driving cancer with the tumour microenvironment behind the wheel
10.1038/s41568-023-00660-9 · 2024 · External reference
Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression
10.1038/s41563-020-00849-5 · 2021 · External reference
Matrix stiffening facilitates the collective invasion of breast cancer through the periostin-integrin mechanotransduction pathway
10.1016/j.matbio.2023.05.006 · 2023 · External reference
Osr2 functions as a biomechanical checkpoint to aggravate CD8(+) T cell exhaustion in tumor
10.1016/j.cell.2024.04.023 · 2024 · External reference
Probing the physical hallmarks of cancer
10.1038/s41592-024-02564-4 · 2025 · External reference
Breast tumor stiffness instructs bone metastasis via maintenance of mechanical conditioning
10.1016/j.celrep.2021.109293 · 2021 · External reference
Matrix stiffness epigenetically regulates the oncogenic activation of the Yes-associated protein in gastric cancer
10.1038/s41551-020-00657-x · 2021 · External reference
β2-Integrin Adhesion Regulates Dendritic Cell Epigenetic and Transcriptional Landscapes to Restrict Dendritic Cell Maturation and Tumor Rejection
10.1158/2326-6066.cir-21-0094 · 2021 · External reference
Local soft niches in mechanically heterogeneous primary tumors promote brain metastasis via mechanotransduction-mediated HDAC3 activity
10.1126/sciadv.adq2881 · 2025 · External reference
Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets
10.1038/s41392-023-01480-x · 2023 · External reference
Extracellular Matrix Topography Drives Adrenergic to Mesenchymal Transition in Neuroblastoma
10.1002/adma.202501526 · 2025 · External reference
Mena regulates nesprin-2 to control actin-nuclear lamina associations, trans-nuclear membrane signalling and gene expression
10.1038/s41467-023-37021-x · 2023 · External reference
High matrix stiffness triggers the YAP-OPA1-TET1/3 loop to drive chemoresistance via enhanced nuclear-mitochondrial communication
10.1016/j.isci.2025.113996 · 2025 · External reference
KIF5A upregulation by FAK-mediated downregulation of epigenetic modifiers promotes mitochondrial dynamics in neuronal differentiation
10.1002/1873-3468.70177 · 2026 · External reference
Histone deacetylase inhibitors promote breast cancer metastasis by elevating NEDD9 expression
10.1038/s41392-022-01221-6 · 2023 · External reference
Smoke-induced SAV1 Gene Promoter Hypermethylation Disrupts YAP Negative Feedback and Promotes Malignant Progression of Non-small Cell Lung Cancer
10.7150/ijbs.73428 · 2022 · External reference
Histone H1.0 couples cellular mechanical behaviors to chromatin structure
10.1038/s44161-024-00460-w · 2024 · External reference
Linking cell mechanical memory and cancer metastasis
10.1038/s41568-023-00656-5 · 2024 · External reference
Compressive stress-driven Piezo1 activation and Rho-ROCK mechanotransduction promote tumor progression via epigenetic mechanical memory
10.1126/sciadv.aeb1271 · 2026 · External reference
Engineered matrices reveal stiffness-mediated chemoresistance in patient-derived pancreatic cancer organoids
10.1038/s41563-024-01908-x · 2024 · External reference
Decoding gene regulatory circuitry underlying TNBC chemoresistance reveals biomarkers for therapy response and therapeutic targets
10.1038/s41698-024-00529-6 · 2024 · External reference
Synergistic effects of combined BET and FAK inhibition against Vestibular Schwannomas in NF2-related Schwannomatosis
10.1038/s41388-024-03144-8 · 2024 · External reference
Discovery of the First-in-Class Dual-Target ROCK/HDAC Inhibitor with Potent Antitumor Efficacy in Vivo That Trigger Antitumor Immunity
10.1021/acs.jmedchem.4c02183 · 2024 · External reference
Focal Adhesion Kinase Intersects With the BRD4-MYC Axis and YAP1 to Drive Tumor Cell Growth, Phenotypic Plasticity, Stemness, and Metastatic Potential in Colorectal Cancer
10.1002/cam4.71227 · 2025 · External reference
Biophysics in tumor growth and progression: from single mechano-sensitive molecules to mechanomedicine
10.1038/s41388-023-02844-x · 2023 · External reference
Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets
