Research graph
References from Sphingofungin-based aminopolyols and DIX-like azasugars – their synthesis and in vitro biological profile. Local targets link to admitted publications; unresolved targets remain external evidence.
Sphingolipid and Glycosphingolipid Metabolic Pathways in the Era of Sphingolipidomics
10.1021/cr2002917 · 2011 · External reference
Sphingolipids and their metabolism in physiology and disease
10.1038/nrm.2017.107 · 2018 · External reference
Sphingolipid biosynthesis in man and microbes
10.1039/c8np00019k · 2018 · External reference
Glycosphingolipids‒Nature, Function, and Pharmacological Modulation
10.1002/anie.200902620 · 2009 · External reference
Chapter Eight – Natural Products as Platforms for the Design of Sphingolipid-Related Anticancer Agents
10.1016/b978-0-12-394274-6.00008-x · 2013 · External reference
Sphingolipid metabolism in cancer signalling and therapy
10.1038/nrc.2017.96 · 2018 · External reference
Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis
10.1038/nrd3248 · 2010 · External reference
Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: discovery of a novel immunosuppressant
10.1016/0960-894x(95)00127-f · 1995 · External reference
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Myriocin, a new antifungal antibiotic from Myricoccum albomyces
10.7164/antibiotics.25.109 · 1972 · External reference
C. Scolastico, Isolation and structure determination of a new antifungal α-hydroxymethyl-α-amino acid
10.1016/s0040-4020(01)93872-4 · 1972 · External reference
Elucidation of structure and stereochemistry of myriocin. Novel antifungal antibiotic
10.1021/jo00947a001 · 1973 · External reference
Fungal Metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite
10.7164/antibiotics.47.208 · 1994 · External reference
The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors
10.1074/jbc.c200176200 · 2002 · External reference
A. Billich, Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720
10.1182/blood-2005-07-2628 · 2006 · External reference
Sphingosine-1-phosphate signalling
10.1242/dev.094805 · 2014 · External reference
An update on the biology of sphingosine-1-phosphate receptors
10.1194/jlr.r046300 · 2014 · External reference
Alteration of lymphocyte trafficking by Sphingosine-1-Phosphate receptor agonists
10.1126/science.1070238 · 2002 · External reference
The identification of myriocin-binding proteins
10.1016/s1074-5521(99)80038-6 · 1999 · External reference
Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism
10.1016/s1388-1981(03)00059-3 · 2003 · External reference
Inhibitors of sphingolipid metabolism enzymes
10.1016/j.bbamem.2006.08.017 · 2006 · External reference
Characterization of a novel, potent, and specific inhibitor of serine palmitoyltransferase
10.1016/s0021-9258(19)74001-0 · 1992 · External reference
Catalytic Asymmetric Syntheses of Antifungal Sphingofungins and Their Biological Activity as Potent Inhibitors of Serine Palmitoyltransferase (SPT)
10.1021/ja9730829 · 1998 · External reference
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Biology and Chemistry of Sphingosine-Related Metabolites
10.2174/1385272043369638 · 2004 · External reference
Chemistry and biology of sphingolipids
10.1016/j.tet.2005.02.075 · 2005 · External reference
Stereoselective Total Synthesis of Serine Palmitoyl-CoA Transferase Inhibitors
2006 · External reference
Total Synthesis of Myriocin, Mycestericins and Sphingofungin E: Sphingosine Analogues Containing a β,βꞌ-Dihydroxy α-Amino acid Framework
10.1246/cl.210133 · 2021 · External reference
B, C and D; A NEW FAMILY OF ANTIFUNGAL AGENTS I. FERMENTATION, ISOLATION, AND BIOLOGICAL ACTIVITY
