Research graph
References from MtROS-Drp1-mediated mitochondria fission contributes to microglia BV2 cell apoptosis induced by titanium dioxide nanoparticles. Local targets link to admitted publications; unresolved targets remain external evidence.
Titanium dioxide nanoparticles: prospects and applications in medicine
10.3390/nano10020387 · 2020 · External reference
Titanium dioxide nanoparticle: a comprehensive review on synthesis, applications and toxicity
10.3390/plants13212964 · 2024 · External reference
Synthesis, modification and application of titanium dioxide nanoparticles: a review
10.1039/d1nr08349j · 2022 · External reference
Effects of titanium dioxide nanoparticles exposure on human Health-a review
10.1007/s12011-019-01706-6 · 2020 · External reference
Review on nanoparticles and nanostructured materials: bioimaging, biosensing, drug delivery, tissue engineering, antimicrobial, and agro-food applications
10.3390/nano12030457 · 2022 · External reference
Human and environmental impacts of nanoparticles: a scoping review of the current literature
10.1186/s12889-023-15958-4 · 2023 · External reference
Biomedical applications of TiO2 nanostructures: recent advances
10.2147/ijn.s249441 · 2020 · External reference
Overcoming blood-brain barrier transport: advances in nanoparticle-based drug delivery strategies
10.1016/j.mattod.2020.02.001 · 2020 · External reference
Nanoscale-alumina induces oxidative stress and accelerates amyloid beta (Aβ) production in ICR female mice
10.1039/c5nr03598h · 2015 · External reference
A study on cognitive impairment of mice exposed to nano-alumina particles by nasal drip
10.1016/j.jtemb.2022.127003 · 2022 · External reference
Brain-targeted distribution and high retention of silver by chronic intranasal instillation of silver nanoparticles and ions in sprague-dawley rats
10.1002/jat.3260 · 2016 · External reference
Neurotoxicity and mechanism of metal and metal oxide nanoparticles
10.1016/j.cbi.2026.111953 · 2026 · External reference
Advances in genotoxicity of titanium dioxide nanoparticles in vivo and in vitro
10.1016/j.impact.2021.100377 · 2022 · External reference
Biodistribution of cerium dioxide and titanium dioxide nanomaterials in rats after single and repeated inhalation exposures
10.1186/s12989-024-00588-4 · 2024 · External reference
Neurotoxic characteristics of spatial recognition damage of the hippocampus in mice following subchronic peroral exposure to TiO2 nanoparticles
10.1016/j.jhazmat.2013.10.072 · 2014 · External reference
Microglial tissue surveillance: the never-resting gardener in the developing and adult CNS
10.1002/eji.202250232 · 2023 · External reference
The ins and outs of microglial cells in brain health and disease
10.3389/fimmu.2024.1305087 · 2024 · External reference
Silver nanoparticle-induced impaired autophagic flux and lysosomal dysfunction contribute to the microglia inflammation polarization
10.1016/j.fct.2022.113469 · 2022 · External reference
TGF-beta1/SMADs signaling involved in alleviating inflammation induced by nanoparticulate titanium dioxide in BV2 cells
10.1016/j.tiv.2021.105303 · 2022 · External reference
Neuroinflammation is induced by tongue-instilled ZnO nanoparticles via the Ca2+-dependent NF-kappaB and MAPK pathways
10.1186/s12989-018-0274-0 · 2018 · External reference
Human microglial state dynamics in alzheimer's disease progression
10.1016/j.cell.2023.08.037 · 2023 · External reference
Neuroinflammation in parkinson's disease: its role in neuronal death and implications for therapeutic intervention
10.1016/j.nbd.2009.11.004 · 2010 · External reference
Neurotoxicity mediated by oxidative stress caused by titanium dioxide nanoparticles in human neuroblastoma (SH-SY5Y) cells
10.1016/j.jtemb.2019.126413 · 2020 · External reference
