Research graph
References from Quinoline-aminothiophenol derivative triggers pronounced mitochondrial dysfunction and cell death in Leishmania infantum. Local targets link to admitted publications; unresolved targets remain external evidence.
Leishmaniasis
10.1016/s0140-6736(18)31204-2 · 2018 · External reference
Unresolved reference
2025 · External reference
What makes mucosal and anergic diffuse cutaneous leishmaniases so clinically and immunopathogically different? A review in Brazil
10.1093/trstmh/trz037 · 2019 · External reference
From infection to death: an overview of the pathogenesis of visceral leishmaniasis
10.3390/pathogens12070969 · 2023 · External reference
Leishmaniasis
10.1038/s41572-025-00663-w · 2025 · External reference
Leishmaniasis in humans and animals: a One Health approach for surveillance, prevention and control in a changing world
10.3390/tropicalmed9110258 · 2024 · External reference
Advances in development of new treatment for leishmaniasis
10.1155/2015/815023 · 2015 · External reference
Leishmaniases: strategies in treatment development
2025 · External reference
Therapeutic success and failure in using miltefosine to treat dogs naturally infected with Leishmania infantum
10.1590/s1984-29612024012 · 2024 · External reference
4-Aminoquinoline as a privileged scaffold for the design of leishmanicidal agents: structure-property relationships and key biological targets
10.3389/fchem.2024.1527946 · 2025 · External reference
Evolution of the quinoline scaffold for the treatment of leishmaniasis: a structural perspective
10.3390/ph17030285 · 2024 · External reference
Parasitological and immunological evaluation of a quinoline derivative salt incorporated into a polymeric micelle formulation against Leishmania infantum infection
10.1007/s00436-022-07544-1 · 2022 · External reference
Synthesis and biological activity of novel 4-aminoquinoline/1,2,3-triazole hybrids against Leishmania amazonensis
10.1016/j.biopha.2021.111857 · 2021 · External reference
Novel organic salts based on quinoline derivatives: the in vitro activity trigger apoptosis inhibiting autophagy in Leishmania spp
10.1016/j.cbi.2018.08.003 · 2018 · External reference
In vivo antimalarial and in vitro antileishmanial activity of 4-aminoquinoline derivatives hybridized to isoniazid or sulfa or hydrazine groups
10.2174/1570180813666160927113743 · 2017 · External reference
Small molecules containing chalcogen elements (S, Se, Te) as new warhead to fight neglected tropical diseases
10.1016/j.ejmech.2022.115002 · 2023 · External reference
Insights about resveratrol analogs against trypanothione reductase of Leishmania braziliensis: molecular modeling, computational docking and in vitro antileishmanial studies
10.1080/07391102.2018.1502096 · 2019 · External reference
10.1016/j.cbi.2022.110333
10.1016/j.cbi.2022.110333 · 2023 · External reference
Multiple mechanisms of action of a triazole-derived salt against Leishmania amazonensis: Apoptosis-like death and autophagy
10.1016/j.cbi.2025.111409 · 2025 · External reference
Effect of 1,2,3-triazole salts, non-classical bioisosteres of miltefosine, on Leishmania amazonensis
10.1016/j.bmc.2017.03.051 · 2017 · External reference
Resveratrol analogues present effective antileishmanial activity against promastigotes and amastigotes from distinct Leishmania species by multitarget action in the parasites
10.1111/jphp.13177 · 2019 · External reference
ADMET-AI: a machine learning ADMET platform for evaluation of large-scale chemical libraries
10.1093/bioinformatics/btae416 · 2024 · External reference
ADMETlab 3.0: an updated comprehensive online ADMET prediction platform enhanced with broader coverage, improved performance, API functionality and decision support
10.1093/nar/gkae236 · 2024 · External reference
