Research graph
References from Doxorubicin-induced cardiotoxicity: SESN2-directed FBXO7 ubiquitination of CRY1 restores glycolytic homeostasis. Local targets link to admitted publications; unresolved targets remain external evidence.
Clinical evaluation of adriamycin, a new antitumour antibiotic
10.1136/bmj.3.5669.503 · 1969 · External reference
Phase I and preliminary phase II evaluation of adriamycin (NSC 123127)
1970 · External reference
The anthracyclines: will we ever find a better doxorubicin?
1992 · External reference
Long-term follow-up of patients with doxorubicin-induced cardiac toxicity after chemotherapy for osteosarcoma
10.1097/cad.0b013e32803d36fe · 2007 · External reference
Anthracycline chemotherapy and cardiotoxicity
10.1007/s10557-016-6711-0 · 2017 · External reference
Congestive heart failure in patients treated with doxorubicin: a retrospective analysis of three trials
10.1002/cncr.11407 · 2003 · External reference
ESC position paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC committee for practice guidelines: the task force for cancer treatments and cardiovascular toxicity of the european society of cardiology (ESC)
10.1093/eurheartj/ehw211 · 2016 · External reference
Research progress of therapeutic drugs for doxorubicin-induced cardiomyopathy
10.1016/j.biopha.2022.113903 · 2022 · External reference
Cardioprotective strategies against doxorubicin-induced cardiotoxicity: a review from standard therapies to emerging mitochondrial transplantation
10.1016/j.biopha.2025.118315 · 2025 · External reference
Metabolic remodelling in heart failure
10.1038/s41569-018-0044-6 · 2018 · External reference
Glycolysis: a multifaceted metabolic pathway and signaling hub
10.1016/j.jbc.2024.107906 · 2024 · External reference
PFKM inhibits doxorubicin-induced cardiotoxicity by enhancing oxidative phosphorylation and glycolysis
2022 · External reference
Breviscapine remodels myocardial glucose and lipid metabolism by regulating serotonin to alleviate doxorubicin-induced cardiotoxicity
2022 · External reference
Mfn2-mediated mitochondrial fusion alleviates doxorubicin-induced cardiotoxicity with enhancing its anticancer activity through metabolic switch
2022 · External reference
Neuraminidase 1 exacerbated glycolytic dysregulation and cardiotoxicity by destabilizing SIRT1 through interactions with NRF2 and HIF1α
2025 · External reference
CRISPRi/a screens in human iPSC-cardiomyocytes identify glycolytic activation as a druggable target for doxorubicin-induced cardiotoxicity
10.1016/j.stem.2024.10.007 · 2024 · External reference
Cardiac Slc25a49-Mediated energy reprogramming governs doxorubicin-induced cardiomyopathy through the G6P-AP-1-Sln axis
2025 · External reference
Regulatory mechanisms of Sesn2 and its role in multi-organ diseases
2021 · External reference
Cardiac SIRT1 ameliorates doxorubicin-induced cardiotoxicity by targeting sestrin 2
2022 · External reference
SESN2-Mediated AKT/GSK-3β/NRF2 activation to ameliorate adriamycin cardiotoxicity in high-fat diet-induced Obese mice
10.1089/ars.2022.0156 · 2024 · External reference
Sestrins orchestrate cellular metabolism to attenuate aging
10.1016/j.cmet.2013.08.018 · 2013 · External reference
Sestrin2-mediated disassembly of stress granules dampens aerobic glycolysis to overcome glucose starvation
10.1038/s41420-023-01411-3 · 2023 · External reference
Knockdown of SESN2 exacerbates cerebral ischemia-reperfusion injury through enhancing glycolysis via the mTOR/HIF-1α pathway
10.1111/cns.70314 · 2025 · External reference
Multitranscript analysis reveals an effect of 2-deoxy-d-glucose on gene expression linked to unfolded protein response and integrated stress response in primary human monocytes and monocyte-derived macrophages
10.1016/j.bbagen.2023.130397 · 2023 · External reference
A new FGF1 variant protects against adriamycin-induced cardiotoxicity via modulating p53 activity
10.1016/j.redox.2021.102219 · 2022 · External reference
Resveratrol and FGF1 synergistically ameliorates doxorubicin-induced cardiotoxicity via activation of SIRT1-NRF2 pathway
10.3390/nu14194017 · 2022 · External reference
Diabetes-associated sleep fragmentation impairs liver and heart function via SIRT1-dependent epigenetic modulation of NADPH oxidase 4
10.1016/j.apsb.2024.12.031 · 2025 · External reference
HY4 gene of A. thaliana encodes a protein with characteristics of a blue-light photoreceptor
10.1038/366162a0 · 1993 · External reference
