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References from Advances in molecular techniques for detecting Mycobacterium leprae: A narrative review of progress, challenges, and future directions. Local targets link to admitted publications; unresolved targets remain external evidence.
Exploring the neurological manifestations of leprosy: clinical insights and implications
2025 · External reference
Pathogenicity and virulence of Mycobacterium leprae
10.1080/21505594.2022.2141987 · 2022 · External reference
Unresolved reference
External reference
Mycobacterium leprae transmission characteristics during the declining stages of leprosy incidence: a systematic review
10.1371/journal.pntd.0009436 · 2021 · External reference
Leprosy in the 21st century: a comprehensive review of immunological mechanisms, diagnosis, and treatment
10.1590/s1678-9946202567074 · 2025 · External reference
Shared challenges to the control of complex intracellular neglected pathogens
10.3389/fpubh.2024.1423420 · 2024 · External reference
Drug resistance in leprosy: an update following 70 years of chemotherapy
10.1016/j.idnow.2022.04.001 · 2022 · External reference
Challenges and advances in serological and molecular tests to aid leprosy diagnosis
2023 · External reference
Genetic variability, genotyping, and genomics of Mycobacterium leprae
10.1093/femsre/fuaf012 · 2025 · External reference
Phylogenomics of Mycobacterium leprae
2024 · External reference
Massive gene decay in the leprosy bacillus
10.1038/35059006 · 2001 · External reference
Mycobacterium leprae: genes, pseudogenes and genetic diversity
10.2217/fmb.10.153 · 2011 · External reference
Reconstructing the ancestor of Mycobacterium leprae: the dynamics of gene loss and genome reduction
10.1101/gr.6360207 · 2007 · External reference
Advances in the diagnosis of leprosy
10.3389/fitd.2022.893653 · 2022 · External reference
Biosensor-based platforms for the detection and screening of Mycobacterium leprae infection
10.1021/acsinfecdis.5c00851 · 2026 · External reference
Unraveling drug resistance in Mycobacterium leprae: exploring genetic mutations to enhance treatment strategies for human leprosy—a narrative review
10.1155/ijm/7204337 · 2025 · External reference
An update of the diagnosis, treatment, and prevention of leprosy: a narrative review
2024 · External reference
Ultra-sensitive detection of Mycobacterium leprae: DNA extraction and PCR assays
10.1371/journal.pntd.0008325 · 2020 · External reference
Accuracy of the qPCR method in intradermal scraping samples from individuals with suspected leprosy in a Brazilian macroregion
2025 · External reference
PCR-based techniques for leprosy diagnosis: from the laboratory to the clinic
10.1371/journal.pntd.0002655 · 2014 · External reference
Utility of multiplex PCR for early diagnosis and household contact surveillance for leprosy
10.1016/j.diagmicrobio.2019.06.007 · 2019 · External reference
A comparative study on the detection of Mycobacterium leprae DNA in urine samples of leprosy patients using Rlep-PCR with other conventional samples
10.1007/s11033-024-09470-0 · 2024 · External reference
Evaluation of multiplex PCR, RLEP PCR and LAMP PCR in urine, stool and blood samples for the diagnosis of pediatric leprosy - a cross-sectional study
10.1007/s13312-024-3232-y · 2024 · External reference
FTA card utility for PCR detection of Mycobacterium leprae
10.7883/yoken.64.246 · 2011 · External reference
Polymerase chain reaction (PCR) as a potential point of care laboratory test for leprosy diagnosis—a systematic review
10.3390/tropicalmed3040107 · 2018 · External reference
qPCR-high resolution melt analysis for drug susceptibility testing of Mycobacterium leprae directly from clinical specimens of leprosy patients
10.1371/journal.pntd.0005506 · 2017 · External reference
Impact of storage conditions on the quality of nucleic acids in paraffin embedded tissues
10.1371/journal.pone.0203608 · 2018 · External reference
Unlocking pathogens from preserved tissues: challenges and limitations of microbial retrieval from formalin-fixed paraffin-embedded (FFPE) samples in clinical diagnostics
10.1016/j.mpdhp.2026.06.012 · 2026 · External reference
Validation of the performance of a point of care molecular test for leprosy: from a simplified DNA extraction protocol to a portable qPCR
10.1371/journal.pntd.0012032 · 2024 · External reference
Molecular determination of Mycobacterium leprae viability by use of real-time PCR
10.1128/jcm.00512-09 · 2009 · External reference
Development of a combined RLEP/16S rRNA (RT) qPCR assay for the detection of viable M. Leprae from nasal swab samples
10.1186/s12879-019-4349-9 · 2019 · External reference
