Research graph
References from Multiplexed molecular imaging for spatial transcriptomics and proteomics. Local targets link to admitted publications; unresolved targets remain external evidence.
Observing A protein in its natural habitat
2024 · External reference
Super-resolution microscopy at its sharpest
10.1038/s41566-025-01632-1 · 2025 · External reference
Spatial organization of the somatosensory cortex revealed by osmFISH
10.1038/s41592-018-0175-z · 2018 · External reference
Three-dimensional intact-tissue sequencing of single-cell transcriptional states
10.1126/science.aat5691 · 2018 · External reference
Spatial multi-omics of nuclear architecture with two-layer seqFISH+
10.1038/s41576-025-00868-5 · 2025 · External reference
Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH+
10.1038/s41586-019-1049-y · 2019 · External reference
Expansion sequencing: spatially precise in situ transcriptomics in intact biological systems
10.1126/science.aax2656 · 2021 · External reference
Hybridization-based in situ sequencing (HybISS) for spatially resolved transcriptomics in human and mouse brain tissue
10.1093/nar/gkaa792 · 2020 · External reference
Mapping human tissues with highly multiplexed RNA in situ hybridization
10.1038/s41467-024-46437-y · 2024 · External reference
Highly sensitive spatial transcriptomics using FISHnCHIPs of multiple co-expressed genes
10.1038/s41467-024-46669-y · 2024 · External reference
Deep-tissue transcriptomics and subcellular imaging at high spatial resolution
10.1126/science.adq2084 · 2025 · External reference
Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution
10.1016/j.cell.2025.09.006 · 2025 · External reference
Optimizing Xenium in Situ data utility by quality assessment and best-practice analysis workflows
10.1038/s41592-025-02617-2 · 2025 · External reference
Scalable spatial single-cell transcriptomics and translatomics in 3D thick tissue blocks
10.1038/s41592-025-02867-0 · 2025 · External reference
Spatial multi-omics reveals cell-type-specific nuclear compartments
10.1038/s41586-025-08838-x · 2025 · External reference
Left-handed DNA for efficient highly multiplexed imaging at single-protein resolution
10.1038/s41467-025-64228-x · 2025 · External reference
Spatial proteomics in neurons at single-protein resolution
10.1016/j.cell.2024.02.045 · 2024 · External reference
Protocol for SUM-PAINT spatial proteomic imaging generating neuronal architecture maps in rat hippocampal neurons
10.1016/j.xpro.2025.103637 · 2025 · External reference
Unresolved reference
2026 · External reference
Ångström-resolution fluorescence microscopy
10.1038/s41586-023-05925-9 · 2023 · External reference
Ångström-resolution imaging of cell-surface glycans
10.1038/s41565-025-01966-5 · 2025 · External reference
Molecular pixelation: spatial proteomics of single cells by sequencing
10.1038/s41592-024-02268-9 · 2024 · External reference
nELISA: a high-throughput, high-plex platform enables quantitative profiling of the inflammatory secretome
10.1038/s41592-025-02861-6 · 2025 · External reference
Multiplexed expansion revealing for imaging multiprotein nanostructures in healthy and diseased brain
10.1038/s41467-024-53729-w · 2024 · External reference
Multiplex immunofluorescence staining of coverslip-mounted paraffin-embedded tissue sections
10.1111/apm.13329 · 2023 · External reference
Multiplex imaging analysis of the tumor immune microenvironment for guiding precision immunotherapy
2025 · External reference
Multiplexed volumetric CLEM enabled by scFvs provides insights into the cytology of cerebellar cortex
10.1038/s41467-024-50411-z · 2024 · External reference
NanoPlex: a universal strategy for fluorescence microscopy multiplexing using nanobodies with erasable signals
10.1038/s41467-024-53030-w · 2024 · External reference
A new set of highly efficient, tag-cleaving proteases for purifying recombinant proteins
