Research graph
References from A mushroom-derived bioactive compound, Vialinin A, attenuates doxorubicin-induced cardiotoxicity via SUCLG2-associated mitochondrial protection. Local targets link to admitted publications; unresolved targets remain external evidence.
A comprehensive review on time-tested anticancer drug doxorubicin
10.1016/j.lfs.2021.119527 · 2021 · External reference
Clinical ascertainment of health outcomes among adults treated for childhood cancer
10.1001/jama.2013.6296 · 2013 · External reference
Exploring the effects of doxorubicin on survival rates in glioma patients: a comprehensive systematic review
10.1186/s40001-025-02674-5 · 2025 · External reference
Emerging research and future directions on doxorubicin: a snapshot
10.31557/apjcp.2025.26.1.5 · 2025 · External reference
Drug‐induced oxidative stress and toxicity
2012 · External reference
Cardiomyocyte autophagy and cancer chemotherapy
10.1016/j.yjmcc.2013.11.007 · 2014 · External reference
Doxorubicin‐induced cardiomyopathy in children
10.1002/j.2040-4603.2019.tb00082.x · 2019 · External reference
Doxorubicin-induced apoptosis: implications in cardiotoxicity
10.1023/a:1015976430790 · 2002 · External reference
Immunotherapy for brain tumors: understanding early successes and limitations
10.1080/14737175.2018.1425617 · 2018 · External reference
2016 ESC position paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC committee for practice guidelines the task force for cancer treatments and cardiovascular toxicity of the european society of cardiology (ESC)
10.1002/ejhf.654 · 2017 · External reference
Doxorubicin-induced cardiotoxicity: an overview on pre-clinical therapeutic approaches
10.1007/s12012-022-09721-1 · 2022 · External reference
Anthracycline-induced cardiotoxicity—are we about to clear this hurdle?
10.1016/j.ejca.2023.02.019 · 2023 · External reference
Anthracycline chemotherapy and cardiotoxicity
10.1007/s10557-016-6711-0 · 2017 · External reference
Dexrazoxane-associated risk for acute myeloid leukemia/myelodysplastic syndrome and other secondary malignancies in pediatric Hodgkin's disease
10.1200/jco.2005.02.3879 · 2007 · External reference
Targeting mitochondrial dynamics proteins for the treatment of doxorubicin-induced cardiotoxicity
10.3389/fmolb.2023.1241225 · 2023 · External reference
Mitochondrial quality control mechanisms as molecular targets in cardiac ageing
10.1038/s41569-018-0059-z · 2018 · External reference
Mitochondrial determinants of doxorubicin-induced cardiomyopathy
10.1161/circresaha.119.314681 · 2020 · External reference
Mechanisms and advantages of natural derived small molecule compounds in the prevention and treatment of colorectal cancer: a review
10.3389/fphar.2025.1658493 · 2025 · External reference
Natural products and ferroptosis: a novel approach for heart failure management
10.1016/j.phymed.2025.156783 · 2025 · External reference
Withania somnifera ameliorates doxorubicin-induced nephrotoxicity and potentiates its therapeutic efficacy targeting SIRT1/Nrf2, oxidative stress, inflammation, and apoptosis
10.3390/ph18020248 · 2025 · External reference
TLRs-JNK/NF-κB pathway underlies the protective effect of the sulfide salt against liver toxicity
10.3389/fphar.2022.850066 · 2022 · External reference
Edible mushrooms as potential functional foods in amelioration of hypertension
10.1002/ptr.7865 · 2023 · External reference
Fungal mushrooms: a natural compound with therapeutic applications
10.3389/fphar.2022.925387 · 2022 · External reference
Marine fungi bioactives with anti-inflammatory, antithrombotic and antioxidant health-promoting properties against inflammation-related chronic diseases
10.3390/md22110520 · 2024 · External reference
Anticancer activities of thelephantin O and vialinin A isolated from Thelephora aurantiotincta
10.1021/jf200461j · 2011 · External reference
Vialinin A, a novel potent inhibitor of TNF-α production from RBL-2H3 cells
10.1248/bpb.31.831 · 2008 · External reference
Ubiquitously specific protease 4 inhibitor‐vialinin a attenuates inflammation and fibrosis in S100‐induced hepatitis mice through Rheb/mTOR signalling
10.1111/jcmm.16180 · 2021 · External reference
