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References from Liquid biopsy for early detection and biomarker applications in gynecological cancers: current status and future directions. Local targets link to admitted publications; unresolved targets remain external evidence.
The global burden and associated factors of ovarian cancer in 1990–2019: findings from the Global Burden of Disease Study 2019
2022 · External reference
Incidence and Mortality of Cancers in Female Genital Organs — China, 2022
10.46234/ccdcw2024.040 · 2024 · External reference
An umbrella review of socioeconomic status and cancer
2024 · External reference
Clinicopathologic and Genomic Analysis of TP53 -Mutated Endometrial Carcinomas
10.1158/1078-0432.ccr-20-4436 · 2021 · External reference
Homologous recombination proficiency in ovarian and breast cancer patients
2021 · External reference
The proportion of endometrial tumours associated with Lynch syndrome (PETALS): A prospective cross-sectional study
2020 · External reference
Socioeconomic Burden of Ovarian Cancer in 11 Countries
2025 · External reference
Economic burden and treatment patterns of gynecologic cancers in the United States: evidence from the Medical Expenditure Panel Survey 2007–2014
2020 · External reference
Invasive Epithelial Ovarian Cancer Survival by Histotype and Disease Stage
10.1093/jnci/djy071 · 2018 · External reference
Correction: Liquid biopsy in gynecological cancers: a translational framework from molecular insights to precision oncology and clinical practice
2025 · External reference
Screening for Ovarian Cancer: US Preventive Services Task Force Recommendation Statement
10.1097/01.ogx.0000534156.01931.80 · 2018 · External reference
Current and Emerging Strategies for Tubo-Ovarian Cancer Diagnostics
10.3390/diagnostics13213331 · 2023 · External reference
Liquid biopsy in cancer: current status, challenges and future prospects
2024 · External reference
Ovarian cancer detection by DNA methylation in cervical scrapings
2019 · External reference
Liquid Biopsy: Blood-Based Analyses of ctDNA and CTCs
10.1093/clinchem/hvab168 · 2021 · External reference
Towards Preanalytical Best Practices for Liquid Biopsy Studies: A BLOODPAC Landscape Analysis
10.1002/cpt.3416 · 2024 · External reference
Assessment of Pre-Analytical Sample Handling Conditions for Comprehensive Liquid Biopsy Analysis
10.1016/j.jmoldx.2020.05.006 · 2020 · External reference
Multi-analyte approach combining cfDNA sequencing and protein testing for early ovarian cancer detection
10.1016/j.isci.2025.112617 · 2025 · External reference
Clinical utility of various liquid biopsy samples for the early detection of ovarian cancer: a comprehensive review
2025 · External reference
Recommendations for Cell-Free DNA Assay Validations
10.1016/j.jmoldx.2023.09.004 · 2023 · External reference
Circulating Cell-Free DNA Methylation Profiles in the Early Detection of Ovarian Cancer: A Scoping Review of the Literature
2021 · External reference
Cell-free DNA fragmentomics in cancer
10.1016/j.ccell.2025.09.006 · 2025 · External reference
QUADAS-2: A Revised Tool for the Quality Assessment of Diagnostic Accuracy Studies
10.7326/0003-4819-155-8-201110180-00009 · 2011 · External reference
REporting recommendations for tumour MARKer prognostic studies (REMARK)
10.1038/sj.bjc.6602678 · 2005 · External reference
Liquid Biopsy, ctDNA Diagnosis through NGS
2021 · External reference
Next-generation sequencing methodologies to detect low-frequency mutations: “Catch me if you can”
2023 · External reference
Development of a highly sensitive liquid biopsy platform to detect clinically-relevant cancer mutations at low allele fractions in cell-free DNA
2018 · External reference
Targeted next-generation sequencing of endometrial cancer and matched circulating tumor DNA: identification of plasma-based, tumor-associated mutations in early stage patients
10.1038/s41379-018-0158-8 · 2019 · External reference
Ultra-deep sequencing detects ovarian cancer cells in peritoneal fluid and reveals somatic TP53 mutations in noncancerous tissues
10.1073/pnas.1601311113 · 2016 · External reference
Early detection, clinicopathological subtyping, and prognosis prediction for endometrial cancer patients using fragmentomics liquid biopsy assay
2025 · External reference
Fragmentomics features of ovarian cancer
10.1002/ijc.34981 · 2024 · External reference
Refined characterization of circulating tumor DNA through biological feature integration
2022 · External reference
Cell-free DNA end characteristics enable accurate and sensitive cancer diagnosis
2024 · External reference
Effects of Collection and Processing Procedures on Plasma Circulating Cell-Free DNA from Cancer Patients
10.1016/j.jmoldx.2018.07.005 · 2018 · External reference