10.1016/j.chroma.2014.02.029 · 2014 · External reference
Precise immunofluorescence canceling for highly multiplexed imaging to capture specific cell states
10.1038/s41467-024-47989-9 · 2024 · External reference
Fluorescence-activating and absorption-shifting tags for advanced imaging and biosensing
10.1021/acs.accounts.2c00098 · 2022 · External reference
HaloTag: a novel protein labeling technology for cell imaging and protein analysis
10.1021/cb800025k · 2008 · External reference
Small fluorescence-activating and absorption-shifting tag for tunable protein imaging in vivo
10.1073/pnas.1513094113 · 2016 · External reference
Genetically encoded fluorescence lifetime biosensors: overview, advances, and opportunities
10.1039/d3an01201h · 2023 · External reference
A palette of bridged bicycle-strengthened fluorophores
10.1038/s41592-025-02693-4 · 2025 · External reference
Stimulated emission depletion microscopy
10.1038/s43586-024-00335-1 · 2024 · External reference
Multiphoton fluorescence microscopy for in vivo imaging
10.1016/j.cell.2024.07.036 · 2024 · External reference
Fluorescence lifetime multiplexing with fluorogen activating protein FAST variants
10.1038/s42003-024-06501-1 · 2024 · External reference
Fluorescence lifetime multiplexing with Fluorogen-Activating FAST protein variants and red-shifted arylidene–imidazolone derivative as fluorogen
10.3390/bios15050274 · 2025 · External reference
Fluorescence lifetime multiplexing with environment-sensitive chemigenetic probes
10.1002/cbic.202500174 · 2025 · External reference
Single-cell synaptome mapping of endogenous protein subpopulations in mammalian brain
10.1038/s41467-025-65813-w · 2025 · External reference
DELTA: a method for brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning
10.1038/s41593-025-01923-4 · 2025 · External reference
A protein-tagging system for signal amplification in gene expression and fluorescence imaging
10.1016/j.cell.2014.09.039 · 2014 · External reference
Single-molecule dynamics of the TRiC chaperonin system in vivo
10.1038/s41586-026-10376-z · 2026 · External reference
Selective identification of newly synthesized proteins in mammalian cells using bioorthogonal noncanonical amino acid tagging (BONCAT)
10.1073/pnas.0601637103 · 2006 · External reference
Labeling, detection and identification of newly synthesized proteomes with bioorthogonal non-canonical amino-acid tagging
10.1038/nprot.2007.52 · 2007 · External reference
The prevalence and specificity of local protein synthesis during neuronal synaptic plasticity
10.1126/sciadv.abj0790 · 2021 · External reference
Cell-selective multiplexed bioorthogonal noncanonical amino acid tagging for nascent proteomics
10.1038/s41589-025-02039-3 · 2026 · External reference
Expanding the genetic code
10.1002/anie.200460627 · 2005 · External reference
Genetic code expansion history and modern innovations
10.1021/acs.chemrev.4c00275 · 2024 · External reference
Genetic code expansion: recent developments and emerging applications
10.1021/acs.chemrev.4c00216 · 2025 · External reference
Minimal tags for rapid dual-color live-cell labeling and super-resolution microscopy
10.1002/anie.201309847 · 2014 · External reference
Dual-color expansion microscopy of membrane proteins using bioorthogonal labeling
10.1021/acs.nanolett.5c05301 · 2026 · External reference
A single bioorthogonal reaction for multiplex cell surface protein labeling
10.1021/jacs.4c11701 · 2025 · External reference
A technical comparison of spatial transcriptomics platforms across six cancer types
10.1186/s13059-026-03937-y · 2026 · External reference
Spatially resolved proteomics via tissue expansion
10.1038/s41467-022-34824-2 · 2022 · External reference
TEMI: tissue-expansion mass-spectrometry imaging
10.1038/s41592-025-02664-9 · 2025 · External reference
iPEX enables micrometre-resolution deep spatial proteomics via tissue expansion
10.1038/s41586-025-09734-0 · 2026 · External reference
