Research graph
References from TDP-43 post-transcriptionally regulates SLC7A7 to promote ferroptosis and metabolic dysfunction-associated steatohepatitis upon arsenic exposure. Local targets link to admitted publications; unresolved targets remain external evidence.
Arsenic: a global environmental challenge
10.1146/annurev-pharmtox-030220-013418 · 2021 · External reference
High exposure to inorganic arsenic by food: the need for risk reduction
10.1007/s00204-015-1627-1 · 2015 · External reference
Arsenic exposure: a public health problem leading to several cancers
10.1016/j.yrtph.2019.104539 · 2020 · External reference
Global threat of arsenic in groundwater
10.1126/science.aba1510 · 2020 · External reference
'Environmental standard limit concentration' arsenic exposure is associated with anxiety, depression, and autism-like changes in early-life stage zebrafish
10.1016/j.jhazmat.2024.133953 · 2024 · External reference
Arsenic exposure and cardiovascular disease: an updated systematic review
10.1007/s11883-012-0280-x · 2012 · External reference
The association of Arsenic exposure and metabolism biomarkers with subclinical measures of liver disease: a cross-sectional investigation in the multi-ethnic study of atherosclerosis
10.1021/ehp.6c00759 · 2025 · External reference
Lung and kidney cancer mortality associated with arsenic in drinking water in Córdoba, Argentina
10.1093/ije/27.4.561 · 1998 · External reference
Construction of an adverse outcome pathway framework based on integrated data to evaluate arsenic-induced non-alcoholic fatty liver disease
10.1016/j.envint.2023.108381 · 2024 · External reference
Found in translation-fibrosis in metabolic dysfunction-associated steatohepatitis (MASH)
10.1126/scitranslmed.adi0759 · 2023 · External reference
Cellular stress in the pathogenesis of nonalcoholic steatohepatitis and liver fibrosis
10.1038/s41575-023-00832-w · 2023 · External reference
AS3MT facilitates NLRP3 inflammasome activation by m(6)A modification during arsenic-induced hepatic insulin resistance
10.1007/s10565-022-09703-7 · 2023 · External reference
Taurine attenuates arsenic-induced pyroptosis and nonalcoholic steatohepatitis by inhibiting the autophagic-inflammasomal pathway
10.1038/s41419-018-1004-0 · 2018 · External reference
Ferroptosis: mechanisms, biology and role in disease
10.1038/s41580-020-00324-8 · 2021 · External reference
Ferroptosis at the intersection of lipid metabolism and cellular signaling
10.1016/j.molcel.2022.03.022 · 2022 · External reference
Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies
10.1038/s41392-024-01769-5 · 2024 · External reference
Ferroptosis as a novel therapeutic target for cardiovascular disease
10.7150/thno.54113 · 2021 · External reference
Ferroptosis mediated by the interaction between Mfn2 and IREα promotes arsenic-induced nonalcoholic steatohepatitis
10.1016/j.envres.2020.109824 · 2020 · External reference
RNA-binding proteins and their role in kidney disease
10.1038/s41581-021-00497-1 · 2022 · External reference
RNA-binding proteins in regulating mRNA stability and translation: roles and mechanisms in cancer
10.1016/j.semcancer.2022.03.025 · 2022 · External reference
Activation of cGAS/STING pathway upon TDP-43-mediated mitochondrial injury may be involved in the pathogenesis of liver fibrosis
10.1111/liv.14895 · 2021 · External reference
NLRP3 inflammasome blocked the glycolytic pathway via targeting to PKLR in arsenic-induced hepatic insulin resistance
10.1016/j.ecoenv.2021.112590 · 2021 · External reference
Amino acid transporter LAT1 in tumor-associated vascular endothelium promotes angiogenesis by regulating cell proliferation and VEGF-A-dependent mTORC1 activation
10.1186/s13046-020-01762-0 · 2020 · External reference
SLC7A11-ROS/αKG-AMPK axis regulates liver inflammation through mitophagy and impairs liver fibrosis and NASH progression
10.1016/j.redox.2024.103159 · 2024 · External reference
Regulation of TRIB1 abundance in hepatocyte models in response to proteasome inhibition
10.1038/s41598-023-36512-7 · 2023 · External reference
A stress-dependent TDP-43 SUMOylation program preserves neuronal function
10.1186/s13024-025-00826-z · 2025 · External reference
SUMOylation regulates TDP-43 splicing activity and nucleocytoplasmic distribution
10.1007/s12035-021-02505-8 · 2021 · External reference