10.1038/s41392-023-01501-9 · 2023 · External reference
Matrix-induced nuclear remodeling and mechano-therapeutics
10.1016/j.celrep.2025.116176 · 2025 · External reference
Mechanical force application to the nucleus regulates nucleocytoplasmic transport
10.1038/s41556-022-00927-7 · 2022 · External reference
Activation of Piezo1 contributes to matrix stiffness-induced angiogenesis in hepatocellular carcinoma
10.1002/cac2.12364 · 2022 · External reference
Capillary constrictions prime cancer cell tumorigenicity through PIEZO1
10.1038/s41467-025-63374-6 · 2025 · External reference
An Agrin-YAP/TAZ Rigidity Sensing Module Drives EGFR-Addicted Lung Tumorigenesis
2025 · External reference
Dissecting cell membrane tension dynamics and its effect on Piezo1-mediated cellular mechanosensitivity using force-controlled nanopipettes
10.1038/s41592-024-02277-8 · 2024 · External reference
Ligand binding initiates single-molecule integrin conformational activation
10.1016/j.cell.2024.04.049 · 2024 · External reference
Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair
10.1038/s41467-021-22602-5 · 2021 · External reference
Force transmission by retrograde actin flow-induced dynamic molecular stretching of Talin
10.1038/s41467-023-44018-z · 2023 · External reference
Stretching single talin rod molecules activates vinculin binding
10.1126/science.1162912 · 2009 · External reference
Alternative molecular mechanisms for force transmission at adherens junctions via β-catenin-vinculin interaction
10.1038/s41467-024-49850-5 · 2024 · External reference
Matrix stiffness induces epithelial-to-mesenchymal transition via Piezo1-regulated calcium flux in prostate cancer cells
10.1016/j.isci.2023.106275 · 2023 · External reference
Cell-extracellular matrix mechanotransduction in 3D
10.1038/s41580-023-00583-1 · 2023 · External reference
Nuclear deformation and dynamics of migrating cells in 3D confinement reveal adaptation of pulling and pushing forces
10.1126/sciadv.adm9195 · 2024 · External reference
The nuclear piston activates mechanosensitive ion channels to generate cell migration paths in confining microenvironments
10.1126/sciadv.abd4058 · 2021 · External reference
Mechanosensitive calcium channels and integrins coordinate the reprogramming of colorectal cancer cells into a fetal-like state
10.1016/j.celrep.2025.116308 · 2025 · External reference
Focal adhesion kinase: from biological functions to therapeutic strategies
10.1186/s40164-023-00446-7 · 2023 · External reference
ROCK isoforms differentially modulate cancer cell motility by mechanosensing the substrate stiffness
10.1016/j.actbio.2019.02.015 · 2019 · External reference
The mechanical microenvironment regulates ovarian cancer cell morphology, migration, and spheroid disaggregation
10.1038/s41598-018-25589-0 · 2018 · External reference
Decoding mechanical cues by molecular mechanotransduction
10.1016/j.ceb.2021.05.006 · 2021 · External reference
E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand shedding
10.1126/scisignal.adr7926 · 2025 · External reference
Mechanosensor Piezo1 mediates bimodal patterns of intracellular calcium and FAK signaling
10.15252/embj.2022111799 · 2022 · External reference
The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening
10.1038/s41467-021-24383-3 · 2021 · External reference
Dynamic Heterochromatin States in Anisotropic Nuclei of Cells on Aligned Nanofibers
10.1021/acsnano.2c02660 · 2022 · External reference
Environmental stiffness restores mechanical homeostasis in vimentin-depleted cells
10.1038/s41598-023-44835-8 · 2023 · External reference
Aberrant MET activation impairs perinuclear actin cap organization with YAP1 cytosolic relocation
10.1038/s42003-023-05411-y · 2023 · External reference
Dynamic substrate topographies drive actin- and vimentin-mediated nuclear mechanoprotection events in human fibroblasts
10.1186/s12915-025-02199-7 · 2025 · External reference
The laminin-keratin link shields the nucleus from mechanical deformation and signalling
10.1038/s41563-023-01657-3 · 2023 · External reference