Indirect effects of TiO2 nanoparticle on neuron-glial cell interactions
10.1016/j.cbi.2016.05.024 · 2016 · External reference
Nanosize titanium dioxide stimulates reactive oxygen species in brain microglia and damages neurons in vitro
10.1289/ehp.10216 · 2007 · External reference
Nanogold induces anti-inflammation against oxidative stress induced in human neural stem cells exposed to amyloid-beta peptide
10.1016/j.neuint.2021.104992 · 2021 · External reference
DBDPE and ZnO NPs synergistically induce neurotoxicity of SK-N-SH cells and activate mitochondrial apoptosis signaling pathway and Nrf2-mediated antioxidant pathway
10.1016/j.jhazmat.2022.129872 · 2023 · External reference
Chitosan attenuated the neurotoxicity-induced titanium dioxide nanoparticles in brain of adult rats
10.1002/tox.23429 · 2022 · External reference
Drp1 aggravates copper nanoparticle-induced ER-Phagy by disturbing mitochondria-associated membranes in chicken hepatocytes
10.1021/acs.jafc.4c03978 · 2024 · External reference
Silver nanoparticles induced synaptic degeneration via Ca2+/CaMKII signal and Drp1-dependent mitochondrial disorder in HT22 cells
10.1016/j.fct.2024.114577 · 2024 · External reference
Nanomaterials-induced programmed cell death: focus on mitochondria
10.1016/j.tox.2024.153803 · 2024 · External reference
Autophagy modulated by inorganic nanomaterials
10.7150/thno.40414 · 2020 · External reference
Involvement of mitophagy in primary cultured rat neurons treated with nanoalumina
10.1007/s12640-022-00549-9 · 2022 · External reference
Biomedical applications of reactive oxygen species generation by metal nanoparticles
10.3390/ma14010053 · 2020 · External reference
Neuropathological and cognitive effects induced by CuO-NPs in rats and trials for prevention using pomegranate juice
10.1007/s11064-021-03264-7 · 2021 · External reference
CdTe quantum dots trigger oxidative stress and endoplasmic reticulum stress-induced apoptosis and autophagy in rat Schwann cell line RSC96
10.1002/jat.4367 · 2022 · External reference
Review on the role of autophagy in the toxicity of nanoparticles and the signaling pathways involved
10.1016/j.cbi.2024.111356 · 2025 · External reference
Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine
10.1186/s12989-020-00372-0 · 2020 · External reference
The combined neurotoxicity of DBP and nano-TiO2 in embryonic zebrafish (Danio rerio) revealed by oxidative activity, neuro-development genes expression and metabolomics changes
10.1016/j.aquatox.2024.106881 · 2024 · External reference
A systematic review of the potential neurotoxicity of micro-and nanoplastics: the known and unknown
10.1186/s12989-025-00647-4 · 2025 · External reference
Predictive metabolomic signatures for safety assessment of metal oxide nanoparticles
10.1021/acsnano.9b05793 · 2019 · External reference
Mechanistic insights into toxicity of titanium dioxide nanoparticles at the Micro- and macro-levels
10.1021/acs.chemrestox.4c00235 · 2024 · External reference
Endosomal sorting results in a selective separation of the protein corona from nanoparticles
2023 · External reference
The protein corona on nanoparticles as viewed from a nanoparticle-sizing perspective
10.1002/wnan.1500 · 2018 · External reference
Influence of the physicochemical features of TiO2 nanoparticles on the formation of a protein corona and impact on cytotoxicity
10.1039/d0ra08429h · 2020 · External reference
Overcoming colloidal nanoparticle aggregation in biological milieu for cancer therapeutic delivery: perspectives of materials and particle design
10.1016/j.cis.2024.103094 · 2024 · External reference
Label free tracking to quantify nanoparticle diffusion through biological media
10.1038/s41598-024-69506-0 · 2024 · External reference