Expanding the genetic code
10.1002/anie.200460627 · ExternalCitation · doi-reference
Minimal tags for rapid dual-color live-cell labeling and super-resolution microscopy
10.1002/anie.201309847 · ExternalCitation · doi-reference
Fluorescence lifetime multiplexing with environment-sensitive chemigenetic probes
10.1002/cbic.202500174 · ExternalCitation · doi-reference
A protein-tagging system for signal amplification in gene expression and fluorescence imaging
10.1016/j.cell.2014.09.039 · ExternalCitation · doi-reference
Spatial proteomics in neurons at single-protein resolution
10.1016/j.cell.2024.02.045 · ExternalCitation · doi-reference
Multiphoton fluorescence microscopy for in vivo imaging
10.1016/j.cell.2024.07.036 · ExternalCitation · doi-reference
Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution
10.1016/j.cell.2025.09.006 · ExternalCitation · doi-reference
A new set of highly efficient, tag-cleaving proteases for purifying recombinant proteins
10.1016/j.chroma.2014.02.029 · ExternalCitation · doi-reference
Protocol for SUM-PAINT spatial proteomic imaging generating neuronal architecture maps in rat hippocampal neurons
10.1016/j.xpro.2025.103637 · ExternalCitation · doi-reference
Fluorescence-activating and absorption-shifting tags for advanced imaging and biosensing
10.1021/acs.accounts.2c00098 · ExternalCitation · doi-reference
Genetic code expansion: recent developments and emerging applications
10.1021/acs.chemrev.4c00216 · ExternalCitation · doi-reference
Genetic code expansion history and modern innovations
10.1021/acs.chemrev.4c00275 · ExternalCitation · doi-reference
Dual-color expansion microscopy of membrane proteins using bioorthogonal labeling
10.1021/acs.nanolett.5c05301 · ExternalCitation · doi-reference
HaloTag: a novel protein labeling technology for cell imaging and protein analysis
10.1021/cb800025k · ExternalCitation · doi-reference
A single bioorthogonal reaction for multiplex cell surface protein labeling
10.1021/jacs.4c11701 · ExternalCitation · doi-reference
Labeling, detection and identification of newly synthesized proteomes with bioorthogonal non-canonical amino-acid tagging
10.1038/nprot.2007.52 · ExternalCitation · doi-reference
Spatially resolved proteomics via tissue expansion
10.1038/s41467-022-34824-2 · ExternalCitation · doi-reference
Mapping human tissues with highly multiplexed RNA in situ hybridization
10.1038/s41467-024-46437-y · ExternalCitation · doi-reference
Highly sensitive spatial transcriptomics using FISHnCHIPs of multiple co-expressed genes
10.1038/s41467-024-46669-y · ExternalCitation · doi-reference
Precise immunofluorescence canceling for highly multiplexed imaging to capture specific cell states
10.1038/s41467-024-47989-9 · ExternalCitation · doi-reference
Multiplexed volumetric CLEM enabled by scFvs provides insights into the cytology of cerebellar cortex
10.1038/s41467-024-50411-z · ExternalCitation · doi-reference
NanoPlex: a universal strategy for fluorescence microscopy multiplexing using nanobodies with erasable signals
10.1038/s41467-024-53030-w · ExternalCitation · doi-reference
Multiplexed expansion revealing for imaging multiprotein nanostructures in healthy and diseased brain
10.1038/s41467-024-53729-w · ExternalCitation · doi-reference
Left-handed DNA for efficient highly multiplexed imaging at single-protein resolution
10.1038/s41467-025-64228-x · ExternalCitation · doi-reference
Single-cell synaptome mapping of endogenous protein subpopulations in mammalian brain
10.1038/s41467-025-65813-w · ExternalCitation · doi-reference
Ångström-resolution imaging of cell-surface glycans
10.1038/s41565-025-01966-5 · ExternalCitation · doi-reference
Super-resolution microscopy at its sharpest
10.1038/s41566-025-01632-1 · ExternalCitation · doi-reference
Spatial multi-omics of nuclear architecture with two-layer seqFISH+
10.1038/s41576-025-00868-5 · ExternalCitation · doi-reference
Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH+
10.1038/s41586-019-1049-y · ExternalCitation · doi-reference
Ångström-resolution fluorescence microscopy
10.1038/s41586-023-05925-9 · ExternalCitation · doi-reference
Spatial multi-omics reveals cell-type-specific nuclear compartments
10.1038/s41586-025-08838-x · ExternalCitation · doi-reference
iPEX enables micrometre-resolution deep spatial proteomics via tissue expansion
10.1038/s41586-025-09734-0 · ExternalCitation · doi-reference
Single-molecule dynamics of the TRiC chaperonin system in vivo
10.1038/s41586-026-10376-z · ExternalCitation · doi-reference
Cell-selective multiplexed bioorthogonal noncanonical amino acid tagging for nascent proteomics
10.1038/s41589-025-02039-3 · ExternalCitation · doi-reference
Spatial organization of the somatosensory cortex revealed by osmFISH
10.1038/s41592-018-0175-z · ExternalCitation · doi-reference
Molecular pixelation: spatial proteomics of single cells by sequencing
10.1038/s41592-024-02268-9 · ExternalCitation · doi-reference
Optimizing Xenium in Situ data utility by quality assessment and best-practice analysis workflows
10.1038/s41592-025-02617-2 · ExternalCitation · doi-reference
TEMI: tissue-expansion mass-spectrometry imaging
10.1038/s41592-025-02664-9 · ExternalCitation · doi-reference
A palette of bridged bicycle-strengthened fluorophores
10.1038/s41592-025-02693-4 · ExternalCitation · doi-reference
nELISA: a high-throughput, high-plex platform enables quantitative profiling of the inflammatory secretome
10.1038/s41592-025-02861-6 · ExternalCitation · doi-reference
Scalable spatial single-cell transcriptomics and translatomics in 3D thick tissue blocks
10.1038/s41592-025-02867-0 · ExternalCitation · doi-reference
DELTA: a method for brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning
10.1038/s41593-025-01923-4 · ExternalCitation · doi-reference
Fluorescence lifetime multiplexing with fluorogen activating protein FAST variants
10.1038/s42003-024-06501-1 · ExternalCitation · doi-reference
Stimulated emission depletion microscopy
10.1038/s43586-024-00335-1 · ExternalCitation · doi-reference
Genetically encoded fluorescence lifetime biosensors: overview, advances, and opportunities
10.1039/d3an01201h · ExternalCitation · doi-reference
Selective identification of newly synthesized proteins in mammalian cells using bioorthogonal noncanonical amino acid tagging (BONCAT)
10.1073/pnas.0601637103 · ExternalCitation · doi-reference
Small fluorescence-activating and absorption-shifting tag for tunable protein imaging in vivo
10.1073/pnas.1513094113 · ExternalCitation · doi-reference
Hybridization-based in situ sequencing (HybISS) for spatially resolved transcriptomics in human and mouse brain tissue
10.1093/nar/gkaa792 · ExternalCitation · doi-reference
Multiplex immunofluorescence staining of coverslip-mounted paraffin-embedded tissue sections
10.1111/apm.13329 · ExternalCitation · doi-reference
The prevalence and specificity of local protein synthesis during neuronal synaptic plasticity
10.1126/sciadv.abj0790 · ExternalCitation · doi-reference
Three-dimensional intact-tissue sequencing of single-cell transcriptional states
10.1126/science.aat5691 · ExternalCitation · doi-reference
Expansion sequencing: spatially precise in situ transcriptomics in intact biological systems
10.1126/science.aax2656 · ExternalCitation · doi-reference
Deep-tissue transcriptomics and subcellular imaging at high spatial resolution
10.1126/science.adq2084 · ExternalCitation · doi-reference
A technical comparison of spatial transcriptomics platforms across six cancer types
10.1186/s13059-026-03937-y · ExternalCitation · doi-reference
Fluorescence lifetime multiplexing with Fluorogen-Activating FAST protein variants and red-shifted arylidene–imidazolone derivative as fluorogen
10.3390/bios15050274 · ExternalCitation · doi-reference
