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References from The emerging contaminant HFPO-TA impairs hepatic glucose metabolism and induces pparγ-associated lipid metabolic disorders in zebrafish. Local targets link to admitted publications; unresolved targets remain external evidence.
Themed issues on per- and polyfluoroalkyl substances
10.1039/c9em90047k · 2019 · External reference
Exposure to GenX and its novel analogs disrupts fatty acid metabolism in male mice
10.1016/j.envpol.2021.118202 · 2021 · External reference
Alternative and legacy Perfluoroalkyl substances: differences between European and Chinese River/Estuary systems
10.1021/acs.est.5b01648 · 2015 · External reference
Impact of a hexafluoropropylene oxide trimer acid (HFPO-TA) exposure on impairing the gut microbiota in mice
2022 · External reference
Hepatotoxic effects of hexafluoropropylene oxide trimer acid (HFPO-TA), A novel perfluorooctanoic acid (PFOA) alternative, on mice
10.1021/acs.est.8b01714 · 2018 · External reference
Profiling biotoxicities of hexafluoropropylene oxide trimer acid with human embryonic stem cell-based assays
10.1016/j.jes.2021.08.012 · 2022 · External reference
Adipogenic activity of oligomeric hexafluoropropylene oxide (perfluorooctanoic acid alternative) through Peroxisome proliferator-activated receptor gamma pathway
10.1021/acs.est.8b06978 · 2019 · External reference
Swimming exercise ameliorates insulin resistance and nonalcoholic fatty liver by negatively regulating PPARgamma transcriptional network in mice fed high fat diet
10.1186/s10020-023-00740-4 · 2023 · External reference
Transcriptome and Metabolome analysis reveal HFPO-TA induced disorders of hepatic glucose and lipid metabolism in rat by interfering with PPAR signaling pathway
10.1016/j.fct.2024.114632 · 2024 · External reference
Systemic PPARγ deletion in mice provokes lipoatrophy, organomegaly, severe type 2 diabetes and metabolic inflexibility
10.1016/j.metabol.2019.03.003 · 2019 · External reference
Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux
10.1128/mcb.22.8.2607-2619.2002 · 2002 · External reference
Tamoxifen-induced hepatotoxicity via lipid accumulation and inflammation in zebrafish
10.1016/j.chemosphere.2019.124705 · 2020 · External reference
The emerging use of zebrafish to model metabolic disease
10.1242/dmm.011346 · 2013 · External reference
AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility
10.1002/jcc.21256 · 2009 · External reference
Thyroid disrupting effects and the developmental toxicity of hexafluoropropylene oxide oligomer acids in zebrafish during early development
10.1016/j.chemosphere.2024.142462 · 2024 · External reference
Immune responses in the liver
10.1146/annurev-immunol-051116-052415 · 2018 · External reference
Correlations between frailty index and inflammatory markers derived from blood cell count in the United States
10.1186/s12889-024-20908-9 · 2024 · External reference
Exposure to PFOA and its novel analogs disrupts lipid metabolism in zebrafish
10.1016/j.ecoenv.2023.115020 · 2023 · External reference
The implications of FASN in immune cell biology and related diseases
10.1038/s41419-024-06463-6 · 2024 · External reference
FASN promotes anoikis resistance in colorectal liver metastases through the ERK1/2 pathway
10.1016/j.bbrc.2024.150494 · 2024 · External reference
Kaempferol suppresses lipid accumulation by inhibiting early adipogenesis in 3T3-L1 cells and zebrafish
10.1039/c5fo00481k · 2015 · External reference
Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases
10.1146/annurev.nutr.24.121803.063211 · 2004 · External reference
Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol
10.1016/s0022-2275(20)33401-5 · 1999 · External reference
Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation
10.1128/mcb.00077-06 · 2006 · External reference
Assessment of Fatty Acid desaturase (Fads2) structure-function properties in fish in the context of environmental adaptations and as a target for genetic engineering
10.3390/biom10020206 · 2020 · External reference
Type I IFN induces long-chain acyl-CoA synthetase 1 to generate a phosphatidic acid reservoir for lipotoxic saturated fatty acids
10.1016/j.jlr.2024.100730 · 2025 · External reference
The role of Acyl-CoA synthetase 1 in bioactive lipid accumulation and the development of hepatic insulin resistance
10.3390/nu16071003 · 2024 · External reference
CD36 deficiency protects lipopolysaccharide-induced sepsis via inhibiting CerS6-mediated endoplasmic reticulum stress
2024 · External reference
Chronic perfluorooctanesulfonic acid exposure disrupts lipid metabolism in zebrafish
10.1177/0960327116646615 · 2017 · External reference
A model construction of starvation induces hepatic steatosis and transcriptome analysis in zebrafish Larvae
10.3390/biology10020092 · 2021 · External reference
Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice
10.1002/hep.25740 · 2012 · External reference
The role of hepatic fat accumulation in glucose and insulin homeostasis-dysregulation by the liver
10.3390/jcm10030390 · 2021 · External reference
Liver-specific overexpression of lipoprotein lipase improves glucose metabolism in high-fat diet-fed mice
10.1371/journal.pone.0274297 · 2022 · External reference
Glucose metabolism is required for oocyte maturation of zebrafish
10.1016/j.bbrc.2021.04.059 · 2021 · External reference
DNA methylation-regulated HK1 overexpression contributes to irradiation-resistance by promoting glycolysis in non-small cell lung cancer
10.62347/qmgj2157 · 2024 · External reference
Insulin signalling and the regulation of glucose and lipid metabolism
10.1038/414799a · 2001 · External reference
Pediatric patient with hyperketotic hypoglycemia diagnosed with glycogen synthase deficiency due to the novel homozygous mutation in GYS2
2015 · External reference
Base-editing corrects metabolic abnormalities in a humanized mouse model for glycogen storage disease type-Ia
10.1038/s41467-024-54108-1 · 2024 · External reference
Gluconeogenesis in cancer: function and regulation of PEPCK, FBPase, and G6Pase
10.1016/j.trecan.2018.11.003 · 2019 · External reference
Hepatic glucose-6-phosphatase-alpha deficiency leads to metabolic reprogramming in glycogen storage disease type Ia
10.1016/j.bbrc.2018.03.083 · 2018 · External reference
The metabolic implications of aquaporin 7 (AQP7) promoter variants in lean children and children with obesity
10.1007/s42000-020-00184-z · 2020 · External reference
PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro
10.1016/s1097-2765(00)80211-7 · 1999 · External reference
Berberine modulates deacetylation of PPARgamma to promote adipose tissue remodeling and thermogenesis via AMPK/SIRT1 pathway
10.7150/ijbs.62556 · 2021 · External reference
Persistent metabolic toxicities following developmental exposure to hexafluoropropylene oxide trimer acid (HFPO-TA): roles of peroxisome proliferator activated receptor gamma
10.1016/j.jhazmat.2024.134337 · 2024 · External reference
PPARgamma and TGFbeta-Major regulators of metabolism, inflammation, and fibrosis in the lungs and kidneys
10.3390/ijms221910431 · 2021 · External reference
New approach in the treatment of T2DM and metabolic syndrome (focus on a novel insulin sensitizer)
2006 · External reference
Oleanolic acid induces a dual agonist action on PPARgamma/alpha and GLUT4 translocation: a pentacyclic triterpene for dyslipidemia and type 2 diabetes
10.1016/j.ejphar.2020.173252 · 2020 · External reference
