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References from Targeting Dectin-1/Syk axis alleviates chemotherapy-induced cognitive impairment via STING signaling pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
Chemobrain in breast cancer: mechanisms, clinical manifestations, and potential interventions
10.1007/s40264-022-01182-3 · 2022 · External reference
Targeting the meningeal compartment to resolve chemobrain and neuropathy via nasal delivery of functionalized mitochondria
10.1002/adhm.202102153 · 2022 · External reference
Doxorubicin-An agent with multiple mechanisms of anticancer activity
10.3390/cells12040659 · 2023 · External reference
Doxorubicin-induced cognitive impairment: the mechanistic insights
10.3389/fonc.2021.673340 · 2021 · External reference
Hippocampal neural stem cells facilitate access from circulation via apical cytoplasmic processes
10.7554/elife.52134 · 2020 · External reference
10.1016/j.freeradbiomed.2018.12.029
10.1016/j.freeradbiomed.2018.12.029 · 2019 · External reference
Pharmacological modulation of blood-brain barrier increases permeability of doxorubicin into the rat brain
2013 · External reference
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
10.1038/nature07317 · 2008 · External reference
Ursodeoxycholic acid alleviates sepsis-induced lung injury by blocking PANoptosis via STING pathway
10.1016/j.intimp.2023.111161 · 2023 · External reference
Structures and mechanisms in the cGAS-STING innate immunity pathway
10.1016/j.immuni.2020.05.013 · 2020 · External reference
STING signaling in the brain: molecular threats, signaling activities, and therapeutic challenges
10.1016/j.neuron.2023.10.014 · 2024 · External reference
Role of cGAS-Sting signaling in alzheimer's disease
10.3390/ijms24098151 · 2023 · External reference
Mitochondrial DNA release contributes to intestinal ischemia/reperfusion injury
10.3389/fphar.2022.854994 · 2022 · External reference
PERK-STING-RIPK3 pathway facilitates cognitive impairment by inducing neuronal necroptosis in sepsis-associated encephalopathy
10.1111/cns.14095 · 2023 · External reference
HDAC3 inhibition ameliorates ischemia/reperfusion-induced brain injury by regulating the microglial cGAS-STING pathway
10.7150/thno.47651 · 2020 · External reference
Inhibition of neutrophil extracellular trap formation ameliorates neuroinflammation and neuronal apoptosis via STING-Dependent IRE1alpha/ASK1/JNK signaling pathway in mice with traumatic brain injury
10.1186/s12974-023-02903-w · 2023 · External reference
Critical role of the cGAS-STING pathway in doxorubicin-induced cardiotoxicity
10.1161/circresaha.122.321587 · 2023 · External reference
STING signaling contributes to methotrexate-induced liver injury by regulating ferroptosis in mice
10.1016/j.ecoenv.2024.117306 · 2024 · External reference
Dectin-1 signaling update: new perspectives for trained immunity
10.3389/fimmu.2022.812148 · 2022 · External reference
Dectin-1 acts as a non-classical receptor of Ang II to induce cardiac remodeling
10.1161/circresaha.122.322259 · 2023 · External reference
MCTR1 enhances the resolution of lipopolysaccharide-induced lung injury through STAT6-mediated resident M2 alveolar macrophage polarization in mice
10.1111/jcmm.15481 · 2020 · External reference
Restoring oat nanoparticles mediated brain memory function of mice Fed alcohol by sorting inflammatory Dectin-1 complex into microglial exosomes
2022 · External reference
Dectin-1/Syk signaling triggers neuroinflammation after ischemic stroke in mice
10.1186/s12974-019-1693-z · 2020 · External reference
beta-amyloid binds to microglia Dectin-1 to induce inflammatory response in the pathogenesis of alzheimer's disease
10.7150/ijbs.81900 · 2023 · External reference
Expression of the beta-glucan receptor, Dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactions
10.1189/jlb.0104031 · 2004 · External reference
Age-related decline in hippocampal tyrosine phosphatase PTPRO is a mechanistic factor in chemotherapy-related cognitive impairment
10.1172/jci.insight.166306 · 2023 · External reference
Impaired cognitive function and hippocampal neurogenesis following cancer chemotherapy
10.1158/1078-0432.ccr-11-2000 · 2012 · External reference
Ganoderma lucidum polysaccharides ameliorated depression-like behaviors in the chronic social defeat stress depression model via modulation of Dectin-1 and the innate immune system
10.1016/j.brainresbull.2021.03.002 · 2021 · External reference
Piceatannol attenuates behavioral disorder and neurological deficits in aging mice via activating the Nrf2 pathway
10.1039/c7fo01511a · 2018 · External reference
Chronic supplementation with a mix of Salvia officinalis and Salvia lavandulaefolia improves morris water maze learning in normal adult C57Bl/6J mice
10.3390/nu12061777 · 2020 · External reference
Zinc supplementation ameliorates sorafenib-induced cognitive impairment through ROS/JNK signaling pathway
10.1007/s12011-022-03142-5 · 2023 · External reference
PubChem BioAssay: 2017 update
10.1093/nar/gkw1118 · 2017 · External reference
Vanillic acid restores homeostasis of intestinal epithelium in colitis through inhibiting CA9/STIM1-mediated ferroptosis