Nuclear lamina strain states revealed by intermolecular force biosensor
10.1038/s41467-023-39563-6 · 2023 · External reference
Transient nuclear deformation primes epigenetic state and promotes cell reprogramming
10.1038/s41563-022-01312-3 · 2022 · External reference
Chromatin plasticity in mechanotransduction
10.1016/j.ceb.2024.102376 · 2024 · External reference
Mechanical regulation of chromatin and transcription
10.1038/s41576-022-00493-6 · 2022 · External reference
Confined migration induces heterochromatin formation and alters chromatin accessibility
10.1016/j.isci.2022.104978 · 2022 · External reference
Biophysical forces mediated by respiration maintain lung alveolar epithelial cell fate
10.1016/j.cell.2023.02.010 · 2023 · External reference
Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response
10.1038/s41467-021-27451-w · 2021 · External reference
Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth
10.1038/ncb3216 · 2015 · External reference
YAP1 maintains active chromatin state in head and neck squamous cell carcinomas that promotes tumorigenesis through cooperation with BRD4
10.1016/j.celrep.2022.110970 · 2022 · External reference
YAP induces an oncogenic transcriptional program through TET1-mediated epigenetic remodeling in liver growth and tumorigenesis
10.1038/s41588-022-01119-7 · 2022 · External reference
Matrix stiffness regulates nucleus pulposus cell glycolysis by MRTF-A-dependent mechanotransduction
10.1038/s41413-025-00402-7 · 2025 · External reference
mDia2 is an important mediator of MRTF-A-dependent regulation of breast cancer cell migration
10.1091/mbc.e24-01-0008 · 2024 · External reference
Compression-induced NF-κB activation sustains tumor cell survival in confinement by detoxifying aldehydes and promotes metastasis
10.1038/s41467-025-67452-7 · 2025 · External reference
Actin networks modulate heterogeneous NF-κB dynamics in response to TNFα
10.7554/elife.86042 · 2024 · External reference
Biphasic regulation of epigenetic state by matrix stiffness during cell reprogramming
10.1126/sciadv.adk0639 · 2024 · External reference
Stromal Stiffness-Regulated IGF2BP2 in Pancreatic Cancer Drives Immune Evasion via Sphingomyelin Metabolism
10.1053/j.gastro.2025.03.019 · 2025 · External reference
Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4
10.1038/s41591-018-0158-8 · 2018 · External reference
Matrix stiffness-induced YEATS2 drives HCC progression via epigenetic activation of the TGFBR2-TAZ-AKT pathway
2026 · External reference
Epigenetics-targeted drugs: current paradigms and future challenges
10.1038/s41392-024-02039-0 · 2024 · External reference
DNA methylation in mammalian development and disease
10.1038/s41576-024-00760-8 · 2025 · External reference
Tunable DNMT1 degradation reveals DNMT1/DNMT3B synergy in DNA methylation and genome organization
10.1083/jcb.202307026 · 2024 · External reference
DNA-methylation eraser TET2 activates WTIP expression to suppress an AKT-dependent chemoresistance of gastric cancer
10.1016/j.neo.2025.101166 · 2025 · External reference
A pan-cancer analysis of CpG Island gene regulation reveals extensive plasticity within Polycomb target genes
10.1038/s41467-021-22720-0 · 2021 · External reference
Simulation-guided pan-cancer analysis identifies a novel regulator of CpG island hypermethylation heterogeneity
10.1093/bib/bbaf252 · 2025 · External reference
Oncogenic Transformation Drives DNA Methylation Loss and Transcriptional Activation at Transposable Element Loci
10.1158/0008-5472.can-22-3485 · 2023 · External reference
DNA methylation influences human centromere positioning and function
10.1038/s41588-025-02324-w · 2025 · External reference
Promoter Hypermethylation-Induced Silencing of FXYD1 Drives Breast Cancer Metastasis via DDX5-Mediated Wnt/β-Catenin Pathway Activation
2026 · External reference
Cholesterol in glioblastoma: Impaired Hh signaling enhances epigenetic modifiers and decreases CAV1
10.1247/csf.25168 · 2026 · External reference
Navigating the DNA methylation landscape of cancer
10.1016/j.tig.2021.05.002 · 2021 · External reference
