Research graph
References from Locus-specific rewriting of DNA methylation in mammalian cells. Local targets link to admitted publications; unresolved targets remain external evidence.
DNA methylation: a historical perspective
10.1016/j.tig.2022.03.010 · 2022 · External reference
Researches on pyrimidines. C111. The discovery of 5-methyl-cytosine in tuberculinic acid, the nucleic acid of the tubercle bacillus
1925 · External reference
Rethinking how DNA methylation patterns are maintained
10.1038/nrg2651 · 2009 · External reference
Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation
10.1038/s41467-020-15006-4 · 2020 · External reference
De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells
10.1242/dev.122.10.3195 · 1996 · External reference
Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases
10.1038/890 · 1998 · External reference
DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development
10.1016/s0092-8674(00)81656-6 · 1999 · External reference
Occurrence of 5-Methyl-Cytosine in nucleic acids
10.1038/166237b0 · 1950 · External reference
Recognition and estimation of 5-methylcytosine in nucleic acids
10.1042/bj0480581 · 1951 · External reference
DNA methylation and its basic function
10.1038/npp.2012.112 · 2013 · External reference
DNA methylation in mammalian development and disease
10.1038/s41576-024-00760-8 · 2025 · External reference
Dynamic DNA methylation: in the right place at the right time
10.1126/science.aat6806 · 2018 · External reference
DNA methylation and human disease
10.1038/nrg1655 · 2005 · External reference
Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases
10.1038/s41392-023-01343-5 · 2023 · External reference
DNA damage, demethylation and anticancer activity of DNA methyltransferase (DNMT) inhibitors
10.1038/s41598-023-32509-4 · 2023 · External reference
Epigenetic editing: from concept to clinic
10.1038/s41573-025-01323-0 · 2026 · External reference
The DNA methyltransferase family: a versatile toolkit for epigenetic regulation
10.1038/nrg.2017.80 · 2018 · External reference
DNA methylation and DNA methyltransferases
10.1186/s13072-017-0130-8 · 2017 · External reference
Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms
10.1038/s41467-020-17109-4 · 2020 · External reference
Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B
10.1038/s41586-020-2747-1 · 2020 · External reference
Mechanisms of DNMT3A–3L-mediated de novo DNA methylation on chromatin
10.1038/s41594-025-01704-4 · 2026 · External reference
Structural insight into hierarchical DNMT3A autoinhibition and its dysregulation in disease
10.1038/s41467-026-69563-1 · 2026 · External reference
Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation
10.1038/nature06146 · 2007 · External reference
TET family dioxygenases and DNA demethylation in stem cells and cancers
10.1038/emm.2017.5 · 2017 · External reference
TET (Ten-eleven translocation) family proteins: structure, biological functions and applications
10.1038/s41392-023-01537-x · 2023 · External reference
TET methylcytosine oxidases: new insights from a decade of research
10.1007/s12038-019-9973-4 · 2020 · External reference
DNA methylation pathways and their crosstalk with histone methylation
10.1038/nrm4043 · 2015 · External reference
Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation
10.1038/nature14176 · 2015 · External reference
The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation
10.1074/jbc.m109.089433 · 2010 · External reference
Understanding the relationship between DNA methylation and histone lysine methylation
10.1016/j.bbagrm.2014.02.007 · 2014 · External reference
The interplay between DNA and histone methylation: molecular mechanisms and disease implications
10.15252/embr.202051803 · 2021 · External reference
Epigenetic therapies for cancer
10.1056/nejmra1805035 · 2020 · External reference
Cytosine methylation targetted to pre-determined sequences
10.1038/ng1297-376 · 1997 · External reference
Precision epigenetic editing: technological advances, enduring challenges, and therapeutic applications
10.1016/j.chembiol.2024.07.007 · 2024 · External reference
Inheritable silencing of endogenous genes by hit-and-run targeted epigenetic editing
10.1016/j.cell.2016.09.006 · 2016 · External reference
Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing
10.1016/j.cell.2021.03.025 · 2021 · External reference
Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor
10.1126/science.ado7082 · 2024 · External reference
Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins
10.1038/nbt.2726 · 2013 · External reference
Editing DNA methylation in the Mammalian genome
10.1016/j.cell.2016.08.056 · 2016 · External reference