pkCSM: predicting small-molecule pharmacokinetic and toxicity properties using graph-based signatures
10.1021/acs.jmedchem.5b00104 · 2015 · External reference
Deep-PK: deep learning for small molecule pharmacokinetic and toxicity prediction
10.1093/nar/gkae254 · 2024 · External reference
SuperPred 3.0: drug classification and target prediction-a machine learning approach
10.1093/nar/gkac297 · 2022 · External reference
Antileishmanial activity of a 4-hydrazinoquinoline derivative: induction of autophagy and apoptosis-related processes and effectiveness in experimental cutaneous leishmaniasis
10.1016/j.exppara.2018.10.007 · 2018 · External reference
Trypanosoma cruzi mitochondrial swelling and membrane potential collapse as primary evidence of the mode of action of naphthoquinone analogues
10.1186/1471-2180-13-196 · 2013 · External reference
Epigallocathechin-O-3-Gallate inhibits trypanothione reductase of Leishmania infantum, causing alterations in redox balance and leading to parasite death
2021 · External reference
Screening strategies to identify new chemical diversity for drug development to treat kinetoplastid infections
10.1017/s003118201300142x · 2014 · External reference
Are basic and lipophilic chain groups highly required in leishmanicidal quinolines to favor the phagolysosome accumulation
10.3389/fchem.2025.1655979 · 2025 · External reference
Structure-activity relationships and mechanistic studies of novel mitochondria-targeted, leishmanicidal derivatives of the 4-aminostyrylquinoline scaffold
10.1016/j.ejmech.2019.03.007 · 2019 · External reference
4‐aminoquinoline derivatives as potential antileishmanial agents
10.1111/cbdd.12540 · 2015 · External reference
Mitochondria and trypanosomatids: targets and drugs
10.1007/s11095-011-0586-3 · 2011 · External reference
The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function
10.1038/s41467-018-05655-x · 2018 · External reference
Molecular machineries shaping the mitochondrial inner membrane
10.1038/s41580-025-00854-z · 2025 · External reference
Mitochondrial cristae remodeling: mechanisms, functions, and pathology
10.1016/j.cellin.2025.100285 · 2025 · External reference
Deciphering mitochondria: unveiling their roles in mechanosensing and mechanotransduction
2025 · External reference
Redox metabolism in mitochondria of trypanosomatids
10.1089/ars.2012.4948 · 2013 · External reference
The double-edged sword in pathogenic trypanosomatids: the pivotal role of mitochondria in oxidative stress and bioenergetics
2014 · External reference
Lipid droplets of protozoan parasites: survival and pathogenicity
2022 · External reference
A chloroquinoline derivative presents effective in vitro and in vivo antileishmanial activity against Leishmania species that cause tegumentary and visceral leishmaniasis
10.1016/j.parint.2019.101966 · 2019 · External reference
Leishmania plasma membrane-general composition, structure and biological functions
10.1016/bs.ctm.2025.06.009 · 2025 · External reference
A semi-synthetic neolignan derivative from 42 dihydrodieugenol B selectively affects the bioenergetic system of Leishmania infantum and inhibits cell division
10.1038/s41598-019-42273-z · 2019 · External reference
Cell cycle, telomeres, and telomerase in Leishmania spp.: what do we know so far?
10.3390/cells10113195 · 2021 · External reference
Kojic acid promotes apoptosis-like death and cell cycle arrest in Leishmania (Leishmania) amazonensis promastigotes
10.1021/acsomega.5c04741 · 2025 · External reference
Sesamol induces apoptosis-like cell death in Leishmania donovani
10.3389/fcimb.2021.749420 · 2021 · External reference
Cell death in Leishmania
2019 · External reference
Different drugs, same end: ultrastructural hallmarks of autophagy in pathogenic protozoa
10.3389/fmicb.2022.856686 · 2022 · External reference
Autophagy in protists and their hosts: when, how and why?
