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References from Chemical proteomic identification of STUB1 as a direct target of benzophenone-3 reveals disrupted NRF2 signaling in chondrocytes. Local targets link to admitted publications; unresolved targets remain external evidence.
Inflammaging and osteoarthritis
10.1007/s12016-022-08941-1 · 2023 · External reference
The impact of population ageing on musculoskeletal disorders in 204 countries and territories, 1990-2021: global burden and healthcare costs
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Global, regional, and national burden of osteoarthritis, 1990–2020 and projections to 2050: a systematic analysis for the global burden of disease study 2021
10.1016/s2665-9913(23)00163-7 · 2023 · External reference
Global burden of osteoarthritis among postmenopausal women in 204 countries and territories: a systematic analysis for the global burden of disease study 2021
10.1136/bmjgh-2024-017198 · 2025 · External reference
Global Burden of Early-Onset Osteoarthritis, 1990–2019: results from the Global Burden of Disease Study 2019
10.1136/ard-2023-225324 · 2024 · External reference
The role of metabolism in the pathogenesis of osteoarthritis
10.1038/nrrheum.2017.50 · 2017 · External reference
Interference with SPARC inhibits Benzophenone-3 induced ferroptosis in osteoarthritis: evidence from bioinformatics analyses and biological experimentation
10.1016/j.ecoenv.2024.116217 · 2024 · External reference
The role of oxidative stress in the development of knee osteoarthritis: a comprehensive research review
10.3389/fmolb.2022.1001212 · 2022 · External reference
Environmental pollutants as emerging risk factors in osteoarthritis: mechanistic and epidemiological evidence
10.1016/j.ecoenv.2025.119453 · 2026 · External reference
Benzophenone-3, a chemical UV-Filter in cosmetics: is it really safe for children and pregnant women?
10.5114/ada.2022.113617 · 2022 · External reference
Benzophenone-3: comprehensive review of the toxicological and human evidence with meta-analysis of human biomonitoring studies
10.1016/j.envint.2023.107739 · 2023 · External reference
Association between Organophosphorus Insecticides exposure and osteoarthritis in patients with arteriosclerotic cardiovascular disease
10.1186/s12889-024-19414-9 · 2024 · External reference
Associations of urinary levels of phenols and parabens with osteoarthritis among US adults in NHANES 2005–2014
10.1016/j.ecoenv.2020.110293 · 2020 · External reference
Mechanism of Chondrocyte injury induced by Benzophenone-3 through modulation of the IL-6/JAK2/STAT3 pathway
10.1016/j.envpol.2025.126064 · 2025 · External reference
Molecular interactions of benzophenone UV filters with human serum albumin revealed by spectroscopic techniques and molecular modeling
10.1016/j.jhazmat.2013.10.024 · 2013 · External reference
In-Depth understanding of the structure-based reactive metabolite formation of organic functional groups
10.1080/03602532.2025.2472076 · 2025 · External reference
A protein interactome-based framework reveals the general toxicity of chemicals
10.1021/acs.est.5c08341 · 2025 · External reference
The effect of the nucleolar protein ZNF385A on the ribosomal DNA copy number variation in response to Cr(VI)-Induced DNA damage
10.1016/j.ecoenv.2024.117018 · 2024 · External reference
Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics
10.1074/mcp.m200025-mcp200 · 2002 · External reference
Berberine alleviates ulcerative colitis by inhibiting inflammation through targeting IRGM1
10.1016/j.phymed.2024.155909 · 2024 · External reference
The Perseus computational platform for comprehensive analysis of (Prote)Omics data
10.1038/nmeth.3901 · 2016 · External reference
Identification of Peroxiredoxin 6 as a direct target of Withangulatin A by quantitative chemical proteomics in non-small cell lung cancer
10.1016/j.redox.2021.102130 · 2021 · External reference
Chemical proteomic profiling of lysine crotonylation using minimalist bioorthogonal probes in Mammalian cells
10.1039/d4sc06745b · 2025 · External reference
Chemical proteomics for a comprehensive understanding of functional activity and the interactome