Sensitivity and specificity of multibacillary and paucibacillary leprosy laboratory tests: a systematic review and meta-analysis
10.1016/j.diagmicrobio.2021.115337 · 2021 · External reference
Evaluation of qPCR-based assays for leprosy diagnosis directly in clinical specimens
10.1371/journal.pntd.0001354 · 2011 · External reference
Development and validation of a multiplex real-time qPCR assay using GMP-grade reagents for leprosy diagnosis
10.1371/journal.pntd.0009850 · 2022 · External reference
Identification of Mycobacterium leprae and Mycobacterium lepromatosis cases with broad-range molecular assays at a single large reference laboratory
10.4269/ajtmh.25-0379 · 2026 · External reference
Loop-mediated isothermal amplification (LAMP): expansion of its practical application as a tool to achieve universal health coverage
10.1016/j.jiac.2019.07.020 · 2020 · External reference
Molecular detection of Mycobacterium leprae using RLEP loop-mediated isothermal amplification and a restriction enzyme to ensure amplification specificity
10.7883/yoken.jjid.2024.251 · 2025 · External reference
Rapid detection of Mycobacterium leprae RLEP by recombinase polymerase amplification: a pilot study
10.7883/yoken.jjid.2025.037 · 2026 · External reference
Lateral and vertical flow assays for point-of-care diagnostics
10.1002/adhm.201900244 · 2019 · External reference
Assuring the quality of next-generation sequencing in clinical microbiology and public health laboratories
10.1128/jcm.00949-16 · 2016 · External reference
Diagnostic accuracy of tests for leprosy: a systematic review and meta-analysis
10.1016/j.cmi.2019.05.020 · 2019 · External reference
Genomic characterization of Mycobacterium leprae to explore transmission patterns identifies new subtype in Bangladesh
10.3389/fmicb.2020.01220 · 2020 · External reference
Isolation of Mycobacterium lepromatosis and development of molecular diagnostic assays to distinguish Mycobacterium leprae and M. Lepromatosis
10.1093/cid/ciz1121 · 2020 · External reference
Comparative analysis of the leprosy detection rate regarding its clinical spectrum through PCR using the 16S rRNA gene: a scientometrics and meta-analysis
10.3389/fmicb.2024.1497319 · 2024 · External reference
Evaluation of 16S rRNA qPCR for detection of Mycobacterium leprae DNA in nasal secretion and skin biopsy samples from multibacillary and paucibacillary leprosy cases
10.1080/20477724.2017.1415736 · 2018 · External reference
Mycobacterium lepromatosis as a second agent of Hansen’s disease
10.3389/fmicb.2021.698588 · 2021 · External reference
Application of droplet digital PCR to detection of Mycobacterium tuberculosis and Mycobacterium leprae infections: a narrative review
10.2147/idr.s349607 · 2022 · External reference
Detection of antibiotic resistance in leprosy using GenoType LepraeDR, a novel ready-to-use molecular test
10.1371/journal.pntd.0001739 · 2012 · External reference
HARP: a database of structural impacts of systematic missense mutations in drug targets of Mycobacterium leprae
10.1016/j.csbj.2020.11.013 · 2020 · External reference
Antimicrobial resistance in leprosy: results of the first prospective open survey conducted by a WHO surveillance network for the period 2009–15
10.1016/j.cmi.2018.02.022 · 2018 · External reference
Prospects for new leprosy diagnostic tools, a narrative review considering ELISA and PCR assays
10.1590/0037-8682-0197-2020 · 2020 · External reference
Utility of multi-target nested PCR and ELISPOT assays for the detection of paucibacillary leprosy: a possible conclusion of clinical laboratory misdiagnosis
10.3389/fcimb.2022.814413 · 2022 · External reference
Nested PCR and the TaqMan SNP genotyping assay enhanced the sensitivity of drug resistance testing of Mycobacterium leprae using clinical specimens of leprosy patients
10.1371/journal.pntd.0007946 · 2019 · External reference
Development and evaluation of a droplet digital PCR assay for the diagnosis of paucibacillary leprosy in skin biopsy specimens
10.1371/journal.pntd.0007284 · 2019 · External reference
Pure neuritic leprosy: latest advancements and diagnostic modalities: diagnosis of pure neuritic leprosy
10.1016/j.diagmicrobio.2024.116529 · 2024 · External reference
Leprosy: review of the epidemiological, clinical, and etiopathogenic aspects-part 1
10.1590/abd1806-4841.20142450 · 2014 · External reference
Molecular detection of Mycobacterium leprae and the process of infection and illness in contacts of leprosy patients: a systematic review
10.3390/tropicalmed10020032 · 2025 · External reference
RLEP LAMP for the laboratory confirmation of leprosy: towards a point-of-care test