Therapeutic targeting of DNA methylation alterations in cancer
10.1016/j.pharmthera.2024.108640 · 2024 · External reference
Extracellular Matrix Stiffness Regulates DNA Methylation by PKCα-Dependent Nuclear Transport of DNMT3L
2021 · External reference
The Brain Microenvironment Induces DNMT1 Suppression and Indolence of Metastatic Cancer Cells
10.1016/j.isci.2020.101480 · 2020 · External reference
Extracellular matrix stiffness reduces DNA 6 ma level to facilitate colorectal cancer progression via disrupting P53 binding to CDKN1A promoter
10.1186/s40164-025-00704-w · 2025 · External reference
Clinically relevant molecular hallmarks of PFA ependymomas display intratumoral heterogeneity and correlate with tumor morphology
10.1007/s00401-023-02682-x · 2024 · External reference
Circulating Tumor Cell Clustering Shapes DNA Methylation to Enable Metastasis Seeding
10.1016/j.cell.2018.11.046 · 2019 · External reference
Mechanical compression induces VEGFA overexpression in breast cancer via DNMT3A-dependent miR-9 downregulation
10.1038/cddis.2017.73 · 2017 · External reference
Pancreatic cancer cells render tumor-associated macrophages metabolically reprogrammed by a GARP and DNA methylation-mediated mechanism
10.1038/s41392-021-00769-z · 2021 · External reference
Repeat DNA methylation is modulated by adherens junction signaling
10.1038/s42003-024-05990-4 · 2024 · External reference
Extracellular Matrix in Synthetic Hydrogel-Based Prostate Cancer Organoids Regulate Therapeutic Response to EZH2 and DRD2 Inhibitors
2022 · External reference
Histone post-translational modifications - cause and consequence of genome function
10.1038/s41576-022-00468-7 · 2022 · External reference
Binding of regulatory proteins to nucleosomes is modulated by dynamic histone tails
10.1038/s41467-021-25568-6 · 2021 · External reference
Decoding chromatin states by proteomic profiling of nucleosome readers
10.1038/s41586-024-07141-5 · 2024 · External reference
Enhancers are activated by p300/CBP activity-dependent PIC assembly, RNAPII recruitment, and pause release
10.1016/j.molcel.2021.03.008 · 2021 · External reference
H3K36 methylation maintains cell identity by regulating opposing lineage programmes
10.1038/s41556-023-01191-z · 2023 · External reference
CBP/p300 and HDAC activities regulate H3K27 acetylation dynamics and zygotic genome activation in mouse preimplantation embryos
10.15252/embj.2022112012 · 2022 · External reference
H3K4me2/3 modulate the stability of RNA polymerase II pausing
10.1038/s41422-023-00794-3 · 2023 · External reference
Genome-coverage single-cell histone modifications for embryo lineage tracing
10.1038/s41586-025-08656-1 · 2025 · External reference
Epigenetic signaling and crosstalk in regulation of gene expression and disease progression
10.2217/epi-2023-0235 · 2023 · External reference
The role of histone modifications: from neurodevelopment to neurodiseases
10.1038/s41392-022-01078-9 · 2022 · External reference
Correlating histone acetylation with nucleosome core particle dynamics and function
10.1073/pnas.2301063120 · 2023 · External reference
Targeting dependency on a paralog pair of CBP/p300 against de-repression of KREMEN2 in SMARCB1-deficient cancers
10.1038/s41467-024-49063-w · 2024 · External reference
The PML1-WDR5 axis regulates H3K4me3 marks and promotes stemness of estrogen receptor-positive breast cancer
10.1038/s41418-024-01294-6 · 2024 · External reference
Impaired histone inheritance promotes tumor progression
10.1038/s41467-023-39185-y · 2023 · External reference
Substrate stiffness modulates osteogenic and adipogenic differentiation of osteosarcoma through PIEZO1 mediated signaling pathway
10.1016/j.cellsig.2025.111601 · 2025 · External reference
Matrix stiffness-dependent PD-L2 deficiency improves SMYD3/xCT-mediated ferroptosis and the efficacy of anti-PD-1 in HCC
10.1016/j.jare.2024.08.021 · 2025 · External reference
Tumor peripheral stiffness modulates lenvatinib resistance in HCC preclinical models by regulating FIS1-dependent mitophagy
2025 · External reference
Compressive stress-mediated p38 activation required for ERα + phenotype in breast cancer
