Research graph
References from Integrated network toxicology, machine learning, and multi-omics characterization of 2,4-DTBP neurotoxicity. Local targets link to admitted publications; unresolved targets remain external evidence.
Distribution and fate of synthetic phenolic antioxidants in various wastewater treatment processes in Canada
10.1016/j.chemosphere.2018.12.068 · 2019 · External reference
Natural sources and bioactivities of 2,4-Di-Tert-Butylphenol and its analogs
10.3390/toxins12010035 · 2020 · External reference
Effects of the plastic additive 2,4-di-tert-butylphenol on intestinal microbiota of zebrafish
10.1016/j.jhazmat.2024.133987 · 2024 · External reference
Synthetic phenolic antioxidants: a review of environmental occurrence, fate, human exposure, and toxicity
10.1021/acs.est.0c05077 · 2020 · External reference
Occurrence of synthetic phenolic antioxidants and transformation products in urban and rural indoor dust
10.1016/j.envpol.2016.11.069 · 2017 · External reference
Exposure to environmental levels of 2,4-di-tert-butylphenol affects digestive glands and induces inflammation in Asian clam (Corbicula fluminea)
10.1016/j.scitotenv.2024.170054 · 2024 · External reference
Reactive oxygen species and cell signaling. Review
10.1016/j.bbamcr.2023.119573 · 2024 · External reference
Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging
10.1007/s00204-023-03562-9 · 2023 · External reference
Synthetic phenolic antioxidants: metabolism, hazards and mechanism of action
10.1016/j.foodchem.2021.129488 · 2021 · External reference
Synthetic phenolic antioxidants cause perturbation in steroidogenesis in vitro and in vivo
10.1021/acs.est.7b05057 · 2018 · External reference
Ovarian toxicity of 2,6-di-tert-butyl-hydroxytoluene on female ruditapes philippinarum: reproductive endocrine disruption and oxidative stress
10.1016/j.jhazmat.2025.138289 · 2025 · External reference
Long-term exposure to 2,4-di-tert-butylphenol impairs zebrafish fecundity and affects offspring development
10.1016/j.jhazmat.2025.138108 · 2025 · External reference
2,4-Di-tert-butylphenol induces adipogenesis in human mesenchymal stem cells by activating retinoid X receptors
10.1210/endocr/bqad021 · 2023 · External reference
Traumatic brain injuries: pathophysiology and potential therapeutic targets
10.3389/fncel.2019.00528 · 2019 · External reference
Role of environmental toxicants on neurodegenerative disorders
10.3389/ftox.2022.837579 · 2022 · External reference
Environmental toxins in neurodegeneration - a narrative review
10.1186/s42466-025-00452-6 · 2025 · External reference
MPP+ induces necrostatin-1- and ferrostatin-1-sensitive necrotic death of neuronal SH-SY5Y cells
10.1038/cddiscovery.2017.13 · 2017 · External reference
BID links ferroptosis to mitochondrial cell death pathways
10.1016/j.redox.2017.03.007 · 2017 · External reference
Downregulated NT-3 and PI3K/AKT signaling pathway mediates arsenic-induced apoptosis in hippocampal neurons in vivo and in vitro
10.1016/j.ecoenv.2025.118372 · 2025 · External reference
Activation of PI3k/Akt/mTOR signaling induces deposition of p-tau to promote aluminum neurotoxicity
10.1007/s12640-022-00573-9 · 2022 · External reference
NF-κB as an inducible regulator of inflammation in the central nervous system
10.3390/cells13060485 · 2024 · External reference
Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)
10.1186/1742-2094-8-79 · 2011 · External reference
Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases
10.1016/j.neuron.2014.06.007 · 2014 · External reference
On the modulatory roles of Neuregulins/ErbB signaling on synaptic plasticity
10.3390/ijms21010275 · 2019 · External reference
Parkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degeneration
10.1172/jci79300 · 2015 · External reference
GDNF/RET signaling pathway activation eliminates lewy body pathology in midbrain dopamine neurons
10.1002/mds.28258 · 2020 · External reference
Brain ischemia downregulates the neuroprotective GDNF-ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons
10.1038/cddis.2014.578 · 2015 · External reference
Soluble CSF1R promotes microglial activation and amyloid clearance in Alzheimer'S disease
10.1186/s12974-025-03558-5 · 2025 · External reference
Mutations in the human CSF1R gene impact microglia's maintenance of brain white matter integrity
10.1038/s41590-025-02195-7 · 2025 · External reference
Microglial depletion, a new tool in neuroinflammatory disorders: comparison of pharmacological inhibitors of the CSF-1R
10.1002/glia.24664 · 2025 · External reference
CSF1R signaling is a regulator of pathogenesis in progressive MS
10.1038/s41419-020-03084-7 · 2020 · External reference
The C-C chemokines CCL17 and CCL22 and their receptor CCR4 in CNS autoimmunity
10.3390/ijms18112306 · 2017 · External reference
The role of chemokines and chemokine receptors in multiple sclerosis
10.1016/j.intimp.2020.106314 · 2020 · External reference
Regulation of the ATP-Binding cassette transporters ABCB1, ABCG2 and ABCC5 by nuclear receptors in porcine blood-brain barrier endothelial cells
10.1111/bph.16196 · 2023 · External reference
Liproxstatin-1 protects SH-SY5Y cells by inhibiting H(2)O(2)-Induced excessive mitophagy and apoptosis
10.3390/ijms262311641 · 2025 · External reference
Targeting molecular mediators of ferroptosis and oxidative stress for neurological disorders
2022 · External reference
Ferroptosis at the crossroads of manganese-induced neurotoxicity: a retrospective study
10.1016/j.tox.2024.153727 · 2024 · External reference
Ferrostatin-1 inhibits ferroptosis and alleviates organophosphate nerve agent-induced cognitive deficits by regulating ACSL4/GPX4 and NCOA4/FTH1 pathways in the hippocampus of Guinea pigs
10.1016/j.ecoenv.2026.120401 · 2026 · External reference
Therapeutic potential of natural compounds for brain ischemia-reperfusion injury
10.3390/biology14091153 · 2025 · External reference
Environmental concentrations of 2, 4-DTBP cause immunotoxicity in zebrafish (Danio rerio) and May elicit ecological risk to wildlife
10.1016/j.chemosphere.2022.136465 · 2022 · External reference
NF-κB and JAK/STAT signaling pathways as crucial regulators of neuroinflammation and Astrocyte modulation in spinal cord injury
10.3390/cells13070581 · 2024 · External reference
Protein kinases in neurodegenerative diseases: current understandings and implications for drug discovery
10.1038/s41392-025-02179-x · 2025 · External reference
Ca(2+) dyshomeostasis disrupts neuronal and synaptic function in Alzheimer's Disease
10.3390/cells9122655 · 2020 · External reference
Amino acid metabolism in health and disease
10.1038/s41392-023-01569-3 · 2023 · External reference
Oxidative stress and inflammation in the pathogenesis of neurological disorders: mechanisms and implications
10.1016/j.apsb.2024.10.004 · 2025 · External reference
Neurons in a dish: a review of in vitro cell models for studying neurogenesis
10.1111/jnc.70344 · 2026 · External reference
