Research graph
References from Emerging classes of copper enzymes. Local targets link to admitted publications; unresolved targets remain external evidence.
Iron: life’s primeval transition metal
10.1073/pnas.2318692121 · 2024 · External reference
Gene-guided discovery and engineering of branched cyclic peptides in plants
10.1073/pnas.1813993115 · 2018 · External reference
Genome mining methods to discover bioactive natural products
10.1039/d1np00032b · 2021 · External reference
Reducing dioxygen to water: multi-copper oxidases
2007 · External reference
Copper active sites in biology
10.1021/cr400327t · 2014 · External reference
Copper-containing proteins: an alternative to biological iron
2013 · External reference
Structures of methane and ammonia monooxygenases in native membranes
10.1073/pnas.2417993121 · 2025 · External reference
Simultaneous occupancy of CuC and CuD in the ammonia monooxygenase active site
10.1039/d5sc08447d · 2026 · External reference
Ammonia monooxygenase: a work in progress
10.1039/d6sc01048b · 2026 · External reference
The copper-enzyme family of Dopamine β-Monooxygenase and peptidylglycine α-Hydroxylating monooxygenase: resolving the chemical pathway for substrate hydroxylation
10.1074/jbc.r500011200 · 2006 · External reference
Capturing the binuclear copper state of peptidylglycine monooxygenase using a peptidyl-homocysteine lure
10.1021/jacs.3c14705 · 2024 · External reference
Radical chemistry in metalloenzymes: bridging inorganic centers and biological catalysis
10.1146/annurev-biochem-051024-013029 · 2026 · External reference
Copper-dependent polysaccharide monooxygenases: mechanism and function
10.1021/acs.chemrev.6c00006 · 2026 · External reference
Copper monooxygenase reactivity: do consensus mechanisms accurately reflect experimental observations?
10.1016/j.jinorgbio.2022.111780 · 2022 · External reference
Discovery and biosynthesis of cyclic plant peptides via autocatalytic cyclases
10.1038/s41589-021-00892-6 · 2022 · External reference
Gene-guided discovery and ribosomal biosynthesis of Moroidin peptides
10.1021/jacs.2c00014 · 2022 · External reference
A widely distributed biosynthetic cassette is responsible for diverse plant side chain cross-linked cyclopeptides
10.1002/anie.202218082 · 2023 · External reference
Copper-dependent halogenase catalyses unactivated C−H bond functionalization
10.1038/s41586-024-08362-4 · 2025 · External reference
Cyclochlorotine hydroxylase CctR reveals DUF3328 as a family of copper-dependent metalloenzymes
10.1002/anie.202512449 · 2025 · External reference
Peptide crosslinking by a class of plant copper enzymes
10.1016/j.trechm.2024.09.002 · 2024 · External reference
Binuclear copper-dependent oxidative enzymes involved in fungal natural product modifications
2026 · External reference
Cyclic peptides for drug development
10.1002/ange.202308251 · 2024 · External reference
Cyclic peptides: a powerful instrument for advancing biomedical nanotechnologies and drug development
10.1016/j.jpba.2024.116488 · 2025 · External reference
An intramolecular macrocyclase in plant ribosomal peptide biosynthesis
10.1038/s41589-024-01552-1 · 2024 · External reference
Peptide recognition sequence guides catalytic side chain cross-linking of plant peptides by copper-dependent cyclases
10.1021/jacs.4c15470 · 2025 · External reference
Plant peptides – redefining an area of ribosomally synthesized and post-translationally modified peptides
10.1039/d3np00042g · 2024 · External reference
Aromatic side-chain crosslinking in RiPP biosynthesis
10.1038/s41589-024-01795-y · 2025 · External reference
Protein storage vacuoles of Brassica napus zygotic embryos accumulate a BURP domain protein and perturbation of its production distorts the PSV
10.1007/s11103-009-9541-7 · 2009 · External reference
