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References from Precision medicine in MASLD: Integrating genetics, multi-omics, and artificial intelligence for risk stratification and targeted therapy. Local targets link to admitted publications; unresolved targets remain external evidence.
Precision medicine and nucleotide-based therapeutics to treat steatotic liver disease
10.3350/cmh.2024.0438 · 2025 · External reference
A multisociety Delphi consensus statement on new fatty liver disease nomenclature
10.1016/j.jhep.2023.06.003 · 2023 · External reference
A review of the therapeutic effects of polyphenols on non-alcoholic fatty liver disease: focus on oxidative stress
10.18502/abi.v2i1.16242 · 2024 · External reference
Perspectives on precision medicine approaches to NAFLD diagnosis and management
10.1007/s12325-021-01690-1 · 2021 · External reference
Current status of liver transplantation in Europe
10.1016/j.ijsu.2020.05.062 · 2020 · External reference
Recent advances in nanodelivery systems for polyphenols in metabolic dysfunction-associated steatotic liver disease (MASLD): an update
2025 · External reference
Systemic impacts of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) on heart, muscle, and kidney related diseases
10.3389/fcell.2024.1433857 · 2024 · External reference
Integrated Management of Cardiovascular-Renal-Hepatic-Metabolic Syndrome: expanding roles of SGLT2is, GLP-1RAs, and GIP/GLP-1RAs
10.3390/biomedicines13010135 · 2025 · External reference
From cardiovascular-kidney-metabolic syndrome to cardiovascular-renal-hepatic-metabolic syndrome: proposing an expanded framework
10.3390/biom15020213 · 2025 · External reference
The potential pathophysiological role of altered lipid metabolism and electronegative low-density lipoprotein (LDL) in non-alcoholic fatty liver disease and cardiovascular diseases
10.1016/j.cca.2021.10.018 · 2021 · External reference
Metabolic dysfunction-associated steatotic liver disease: heterogeneous pathomechanisms and effectiveness of metabolism-based treatment
10.1016/s2213-8587(24)00318-8 · 2025 · External reference
Interactions between Genetic and Environmental Risk Factors in Lifestyle Diseases
2025 · External reference
Environmental pollutants and metabolic disorders: the multi-exposure scenario of life
10.3389/fendo.2018.00582 · 2018 · External reference
Nonalcoholic steatohepatitis in precision medicine: Unraveling the factors that contribute to individual variability
10.1016/j.pharmthera.2015.03.005 · 2015 · External reference
P4 medicine: how systems medicine will transform the healthcare sector and society
2013 · External reference
Precision oncology: transforming cancer care through personalized medicine
10.1007/s12032-025-02817-y · 2025 · External reference
Molecular mechanisms in MASLD/MASH-related HCC
10.1097/hep.0000000000000786 · 2025 · External reference
Advancements in personalized medicine for Leukemia: integrating genetic, transcriptomic, and artificial intelligence insights
10.2174/0113816128402252251005215721 · 2025 · External reference
Precision medicine in colorectal cancer: leveraging multi-omics, spatial omics, and artificial intelligence
10.1016/j.cca.2024.119686 · 2024 · External reference
Multiomics biomarkers for the prediction of nonalcoholic fatty liver disease severity
10.3748/wjg.v24.i15.1601 · 2018 · External reference
The role of omics in the pathophysiology, diagnosis and treatment of non-alcoholic fatty liver disease
2020 · External reference
Predictive, personalized, preventive, participatory (P4) cancer medicine
10.1038/nrclinonc.2010.227 · 2011 · External reference
Recent advances in nonalcoholic fatty liver disease metabolomics
10.3350/cmh.2021.0127 · 2021 · External reference
Genetics of metabolic dysfunction-associated steatotic liver disease: the state of the art update
10.1016/j.cgh.2024.05.052 · 2024 · External reference
Precision medicine in nonalcoholic fatty liver disease: new therapeutic insights from genetics and systems biology
10.3350/cmh.2020.0136 · 2020 · External reference
siRNA-mediated gene silencing for non-alcoholic fatty liver disease: a comprehensive review of molecular targets
10.1016/j.eurpolymj.2024.112866 · 2024 · External reference
Exploring the role of genetic variations in NAFLD: implications for disease pathogenesis and precision medicine approaches
10.1186/s40001-024-01708-8 · 2024 · External reference
A protein-truncating HSD17B13 variant and protection from chronic liver disease
10.1056/nejmoa1712191 · 2018 · External reference
Kurbasic, predicting and elucidating the etiology of fatty liver disease: a machine learning modeling and validation study in the IMI
2020 · External reference
Clinical use of current polygenic risk scores may exacerbate health disparities
10.1038/s41588-019-0379-x · 2019 · External reference
A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation
10.1038/s41588-022-01078-z · 2022 · External reference
Performance of noninvasive tests of fibrosis among Asians, Hispanic, and non-Hispanic whites in the STELLAR trials
10.1016/j.cgh.2022.01.015 · 2023 · External reference
Gender differences in nonalcoholic fatty liver disease
2022 · External reference
NAFLD as a sexual dimorphic disease: role of gender and reproductive status in the development and progression of nonalcoholic fatty liver disease and inherent cardiovascular risk
10.1007/s12325-017-0556-1 · 2017 · External reference