10.1016/j.phrs.2024.107128 · 2024 · External reference
Immunity to commensal fungi: Detente and disease
10.1146/annurev-pathol-052016-100342 · 2017 · External reference
Bruceine D inhibits HIF-1alpha-mediated glucose metabolism in hepatocellular carcinoma by blocking ICAT/beta-catenin interaction
10.1016/j.apsb.2021.05.009 · 2021 · External reference
Microglia, astrocytes, and oligodendrocytes in parkinson's disease: neuroinflammatory crosstalk and emerging therapeutic strategies
10.3390/biom16010156 · 2026 · External reference
Astrocyte-targeting therapy rescues cognitive impairment caused by neuroinflammation via the Nrf2 pathway
10.1073/pnas.2303809120 · 2023 · External reference
Blocking HMGB1/RAGE signaling by berberine alleviates A1 astrocyte and attenuates sepsis-associated encephalopathy
10.3389/fphar.2021.760186 · 2021 · External reference
Inhibition of inflammation by berberine: molecular mechanism and network pharmacology analysis
10.1016/j.phymed.2023.155258 · 2024 · External reference
Galangin mitigates DOX-Induced cognitive impairment in rats: implication of NOX-1/Nrf-2/HMGB1/TLR4 and TNF-alpha/MAPKs/RIPK/MLKL/BDNF
10.1016/j.neuro.2022.07.005 · 2022 · External reference
Methotrexate chemotherapy induces persistent tri-glial dysregulation that underlies chemotherapy-related cognitive impairment
10.1016/j.cell.2018.10.049 · 2019 · External reference
Neuroprotective potential of berberine against doxorubicin-induced toxicity in rat's brain
10.1007/s11064-021-03428-5 · 2021 · External reference
Melatonin and metformin counteract cognitive dysfunction equally in Male rats with doxorubicin-induced chemobrain
10.1016/j.neuro.2022.11.012 · 2023 · External reference
The spatiotemporal dynamic evolution of post-stroke neuroinflammation: energy metabolism mechanisms of acute response and chronic progression
10.3389/fphar.2026.1762764 · 2026 · External reference
Sesamol alleviates manganese-induced neuroinflammation and cognitive impairment via regulating the microglial cGAS-STING/NF-kappaB pathway
10.1016/j.envpol.2022.120988 · 2023 · External reference
Peroxiredoxin 1 aggravates acute kidney injury by promoting inflammation through Mincle/Syk/NF-kappaB signaling
10.1016/j.kint.2023.04.013 · 2023 · External reference
Isoliquiritigenin attenuates UUO-induced renal inflammation and fibrosis by inhibiting Mincle/Syk/NF-Kappa B signaling pathway
10.2147/dddt.s243420 · 2020 · External reference
The tyrosine kinases syk and lyn exert opposing effects on the activation of protein kinase Akt/PKB in B lymphocytes
10.1073/pnas.96.12.6890 · 1999 · External reference
TAK-242 alleviates neuroinflammation and poststroke cognitive impairment by targeting the TLR4/SYK/NF-kappaB pathway in a cerebral ischemia/reperfusion rat model
10.1016/j.ejphar.2026.178813 · 2026 · External reference
BAY61-3606 attenuates neuroinflammation and neurofunctional damage by inhibiting microglial mincle/syk signaling response after traumatic brain injury
2022 · External reference
Toll-like receptor 4 mediates retinal ischemia/reperfusion injury through nuclear factor-kappaB and spleen tyrosine kinase activation
10.1167/iovs.13-11932 · 2013 · External reference
Syk inhibition in ischemic stroke
10.1161/atvbaha.116.307709 · 2016 · External reference
SYK promotes the formation of neutrophil extracellular traps by inducing PKM2 nuclear translocation and promoting STAT3 phosphorylation to exacerbate hepatic ischemia-reperfusion injury and tumor recurrence
10.1186/s10020-024-00907-7 · 2024 · External reference
Macrophage STING signaling promotes fibrosis in benign airway stenosis via an IL6-STAT3 pathway
10.1038/s41467-024-55170-5 · 2025 · External reference
Lactate binds and inhibits the innate immune sensor STING to promote tumor immune evasion
10.1016/j.immuni.2026.06.004 · 2026 · External reference
Elevated level of circulatory sTLT1 induces inflammation through SYK/MEK/ERK signalling in coronary artery disease
10.1042/cs20190999 · 2019 · External reference
Isoliquiritin ameliorates depression by suppressing NLRP3-mediated pyroptosis via miRNA-27a/SYK/NF-kappaB axis
10.1186/s12974-020-02040-8 · 2021 · External reference
STING signals to NF-kappaB from late endolysosomal compartments using IRF3 as an adaptor
10.1038/s41590-025-02283-8 · 2025 · External reference
STING-mediated interferon induction by Herpes simplex virus 1 requires the protein tyrosine kinase syk
10.1128/mbio.03228-21 · 2021 · External reference
Dectin-1 is required for beta-glucan recognition and control of fungal infection
10.1038/ni1408 · 2007 · External reference
Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance
10.1038/nm.4314 · 2017 · External reference
Laminarin ameliorates iodoacetamide-induced functional dyspepsia via modulation of 5-HT(3) receptors and the gut microbiota
10.1016/j.ijbiomac.2024.131640 · 2024 · External reference
Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge
10.1124/jpet.105.085415 · 2005 · External reference
Piceatannol affects gastric ulcers induced by indomethacin: association of antioxidant, anti-inflammatory, and angiogenesis mechanisms in rats
10.3390/life12030356 · 2022 · External reference