Characterization of Plasma Cell-Free DNA Variants as of Tumor or Clonal Hematopoiesis Origin in 16,812 Advanced Cancer Patients
10.1158/1078-0432.ccr-24-3335 · 2025 · External reference
Preexisting TP53-Variant Clonal Hematopoiesis and Risk of Secondary Myeloid Neoplasms in Patients With High-grade Ovarian Cancer Treated With Rucaparib
2021 · External reference
The impact of preanalytical variables on the analysis of cell-free DNA from blood and urine samples
2024 · External reference
Circulating tumor cell isolation for cancer diagnosis and prognosis
10.1016/j.ebiom.2022.104237 · 2022 · External reference
Circulating tumor cells: from new biological insights to clinical practice
2024 · External reference
Gene expression profiling of single circulating tumor cells in ovarian cancer – Establishment of a multi-marker gene panel
10.1016/j.molonc.2016.04.002 · 2016 · External reference
The Role of Circulating Tumor Cells in Ovarian Cancer Dissemination
10.3390/cancers14246030 · 2022 · External reference
Enrichment and detection method for the prognostic value of circulating tumor cells in ovarian cancer: A meta-analysis
10.1016/j.ygyno.2021.02.024 · 2021 · External reference
Prognostic Value of Circulating Tumor Cells in Ovarian Cancer: A Meta-Analysis
2015 · External reference
Circulating tumour cells: The Good, the Bad and the Ugly
2023 · External reference
Exosomal microRNA biomarkers in ovarian cancer detection: systematic review and meta-analysis
10.1016/j.cca.2025.120771 · 2026 · External reference
OCaMIR—A Noninvasive, Diagnostic Signature for Early-Stage Ovarian Cancer: A Multi-cohort Retrospective and Prospective Study
10.1158/1078-0432.ccr-21-0267 · 2021 · External reference
A novel circulating miRNA panel for non-invasive ovarian cancer diagnosis and prognosis
10.1038/s41416-022-01925-0 · 2022 · External reference
Circulating Exosomal miRNAs as Biomarkers in Epithelial Ovarian Cancer
10.3390/biomedicines9101433 · 2021 · External reference
Review on Strategies and Technologies for Exosome Isolation and Purification
2022 · External reference
A review of exosomal isolation methods: is size exclusion chromatography the best option?
10.3390/ijms21186466 · 2020 · External reference
Predictive value of an exosomal microRNA-based signature for tumor immunity in cervical cancer patients treated with chemoradiotherapy
10.1007/s00795-022-00338-5 · 2022 · External reference
Predict ovarian cancer by pairing serum miRNAs: Construct of single sample classifiers
2022 · External reference
Early diagnosis of ovarian cancer based on methylation profiles in peripheral blood cell-free DNA: a systematic review
2023 · External reference
A multiplex methylation-specific PCR assay for the detection of early-stage ovarian cancer using cell-free serum DNA
10.1016/j.ygyno.2013.04.048 · 2013 · External reference
Highly Specific Droplet-Digital PCR Detection of Universally Methylated Circulating Tumor DNA in Endometrial Carcinoma
10.1093/clinchem/hvac020 · 2022 · External reference
Role of cfDNA and ctDNA to improve the risk stratification and the disease follow-up in patients with endometrial cancer: towards the clinical application
2024 · External reference
Precision gynecologic oncology: circulating cell free DNA epigenomic analysis, artificial intelligence and the accurate detection of ovarian cancer
2022 · External reference
Integrated Epigenomics Analysis Reveals a DNA Methylation Panel for Endometrial Cancer Detection Using Cervical Scrapings
10.1158/1078-0432.ccr-16-0863 · 2017 · External reference
Performance of Liquid Biopsy-Based Multi-Omics Biomarkers for Early Detection of Gynecological Malignancies: A Prospective Study (PERCEIVE-I)
2025 · External reference
Clinical validation of a targeted methylation-based multi-cancer early detection test using an independent validation set
10.1016/j.annonc.2021.05.806 · 2021 · External reference
Multi-cancer early detection test sensitivity for cancers with and without current population-level screening options
10.1177/03008916221133136 · 2022 · External reference
New genomic technologies for multi-cancer early detection: Rethinking the scope of cancer screening
10.1016/j.ccell.2022.01.012 · 2022 · External reference
Extracellular vesicle and particle-based blood test for ovarian cancer screening of average risk population: a promising nested case control study using preclinical samples
10.1016/j.ygyno.2025.10.003 · 2025 · External reference
Circulating tumor DNA in the diagnosis of ovarian cancer: a systematic review
2026 · External reference
Integration of ultrasonography and circulating tumor DNA analysis enhances early detection of asymptomatic ovarian cancer
10.5603/gpl.103762 · 2026 · External reference
Diagnostic Accuracy of Liquid Biopsy in Endometrial Cancer