SUMO2/3 conjugation of TDP-43 protects against aggregation
10.1126/sciadv.adq2475 · 2025 · External reference
Regulation of glypican 6-mediated Wnt activation maintains TDP-43 nuclear localization in neurons
10.1038/s41598-025-32069-9 · 2025 · External reference
Nuclear pore complex dysfunction drives TDP-43 pathology in ALS
10.1016/j.redox.2025.103824 · 2025 · External reference
Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export
10.1016/j.celrep.2022.111106 · 2022 · External reference
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
10.1038/nn.2779 · 2011 · External reference
TDP-43 binds to RNA G-quadruplex structure and regulates mRNA stability and translation
10.1093/nar/gkaf820 · 2025 · External reference
TDP-43 upregulates lipid metabolism modulator ABHD2 to suppress apoptosis in hepatocellular carcinoma
10.1038/s42003-022-03788-w · 2022 · External reference
TDP-43 associates with stalled ribosomes and contributes to cell survival during cellular stress
10.1111/jnc.12194 · 2013 · External reference
TDP-43, an ALS linked protein, regulates fat deposition and glucose homeostasis
10.1371/journal.pone.0071793 · 2013 · External reference
Western diet promotes the progression of metabolic dysfunction-associated steatotic liver disease in association with ferroptosis in male mice
2024 · External reference
Ferroptosis: biology and role in liver disease
10.1007/s00535-025-02300-5 · 2025 · External reference
Interactions of y+LAT1 and 4F2hc in the y+l amino acid transporter complex: consequences of lysinuric protein intolerance-causing mutations
10.4149/gpb_2013050 · 2013 · External reference
CD98 heavy chain as a prognostic biomarker and target for cancer treatment
10.3389/fonc.2023.1251100 · 2023 · External reference
Identification and characterisation of human xCT that co-expresses, with 4F2 heavy chain, the amino acid transport activity system xc
10.1007/s004240100537 · 2001 · External reference
Empagliflozin alleviates type 2 diabetic renal fibrosis by inhibiting SLC7A7-mediated ferroptosis
10.1186/s13098-025-01902-6 · 2025 · External reference
Liver ALKBH5 regulates glucose and lipid homeostasis independently through GCGR and mTORC1 signaling
10.1126/science.adp4120 · 2025 · External reference
High exposure to inorganic arsenic by food: the need for risk reduction
10.1007/s00204-015-1627-1 · ExternalCitation · doi-reference
Identification and characterisation of human xCT that co-expresses, with 4F2 heavy chain, the amino acid transport activity system xc
10.1007/s004240100537 · ExternalCitation · doi-reference
Ferroptosis: biology and role in liver disease
10.1007/s00535-025-02300-5 · ExternalCitation · doi-reference
AS3MT facilitates NLRP3 inflammasome activation by m(6)A modification during arsenic-induced hepatic insulin resistance
10.1007/s10565-022-09703-7 · ExternalCitation · doi-reference
Arsenic exposure and cardiovascular disease: an updated systematic review
10.1007/s11883-012-0280-x · ExternalCitation · doi-reference
SUMOylation regulates TDP-43 splicing activity and nucleocytoplasmic distribution
10.1007/s12035-021-02505-8 · ExternalCitation · doi-reference
Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export
10.1016/j.celrep.2022.111106 · ExternalCitation · doi-reference
NLRP3 inflammasome blocked the glycolytic pathway via targeting to PKLR in arsenic-induced hepatic insulin resistance
10.1016/j.ecoenv.2021.112590 · ExternalCitation · doi-reference
Construction of an adverse outcome pathway framework based on integrated data to evaluate arsenic-induced non-alcoholic fatty liver disease
10.1016/j.envint.2023.108381 · ExternalCitation · doi-reference
Ferroptosis mediated by the interaction between Mfn2 and IREα promotes arsenic-induced nonalcoholic steatohepatitis
10.1016/j.envres.2020.109824 · ExternalCitation · doi-reference
'Environmental standard limit concentration' arsenic exposure is associated with anxiety, depression, and autism-like changes in early-life stage zebrafish
10.1016/j.jhazmat.2024.133953 · ExternalCitation · doi-reference
Ferroptosis at the intersection of lipid metabolism and cellular signaling
10.1016/j.molcel.2022.03.022 · ExternalCitation · doi-reference
SLC7A11-ROS/αKG-AMPK axis regulates liver inflammation through mitophagy and impairs liver fibrosis and NASH progression
10.1016/j.redox.2024.103159 · ExternalCitation · doi-reference