The BURP domain protein AtUSPL1 of Arabidopsis thaliana is destined to the protein storage vacuoles and overexpression of the cognate gene distorts seed development
10.1007/s11103-009-9526-6 · 2009 · External reference
AtPGL3 is an arabidopsis BURP domain protein that is localized to the cell wall and promotes cell enlargement
10.3389/fpls.2015.00412 · 2015 · External reference
Expression of a vacuole-localized BURP-domain protein from soybean (SALI3-2) enhances tolerance to cadmium and copper stresses
2014 · External reference
Genome-wide identification of BURP domain-containing genes in rice reveals a gene family with diverse structures and responses to abiotic stresses
10.1007/s00425-009-0929-z · 2009 · External reference
BURP domain-containing genes in legumes: genome-wide identification, structure, and expression analysis under stresses and development
10.1007/s11816-022-00752-2 · 2022 · External reference
A conserved BURP domain defines a novel group of plant proteins with unusual primary structures
10.1007/s004380050832 · 1998 · External reference
Expression of the BnmNAP subfamily of napin genes coincides with the induction of Brassica microspore embryogenesis
10.1007/bf00019486 · 1994 · External reference
Abundant embryonic mRNA in field bean (Vicia faba L.) codes for a new class of seed proteins: cDNA cloning and characterization of the primary translation product
10.1007/bf00027389 · 1988 · External reference
The plant hormone abscisic acid mediates the drought-induced expression but not the seed-specific expression of rd22, a gene responsive to dehydration stress in Arabidopsis thaliana
10.1007/bf00279525 · 1993 · External reference
The beta subunit of tomato fruit polygalacturonase isoenzyme 1: isolation, characterization, and identification of unique structural features
1992 · External reference
Accurate structure prediction of biomolecular interactions with AlphaFold 3
10.1038/s41586-024-07487-w · 2024 · External reference
When the wrong metal stops the cycle: dynamics and specificity in plant copper-dependent peptide cyclases
10.1016/j.jinorgbio.2025.113201 · 2026 · External reference
Amidation of bioactive peptides: the structure of peptidylglycine α-Hydroxylating monooxygenase
10.1126/science.278.5341.1300 · 1997 · External reference
Multicopper oxidases: modular structure, sequence space, and evolutionary relationships
10.1002/prot.25952 · 2020 · External reference
Reaction mechanism of cytochrome c oxidase
10.1021/cr500266a · 2015 · External reference
Electron transfer and reaction mechanism of laccases
10.1007/s00018-014-1826-6 · 2015 · External reference
Subcellular distribution of ascorbate in plants
10.4161/psb.6.3.14342 · 2011 · External reference
High resolution imaging of subcellular glutathione concentrations by quantitative immunoelectron microscopy in different leaf areas of Arabidopsis
10.1016/j.micron.2012.11.006 · 2013 · External reference
Characterization of the biosynthetic gene cluster for the ribosomally synthesized cyclic peptide ustiloxin B in Aspergillus flavus
10.1016/j.fgb.2014.04.011 · 2014 · External reference
Biosynthetic investigation of phomopsins reveals a widespread pathway for ribosomal natural products in Ascomycetes
10.1073/pnas.1522907113 · 2016 · External reference
Victorin, the host-selective cyclic peptide toxin from the oat pathogen Cochliobolus victoriae , is ribosomally encoded
10.1073/pnas.2010573117 · 2020 · External reference
Iterative catalysis in the biosynthesis of mitochondrial complex II inhibitors harzianopyridone and atpenin B
10.1021/jacs.0c03438 · 2020 · External reference
Biosynthesis of cyclochlorotine: identification of the genes involved in oxidative transformations and intramolecular O , N -Transacylation
10.1021/acs.orglett.1c00525 · 2021 · External reference
Unveiling the biosynthetic pathway of the ribosomally synthesized and post-translationally modified peptide ustiloxin B in filamentous fungi