Inhibitory effects of vialinin A and its analog on tumor necrosis factor-α release and production from RBL-2H3 cells
10.1016/j.cellimm.2012.10.008 · 2012 · External reference
Vialinin A alleviates oxidative stress and neuronal injuries after ischaemic stroke by accelerating Keap1 degradation through inhibiting USP4-mediated deubiquitination
10.1016/j.phymed.2023.155304 · 2024 · External reference
Vialinin A, an antioxidant derived from edible mushrooms, prevents ocular inflammation
2025 · External reference
Inhibition of USP4 attenuates pathological scarring by downregulation of the TGF-β/Smad signaling pathway
2019 · External reference
Vialinin-A, an antioxidant isolated from edible mushroom thelephora vialis, inhibits colorectal cancer growth
10.1158/1538-7445.am2025-6321 · 2025 · External reference
Indole‐3‐Lactic acid inhibits doxorubicin‐induced ferroptosis through activating aryl hydrocarbon receptor/nrf2 signalling pathway
10.1111/jcmm.70358 · 2025 · External reference
Kartogenin improves Doxorubicin-Induced cardiotoxicity by alleviating oxidative stress and protecting mitochondria
10.3390/ijms26062434 · 2025 · External reference
SIRT3 promotes metabolic maturation of human iPSC-derived cardiomyocytes via OPA1-controlled mitochondrial dynamics
10.1016/j.freeradbiomed.2022.12.101 · 2023 · External reference
10-hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence in male mice preclinically
10.1038/s41467-024-51746-3 · 2024 · External reference
Cardioprotection with dexrazoxane for doxorubicin-containing therapy in advanced breast cancer
10.1200/jco.1997.15.4.1318 · 1997 · External reference
Doxorubicin and CpG loaded liposomal spherical nucleic acid for enhanced Cancer treatment
10.1186/s12951-022-01353-5 · 2022 · External reference
The role of mitochondrial dynamics in doxorubicin‐induced disease: implications for therapy
10.1002/jcp.70064 · 2025 · External reference
Assessing drug-induced mitochondrial toxicity in cardiomyocytes: implications for preclinical cardiac safety evaluation
10.3390/pharmaceutics14071313 · 2022 · External reference
Mitochondrial quality control mechanisms as therapeutic targets in doxorubicin-induced cardiotoxicity
10.1016/j.tips.2022.10.003 · 2023 · External reference
Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling
10.1073/pnas.1414665111 · 2014 · External reference
Protective role of key micronutrients in chemotherapy-induced organ toxicity: a comprehensive review of mechanistic insights and clinical implications
10.3390/nu17172838 · 2025 · External reference
SUCLG2 regulates mitochondrial dysfunction through succinylation in lung adenocarcinoma
10.1002/advs.202303535 · 2023 · External reference
Knockdown of SUCLG2 inhibits glioblastoma proliferation and promotes apoptosis through LMNA acetylation and the mediation of H4K16la lactylation
10.1038/s41420-025-02856-4 · 2025 · External reference
CircPSD3 aggravates tumor progression by maintaining TCA cycle and mitochondrial function via regulating SUCLG2 in thyroid carcinoma
10.1038/s41419-025-07856-x · 2025 · External reference
Polyphenolic-enriched olive leaf extract attenuated doxorubicin-induced cardiotoxicity in rats via suppression of oxidative stress and inflammation
10.1186/s41936-021-00251-w · 2021 · External reference
Cardioprotective potential of Moringa oleifera leaf extract loaded niosomes nanoparticles-against doxorubicin toxicity in rats
10.2174/0113892010303097240605105013 · 2025 · External reference
Biochanin a alleviated doxorubicin‐induced cardiotoxicity but did not interfere with the antitumor effect of doxorubicin
10.1002/ptr.8525 · 2025 · External reference
Binding of vialinin A and p-Terphenyl derivatives to ubiquitin-specific protease 4 (USP4): a molecular docking study
10.3390/molecules27185909 · 2022 · External reference
Unraveling the mechanism of action of ubiquitin-specific protease 5 and its inhibitors in tumors
10.1177/11795549241281932 · 2024 · External reference
Vialinin A and thelephantin G, potent inhibitors of tumor necrosis factor-α production, inhibit sentrin/SUMO-specific protease 1 enzymatic activity
10.1016/j.bmcl.2016.07.051 · 2016 · External reference