2023 · External reference
Biological roles for the NOX family NADPH oxidases
10.1074/jbc.r700045200 · 2008 · External reference
Role of nitric oxide in immune responses against viruses: beyond microbicidal activity
10.1007/s00011-015-0857-2 · 2015 · External reference
Induction, propagation, and activity of host nitric oxide: lessons from Leishmania infection
10.1016/j.pt.2015.08.001 · 2015 · External reference
Crucial role of cytosolic tryparedoxin peroxidase in Leishmania donovani survival, drug response and virulence
2008 · External reference
Role of nitric oxide in immune responses against viruses: beyond microbicidal activity
10.1007/s00011-015-0857-2 · ExternalCitation · doi-reference
Parasitological and immunological evaluation of a quinoline derivative salt incorporated into a polymeric micelle formulation against Leishmania infantum infection
10.1007/s00436-022-07544-1 · ExternalCitation · doi-reference
Mitochondria and trypanosomatids: targets and drugs
10.1007/s11095-011-0586-3 · ExternalCitation · doi-reference
Leishmania plasma membrane-general composition, structure and biological functions
10.1016/bs.ctm.2025.06.009 · ExternalCitation · doi-reference
Synthesis and biological activity of novel 4-aminoquinoline/1,2,3-triazole hybrids against Leishmania amazonensis
10.1016/j.biopha.2021.111857 · ExternalCitation · doi-reference
Effect of 1,2,3-triazole salts, non-classical bioisosteres of miltefosine, on Leishmania amazonensis
10.1016/j.bmc.2017.03.051 · ExternalCitation · doi-reference
Novel organic salts based on quinoline derivatives: the in vitro activity trigger apoptosis inhibiting autophagy in Leishmania spp
10.1016/j.cbi.2018.08.003 · ExternalCitation · doi-reference
10.1016/j.cbi.2022.110333
10.1016/j.cbi.2022.110333 · ExternalCitation · doi-reference
Multiple mechanisms of action of a triazole-derived salt against Leishmania amazonensis: Apoptosis-like death and autophagy
10.1016/j.cbi.2025.111409 · ExternalCitation · doi-reference
Mitochondrial cristae remodeling: mechanisms, functions, and pathology
10.1016/j.cellin.2025.100285 · ExternalCitation · doi-reference
Structure-activity relationships and mechanistic studies of novel mitochondria-targeted, leishmanicidal derivatives of the 4-aminostyrylquinoline scaffold
10.1016/j.ejmech.2019.03.007 · ExternalCitation · doi-reference
Small molecules containing chalcogen elements (S, Se, Te) as new warhead to fight neglected tropical diseases
10.1016/j.ejmech.2022.115002 · ExternalCitation · doi-reference
Antileishmanial activity of a 4-hydrazinoquinoline derivative: induction of autophagy and apoptosis-related processes and effectiveness in experimental cutaneous leishmaniasis
10.1016/j.exppara.2018.10.007 · ExternalCitation · doi-reference
A chloroquinoline derivative presents effective in vitro and in vivo antileishmanial activity against Leishmania species that cause tegumentary and visceral leishmaniasis
10.1016/j.parint.2019.101966 · ExternalCitation · doi-reference
Induction, propagation, and activity of host nitric oxide: lessons from Leishmania infection
10.1016/j.pt.2015.08.001 · ExternalCitation · doi-reference
Leishmaniasis
10.1016/s0140-6736(18)31204-2 · ExternalCitation · doi-reference
Screening strategies to identify new chemical diversity for drug development to treat kinetoplastid infections
10.1017/s003118201300142x · ExternalCitation · doi-reference
pkCSM: predicting small-molecule pharmacokinetic and toxicity properties using graph-based signatures
10.1021/acs.jmedchem.5b00104 · ExternalCitation · doi-reference
Kojic acid promotes apoptosis-like death and cell cycle arrest in Leishmania (Leishmania) amazonensis promastigotes
10.1021/acsomega.5c04741 · ExternalCitation · doi-reference
The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function
10.1038/s41467-018-05655-x · ExternalCitation · doi-reference
Leishmaniasis
10.1038/s41572-025-00663-w · ExternalCitation · doi-reference