10.7164/antibiotics.45.861 · 1992 · External reference
Sphingofungins E and F: NOVEL SERINEPALMITOYL TRANSFERASE INHIBITORS FROM Paecelomyces variotti
10.7164/antibiotics.45.1692 · 1992 · External reference
Sphingofungins G and H: new five-membered lactones from Aspergillus penicilliodes Speg
10.1080/14786419.2018.1470627 · 2019 · External reference
Determination of the relative and absolute stereochemistry of sphingofungins A, B, C and D
10.1016/s0040-4039(00)74115-3 · 1992 · External reference
Total Synthesis and Absolute Configuration of Sphingofungin D (N-Acetyl Asperfungin)
10.1080/10575639508043174 · 1995 · External reference
The Asymmetric Synthesis of Sphingofungin D and the Determination of Its Stereochemistry
10.1055/s-1997-783 · 1997 · External reference
The First Total Synthesis of Sphingofungin E and the Determination of Its Stereochemistry
10.1055/s-2001-14662 · 2001 · External reference
A modular approach to the antifungal Sphingofungin family: concise total synthesis of Sphingofungin A and C
10.1002/anie.202112616 · 2022 · External reference
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Asymmetric Synthesis of Antifungal Agents Sphingofungins Using Catalytic Asymmetric Aldol Reactions
10.1055/s-1996-5583 · 1996 · External reference
Use of heterocycles as chiral ligands and auxiliaries in asymmetric syntheses of sphingosine, sphingofungin B and F
10.1016/s0040-4020(98)00484-0 · 1998 · External reference
Chirality extension of an oxazine building block en route to total syntheses of (+)-hyacinthacine A2 and sphingofungin B
10.1039/c5ob00251f · 2015 · External reference
Total synthesis of d-lyxo- and d-xylo-phytosphingosines and fully acylated sphingofungin B
10.1016/j.tet.2025.134657 · 2025 · External reference
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Synthesis of Sphingofungin D and Its Three Diastereoisomers
10.1002/(sici)1099-0690(199908)1999:8<1795::aid-ejoc1795>3.0.co;2-y · 1999 · External reference
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Total Synthesis of Sphingofungin E
10.1016/s0040-4039(01)00246-5 · 2001 · External reference
gem-Diacetates as Carbonyl Surrogates for Asymmetric Synthesis. Total Syntheses of Sphingofungins E and F
10.1021/ja0118338 · 2001 · External reference
Total Synthesis of Sphingofungin E from d-Glucose
10.1021/ol0171620 · 2002 · External reference
Total Synthesis of (+)-Myriocin and (‒)-Sphingofungin from Aldohexoses Using Overman Rearrangement as the Key Reaction
10.1246/bcsj.75.1927 · 2002 · External reference
Total synthesis of sphingofungin E from d-glucose derivative
10.1016/s0040-4020(02)01058-x · 2002 · External reference
A Flexible Common Approach to a α-Substituted Serines and Alanines: Diastereodivergent Syntheses of Sphingofungins E and F
10.1002/ejoc.200900772 · 2009 · External reference
Stereocontrolled Total Synthesis of Sphingofungin E
10.1002/ejoc.201301065 · 2013 · External reference
Total Synthesis of Sphingofungin E and 4,5-Di-epi-sphingofungin E
10.1248/cpb.c17-00322 · 2017 · External reference
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A New Strategy for the Synthesis of Sphingosine Analogues. Sphingofungin F
10.1021/ja981141s · 1998 · External reference
An Efficient and Convenient Approach to the Total Synthesis of Sphingofungin
10.1021/jo005612g · 2000 · External reference
Total Synthesis of Spingofungin F
10.1021/ol020164f · 2002 · External reference
Total Synthesis of Sphingofungin F
10.1055/s-2006-947333 · 2006 · External reference
Total Synthesis of Sphingofungin F Based on the Chiral Tricyclic Iminolactone
10.1021/jo100183d · 2010 · External reference