Microglial cells (BV-2) internalize titanium dioxide (TiO2) nanoparticles: toxicity and cellular responses
10.1007/s11356-016-6190-7 · 2016 · External reference
Titanium dioxide nanoparticles inhibit proliferation and induce morphological changes and apoptosis in glial cells
10.1016/j.tox.2012.09.005 · 2012 · External reference
TDCPP and TiO2 NPs aggregates synergistically induce SH-SY5Y cell neurotoxicity by excessive mitochondrial fission and mitophagy inhibition
10.1016/j.envpol.2024.123740 · 2024 · External reference
Microglial activation and pyroptosis induced by nano-TiO2 in marine medaka brain
10.1016/j.aquatox.2024.107034 · 2024 · External reference
Manipulation of mitochondria dynamics reveals separate roles for form and function in mitochondria distribution
10.1016/j.celrep.2018.04.017 · 2018 · External reference
Targeting DRP1 with Mdivi-1 to correct mitochondrial abnormalities in ADOA+ syndrome
10.1172/jci.insight.180582 · 2024 · External reference
Promoting Drp1-Mediated mitochondrial division in nickel nanoparticles-induced reproductive toxicity in GC-2 cells
10.3390/nano16010034 · 2025 · External reference
Oxidative stress and potential effects of metal nanoparticles: a review of biocompatibility and toxicity concerns
10.1016/j.envpol.2024.123617 · 2024 · External reference
Contribution of oxidative stress to TiO2 nanoparticle-induced toxicity
10.1016/j.etap.2016.10.013 · 2016 · External reference
Immunotoxicity of titanium dioxide nanoparticles via simultaneous induction of apoptosis and multiple toll-like receptors signaling through ROS-dependent SAPK/JNK and p38 MAPK activation
10.2147/ijn.s176087 · 2018 · External reference
Moringa seed extract alleviates titanium oxide nanoparticles (TiO2-NPs)-induced cerebral oxidative damage, and increases cerebral mitochondrial viability
10.1007/s11356-019-05514-2 · 2019 · External reference
Recent insights into autophagy and metals/nanoparticles exposure
10.1007/s43188-023-00184-2 · 2023 · External reference
Nano-TiO2 regulates the MAPK (ERK, P38) pathway to promote apoptosis and inhibit proliferation of human colon cells
10.1016/j.ecoenv.2024.116973 · 2024 · External reference
Navigating nanotoxicity: unraveling nanomaterial-induced effects via multi-omics integration
10.1016/j.impact.2025.100565 · 2025 · External reference
Multi-omics approaches to decipher the interactions of nanoparticles and biological systems
10.1038/s44222-024-00264-4 · 2025 · External reference
The toxicity of nanoparticles and their interaction with cells: an in vitro metabolomic perspective
10.1039/d2na00534d · 2023 · External reference
Hexavalent-chromium-induced disruption of mitochondrial dynamics and apoptosis in the liver via the AMPK-PGC-1α pathway in ducks
10.3390/ijms242417241 · 2023 · External reference
Crosstalk between the mitochondrial dynamics and oxidative stress in zinc-induced cytotoxicity
10.1007/s12011-022-03504-z · 2022 · External reference
Exposure to an environmentally relevant mixture of polychlorinated biphenyls affects mitochondrial bioenergetics and plasticity
10.1016/j.redox.2025.103862 · 2025 · External reference
Propionic acid induces alterations in mitochondrial morphology and dynamics in SH-SY5Y cells
10.1038/s41598-023-40130-8 · 2023 · External reference
Ursolic acid ameliorates doxorubicin-induced cardiotoxicity by inhibiting DRP1-mediated excessive mitochondrial fission and oxidative stress
2025 · External reference
Mitochonic acid 5 rescues cardiomyocytes from doxorubicin-induced toxicity via repressing the TNF-α/NF-κB/NLRP3 -mediated pyroptosis
10.1016/j.intimp.2023.110736 · 2023 · External reference
Time-dependent translocation of titanium dioxide nanoparticles to the brain: a histopathological and spectrometric study
10.1016/j.jtemb.2026.127864 · 2026 · External reference