10.1186/s12879-021-06882-2 · 2021 · External reference
Highly sensitive and rapid determination of Mycobacterium leprae based on real-time multiple cross displacement amplification
10.1186/s12866-023-03004-7 · 2023 · External reference
Accelerated reaction by loop-mediated isothermal amplification using loop primers
10.1006/mcpr.2002.0415 · 2002 · External reference
Molecular diagnosis of human cutaneous leishmaniasis and identification of the causative leishmania species in Iran: a narrative review
10.61186/ibj.4239 · 2024 · External reference
Loop-mediated isothermal amplification (LAMP): a rapid, accurate, and cost-effective diagnostic method for infectious diseases
10.1007/s10156-009-0669-9 · 2009 · External reference
Loop-mediated isothermal amplification (LAMP) assay targeting RLEP for detection of Mycobacterium leprae in leprosy patients
10.1016/j.ijid.2021.04.041 · 2021 · External reference
Development of a loop-mediated isothermal amplification (LAMP) technique for specific and early detection of Mycobacterium leprae in clinical samples
10.1038/s41598-021-89304-2 · 2021 · External reference
Development of a novel loop-mediated isothermal amplification assay for rapid detection of Mycobacterium leprae in clinical samples
10.25259/ijdvl_248_19 · 2021 · External reference
Loop-mediated isothermal amplification (LAMP) of gene sequences and simple visual detection of products
10.1038/nprot.2008.57 · 2008 · External reference
Loop mediated isothermal amplification (LAMP): a new generation of innovative gene amplification technique; perspectives in clinical diagnosis of infectious diseases
10.1002/rmv.593 · 2008 · External reference
Multiplexing LAMP assays: a methodological review and diagnostic application
10.3390/ijms25126374 · 2024 · External reference
LAMP-based point-of-care biosensors for rapid pathogen detection
10.3390/bios12121068 · 2022 · External reference
Critical insight into recombinase polymerase amplification technology
10.1080/14737159.2022.2109964 · 2022 · External reference
Application of recombinase polymerase amplification with lateral flow assay to pathogen point-of-care diagnosis
10.3389/fcimb.2024.1475922 · 2024 · External reference
Advances in the application of recombinase-aided amplification combined with CRISPR-Cas technology in quick detection of pathogenic microbes
2023 · External reference
Recombinase polymerase amplification: basics, applications and recent advances, trends
2018 · External reference
Current and future perspectives on isothermal nucleic acid amplification technologies for diagnosing infections
10.2147/idr.s217571 · 2020 · External reference
Biosensor-based multiple cross displacement amplification for the rapid detection of Mycobacterium leprae
10.1021/acsinfecdis.3c00213 · 2023 · External reference
Isothermal amplification of nucleic acids: the race for the next “gold standard”
10.3389/fsens.2021.752600 · 2021 · External reference
Democratizing nucleic acid-based molecular diagnostic tests for infectious diseases at resource-limited settings–from point of care to extreme point of care
10.1039/d3sd00304c · 2024 · External reference
Emerging therapeutic strategies for leprosy: trends, challenges, and innovations
10.22207/jpam.19.3.65 · 2025 · External reference
Use of NASBA RNA amplification for detection of Mycobacterium leprae in skin biopsies from untreated and treated leprosy patients
1996 · External reference
Progress in the application of isothermal amplification technology in the diagnosis of infectious diseases
10.3389/fmicb.2025.1601644 · 2025 · External reference
A new paradigm for leprosy diagnosis based on host gene expression
10.1371/journal.ppat.1009972 · 2021 · External reference
In search of biomarkers for leprosy by unraveling the host immune response to Mycobacterium leprae
10.1111/imr.12966 · 2021 · External reference
The critical role of RNA processing and degradation in the control of gene expression
10.1111/j.1574-6976.2010.00242.x · 2010 · External reference
Neglected tropical disease (NTD) diagnostics: current development and operations to advance control
10.1080/20477724.2023.2272095 · 2024 · External reference
Diagnosing point-of-care diagnostics for neglected tropical diseases
10.1371/journal.pntd.0009405 · 2021 · External reference
CRISPR-based diagnostic approaches: implications for rapid management of future pandemics
10.3892/mmr.2023.13005 · 2023 · External reference
Nucleic acid detection with CRISPR-Cas13a/C2c2
10.1126/science.aam9321 · 2017 · External reference
SHERLOCK: nucleic acid detection with CRISPR nucleases
10.1038/s41596-019-0210-2 · 2019 · External reference
CRISPR-Cas12a-based detection and differentiation of Mycobacterium spp