Durable and efficient gene silencing in vivo by hit-and-run epigenome editing
10.1038/s41586-024-07087-8 · 2024 · External reference
A potent epigenetic editor targeting human PCSK9 for durable reduction of low-density lipoprotein cholesterol levels
10.1038/s41591-025-03508-x · 2025 · External reference
Evolution-guided protein design of IscB for persistent epigenome editing in vivo
2025 · External reference
Design of optimized epigenetic regulators for durable gene silencing with application to PCSK9 in nonhuman primates
2025 · External reference
Multiplexed epigenetic memory editing using CRISPRoff sensitizes glioblastoma to chemotherapy
10.1093/neuonc/noaf055 · 2025 · External reference
CRISPR/dCas9 DNA methylation editing is heritable during human hematopoiesis and shapes immune progeny
10.1073/pnas.2300224120 · 2023 · External reference
Epigenome editing strategies for the functional annotation of CTCF insulators
10.1038/s41467-019-12166-w · 2019 · External reference
Epigenetic editing at individual age-associated CpGs affects the genome-wide epigenetic aging landscape
10.1038/s43587-025-00841-1 · 2025 · External reference
Systematic epigenome editing captures the context-dependent instructive function of chromatin modifications
10.1038/s41588-024-01706-w · 2024 · External reference
Analog epigenetic memory revealed by targeted chromatin editing
2025 · External reference
A combinatorial domain screening platform reveals epigenetic effector interactions for transcriptional perturbation
10.1038/s41467-026-72227-9 · 2026 · External reference
Requirements for establishment and epigenetic stability of mammalian heterochromatin
10.1016/j.molcel.2025.08.025 · 2025 · External reference
Programmable epigenome editing by transient delivery of CRISPR epigenome editor ribonucleoproteins
10.1038/s41467-025-63167-x · 2025 · External reference
Genome-wide tracking of dCas9-methyltransferase footprints
10.1038/s41467-017-02708-5 · 2018 · External reference
Comprehensive profiling of CRISPR/dCas9 epigenome editors indicates a complex link between on and off target effects
10.1186/s13059-026-03967-6 · 2026 · External reference
Efficient targeted DNA methylation with chimeric dCas9–Dnmt3a–Dnmt3L methyltransferase
10.1093/nar/gkw1112 · 2017 · External reference
AI-redesigned starting points and outcomes enhance protein evolution
2026 · External reference
Computational design of sequence-specific DNA-binding proteins
10.1038/s41594-025-01669-4 · 2025 · External reference
Computational design of serine hydrolases
10.1126/science.adu2454 · 2025 · External reference
TET methylcytosine oxidases: new insights from a decade of research
10.1007/s12038-019-9973-4 · ExternalCitation · doi-reference
Understanding the relationship between DNA methylation and histone lysine methylation
10.1016/j.bbagrm.2014.02.007 · ExternalCitation · doi-reference
Editing DNA methylation in the Mammalian genome
10.1016/j.cell.2016.08.056 · ExternalCitation · doi-reference
Inheritable silencing of endogenous genes by hit-and-run targeted epigenetic editing
10.1016/j.cell.2016.09.006 · ExternalCitation · doi-reference
Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing
10.1016/j.cell.2021.03.025 · ExternalCitation · doi-reference
Precision epigenetic editing: technological advances, enduring challenges, and therapeutic applications
10.1016/j.chembiol.2024.07.007 · ExternalCitation · doi-reference
Requirements for establishment and epigenetic stability of mammalian heterochromatin
10.1016/j.molcel.2025.08.025 · ExternalCitation · doi-reference
DNA methylation: a historical perspective
10.1016/j.tig.2022.03.010 · ExternalCitation · doi-reference
DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development
10.1016/s0092-8674(00)81656-6 · ExternalCitation · doi-reference
Occurrence of 5-Methyl-Cytosine in nucleic acids
10.1038/166237b0 · ExternalCitation · doi-reference
Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases
10.1038/890 · ExternalCitation · doi-reference
TET family dioxygenases and DNA demethylation in stem cells and cancers
10.1038/emm.2017.5 · ExternalCitation · doi-reference
Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation
10.1038/nature06146 · ExternalCitation · doi-reference
Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation
10.1038/nature14176 · ExternalCitation · doi-reference
Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins
10.1038/nbt.2726 · ExternalCitation · doi-reference
Cytosine methylation targetted to pre-determined sequences
10.1038/ng1297-376 · ExternalCitation · doi-reference
DNA methylation and its basic function
10.1038/npp.2012.112 · ExternalCitation · doi-reference
The DNA methyltransferase family: a versatile toolkit for epigenetic regulation