Total Synthesis of Sphingofungin F by Orthoamide-Type Overman Rearrangement of an Unsaturated Ester
10.1021/acs.orglett.5b00475 · 2015 · External reference
Synthesis of β-Hydroxy-α,α-disubstituted Amino Acids through the Orthoamide-Type Overman Rearrangement of an α,β-Unsaturated Ester and Stereodivergent Intramolecular SN2ꞌ Reaction: Development and Application to the Total Synthesis of Sphingofungin F
10.1246/bcsj.20170408 · 2018 · External reference
Synthesis of sphingofungin D and its stereoisomer at C-14
10.1016/0040-4039(94)88467-6 · 1994 · External reference
Synthetic pathways to 3,4,5-Trihydroxypyridines from the chiral pool
10.1002/ejoc.201800943 · 2018 · External reference
Three trihydroxypiperidines, glycosidase inhibitors, from Eupatorium fortunei Turz
1995 · External reference
Glycomimetic-based pharmacological chaperones for lysosomal storage disorders: lessons from Gaucher, GM1-gangliosidosis and Fabry diseases
10.1039/c6cc01564f · 2016 · External reference
A review of gaucher disease pathophysiology, clinical presentation and treatments
10.3390/ijms18020441 · 2017 · External reference
Design and synthesis of highly potent and selective pharmacological chaperones for the treatment of Gaucher's disease
10.1002/cbic.200600217 · 2006 · External reference
Second-Generation Iminoxylitol-Based pharmacological chaperones for the treatment of gaucher disease
10.1002/cmdc.201000469 · 2011 · External reference
Rapid assembly of a Library of lipophilic iminosugars via the Thiol-Ene reaction yields promising pharmacological chaperones for the treatment of gaucher disease
10.1021/jm201633y · 2012 · External reference
Synthesis of polyhydroxy piperidines and their analogues: a novel approach towards selective inhibitors of α-glucosidase
10.1039/b804278k · 2008 · External reference
Synthesis and in vitro anticancer activity of penaresidin-related stereoisomeric analogues
2021 · External reference
A straightforward approach toward cytotoxic pyrrolidine alkaloids: Novel analogues of natural broussonetines
10.1016/j.tet.2021.132380 · 2021 · External reference
Synthesis and in vitro antiproliferative profile of novel isomeric aza-analogues of natural jaspine B
10.1016/j.tet.2021.132570 · 2022 · External reference
A straightforward route to cytotoxic isomeric anhydrophytosphingosines
2025 · External reference
The convergent total synthesis of cytotoxic homospisulosine and its 3-epi-analogue
10.1016/j.tetasy.2015.11.001 · 2015 · External reference
A facile synthesis of 1,2-anhydroglucofuranose benzyl ethers
10.1016/0040-4039(94)02311-x · 1995 · External reference
Stereoselective Glycosidic Coupling Reactions of Fully Benzylated 1,2-Anhydro Sugars with N-Tosyl- or N-Benzyloxycarbonyl-l-serine Methyl Ester
10.1080/07328309508002076 · 1995 · External reference
Stereodivergent synthesis and antiproliferative profile of C-tridecyl piperidine-3,4,5-triols
10.1016/j.molstruc.2025.144943 · 2026 · External reference
A ‘chiron’ approach to divergent synthesis of 2-C-tridecyl 1-N-iminosugar mimetics and their anticancer profile
10.1016/j.carres.2025.109742 · 2026 · External reference
Stereoselective β-hydroxy-α-amino acid synthesis via an ether-directed, palladium-catalysed aza-Claisen rearrangement
10.1039/b510808j · 2005 · External reference
Stereoselective synthesis of the bicyclic guanidine alkaloid (+)-monanchorin
10.1039/c0ob00219d · 2010 · External reference
Total synthesis of clavaminol A, C and H
10.1039/c1ob06060k · 2011 · External reference
Preparation of anti-Vicinal Amino Alcohols: Asymmetric Synthesis of d-erythro-Sphinganine, (+)-Spisulosine, and d-ribo-Phytosphingosine
10.1021/jo401211j · 2013 · External reference
Pd(II)-catalyzed acetal/ketal hydrolysis/exchange reactions