10.1002/anie.201602611 · 2016 · External reference
Biosynthetic studies of phomopsins unveil posttranslational installation of dehydroamino acids by UstYa family proteins
10.1002/anie.202111076 · 2021 · External reference
Characterization of the biosynthetic gene cluster for the ribosomally synthesized cyclic peptide epichloëcyclins in Epichloë festucae
10.1021/acs.jafc.3c03073 · 2023 · External reference
Transcriptomics-Driven discovery of new meroterpenoid rhynchospenes involved in the virulence of the barley pathogen Rhynchosporium commune
10.1021/acschembio.4c00731 · 2025 · External reference
Bioinformatic exploration of RiPP biosynthetic gene clusters in lichens
10.1186/s40694-025-00197-6 · 2025 · External reference
Copper-dependent hydroxylation catalyzed by the DUF3328 enzyme CctR
10.1021/acs.orglett.5c02280 · 2025 · External reference
Fungal RiPPs side chain macrocyclization catalyzed by copper-dependent DUF3328 enzyme
10.1021/jacs.4c18770 · 2025 · External reference
Copper-dependent oxidase catalyzes Aryl cross-coupling in the biosynthesis of a minimal ribosomally derived natural product
10.1021/jacs.5c17946 · 2025 · External reference
Dynamic metal coordination controls chemoselectivity in a radical halogenase
10.1038/s41589-025-02077-x · 2026 · External reference
A family of radical halogenases for the engineering of amino-acid-based products
10.1038/s41589-019-0355-x · 2019 · External reference
A comparative review on the catalytic mechanism of nonheme iron hydroxylases and halogenases
10.3390/catal8080314 · 2018 · External reference
Radical enzymatic peptide cyclization in natural product biosynthesis
10.1039/d5cs00585j · 2026 · External reference
Radical-mediated cross-linking enzymes in RiPP biosynthesis
10.1039/d6np00029k · 2026 · External reference
Enzymatic hydroxylations of sp3-Carbons
10.1021/acscatal.1c00759 · 2021 · External reference
Design principles for site-selective hydroxylation by a Rieske oxygenase
10.1038/s41467-021-27822-3 · 2022 · External reference
Recent examples of α-ketoglutarate-dependent mononuclear non-haem iron enzymes in natural product biosyntheses
10.1039/c7np00067g · 2018 · External reference
Radical S-Adenosyl-l-Methionine oxygenase DarE forms ether bond via a partially delocalized tryptophan Cβ radical
10.1021/jacs.5c19314 · 2026 · External reference
Enzymatic production of (−)-Indolactam V by LtxB, a cytochrome P450 monooxygenase
10.1021/np900481a · 2010 · External reference
Molecular basis for the P450-catalyzed C–N bond formation in indolactam biosynthesis
10.1038/s41589-019-0380-9 · 2019 · External reference
Bacterial cytochrome P450 catalyzed post-translational macrocyclization of ribosomal peptides
10.1002/anie.202311533 · 2023 · External reference
Signal peptides: from molecular mechanisms to applications in protein and vaccine engineering
10.3390/biom15060897 · 2025 · External reference
Genome-wide identification and expression analysis of the BURP domain-containing genes in Gossypium hirsutum
10.1186/s12864-019-5948-y · 2019 · External reference
Identification and expression analysis of BURP domain-containing genes in jujube and their involvement in low temperature and drought response
10.1186/s12864-022-08907-9 · 2022 · External reference
Cellular compartmentalization of secondary metabolism
10.3389/fmicb.2015.00068 · 2015 · External reference
Cellular development associated with induced mycotoxin synthesis in the filamentous fungus Fusarium graminearum
10.1371/journal.pone.0063077 · 2013 · External reference
Chemistry and biology of ustiloxin analogs as mycotoxins
10.1021/acs.jafc.5c05629 · 2025 · External reference
Subcellular compartmentalized localization of transmembrane proteins essential for production of fungal cyclic peptide cyclochlorotine
10.1093/bbb/zbae122 · 2024 · External reference
Long-range electron transfer
10.1073/pnas.0408029102 · 2005 · External reference
