Research graph
References from Chronic tetracycline exposure resulted in VPS13 dysregulation, lipid accumulation, and physiological impairments in Drosophila melanogaster. Local targets link to admitted publications; unresolved targets remain external evidence.
Chronic exposure to environmentally relevant concentrations of tetracycline perturbs gut homeostasis in Zebrafish
10.1021/envhealth.3c00072 · 2023 · External reference
Antibiotics in the environment: causes and consequences
10.15386/mpr-1742 · 2020 · External reference
Remediation of tetracycline pollution using microplastics, green materials, membranes and sonocatalysts: a review
10.1007/s10311-024-01777-5 · 2024 · External reference
A wearable gloved sensor based on fluorescent Ag nanoparticles and europium complexes for visualized assessment of tetracycline in food samples
10.1016/j.foodchem.2023.136376 · 2023 · External reference
Multigenerational effects of the antibiotic tetracycline on transcriptional responses of Daphnia magna and its relationship to higher levels of biological organizations
10.1021/acs.est.7b05050 · 2017 · External reference
Combined exposure to titanium dioxide and tetracycline induces neurotoxicity in Zebrafish
2023 · External reference
Sex-dependent obesogenic effect of tetracycline on Drosophila melanogaster deteriorated by dysrhythmia
10.1016/j.jes.2021.11.029 · 2023 · External reference
Changes in weight and body fat after use of tetracycline and Lactobacillus gasseri in rats
10.1590/s2175-97902017000116059 · 2017 · External reference
Increased hepatic fatty acid uptake and esterification contribute to tetracycline-induced steatosis in mice
10.1093/toxsci/kfv049 · 2015 · External reference
The Vps13 family of lipid transporters and its role at membrane contact sites
10.3390/ijms22062905 · 2021 · External reference
Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility
10.7554/elife.43561 · 2019 · External reference
Low doses of the organic insecticide spinosad trigger lysosomal defects, elevated ROS, lipid dysregulation, and neurodegeneration in flies
10.7554/elife.73812 · 2022 · External reference
The herbicide acetochlor causes lipid peroxidation by inhibition of glutathione peroxidase activity
10.1093/toxsci/kfae113 · 2024 · External reference
Drosophila–a versatile model in biology & medicine
10.1016/s1369-7021(11)70113-4 · 2011 · External reference
Formulation of Drosophila food for various feeding studies
2019 · External reference
Tetracyclines disturb mitochondrial function across eukaryotic models: a call for caution in biomedical research
10.1016/j.celrep.2015.02.034 · 2015 · External reference
Energy homeostasis control in Drosophila adipokinetic hormone mutants
10.1534/genetics.115.178897 · 2015 · External reference
A trade-off between desiccation resistance and developmental humidity for pupation height in the North Indian seasonal population of Drosophilid-Zaprionus indianus
10.1016/j.cbpa.2024.111684 · 2024 · External reference
Motor dysfunction in Drosophila melanogaster as a biomarker for developmental neurotoxicity
10.1016/j.isci.2022.104541 · 2022 · External reference
Ecdysone quantification from whole body samples of Drosophila melanogaster larvae
10.21769/bioprotoc.3915 · 2021 · External reference
Stop codon readthrough alters the activity of a POU/Oct transcription factor during Drosophila development
10.1186/s12915-021-01106-0 · 2021 · External reference
Cooperative control of ecdysone biosynthesis in Drosophila by transcription factors Séance, Ouija board, and molting defective
10.1534/genetics.117.300268 · 2018 · External reference
A buoyancy-based screen of Drosophila larvae for fat-storage mutants reveals a role for Sir2 in coupling fat storage to nutrient availability
10.1371/journal.pgen.1001206 · 2010 · External reference
Detection of lipid depot within drosophila
2019 · External reference
Biochemical estimation to detect the metabolic pathways of Drosophila
