Research graph
References from Performance assessment of a novel fully automated ELISA for anti-IA2 autoantibody detection in type 1 diabetes. Local targets link to admitted publications; unresolved targets remain external evidence.
Type 1 diabetes mellitus
10.1038/nrdp.2017.16 · 2017 · External reference
Type 1 diabetes: a new vision of the disease based on endotypes
10.1002/dmrr.3770 · 2024 · External reference
What type 1 diabetes endotype is most suitable for anti-CD3 antibodies prevention trials?
10.1016/j.jdiacomp.2025.109132 · 2025 · External reference
From disease and patient heterogeneity to precision medicine in type 1 diabetes
2022 · External reference
Global type 1 diabetes prevalence, incidence, and mortality estimates 2025: results from the International Diabetes Federation Atlas, 11th edition, and the T1D Index version 3.0
10.1016/j.diabres.2025.112277 · 2025 · External reference
Type 1 diabetes: a review
10.1001/jama.2026.0048 · 2026 · External reference
A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives
10.2147/dmso.s319895 · 2021 · External reference
Diagnosis and classification of diabetes: standards of care in diabetes - 2026
10.2337/dc26-s002 · 2026 · External reference
Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies
10.1016/s0140-6736(74)90140-8 · 1974 · External reference
Anti-islet autoantibodies in type 1 diabetes
10.3390/ijms241210012 · 2023 · External reference
Insulin antibodies in insulin-dependent diabetics before insulin treatment
10.1126/science.6362005 · 1983 · External reference
Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase
10.1038/347151a0 · 1990 · External reference
Pancreatic beta cells express two autoantigenic forms of glutamic acid decarboxylase, a 65-kDa hydrophilic form and a 64-kDa amphiphilic form which can be both membrane-bound and soluble
10.1016/s0021-9258(18)54849-3 · 1991 · External reference
ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules
10.1002/j.1460-2075.1996.tb00564.x · 1996 · External reference
IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitus
10.1073/pnas.93.13.6367 · 1996 · External reference
The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes
10.1073/pnas.0705894104 · 2007 · External reference
The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of diabetes (EASD)
10.1007/s00125-021-05568-3 · 2021 · External reference
The challenges of identifying and studying type 1 diabetes in adults
10.1007/s00125-023-06004-4 · 2023 · External reference
Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children
10.1001/jama.2013.6285 · 2013 · External reference
Understanding islet autoantibodies in prediction of type 1 diabetes
10.1210/jendso/bvad160 · 2024 · External reference
EDENT1FI Master Protocol for screening of presymptomatic early-stage type 1 diabetes in children and adolescents
10.1136/bmjopen-2024-088522 · 2025 · External reference
Prediction of insulin-dependent diabetes mellitus in siblings of children with diabetes. A population-based study. The childhood diabetes in Finland study group
10.1172/jci119879 · 1998 · External reference
The dense core transmembrane vesicle protein IA-2 is a regulator of vesicle number and insulin secretion
10.1073/pnas.0408887102 · 2005 · External reference
Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma
10.1089/dna.1994.13.505 · 1994 · External reference
Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes
10.2337/diab.46.8.1270 · 1997 · External reference
Prediction of IDDM in the general population: strategies based on combinations of autoantibody markers
10.2337/diab.46.11.1701 · 1997 · External reference
Comparing the clinical significance and antigen specificity of insulinoma-associated antigen-2 autoantibodies between radioimmunoassay and enzyme-linked immunosorbent assay in Japanese patients with type 1 diabetes
10.1111/jdi.13910 · 2023 · External reference
Prevalence of IA-2 antibody in patients suffering from diabetes and their first-degree relatives
10.1007/s13410-020-00882-9 · 2021 · External reference
IA-2A positivity increases risk of progression within and across established stages of type 1 diabetes
10.1007/s00125-025-06382-x · 2025 · External reference
Predictors of progression from the appearance of islet autoantibodies to early childhood diabetes: the Environmental Determinants of Diabetes in the Young (TEDDY)
10.2337/dc14-2426 · 2015 · External reference
Only multiple autoantibodies to islet cells (ICA), insulin, GAD65, IA-2 and IA-2beta predict immune-mediated (Type 1) diabetes in relatives
10.1006/jaut.1999.0281 · 1999 · External reference
Stratification of type 1 diabetes risk on the basis of islet autoantibody characteristics
10.2337/diabetes.53.2.384 · 2004 · External reference
Islet autoantibody screening in at-risk adolescents to predict type 1 diabetes until young adulthood: a prospective cohort study
10.1016/s2352-4642(22)00350-9 · 2023 · External reference
Toward disease-modifying therapies in type 1 diabetes: focus on teplizumab
10.2337/dci25-0066 · 2026 · External reference
Two-age islet-autoantibody screening for childhood type 1 diabetes: a prospective cohort study
10.1016/s2213-8587(22)00141-3 · 2022 · External reference
Islet autoimmunity and HLA markers of presymptomatic and clinical type 1 diabetes: joint analyses of prospective cohort studies in Finland, Germany, Sweden, and the U.S
10.2337/dc20-1836 · 2021 · External reference
Screening and prevention of type 1 diabetes: where are we?