10.1038/s41467-021-27220-9 · 2021 · External reference
Targeting Piezo1 unleashes innate immunity against cancer and infectious disease
10.1126/sciimmunol.abb5168 · 2020 · External reference
Geometric regulation of histone state directs melanoma reprogramming
10.1038/s42003-020-1067-1 · 2020 · External reference
Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage
10.1016/j.cell.2020.03.052 · 2020 · External reference
GsMTx-4 venom toxin antagonizes biophysical modulation of metastatic traits in human osteosarcoma cells
10.1016/j.ejcb.2024.151469 · 2025 · External reference
Histone Modification of Osteogenesis Related Genes Triggered by Substrate Topography Promotes Human Mesenchymal Stem Cell Differentiation
10.1021/acsami.3c01481 · 2023 · External reference
Chemotherapy-Enriched THBS2-Deficient Cancer Stem Cells Drive Hepatocarcinogenesis through Matrix Softness Induced Histone H3 Modifications
2021 · External reference
Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ
10.1038/s41467-021-22544-y · 2021 · External reference
A methyl-to-acetyl switch in H3K27 drives metabolic reprogramming and resistance to BRAF(V600E) inhibition in melanoma
10.1016/j.neo.2025.101223 · 2025 · External reference
HDAC3 Deficiency Promotes Liver Cancer through a Defect in H3K9ac/H3K9me3 Transition
10.1158/0008-5472.can-18-3767 · 2019 · External reference
Context-specific functions of chromatin remodellers in development and disease
10.1038/s41576-023-00666-x · 2024 · External reference
Chromatin remodellers as therapeutic targets
10.1038/s41573-024-00978-5 · 2024 · External reference
Mammalian SWI/SNF continuously restores local accessibility to chromatin
10.1038/s41588-020-00768-w · 2021 · External reference
Acute depletion of BRG1 reveals its primary function as an activator of transcription
10.1038/s41467-024-48911-z · 2024 · External reference
Global identification of SWI/SNF targets reveals compensation by EP400
10.1016/j.cell.2023.10.006 · 2023 · External reference
Energy-driven genome regulation by ATP-dependent chromatin remodellers
10.1038/s41580-023-00683-y · 2024 · External reference
FAK regulates IL-33 expression by controlling chromatin accessibility at c-Jun motifs
10.1038/s41598-020-80111-9 · 2021 · External reference
Mechanosensitive genomic enhancers potentiate the cellular response to matrix stiffness
10.1126/science.adl1988 · 2025 · External reference
Three dimensional fibrotic extracellular matrix directs microenvironment fiber remodeling by fibroblasts
10.1016/j.actbio.2024.02.008 · 2024 · External reference
Chromatin-site-specific accessibility: A microtopography-regulated door into the stem cell fate
10.1016/j.celrep.2024.115106 · 2025 · External reference
Chromatin compaction during confined cell migration induces and reshapes nuclear condensates
10.1038/s41467-024-54120-5 · 2024 · External reference
β1 integrin signaling governs necroptosis via the chromatin-remodeling factor CHD4
10.1016/j.celrep.2023.113322 · 2023 · External reference
A Novel Bispecific Integrin α5β1/αv Antibody Reprograms the Myc-Regulated Basal Phenotype of Prostate Cancer with NK Cell-Mediated Tumor Elimination
10.1158/1541-7786.mcr-25-0104 · 2025 · External reference
Stromal Rigidity Stress Accelerates Pancreatic Intraepithelial Neoplasia Progression and Chromosomal Instability via Nuclear Protein Tyrosine Kinase 2 Localization
10.1016/j.ajpath.2024.02.023 · 2024 · External reference
Matrix stiffness induces a tumorigenic phenotype in mammary epithelium through changes in chromatin accessibility
10.1038/s41551-019-0420-5 · 2019 · External reference
Understanding 3D genome organization by multidisciplinary methods
10.1038/s41580-021-00362-w · 2021 · External reference
Constricted migration is associated with stable 3D genome structure differences in cancer cells
10.15252/embr.202052149 · 2022 · External reference
Stiff extracellular matrix drives the differentiation of mesenchymal stem cells toward osteogenesis by the multiscale 3D genome reorganization
10.1016/j.biomaterials.2024.122715 · 2025 · External reference