2019 · External reference
In vivo toxicological analysis of MnFe2O4@ poly (t BGE-alt-PA) composite as a hybrid nanomaterial for possible biomedical use
10.1021/acsabm.2c00983 · 2023 · External reference
Platinum accumulation and antioxidant dysregulation drive behavioral impairments, apoptosis and neurodegeneration in Oxaliplatin exposed Drosophila Melanogaster
2025 · External reference
Unravelling the mechanism of N-Acetylcysteine in alleviating smoke-induced hypoxia-driven ocular defects in Drosophila melanogaster
10.1007/s12035-025-05593-y · 2026 · External reference
A high throughput and sensitive method correlates neuronal disorder genotypes to Drosophila larvae crawling phenotypes
10.4161/fly.21582 · 2012 · External reference
Fe3O4 coated guargum nanoparticles as non-genotoxic materials for biological application
10.1016/j.ijbiomac.2020.09.144 · 2020 · External reference
Testing the therapeutic potential of doxycycline in a Drosophila melanogaster model of Alzheimer disease
10.1074/jbc.m111.274548 · 2011 · External reference
Comparative toxicity evaluation of graphene oxide (GO) and zinc oxide (ZnO) nanoparticles on Drosophila melanogaster
10.1016/j.toxrep.2019.07.009 · 2019 · External reference
VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites
10.1083/jcb.201807019 · 2018 · External reference
Role of VPS13, a protein with similarity to ATG2, in physiology and disease
10.1016/j.gde.2020.05.027 · 2020 · External reference
Unresolved reference
2018 · External reference
Ecdysone control of developmental transitions: lessons from Drosophila research
10.1146/annurev-ento-120811-153608 · 2013 · External reference
Endocrine network essential for reproductive success in Drosophila melanogaster
10.1073/pnas.1620760114 · 2017 · External reference
Lipids activate skeletal muscle mitochondrial fission and quality control networks to induce insulin resistance in humans
10.1016/j.metabol.2021.154803 · 2021 · External reference
The impact of tetracycline pollution on the aquatic environment and removal strategies
10.3390/antibiotics12030440 · 2023 · External reference
A review on current pollution and removal methods of tetracycline in soil
10.1080/01496395.2023.2259079 · 2023 · External reference
Tetracycline antibiotics in the environment: a review
10.1007/s10311-013-0404-8 · 2013 · External reference
Unresolved reference
2017 · External reference
Life-history evolution and the genetics of fitness components in Drosophila melanogaster
10.1534/genetics.119.300160 · 2020 · External reference
Endoreplication in the Drosophila melanogaster prothoracic gland is dispensable for the critical weight checkpoint
2023 · External reference
Lifespan and ROS levels in different Drosophila melanogaster strains after 24 h hypoxia exposure
10.1242/bio.059386 · 2022 · External reference
Phantom encodes the 25-hydroxylase of Drosophila melanogaster and Bombyx mori: a P450 enzyme critical in ecdysone biosynthesis
10.1016/j.ibmb.2004.06.009 · 2004 · External reference
Multi-generational obesogenic effects of sulfomethoxazole on Caenorhabditis elegans through epigenetic regulation
10.1016/j.jhazmat.2019.121061 · 2020 · External reference
Toxicological effects of ciprofloxacin exposure to Drosophila melanogaster
10.1016/j.chemosphere.2019.124542 · 2019 · External reference
Obesogenic effect of sulfamethoxazole on Drosophila melanogaster with simultaneous disturbances on eclosion rhythm, glucolipid metabolism, and microbiota
10.1021/acs.est.9b07889 · 2020 · External reference
Influences of sex, rhythm and generation on the obesogenic potential of erythromycin to Drosophila melanogaster
10.1016/j.scitotenv.2021.145315 · 2021 · External reference
Unresolved reference
2025 · External reference
Weight gain by gut microbiota manipulation in productive animals
10.1016/j.micpath.2016.11.002 · 2017 · External reference
Obesity, early life gut microbiota, and antibiotics
