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References from Modulation of NF-κB signaling by Alternaria mycotoxins: in vitro and in silico insights into molecular mechanisms of immunosuppression in THP-1 monocytes. Local targets link to admitted publications; unresolved targets remain external evidence.
Alternaria mycotoxins: an overview of chemical characterization, producers, toxicity, analysis and occurrence in foodstuffs
10.3920/wmj2008.x013 · 2008 · External reference
Co-Occurrence and combinatory effects of alternaria mycotoxins and other xenobiotics of food origin: current scenario and future perspectives
10.3390/toxins11110640 · 2019 · External reference
Altersetin, a new antibiotic from cultures of endophytic alternaria spp. taxonomy, fermentation, isolation, structure elucidation and biological activities
10.7164/antibiotics.55.881 · 2002 · External reference
Absorption and metabolism of the mycotoxins alternariol and alternariol-9-methyl ether in Caco-2 cells in vitro
10.1007/s12550-009-0022-2 · 2009 · External reference
Hazard characterization of alternaria toxins to identify data gaps and improve risk assessment for human health
10.1007/s00204-023-03636-8 · 2024 · External reference
The alternaria mycotoxin alternariol triggers the immune response of IL-1β-stimulated, differentiated Caco-2 cells
10.1002/mnfr.201900341 · 2019 · External reference
THP-1 cell line: an in vitro cell model for immune modulation approach
10.1016/j.intimp.2014.08.002 · 2014 · External reference
Overview of the immune response
10.1016/j.jaci.2009.12.980 · 2010 · External reference
Inhibitory feedback control of NF-κB signalling in health and disease
10.1042/bcj20210139 · 2021 · External reference
NF-κB-An important player in xenoestrogen signaling in immune cells
10.3390/cells10071799 · 2021 · External reference
The mycotoxin alternariol suppresses lipopolysaccharide-induced inflammation in THP-1 derived macrophages targeting the NF-κB signalling pathway
10.1007/s00204-018-2299-4 · 2018 · External reference
Discovery of the alternaria mycotoxins alterperylenol and altertoxin I as novel immunosuppressive and antiestrogenic compounds in vitro
10.1007/s00204-024-03877-1 · 2025 · External reference
Resolving complexity: identification of altersetin and toxin mixtures responsible for the immunomodulatory, antiestrogenic and genotoxic potential of a complex Alternaria mycotoxin extract
10.1016/j.fct.2025.115315 · 2025 · External reference
Immunomodulatory potential of Alternaria mycotoxins on immune and intestinal cells: a comparative systematic in vitro study
10.1007/s00204-026-04346-7 · 2026 · External reference
The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease
10.1016/j.jaci.2013.09.007 · 2013 · External reference
The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression
10.1210/er.2002-0006 · 2003 · External reference
Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors
10.1128/mcb.15.2.943 · 1995 · External reference
Mycotoxin altertoxin II induces lipid peroxidation connecting mitochondrial stress response to NF-κB inhibition in THP-1 macrophages
10.1021/acs.chemrestox.9b00378 · 2020 · External reference
The IKK complex, a central regulator of NF-kappaB activation
10.1101/cshperspect.a000158 · 2010 · External reference
Alternaria toxins as casein kinase 2 inhibitors and possible consequences for estrogenicity: a hybrid in silico/in vitro study
10.1007/s00204-020-02746-x · 2020 · External reference
Combined in vitro and in silico mechanistic approach to explore the potential of Alternaria mycotoxins alternariol and altertoxin II to hamper γH2AX formation in DNA damage signaling pathways
10.1016/j.toxlet.2024.02.008 · 2024 · External reference
Crystal structure of a human IκB kinase β asymmetric dimer
10.1074/jbc.m113.482596 · 2013 · External reference
SwissDock, a protein-small molecule docking web service based on EADock DSS
10.1093/nar/gkr366 · 2011 · External reference
Attracting cavities 2.0: improving the flexibility and robustness for small-molecule docking
10.1021/acs.jcim.3c00054 · 2023 · External reference
VMD: visual molecular dynamics
1996 · External reference
Hit identification of IKK natural product inhibitor
10.1186/2050-6511-14-3 · 2013 · External reference
Ellagic acid and urolithin A modulate the immune response in LPS-stimulated U937 monocytic cells and THP-1 differentiated macrophages