Nuclear pore complex dysfunction drives TDP-43 pathology in ALS
10.1016/j.redox.2025.103824 · ExternalCitation · doi-reference
RNA-binding proteins in regulating mRNA stability and translation: roles and mechanisms in cancer
10.1016/j.semcancer.2022.03.025 · ExternalCitation · doi-reference
Arsenic exposure: a public health problem leading to several cancers
10.1016/j.yrtph.2019.104539 · ExternalCitation · doi-reference
The association of Arsenic exposure and metabolism biomarkers with subclinical measures of liver disease: a cross-sectional investigation in the multi-ethnic study of atherosclerosis
10.1021/ehp.6c00759 · ExternalCitation · doi-reference
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
10.1038/nn.2779 · ExternalCitation · doi-reference
Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies
10.1038/s41392-024-01769-5 · ExternalCitation · doi-reference
Taurine attenuates arsenic-induced pyroptosis and nonalcoholic steatohepatitis by inhibiting the autophagic-inflammasomal pathway
10.1038/s41419-018-1004-0 · ExternalCitation · doi-reference
Cellular stress in the pathogenesis of nonalcoholic steatohepatitis and liver fibrosis
10.1038/s41575-023-00832-w · ExternalCitation · doi-reference
Ferroptosis: mechanisms, biology and role in disease
10.1038/s41580-020-00324-8 · ExternalCitation · doi-reference
RNA-binding proteins and their role in kidney disease
10.1038/s41581-021-00497-1 · ExternalCitation · doi-reference
Regulation of TRIB1 abundance in hepatocyte models in response to proteasome inhibition
10.1038/s41598-023-36512-7 · ExternalCitation · doi-reference
Regulation of glypican 6-mediated Wnt activation maintains TDP-43 nuclear localization in neurons
10.1038/s41598-025-32069-9 · ExternalCitation · doi-reference
TDP-43 upregulates lipid metabolism modulator ABHD2 to suppress apoptosis in hepatocellular carcinoma
10.1038/s42003-022-03788-w · ExternalCitation · doi-reference
Lung and kidney cancer mortality associated with arsenic in drinking water in Córdoba, Argentina
10.1093/ije/27.4.561 · ExternalCitation · doi-reference
TDP-43 binds to RNA G-quadruplex structure and regulates mRNA stability and translation
10.1093/nar/gkaf820 · ExternalCitation · doi-reference
TDP-43 associates with stalled ribosomes and contributes to cell survival during cellular stress
10.1111/jnc.12194 · ExternalCitation · doi-reference
Activation of cGAS/STING pathway upon TDP-43-mediated mitochondrial injury may be involved in the pathogenesis of liver fibrosis
10.1111/liv.14895 · ExternalCitation · doi-reference
SUMO2/3 conjugation of TDP-43 protects against aggregation
10.1126/sciadv.adq2475 · ExternalCitation · doi-reference
Global threat of arsenic in groundwater
10.1126/science.aba1510 · ExternalCitation · doi-reference
Liver ALKBH5 regulates glucose and lipid homeostasis independently through GCGR and mTORC1 signaling
10.1126/science.adp4120 · ExternalCitation · doi-reference
Found in translation-fibrosis in metabolic dysfunction-associated steatohepatitis (MASH)
10.1126/scitranslmed.adi0759 · ExternalCitation · doi-reference
Arsenic: a global environmental challenge
10.1146/annurev-pharmtox-030220-013418 · ExternalCitation · doi-reference
A stress-dependent TDP-43 SUMOylation program preserves neuronal function
10.1186/s13024-025-00826-z · ExternalCitation · doi-reference
Amino acid transporter LAT1 in tumor-associated vascular endothelium promotes angiogenesis by regulating cell proliferation and VEGF-A-dependent mTORC1 activation
10.1186/s13046-020-01762-0 · ExternalCitation · doi-reference
Empagliflozin alleviates type 2 diabetic renal fibrosis by inhibiting SLC7A7-mediated ferroptosis
10.1186/s13098-025-01902-6 · ExternalCitation · doi-reference
TDP-43, an ALS linked protein, regulates fat deposition and glucose homeostasis
10.1371/journal.pone.0071793 · ExternalCitation · doi-reference
CD98 heavy chain as a prognostic biomarker and target for cancer treatment
10.3389/fonc.2023.1251100 · ExternalCitation · doi-reference
Interactions of y+LAT1 and 4F2hc in the y+l amino acid transporter complex: consequences of lysinuric protein intolerance-causing mutations
10.4149/gpb_2013050 · ExternalCitation · doi-reference
Ferroptosis as a novel therapeutic target for cardiovascular disease
10.7150/thno.54113 · ExternalCitation · doi-reference