10.3390/microorganisms9020413 · 2021 · External reference
Antibiotic exposure in early life increases risk of childhood obesity: a systematic review and meta-analysis
10.3389/fendo.2017.00170 · 2017 · External reference
Long-term exposure to TET increases body weight of juvenile Zebrafish as indicated in host metabolism and gut microbiome
10.1016/j.envint.2020.105705 · 2020 · External reference
Induction of vesicular steatosis by amiodarone and tetracycline is associated with up‐regulation of lipogenic genes in heparg cells
10.1002/hep.24290 · 2011 · External reference
Environmentally relevant concentrations of oxytetracycline and copper increased liver lipid deposition through inducing oxidative stress and mitochondria dysfunction in grass carp Ctenopharyngodon idella
10.1016/j.envpol.2021.117079 · 2021 · External reference
Lipid droplet in lipodystrophy and neurodegeneration
10.1111/boc.70009 · 2025 · External reference
Drosophila Vps13 is required for protein homeostasis in the brain
10.1371/journal.pone.0170106 · 2017 · External reference
Loss of VPS13C function in autosomal-recessive parkinsonism causes mitochondrial dysfunction and increases PINK1/Parkin-dependent mitophagy
10.1016/j.ajhg.2016.01.014 · 2016 · External reference
Effects of lipids on mitochondrial functions
2017 · External reference
Lipids associated with autophagy: mechanisms and therapeutic targets
10.1038/s41420-024-02224-8 · 2024 · External reference
Mitochondrial fission, fusion, and stress
10.1126/science.1219855 · 2012 · External reference
Artesunate improves glucose and lipid metabolism in db/db mice by regulating the metabolic profile and the MAPK/PI3K/Akt signalling pathway
10.1016/j.phymed.2024.155382 · 2024 · External reference
Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4‐hydroxy‐2‐nonenal
2014 · External reference
The roles of PINK1, Parkin, and mitochondrial fidelity in Parkinson's disease
10.1016/j.neuron.2014.12.007 · 2015 · External reference
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
10.1083/jcb.200809125 · 2008 · External reference
Fatty acid trafficking in starved cells: regulation by lipid droplet lipolysis, autophagy, and mitochondrial fusion dynamics
10.1016/j.devcel.2015.01.029 · 2015 · External reference
Lipid droplets and lipotoxicity during autophagy
10.1080/15548627.2017.1359451 · 2017 · External reference
Autophagy: renovation of cells and tissues
10.1016/j.cell.2011.10.026 · 2011 · External reference
Mechanisms of mitophagy
10.1038/nrm3028 · 2011 · External reference
Podophyllotoxin mediates hepatic toxicity via the C5a/C5aR/ROS/NLRP3 and cGMP/PKG/mTOR axis in rats based on toxicological evidence chain (TEC) concept by phosphoproteomic analysis
10.1016/j.ecoenv.2024.117441 · 2025 · External reference
20-Hydroxyecdysone protects against oxidative stress-induced neuronal injury by scavenging free radicals and modulating NF-κB and JNK pathways
10.1371/journal.pone.0050764 · 2012 · External reference
Steroid hormone synthesis in mitochondria
10.1016/j.mce.2013.04.014 · 2013 · External reference
Effects of tetracycline on developmental toxicity and molecular responses in Zebrafish (Danio rerio) embryos
10.1007/s10646-015-1417-9 · 2015 · External reference
Variation in mitochondrial DNA affects locomotor activity and sleep in Drosophila melanogaster
10.1038/s41437-022-00554-w · 2022 · External reference
The genetics of ageing
10.1038/nature08980 · 2010 · External reference
The mitochondrial basis of aging and age-related disorders
10.3390/genes8120398 · 2017 · External reference
The composition of the gut microbiota following early-life antibiotic exposure affects host health and longevity in later life
10.1016/j.celrep.2021.109564 · 2021 · External reference
Minocycline treatment increases resistance to oxidative stress and extends lifespan in Drosophila via FOXO
10.18632/oncotarget.21224 · 2017 · External reference