10.1038/nrg.2017.80 · ExternalCitation · doi-reference
DNA methylation and human disease
10.1038/nrg1655 · ExternalCitation · doi-reference
Rethinking how DNA methylation patterns are maintained
10.1038/nrg2651 · ExternalCitation · doi-reference
DNA methylation pathways and their crosstalk with histone methylation
10.1038/nrm4043 · ExternalCitation · doi-reference
Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases
10.1038/s41392-023-01343-5 · ExternalCitation · doi-reference
TET (Ten-eleven translocation) family proteins: structure, biological functions and applications
10.1038/s41392-023-01537-x · ExternalCitation · doi-reference
Genome-wide tracking of dCas9-methyltransferase footprints
10.1038/s41467-017-02708-5 · ExternalCitation · doi-reference
Epigenome editing strategies for the functional annotation of CTCF insulators
10.1038/s41467-019-12166-w · ExternalCitation · doi-reference
Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation
10.1038/s41467-020-15006-4 · ExternalCitation · doi-reference
Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms
10.1038/s41467-020-17109-4 · ExternalCitation · doi-reference
Programmable epigenome editing by transient delivery of CRISPR epigenome editor ribonucleoproteins
10.1038/s41467-025-63167-x · ExternalCitation · doi-reference
Structural insight into hierarchical DNMT3A autoinhibition and its dysregulation in disease
10.1038/s41467-026-69563-1 · ExternalCitation · doi-reference
A combinatorial domain screening platform reveals epigenetic effector interactions for transcriptional perturbation
10.1038/s41467-026-72227-9 · ExternalCitation · doi-reference
Epigenetic editing: from concept to clinic
10.1038/s41573-025-01323-0 · ExternalCitation · doi-reference
DNA methylation in mammalian development and disease
10.1038/s41576-024-00760-8 · ExternalCitation · doi-reference
Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B
10.1038/s41586-020-2747-1 · ExternalCitation · doi-reference
Durable and efficient gene silencing in vivo by hit-and-run epigenome editing
10.1038/s41586-024-07087-8 · ExternalCitation · doi-reference
Systematic epigenome editing captures the context-dependent instructive function of chromatin modifications
10.1038/s41588-024-01706-w · ExternalCitation · doi-reference
A potent epigenetic editor targeting human PCSK9 for durable reduction of low-density lipoprotein cholesterol levels
10.1038/s41591-025-03508-x · ExternalCitation · doi-reference
Computational design of sequence-specific DNA-binding proteins
10.1038/s41594-025-01669-4 · ExternalCitation · doi-reference
Mechanisms of DNMT3A–3L-mediated de novo DNA methylation on chromatin
10.1038/s41594-025-01704-4 · ExternalCitation · doi-reference
DNA damage, demethylation and anticancer activity of DNA methyltransferase (DNMT) inhibitors
10.1038/s41598-023-32509-4 · ExternalCitation · doi-reference
Epigenetic editing at individual age-associated CpGs affects the genome-wide epigenetic aging landscape
10.1038/s43587-025-00841-1 · ExternalCitation · doi-reference
Recognition and estimation of 5-methylcytosine in nucleic acids
10.1042/bj0480581 · ExternalCitation · doi-reference
Epigenetic therapies for cancer
10.1056/nejmra1805035 · ExternalCitation · doi-reference
CRISPR/dCas9 DNA methylation editing is heritable during human hematopoiesis and shapes immune progeny
10.1073/pnas.2300224120 · ExternalCitation · doi-reference
The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation
10.1074/jbc.m109.089433 · ExternalCitation · doi-reference
Efficient targeted DNA methylation with chimeric dCas9–Dnmt3a–Dnmt3L methyltransferase
10.1093/nar/gkw1112 · ExternalCitation · doi-reference
Multiplexed epigenetic memory editing using CRISPRoff sensitizes glioblastoma to chemotherapy
10.1093/neuonc/noaf055 · ExternalCitation · doi-reference
Dynamic DNA methylation: in the right place at the right time
10.1126/science.aat6806 · ExternalCitation · doi-reference
Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor
10.1126/science.ado7082 · ExternalCitation · doi-reference
Computational design of serine hydrolases
10.1126/science.adu2454 · ExternalCitation · doi-reference
Comprehensive profiling of CRISPR/dCas9 epigenome editors indicates a complex link between on and off target effects
10.1186/s13059-026-03967-6 · ExternalCitation · doi-reference
DNA methylation and DNA methyltransferases
10.1186/s13072-017-0130-8 · ExternalCitation · doi-reference
De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells
10.1242/dev.122.10.3195 · ExternalCitation · doi-reference
The interplay between DNA and histone methylation: molecular mechanisms and disease implications
10.15252/embr.202051803 · ExternalCitation · doi-reference