10.3390/cancers13225731 · 2021 · External reference
Detection of endometrial cancer using tampon-based collection and methylated DNA markers
10.1016/j.ygyno.2023.04.014 · 2023 · External reference
DNA Methylation of Combined Gene Markers in Cytological Specimens for Endometrial Cancer Screening
10.1002/dc.70081 · 2026 · External reference
Liquid biopsy biomarkers in cervical cancer: A systematic review and meta-analysis
2025 · External reference
Molecular Triage of Premalignant Lesions in Liquid-Based Cervical Cytology and Circulating Cell-Free DNA from Urine, Using a Panel of Methylated Human Papilloma Virus and Host Genes
10.1158/1940-6207.capr-16-0138 · 2016 · External reference
Circulating cell-free tumor human papillomavirus DNA is a promising biomarker in cervical cancer
10.1016/j.ygyno.2022.07.028 · 2022 · External reference
Liquid Biopsy Analysis of the EV-Associated Micro-RNA Signature in Vulvar Carcinoma May Benefit Disease Diagnosis and Prognosis
10.3390/cancers18030438 · 2026 · External reference
New Trends in the Detection of Gynecological Precancerous Lesions and Early-Stage Cancers
10.3390/cancers13246339 · 2021 · External reference
Applying low coverage whole genome sequencing to detect malignant ovarian mass
2021 · External reference
Exploratory Analysis of TP53 Mutations in Circulating Tumour DNA as Biomarkers of Treatment Response for Patients with Relapsed High-Grade Serous Ovarian Carcinoma: A Retrospective Study
2016 · External reference
Circulating HOXA9-methylated tumour DNA: A novel biomarker of response to poly (ADP-ribose) polymerase inhibition in BRCA-mutated epithelial ovarian cancer
10.1016/j.ejca.2019.11.012 · 2020 · External reference
Epigenetic and Genomic Hallmarks of PARP-Inhibitor Resistance in Ovarian Cancer Patients
10.3390/genes15060750 · 2024 · External reference
Serial Circulating Tumor DNA Analysis with a Tumor-Naïve Next-Generation Sequencing Panel Detects Minimal Residual Disease and Predicts Outcome in Ovarian Cancer
10.1158/0008-5472.can-23-1429 · 2023 · External reference
Dynamic changes in TP53 mutated circulating tumor DNA predicts outcome of patients with high-grade ovarian carcinomas
10.1136/ijgc-2024-005581 · 2024 · External reference
Early ctDNA response to chemotherapy. A potential surrogate marker for overall survival
10.1016/j.ejca.2021.03.006 · 2021 · External reference
Circulating tumor DNA monitoring in ovarian cancer patients receiving PARPi maintenance therapy: Can we further personalize treatment?
10.1016/j.ygyno.2025.11.005 · 2026 · External reference
Circulating tumor DNA as a biomarker for predicting progression-free survival and overall survival in patients with epithelial ovarian cancer: a systematic review and meta-analysis
10.1136/ijgc-2024-005313 · 2024 · External reference
Dynamic analysis of circulating tumor DNA to predict prognosis and monitor therapeutic response in metastatic relapsed cervical cancer
10.1002/ijc.33362 · 2020 · External reference
Liquid biopsy: current technology and clinical applications
2022 · External reference
The Role of Circulating Tumor DNA in Ovarian Cancer
10.3390/cancers16183117 · 2024 · External reference
Circulating tumor DNA monitoring for early recurrence detection in epithelial ovarian cancer
10.1016/j.ygyno.2022.09.004 · 2022 · External reference
Circulating tumor DNA as a prognostic marker in high-risk endometrial cancer
2021 · External reference
Genomic Analysis of Uterine Lavage Fluid Detects Early Endometrial Cancers and Reveals a Prevalent Landscape of Driver Mutations in Women without Histopathologic Evidence of Cancer: A Prospective Cross-Sectional Study
2016 · External reference
Personalized tumor-specific DNA junctions to detect circulating tumor in patients with endometrial cancer
2021 · External reference
Sensitive circulating tumor DNA–based residual disease detection in epithelial ovarian cancer
2024 · External reference
Post-surgical ctDNA-based molecular residual disease detection in patients with stage I uterine malignancies
10.1016/j.ygyno.2023.12.025 · 2024 · External reference
BRCA Reversion Mutations in Circulating Tumor DNA Predict Primary and Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma
10.1158/2159-8290.cd-18-0715 · 2019 · External reference
Reversion of BRCA1/2 Germline Mutations Detected in Circulating Tumor DNA From Patients With High-Grade Serous Ovarian Cancer
10.1200/jco.2016.70.4627 · 2017 · External reference
Noninvasive detection of microsatellite instability in patients with endometrial cancer
10.1002/ijc.34435 · 2023 · External reference
Validation of Microsatellite Instability Detection Using a Comprehensive Plasma-Based Genotyping Panel
10.1158/1078-0432.ccr-19-1324 · 2019 · External reference