10.1016/s0040-4039(00)89114-5 · 1985 · External reference
Extended tight-binding quantum chemistry methods
10.1002/wcms.1493 · 2021 · External reference
GFN2-x-TB‒An accurate and broadly parametrized self-consistent tight-binding quantum chemical method with multipole electrostatics and density-dependent dispersion contributions
10.1021/acs.jctc.8b01176 · 2019 · External reference
Robust and efficient implicit solvation model for fast semiempirical methods
10.1021/acs.jctc.1c00471 · 2021 · External reference
Extension of the D3 dispersion coefficient model
10.1063/1.4993215 · 2017 · External reference
A generally applicable atomic-charge dependent London dispersion correction
10.1063/1.5090222 · 2019 · External reference
Extension and evaluation of the D4 London-dispersion model for periodic systems
10.1039/d0cp00502a · 2020 · External reference
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Practical Synthesis of Pachastrissamine (Jaspine B), 2-epi-Pachastrissamine, and the 2-epi-Pyrrolidine Analogue
10.1248/cpb.c15-00816 · 2016 · External reference
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
10.1016/0022-1759(83)90303-4 · 1983 · External reference
Screening evaluation of antiproliferative, antimicrobial and antioxidant activity of lichen extracts and secondary metabolites in vitro
10.3390/plants12030611 · 2023 · External reference
N-acetylphytosphingosine-induced apoptosis of Jurkat cells is mediated by the conformational change in Bak
10.1007/s10495-006-4569-5 · 2006 · External reference
Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a “come-and-get-me” signal
10.1096/fj.08-107169 · 2008 · External reference
Essential Requirement for Sphingosine-kinase 2 in a Sphingolipid Apoptosis Pathway Activated by FTY720 Analogues
10.1074/jbc.m609124200 · 2007 · External reference
Altered Expression of Signaling Genes in Jurkat Cells upon FTY720 Induced Apoptosis
10.3390/ijms11093087 · 2010 · External reference
Acid β-Glucosidase: Enzymology and Molecular Biology of Gaucher Disease
10.3109/10409239009090616 · 1990 · External reference
Involvement of Acid β-Glucosidase 1 in the Salvage Pathway of Ceramide Formation
10.1074/jbc.m802790200 · 2009 · External reference
Glucocerebrosidase: Functions in and Beyond the Lysosome
10.3390/jcm9030736 · 2020 · External reference
Principles of bioactive lipid signalling: lessons from sphingolipids
10.1038/nrm2329 · 2008 · External reference
Identification of β-glucosidase 1 as a biomarker and its high expression in hepatocellular carcinoma is associated with resistance to chemotherapy drugs
10.3109/1354750x.2015.1134662 · 2016 · External reference
β-Glucosidase inhibition sensitizes breast cancer to chemotherapy
10.1016/j.biopha.2017.04.113 · 2017 · External reference
Potential Binding Sites of Pharmacological Chaperone NCGC00241607 on Mutant β-Glucocerebrosidase and Its Efficacy on Patient-Derived Cell Cultures in Gaucher and Parkinson's Disease
10.3390/ijms24109105 · 2023 · External reference
A New Glucocerebrosidase Chaperone Reduces α-Sinuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism
10.1523/jneurosci.0636-16.2016 · 2016 · External reference
CB-Dock2: improved protein‒ligand blind docking by integrating cavity detection, docking and homologous template fitting
10.1093/nar/gkac394 · 2022 · External reference
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SwissDock, a protein-small molecule docking web service based on EADock DSS
10.1093/nar/gkr366 · 2011 · External reference
A guided tour of the structural biology of gaucher disease: Acid-β-Glucosidase and saposin C
10.4061/2011/973231 · 2011 · External reference