10.1016/j.cca.2024.120101 · 2025 · External reference
Mycobacterium tuberculosis detection using CRISPR technology: an updated systematic review and meta-analysis
10.1007/s40291-024-00741-x · 2024 · External reference
Coming of age: ten years of next-generation sequencing technologies
10.1038/nrg.2016.49 · 2016 · External reference
Phylogenomics and antimicrobial resistance of the leprosy bacillus Mycobacterium leprae
10.1038/s41467-017-02576-z · 2018 · External reference
Comparative genomic and phylogeographic analysis of Mycobacterium leprae
10.1038/ng.477 · 2009 · External reference
Genome-wide comparison of medieval and modern Mycobacterium leprae
10.1126/science.1238286 · 2013 · External reference
Whole genome sequencing distinguishes between relapse and reinfection in recurrent leprosy cases
10.1371/journal.pntd.0005598 · 2017 · External reference
Diagnostics for priority bacterial pathogens: global gaps and research needs for curbing antimicrobial resistance in low-resource settings
10.1016/j.lanmic.2026.101385 · 2026 · External reference
Clinical metagenomic next-generation sequencing for pathogen detection
10.1146/annurev-pathmechdis-012418-012751 · 2019 · External reference
Use of genetic profiling in leprosy to discriminate clinical forms of the disease
10.1126/science.1087785 · 2003 · External reference
Genome-wide screening of mRNA expression in leprosy patients
10.3389/fgene.2015.00334 · 2015 · External reference
RNA sequencing: the teenage years
10.1038/s41576-019-0150-2 · 2019 · External reference
Electrochemical magneto-immunoassay based on Mycobacterium leprae mimotope for serological diagnosis of leprosy
10.1016/j.bios.2024.117022 · 2025 · External reference
Biotechnological and immunological platforms based on PGL-I carbohydrate-like peptide of Mycobacterium leprae for antibodies detection among leprosy clinical forms
10.3389/fmicb.2020.00429 · 2020 · External reference
Epitope imprinting of Mycobacterium leprae bacteria via molecularly imprinted nanoparticles using multiple monomers approach
10.1016/j.bios.2019.111698 · 2019 · External reference
Immunodiagnostic of leprosy exploiting a photoelectrochemical platform based on a recombinant peptide mimetic of a Mycobacterium leprae antigen
2019 · External reference
Engineered biomarkers for leprosy diagnosis using labeled and label-free analysis
10.1016/j.talanta.2018.05.027 · 2018 · External reference
Electrochemical DNA biosensor for Mycobacterium leprae identification
10.1590/1678-4324-2021210030 · 2021 · External reference
A systematic review of immunological studies of erythema nodosum leprosum
10.3389/fimmu.2017.00233 · 2017 · External reference
Laboratory and functional tests in leprosy diagnosis: a practical guide for clinical decision-making
10.1016/j.abd.2026.501297 · 2026 · External reference
Leprosy serology using PGL-I: a systematic review
10.1590/s0037-86822008000700004 · 2008 · External reference
10.1590/0074-02760220317
10.1590/0074-02760220317 · External reference
Unveiling healthy carriers and subclinical infections among household contacts of leprosy patients who play potential roles in the disease chain of transmission
10.1590/s0074-02762012000900010 · 2012 · External reference
Molecular evidence for the aerial route of infection of Mycobacterium leprae and the role of asymptomatic carriers in the persistence of leprosy
10.1093/cid/ciw570 · 2016 · External reference
Latent leprosy infection identified by dual RLEP and anti-PGL-I positivity: implications for new control strategies
10.1371/journal.pone.0251631 · 2021 · External reference
A novel integrated molecular and serological analysis method to predict new cases of leprosy amongst household contacts
10.1371/journal.pntd.0007400 · 2019 · External reference
NDO-BSA, LID-1, and NDO-LID antibody responses for infection and RLEP by quantitative PCR as a confirmatory test for early leprosy diagnosis
10.3389/fitd.2022.850886 · 2022 · External reference
The role of CXCL10 as a biomarker for immunological response among patients with leprosy: a systematic literature review
2024 · External reference
Histological, immunohistochemical, and serological markers of lepra reactions in leprosy
10.4103/ejdv.ejdv_50_23 · 2025 · External reference
Existence of viable Mycobacterium leprae in natural environment and its genetic profiling in a leprosy endemic region
10.3389/fitd.2022.972682 · 2022 · External reference
Skin microbiota–host interactions
10.1038/nature25177 · 2018 · External reference
On the usage of artificial intelligence in leprosy care: a systematic literature review
10.1371/journal.pcbi.1012550 · 2025 · External reference