10.1039/d5cs00381d · 2025 · External reference
Hsc70/Stub1 promotes the removal of Individual oxidatively stressed peroxisomes
10.1038/s41467-020-18942-3 · 2020 · External reference
Ferroptosis in osteoarthritis: towards novel therapeutic strategy
10.1111/cpr.13779 · 2025 · External reference
Ferroptosis in osteoarthritis: metabolic reprogramming, immunometabolic crosstalk, and targeted intervention strategies
10.3389/fimmu.2025.1604652 · 2025 · External reference
Integrated network toxicology and transcriptomics reveal NF- κ B signaling as a key mediator of TDCPP-Induced inflammatory responses in human microglia
10.1016/j.envint.2026.110373 · 2026 · External reference
Elucidating the mechanism of plasticizers inducing breast cancer through network toxicology and molecular docking analysis
10.1016/j.ecoenv.2024.116866 · 2024 · External reference
Integrative network and computational toxicology reveal the molecular mechanisms in PFOA-Induced spermatogenic disorder
10.1016/j.jenvman.2025.125754 · 2025 · External reference
Mechanistic insights into BDE-153-Induced idiopathic pulmonary fibrosis through network toxicology , machine learning , and cellular validation
10.1016/j.fct.2026.116167 · 2026 · External reference
Associations of phenols, Parabens, and phthalate compounds related to personal care products with osteoarthritis: evidence from population-based and network toxicology studies
10.1016/j.envint.2025.109796 · 2025 · External reference
Progress and application of activity-based protein profiling for the discovery of natural product targets
10.1007/s11030-025-11361-w · 2025 · External reference
STUB1 (CHIP) – a prognostic marker in cancer
10.1039/d5mo00205b · 2025 · External reference
STUB1-Mediated ubiquitination and degradation of NSUN2 promotes hepatocyte ferroptosis by decreasing M5C methylation of Gpx4 MRNA
10.1016/j.celrep.2024.114885 · 2024 · External reference
Reversible ubiquitination regulates HSF1 phase separation in response to proteotoxic stress
10.1016/j.lfs.2026.124224 · 2026 · External reference
Exosomes and STUB1/CHIP cooperate to maintain intracellular proteostasis
10.1371/journal.pone.0223790 · 2019 · External reference
Targeting epigenetic and post-translational modifications of NRF2: key regulatory factors in disease treatment
10.1038/s41420-025-02491-z · 2025 · External reference
Nrf2 as a redox checkpoint in Autoimmune joint inflammation: microenvironmental redox control across the arthritis spectrum
2026 · External reference
Nrf2 ameliorates defective autophagic processes and thereby inhibits ferroptosis in acute pancreatitis by suppressing Beclin1-Slc7a11 complex Formation
10.1016/j.freeradbiomed.2025.02.011 · 2025 · External reference
Contribution of ferroptosis and GPX4's dual functions to osteoarthritis progression
10.1016/j.ebiom.2022.103847 · 2022 · External reference
Increased expression of glutathione peroxidase 4 strongly protects retina from oxidative damage
10.1089/ars.2008.2171 · 2009 · External reference
Comprehensive transcriptome sequencing and biochemical studies revealed that Acrolein induced Lung injury in BEAS-2B cells and Male rats through the LncRNA MIR155HG/MiR-155-5p/CD200R1 and Nrf2/SLC7A11/GPX4 ferroptosis pathways
10.1016/j.redox.2025.103832 · 2025 · External reference
Nrf2-Regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress
10.1016/j.freeradbiomed.2008.10.040 · 2009 · External reference
Ferroptosis: mechanisms and therapeutic targets
10.1002/mco2.70010 · 2024 · External reference
Articular cartilage: from Formation to tissue engineering
10.1039/c6bm00068a · 2016 · External reference
Reactive oxygen species, aging and articular cartilage homeostasis
10.1016/j.freeradbiomed.2018.08.038 · 2019 · External reference
Biomonitoring of bisphenols, Parabens, Benzophenone-3 and Triclosan in human urine of Spanish adult population: risk assessment and predictors of exposure
10.1007/s12403-025-00722-3 · 2025 · External reference
Network rewiring in the aging immune System: from chronic inflammation to age-related pathologies
10.3390/cells15050414 · 2026 · External reference