Revealing the Biophysics of Lamina-Associated Domain Formation by Integrating Theoretical Modeling and High-Resolution Imaging
2024 · External reference
The roles and implications of RNA m(6)A modification in cancer
10.1038/s41571-023-00774-x · 2023 · External reference
RNA modifications in gene regulation: Functions and pathways
10.1016/j.cell.2026.01.006 · 2026 · External reference
Detection technologies for RNA modifications
10.1038/s12276-022-00821-0 · 2022 · External reference
The bidirectional interplay between RNA processing and mechanotransduction
10.1016/j.celrep.2025.116175 · 2025 · External reference
Interaction between m6A and YAP1 mechanotransduction pathways is essential for mechanical memory and matrix remodeling in pancreatic cancer
10.7150/ijbs.125330 · 2026 · External reference
Fluid shear stress activates YAP to promote epithelial-mesenchymal transition in hepatocellular carcinoma
10.1002/1878-0261.13061 · 2021 · External reference
mTORC1 Mediates Biphasic Mechano-Response to Orchestrate Adhesion-Dependent Cell Growth and Anoikis Resistance
2024 · External reference
Non-coding RNAs in disease: from mechanisms to therapeutics
10.1038/s41576-023-00662-1 · 2024 · External reference
Unresolved reference
External reference
MBD2a-NuRD binds to the methylated γ-globin gene promoter and uniquely forms a complex required for silencing of HbF expression
10.1073/pnas.2302254120 · 2023 · External reference
Analysis of the complex between MBD2 and the histone deacetylase core of NuRD reveals key interactions critical for gene silencing
10.1073/pnas.2307287120 · 2023 · External reference
Chromatin accessibility: biological functions, molecular mechanisms and therapeutic application
10.1038/s41392-024-02030-9 · 2024 · External reference
Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally
10.1038/s41586-019-1016-7 · 2019 · External reference
H3K36me3-Guided m(6)A Modification of Oncogenic L1CAM-AS1 Drives Macrophage Polarization and Immunotherapy Resistance in Hepatocellular Carcinoma
10.4028/b-xdtcg5 · 2025 · External reference
Crosstalk between histone/DNA modifications and RNA N(6)-methyladenosine modification
10.1016/j.gde.2024.102205 · 2024 · External reference
RBFOX2 recognizes N(6)-methyladenosine to suppress transcription and block myeloid leukaemia differentiation
10.1038/s41556-023-01213-w · 2023 · External reference
Identification of METTL3 and PRMT5 as an oncogenic pair for the prognosis and therapeutic targets of colorectal cancer subtype
10.1186/s13148-026-02144-7 · 2026 · External reference
Crosstalk within and beyond the Polycomb repressive system
10.1083/jcb.202311021 · 2024 · External reference
Crosstalk between EZH2 and DNA methylation mediates neuroendocrine prostate cancer lineage plasticity
10.1038/s41467-026-69308-0 · 2026 · External reference
Mechano-regulation of cancer cell memory in tumor progression and therapy
10.1016/j.mbm.2025.100165 · 2026 · External reference
A Comprehensive Gene Expression Analysis of Extensive Cohorts From Colon Adenocarcinoma Uncovered a Set of Genes Regulated by DNA Hypomethylation and Predominantly Influenced by Lipid Raft-Mediated EGFR-RAS-MAPK Signaling
10.1002/mc.70085 · 2026 · External reference
Targeting epigenetic regulators as a promising avenue to overcome cancer therapy resistance
10.1038/s41392-025-02266-z · 2025 · External reference
PHF14 enhances DNA methylation of SMAD7 gene to promote TGF-β-driven lung adenocarcinoma metastasis
10.1038/s41421-023-00528-0 · 2023 · External reference
Ginsenoside Rg1 Epigenetically Modulates Smad7 Expression in Liver Fibrosis via MicroRNA-152
10.1016/j.jgr.2022.12.005 · 2023 · External reference
DNA methylation subtypes dictate metastatic heterogeneity of osteosarcoma via distinct tumor-stromal interactions: Multi-omics profiling and decitabine validation
2025 · External reference
Downregulation of the TGFβ Pseudoreceptor BAMBI in Non-Small Cell Lung Cancer Enhances TGFβ Signaling and Invasion
10.1158/0008-5472.can-15-1326 · 2016 · External reference