Tumor Mutational Burden in Cervical Cancer as Potential Marker for Immunotherapy Responders
2025 · External reference
Targeted Mutational Analysis of Circulating Tumor DNA to Decipher Temporal Heterogeneity of High-Grade Serous Ovarian Cancer
10.3390/cancers14153697 · 2022 · External reference
Prognostic value of circulating tumor cells and disseminated tumor cells in patients with ovarian cancer: a systematic review and meta-analysis
2015 · External reference
Liquid Biopsy for Monitoring EC Patients: Towards Personalized Treatment
10.3390/cancers14061405 · 2022 · External reference
Epigenetic Alteration by DNA Methylation of ESR1, MYOD1 and hTERT Gene Promoters is Useful for Prediction of Response in Patients of Locally Advanced Invasive Cervical Carcinoma Treated by Chemoradiation
10.1016/j.clon.2015.08.001 · 2015 · External reference
A microRNA expression signature for clinical response in locally advanced cervical cancer
10.1016/j.ygyno.2016.07.093 · 2016 · External reference
Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers
2018 · External reference
Prognostic value of circulating tumor DNA at diagnosis and its early decrease after one cycle of neoadjuvant chemotherapy for patients with advanced epithelial ovarian cancer. An ancillary analysis of the CHIVA phase II GINECO trial
10.1016/j.ygyno.2024.12.004 · 2025 · External reference
Prognostic value of perioperative circulating tumor DNA in endometrial cancer: systematic review & meta-analysis
10.1016/j.ygyno.2025.12.008 · 2026 · External reference
Prognostic significance of circulating tumor DNA detection and quantification in cervical cancer: a systematic review and meta-analysis
2025 · External reference
Ultrasensitive detection and tracking of circulating tumor DNA to predict relapse and survival in patients with locally advanced cervical cancer: phase III CALLA trial analyses
10.1016/j.annonc.2025.05.533 · 2025 · External reference
The prognostic value of tumor-informed minimal residual disease detection using circulating tumor DNA in first-line treatment of ovarian cancer
10.1016/j.ygyno.2024.11.002 · 2025 · External reference
Clinical Validation of Human Papilloma Virus Circulating Tumor DNA for Early Detection of Residual Disease After Chemoradiation in Cervical Cancer
10.1200/jco.23.00954 · 2024 · External reference
Prognostic value of human papillomavirus cell-free DNA in cervical cancer patients: A systematic review and meta-analysis
10.5772/intechopen.107755 · 2024 · External reference
Identification and Validation of a Novel Multiomics Signature for Prognosis and Immunotherapy Response of Endometrial Carcinoma
2022 · External reference
Concordance of Genomic Alterations in Ovarian Cancer Tissues and Circulating-Tumor DNA: A Pilot Study
10.3390/ijms27031305 · 2026 · External reference
Liquid biopsies for the front line therapy decision in non-small cell lung cancer
10.1200/jco.2021.39.15_suppl.e21103 · 2021 · External reference
Liquid Biopsy Versus Tissue Biopsy to Determine Front Line Therapy in Metastatic Non-Small Cell Lung Cancer (NSCLC)
10.1016/j.cllc.2022.11.007 · 2023 · External reference
Specialized Blood Collection Tubes for Liquid Biopsy: Improving the Pre-analytical Conditions
10.1007/s40291-019-00442-w · 2019 · External reference
Cost-effectiveness assessment of liquid biopsy for early detection of lung cancer in Brazil
2025 · External reference
Genomic landscape of liquid biopsy mutations in TP53 and DNA damage genes in cancer patients
2024 · External reference
Direct detection of early-stage cancers using circulating tumor DNA
2017 · External reference
Unresolved reference
2024 · External reference
Socioeconomic impact of artificial intelligence–driven point-of-care testing devices for liquid biopsy in the OncoCheck system
2025 · External reference
Smart biosensors for multiplexed and fully integrated point-of-care diagnostics
10.1039/c6lc90046a · 2016 · External reference
Digital sensing technologies in cancer care: A new era in early detection and personalized diagnosis
2025 · External reference
Single-cell low-pass whole genome sequencing accurately detects circulating tumor cells for liquid biopsy-based multi-cancer diagnosis
2024 · External reference
An artificial intelligence-based model for prediction of clonal hematopoiesis variants in cell-free DNA samples
2025 · External reference
A large-scale, multi-centre validation study of an AI-empowered blood-based test for multi-cancer early detection
2025 · External reference
Blood-based tests for multicancer early detection (PATHFINDER): a prospective cohort study
10.1016/s0140-6736(23)01700-2 · 2023 · External reference
Personalized Circulating Tumor DNA Biomarkers Dynamically Predict Treatment Response and Survival In Gynecologic Cancers
2015 · External reference