Mutation of the human circadian clock gene CRY1 in familial delayed sleep phase disorder
10.1016/j.cell.2017.03.027 · 2017 · External reference
Mammalian Cry1 and Cry 2 are essential for maintenance of circadian rhythms
10.1038/19323 · 1999 · External reference
The circadian clock CRY1 regulates pluripotent stem cell identity and somatic cell reprogramming
10.1016/j.celrep.2023.112590 · 2023 · External reference
Circadian clock interaction with HIF1α mediates oxygenic metabolism and anaerobic glycolysis in skeletal muscle
10.1016/j.cmet.2016.09.010 · 2017 · External reference
Circadian modulation of glucose utilization via CRY1-mediated repression of Pdk1 expression
10.1016/j.jbc.2024.105637 · 2024 · External reference
Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6
10.1038/nm.2061 · 2010 · External reference
Clock genes in the heart: characterization and attenuation with hypertrophy
10.1161/hh1101.091190 · 2001 · External reference
Gene expression changes of humans with primary mitral regurgitation and reduced left ventricular ejection fraction
10.3390/ijms22073454 · 2021 · External reference
The duper mutation reveals previously unsuspected functions of cryptochrome 1 in circadian entrainment and heart disease
10.1073/pnas.2121883119 · 2022 · External reference
Protein post-translational modifications: novel molecular switches and strategies for targeted therapy in ischemic heart disease
10.1016/j.biopha.2025.118357 · 2025 · External reference
Ubiquitin proteasome system in cardiac fibrosis
10.1016/j.jare.2024.12.006 · 2025 · External reference
Tirzepatide alleviates doxorubicin-induced cardiotoxicity via inhibiting HRD1-mediated Nrf2 ubiquitination
10.1093/cvr/cvaf033 · 2025 · External reference
AIG1 protects against doxorubicin-induced cardiomyocyte ferroptosis and cardiotoxicity by promoting ubiquitination-mediated p53 degradation
10.7150/thno.108410 · 2025 · External reference
E3 ubiquitin ligases in signaling, disease, and therapeutics
10.1016/j.tibs.2025.07.009 · 2025 · External reference
Unstructured biology of proteins from ubiquitin-proteasome system: roles in cancer and neurodegenerative diseases
10.3390/biom10050796 · 2020 · External reference
The characteristics of FBXO7 and its role in human diseases
10.1016/j.gene.2022.146972 · 2023 · External reference
FUNDC1 interacts with FBXL2 to govern mitochondrial integrity and cardiac function through an IP3R3-dependent manner in obesity
10.1126/sciadv.abc8561 · 2020 · External reference
Mitochondrial tumor suppressor 1A attenuates myocardial infarction injury by maintaining the coupling between mitochondria and endoplasmic reticulum
10.1161/circulationaha.124.069737 · 2025 · External reference
Fbxo7 promotes Cdk 6 activity to inhibit PFKP and glycolysis in T cells
10.1083/jcb.202203095 · 2022 · External reference
FBXO7 ubiquitinates PRMT1 to suppress serine synthesis and tumor growth in hepatocellular carcinoma
10.1038/s41467-024-49087-2 · 2024 · External reference
Sesn2 serves as a regulator between mitochondrial unfolded protein response and mitophagy in intervertebral disc degeneration
10.7150/ijbs.70211 · 2023 · External reference
Sestrin2 maintains hepatic immune homeostasis and redox balance partially via inhibiting RIPK3-mediated necroptosis in metabolic dysfunction-associated steatohepatitis
10.1016/j.molmet.2023.101865 · 2024 · External reference
Sestrin2 improves intestinal ischemia-reperfusion injury through the TFEB-mediated autophagy/lysosomal pathway
10.1016/j.freeradbiomed.2025.06.037 · 2025 · External reference
MK8722 alleviates osteoarthritis by activating Sesn2 and transcriptionally upregulating BNIP3 to promote mitophagy and inhibit chondrocyte ferroptosis
10.1016/j.jare.2025.09.060 · 2026 · External reference
SESN2 maintains cartilage homeostasis by SREBP1-mediated lipid metabolism during osteoarthritis progression
10.1016/j.isci.2025.113097 · 2025 · External reference
SREBF1-mediated SND1 transcriptional activation promotes prostate cancer progression via MTDH interaction through the SESN2/AMPK/mTOR axis
10.1186/s12967-025-06762-2 · 2025 · External reference
Inhibitory effect of blestriarene C on triple-negative breast cancer: inducing ferroptosis and mitophagy via SESN2/AKT/FOXO4 axis
10.1097/cm9.0000000000003960 · 2026 · External reference
p53-regulated SESN1 and SESN2 regulate cell proliferation and cell death through control of STAT3
10.1186/s12964-025-02104-3 · 2025 · External reference