Methylation silencing of TGF-β receptor type II is involved in malignant transformation of esophageal squamous cell carcinoma
10.1186/s13148-020-0819-6 · 2020 · External reference
Hypermethylation of LATS2 Promoter and Its Prognostic Value in IDH-Mutated Low-Grade Gliomas
10.3389/fcell.2020.586581 · 2020 · External reference
UBR7 in concert with EZH2 inhibits the TGF-β signaling leading to extracellular matrix remodeling
10.1016/j.celrep.2024.114394 · 2024 · External reference
G9a Promotes Invasion and Metastasis of Non-Small Cell Lung Cancer through Enhancing Focal Adhesion Kinase Activation via NF-κB Signaling Pathway
10.1158/1541-7786.mcr-20-0557 · 2021 · External reference
Attenuation of TGFBR2 expression and tumour progression in prostate cancer involve diverse hypoxia-regulated pathways
10.1186/s13046-018-0764-9 · 2018 · External reference
METTL14 suppresses the expression of YAP1 and the stemness of triple-negative breast cancer
10.1186/s13046-024-03225-2 · 2024 · External reference
A Novel Therapeutic Strategy Targeting the Mesenchymal Phenotype of Malignant Pleural Mesothelioma by Suppressing LSD1
10.1158/1541-7786.mcr-21-0230 · 2022 · External reference
Enhancer reprogramming underlies therapeutic utility of a SMARCA2 degrader in SMARCA4 mutant cancer
10.1016/j.chembiol.2024.09.004 · 2024 · External reference
The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ
10.1038/s41586-018-0658-1 · 2018 · External reference
m(6)A-Dependent ITIH1 Regulated by TGF-β Acts as a Target for Hepatocellular Carcinoma Progression
2024 · External reference
O-GlcNAcylation stabilized WTAP promotes GBM malignant progression in an N6-methyladenosine-dependent manner
10.1093/neuonc/noae268 · 2025 · External reference
m(6)A-mediated upregulation of LINC01003 regulates cell migration by targeting the CAV1/FAK signaling pathway in glioma
10.1186/s13062-023-00386-6 · 2023 · External reference
ALKBH5 activates FAK signaling through m6A demethylation in ITGB1 mRNA and enhances tumor-associated lymphangiogenesis and lymph node metastasis in ovarian cancer
10.7150/thno.77441 · 2023 · External reference
FTO facilitates cancer metastasis by modifying the m(6)A level of FAP to induce integrin/FAK signaling in non-small cell lung cancer
10.1186/s12964-023-01343-6 · 2023 · External reference
N6-Methyladenosine Reader YTHDF1 Promotes ARHGEF2 Translation and RhoA Signaling in Colorectal Cancer
10.1053/j.gastro.2021.12.269 · 2022 · External reference
FBLIM1 drives bile duct ligation-induced liver fibrosis by regulating the TGF-β signaling pathway through WTAP-mediated m6A modification
10.1016/j.intimp.2025.114744 · 2025 · External reference
m(6)A modification erased by ALKBH5 promotes tumor growth and metastasis via regulation of YAP/ZEB1 axis in NSCLC
2026 · External reference
m(6)A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2-mediated YAP activity in NSCLC
10.1186/s12943-020-01161-1 · 2020 · External reference
NAT10 regulates tumor progression and immune microenvironment in pancreatic ductal adenocarcinoma via the N4-acetylated LAMB3-mediated FAK/ERK pathway
10.1002/cac2.70045 · 2025 · External reference
N(4)-acetylcytidine modification of ITGB5 mRNA mediated by NAT10 promotes perineural invasion in pancreatic ductal adenocarcinoma
10.1186/s13046-025-03362-2 · 2025 · External reference
CircMAST1 inhibits cervical cancer progression by hindering the N4-acetylcytidine modification of YAP mRNA
10.1186/s11658-024-00540-6 · 2024 · External reference
Mechanically primed cells transfer memory to fibrous matrices for invasion across environments of distinct stiffness and dimensionality
10.1091/mbc.e22-10-0469 · 2023 · External reference
Single-cell transcriptomics identify mechanical-memory-associated cell states in metastatic HR(+) breast cancer
10.1186/s13058-026-02280-1 · 2026 · External reference
Single-cell multiomic modelling of early metastatic events promoted by the extracellular matrix
10.1038/s41416-025-03181-4 · 2025 · External reference
Mechanobiology across timescales
10.1038/s42254-025-00874-w · 2025 · External reference
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