10.1210/clinem/dgad328 · 2023 · External reference
Children diagnosed with presymptomatic type 1 diabetes through public health screening have milder diabetes at clinical manifestation
10.1007/s00125-023-05953-0 · 2023 · External reference
Consensus guidance for monitoring individuals with islet autoantibody-positive pre-stage 3 type 1 diabetes
2024 · External reference
Islet autoantibody analysis: radioimmunoassays
10.1007/7651_2015_292 · 2016 · External reference
A comparison of current methods to measure antibodies in type 1 diabetes
10.1515/cclm-2025-0238 · 2025 · External reference
Evaluation of precision, comparability and linearity of MAGLUMI™ 2000 plus GAD65 antibody assay
10.21037/jlpm.2019.09.03 · 2019 · External reference
A comparative evaluation of the chemiluminescence immunoassay and ELISA for the detection of islet autoantibodies in type 1 diabetes
10.3390/diagnostics15131695 · 2025 · External reference
Sensitive non-isotopic assays for autoantibodies to IA-2 and to a combination of both IA-2 and GAD65
10.1016/j.cccn.2005.02.006 · 2005 · External reference
Development and performance evaluation of a novel, fully automated, high-throughput GAD65 autoantibody assay on the Phadia platform
10.1016/j.jim.2025.113885 · 2025 · External reference
Bridging-type enzyme-linked immunoassay for zinc transporter 8 autoantibody measurements in adult patients with diabetes mellitus
10.1016/j.cca.2015.05.010 · 2015 · External reference
3 screen islet cell autoantibody ELISA: a sensitive and specific ELISA for the combined measurement of autoantibodies to GAD(65), to IA-2 and to ZnT8
10.1016/j.cca.2016.08.013 · 2016 · External reference
Evaluation of the RSR 3 screen ICA and 2 screen ICA as screening assays for type 1 diabetes in Sweden
10.1007/s00592-022-01856-5 · 2022 · External reference
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Diagnostik, Therapie und Verlaufskontrolle des Diabetes mellitus im Kindes- und Jugendalter. S3-Leitlinie der DDG und AGDP 2015. AWMF-Registernummer 057–016
10.1055/s-0042-100779 · 2016 · External reference
S2k-Leitlinie Diagnostik, Therapie und Verlaufskontrolle des Diabetes mellitus im Alter. AWMF-Registernummer 057–017
10.1055/a-0666-0820 · 2018 · External reference
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ELISA test for analyzing of incidence of type 1 diabetes autoantibodies (GAD and IA2) in children and adolescents
10.5455/aim.2016.24.61-65 · 2016 · External reference
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2014 · External reference
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2012 · External reference
Recommendations for the bioanalytical method validation of ligand-binding assays to support pharmacokinetic assessments of macromolecules
10.1023/b:pham.0000003390.51761.3d · 2003 · External reference
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2018 · External reference
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2003 · External reference
Large molecule specific assay operation: recommendation for best practices and harmonization from the global bioanalysis consortium harmonization team
10.1208/s12248-013-9542-y · 2013 · External reference
Unresolved reference
2018 · External reference
Evaluation of analytical performances of magnetic force-assisted electrochemical sandwich immunoassay for the quantification of carcinoembryonic antigen
2021 · External reference
ELISA genotyping of hepatitis B virus in China with antibodies specific for genotypes B and C
10.1038/s41598-024-76023-7 · 2024 · External reference
Unresolved reference
2000 · External reference
The measurement of observer agreement for categorical data
10.2307/2529310 · 1977 · External reference
Unresolved reference
2003 · External reference
The longitudinal loss of islet autoantibody responses from diagnosis of type 1 diabetes occurs progressively over follow-up and is determined by low autoantibody titres, early-onset, and genetic variants
10.1093/cei/uxac087 · 2022 · External reference
The prevalence of islet autoantibodies in children and adolescents with type 1 diabetes mellitus: a global scoping review
10.3389/fendo.2022.815703 · 2022 · External reference
Islet autoantibody type-specific titer thresholds improve stratification of risk of progression to type 1 diabetes in children
10.2337/dc21-0878 · 2022 · External reference
Autoantibodies to IA-2 in type 1 diabetes: measurements with a new enzyme-linked immunosorbent assay
10.1111/j.1749-6632.2002.tb02978.x · 2002 · External reference
Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases
10.4049/jimmunol.152.6.3183 · 1994 · External reference
IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. The Belgian Diabetes Registry
10.1007/s001250050648 · 1997 · External reference
Autoantibodies against islet cell antigens in children with type 1 diabetes mellitus
10.18632/oncotarget.24527 · 2018 · External reference
10.1007/s001250050925
10.1007/s001250050925 · External reference
Method comparison of diabetes mellitus associated autoantibodies in serum specimens
10.1515/cclm-2025-0137 · 2025 · External reference
Identification of autoimmune type 1 diabetes and multiple organ-specific autoantibodies in adult-onset non-insulin-requiring diabetes in China: a population-based multicentre nationwide survey
10.1111/dom.13595 · 2019 · External reference