10.1039/c9fo03008e · 2020 · External reference
Structural similarity with cholesterol reveals crucial insights into mechanisms sustaining the immunomodulatory activity of the mycotoxin alternariol
10.3390/cells9040847 · 2020 · External reference
Structural characterization of the caveolin scaffolding domain in association with cholesterol-rich membranes
10.1021/bi201356v · 2012 · External reference
Caveolin-1 regulates OMV-induced macrophage pro-inflammatory activation and multiple toll-like receptors
10.3389/fimmu.2023.1044834 · 2023 · External reference
Urolithin A attenuates pro-inflammatory mediator production by suppressing PI3-K/Akt/NF-κB and JNK/AP-1 signaling pathways in lipopolysaccharide-stimulated RAW264 macrophages: possible involvement of NADPH oxidase-derived reactive oxygen species
10.1016/j.ejphar.2018.06.023 · 2018 · External reference
The IκB kinase complex in NF-κB regulation and beyond
10.1002/embr.201337983 · 2014 · External reference
Analyzing kinase similarity in small molecule and protein structural space to explore the limits of multi-target screening
10.3390/molecules26030629 · 2021 · External reference
CK2 modulation of NF-kappaB, TP53, and the malignant phenotype in head and neck cancer by anti-CK2 oligonucleotides in vitro or in vivo via sub-50-nm nanocapsules
10.1158/1078-0432.ccr-09-3200 · 2010 · External reference
Alternaria alternata Mycotoxins activate the Aryl hydrocarbon receptor and Nrf2-ARE pathway to Alter the structure and immune response of Colon epithelial cells
10.1021/acs.chemrestox.1c00364 · 2022 · External reference
Urolithins, gut microbiota-derived metabolites of ellagitannins, inhibit LPS-induced inflammation in RAW 264.7 murine macrophages
10.1002/mnfr.201500264 · 2015 · External reference
Proliferatins suppress lipopolysaccharide-induced inflammation via inhibition of the NF-κB and MAPK signaling pathways
10.1016/j.bioorg.2022.105810 · 2022 · External reference
NF-κB inhibition attenuates LPS-induced TLR4 activation in monocyte cells
10.3892/mmr.2016.5825 · 2016 · External reference
The aryl hydrocarbon receptor: multitasking in the immune system
10.1146/annurev-immunol-032713-120245 · 2014 · External reference
Ah receptor and NF-kappaB interactions, a potential mechanism for dioxin toxicity
10.1074/jbc.274.1.510 · 1999 · External reference
Alternaria alternata toxins synergistically activate the Aryl hydrocarbon receptor pathway in vitro
10.3390/biom10071018 · 2020 · External reference
Activation of the Nrf2-ARE pathway by the Alternaria alternata mycotoxins altertoxin I and II
10.1007/s00204-016-1726-7 · 2017 · External reference
Modulation of the cellular redox status by the Alternaria toxins alternariol and alternariol monomethyl ether
10.1016/j.toxlet.2012.11.005 · 2013 · External reference
Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation
10.1016/j.cellsig.2010.06.004 · 2010 · External reference
NF-kappaB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages
10.1074/jbc.m602222200 · 2006 · External reference
NF-κB signaling in inflammation
10.1038/sigtrans.2017.23 · 2017 · External reference
The Alternaria alternata mycotoxin alternariol suppresses lipopolysaccharide-induced inflammation
10.3390/ijms18071577 · 2017 · External reference
MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8
10.18632/aging.100042 · 2009 · External reference
miR-146a is critical for endotoxin-induced tolerance
10.1074/jbc.m109.056317 · 2009 · External reference
NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
10.1073/pnas.0605298103 · 2006 · External reference
Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock
10.4049/jimmunol.179.8.5082 · 2007 · External reference
RelB, a new partner of aryl hydrocarbon receptor-mediated transcription
10.1210/me.2007-0211 · 2007 · External reference
Interaction of aryl hydrocarbon receptor and NF-κB subunit RelB in breast cancer is associated with interleukin-8 overexpression
10.1016/j.abb.2011.05.011 · 2011 · External reference
Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses
10.1084/jem.20090560 · 2009 · External reference
Indoxyl sulfate-induced TNF-α is regulated by crosstalk between the aryl hydrocarbon receptor, NF-κB, and SOCS2 in human macrophages
10.1096/fj.201900730r · 2019 · External reference