Molecular machineries shaping the mitochondrial inner membrane
10.1038/s41580-025-00854-z · ExternalCitation · doi-reference
A semi-synthetic neolignan derivative from 42 dihydrodieugenol B selectively affects the bioenergetic system of Leishmania infantum and inhibits cell division
10.1038/s41598-019-42273-z · ExternalCitation · doi-reference
Biological roles for the NOX family NADPH oxidases
10.1074/jbc.r700045200 · ExternalCitation · doi-reference
Insights about resveratrol analogs against trypanothione reductase of Leishmania braziliensis: molecular modeling, computational docking and in vitro antileishmanial studies
10.1080/07391102.2018.1502096 · ExternalCitation · doi-reference
Redox metabolism in mitochondria of trypanosomatids
10.1089/ars.2012.4948 · ExternalCitation · doi-reference
ADMET-AI: a machine learning ADMET platform for evaluation of large-scale chemical libraries
10.1093/bioinformatics/btae416 · ExternalCitation · doi-reference
SuperPred 3.0: drug classification and target prediction-a machine learning approach
10.1093/nar/gkac297 · ExternalCitation · doi-reference
ADMETlab 3.0: an updated comprehensive online ADMET prediction platform enhanced with broader coverage, improved performance, API functionality and decision support
10.1093/nar/gkae236 · ExternalCitation · doi-reference
Deep-PK: deep learning for small molecule pharmacokinetic and toxicity prediction
10.1093/nar/gkae254 · ExternalCitation · doi-reference
What makes mucosal and anergic diffuse cutaneous leishmaniases so clinically and immunopathogically different? A review in Brazil
10.1093/trstmh/trz037 · ExternalCitation · doi-reference
4‐aminoquinoline derivatives as potential antileishmanial agents
10.1111/cbdd.12540 · ExternalCitation · doi-reference
Resveratrol analogues present effective antileishmanial activity against promastigotes and amastigotes from distinct Leishmania species by multitarget action in the parasites
10.1111/jphp.13177 · ExternalCitation · doi-reference
Advances in development of new treatment for leishmaniasis
10.1155/2015/815023 · ExternalCitation · doi-reference
Trypanosoma cruzi mitochondrial swelling and membrane potential collapse as primary evidence of the mode of action of naphthoquinone analogues
10.1186/1471-2180-13-196 · ExternalCitation · doi-reference
Therapeutic success and failure in using miltefosine to treat dogs naturally infected with Leishmania infantum
10.1590/s1984-29612024012 · ExternalCitation · doi-reference
In vivo antimalarial and in vitro antileishmanial activity of 4-aminoquinoline derivatives hybridized to isoniazid or sulfa or hydrazine groups
10.2174/1570180813666160927113743 · ExternalCitation · doi-reference
4-Aminoquinoline as a privileged scaffold for the design of leishmanicidal agents: structure-property relationships and key biological targets
10.3389/fchem.2024.1527946 · ExternalCitation · doi-reference
Are basic and lipophilic chain groups highly required in leishmanicidal quinolines to favor the phagolysosome accumulation
10.3389/fchem.2025.1655979 · ExternalCitation · doi-reference
Sesamol induces apoptosis-like cell death in Leishmania donovani
10.3389/fcimb.2021.749420 · ExternalCitation · doi-reference
Different drugs, same end: ultrastructural hallmarks of autophagy in pathogenic protozoa
10.3389/fmicb.2022.856686 · ExternalCitation · doi-reference
Cell cycle, telomeres, and telomerase in Leishmania spp.: what do we know so far?
10.3390/cells10113195 · ExternalCitation · doi-reference
From infection to death: an overview of the pathogenesis of visceral leishmaniasis
10.3390/pathogens12070969 · ExternalCitation · doi-reference
Evolution of the quinoline scaffold for the treatment of leishmaniasis: a structural perspective
10.3390/ph17030285 · ExternalCitation · doi-reference
Leishmaniasis in humans and animals: a One Health approach for surveillance, prevention and control in a changing world
10.3390/tropicalmed9110258 · ExternalCitation · doi-reference