Precision non-alcoholic fatty liver disease (NAFLD) diagnosis: leveraging ensemble machine learning and gender insights for cost-effective detection
2024 · External reference
Sex differences in mortality and liver-related events in non-alcoholic fatty liver disease: A systematic review and meta-analysis
10.1111/liv.15910 · 2024 · External reference
Sex disparity in hepatocellular carcinoma owing to NAFLD and non-NAFLD etiology: epidemiological findings and pathobiological mechanisms
2020 · External reference
A machine learning based framework to identify and classify non-alcoholic fatty liver disease in a large-scale population
2022 · External reference
Noninvasive tests to identify liver fibrosis in metabolic dysfunction-associated steatotic liver disease are affected by race
10.1002/oby.23960 · 2024 · External reference
Advancing non-alcoholic fatty liver disease prediction: a comprehensive machine learning approach integrating SHAP interpretability and multi-cohort validation
10.3389/fendo.2024.1450317 · 2024 · External reference
Guidance on use of race, ethnicity, and geographic origin as proxies for genetic ancestry groups in biomedical publications
10.1016/j.ajhg.2024.03.003 · 2024 · External reference
A new definition for metabolic dysfunction-associated fatty liver disease: an international expert consensus statement
10.1016/j.jhep.2020.03.039 · 2020 · External reference
MAFLD: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease
10.1053/j.gastro.2019.11.312 · 2020 · External reference
Phenotypes of non-alcoholic fatty liver disease (NAFLD) and all-cause mortality: unsupervised machine learning analysis of NHANES III
10.1136/bmjopen-2022-067203 · 2022 · External reference
Navigating liver health with metabolomics: A comprehensive review
10.1016/j.cca.2024.120038 · 2025 · External reference
Multiple machine learning identifies key gene PHLDA1 suppressing NAFLD progression
10.1007/s10753-024-02164-6 · 2025 · External reference
Heterogeneity in intrahepatic macrophage populations and druggable target expression in patients with steatotic liver disease-related fibrosis
2024 · External reference
Microarray-based detection of critical overexpressed genes in the progression of hepatic fibrosis in non-alcoholic fatty liver disease: A protein-protein interaction network analysis
10.2174/0929867330666230516123028 · 2024 · External reference
NIS2+™, An optimisation of the blood-based biomarker NIS4® technology for the detection of at-risk NASH: a prospective derivation and validation study
2023 · External reference
Serum identification of at-risk MASH: the metabolomics-advanced steatohepatitis fibrosis score (MASEF)
10.1097/hep.0000000000000542 · 2023 · External reference
Development of a novel non-invasive biomarker panel for hepatic fibrosis in MASLD
2024 · External reference
Obesity, metabolism, large-scale plasma proteomics improves prediction of major adverse liver outcomes in individuals with MASLD
2026 · External reference
Association of per-and polyfluoroalkyl substance exposure with fatty liver disease risk in US adults
2023 · External reference
Association between per-and poly-fluoroalkyl substances and nonalcoholic fatty liver disease: a nested case-control study in northwest China
10.1016/j.envpol.2024.123937 · 2024 · External reference
Associations of urinary organophosphate esters metabolites and diet quality with nonalcoholic/metabolic dysfunction-associated fatty liver diseases in adults
2023 · External reference
DNA methylation and target gene expression in fatty liver progression from simple steatosis to advanced fibrosis
2025 · External reference
Gradual DNA methylation changes reveal transcription factors implicated in metabolic dysfunction-associated steatotic liver disease progression and epigenetic age acceleration
2025 · External reference
Hexokinase 2-mediated metabolic stress and inflammation burden of liver macrophages via histone lactylation in MASLD
10.1016/j.celrep.2025.115350 · 2025 · External reference
Circulating histones as potential biomarkers of MASLD-MASH-HCC progression
2025 · External reference
Multicenter collaborative study to optimize mass spectrometry workflows of clinical specimens
2023 · External reference
A generative AI framework unifies human multi-omics to model aging, metabolic health, and intervention response
2026 · External reference
Validation of two LCHRMS methods for large-scale untargeted metabolomics of serum samples: strategy to establish method fitness-for-purpose
10.1016/j.chroma.2024.465230 · 2024 · External reference
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
10.1038/ng.257 · 2008 · External reference
Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease
10.1038/ng.2901 · 2014 · External reference
Circulating miRNAs as novel diagnostic biomarkers in nonalcoholic fatty liver disease: a systematic review and meta-analysis
10.1155/2019/2096161 · 2019 · External reference
Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: a multicenter validation study
10.1002/hep.23050 · 2009 · External reference
Application of artificial intelligence in non-alcoholic fatty liver disease and liver fibrosis: a systematic review and meta-analysis
10.1177/17562848211062807 · 2021 · External reference
Machine learning models for predicting non-alcoholic fatty liver disease in the general United States population: NHANES database
10.4254/wjh.v13.i10.1417 · 2021 · External reference
Machine learning models for predicting metabolic dysfunction-associated steatotic liver disease prevalence using basic demographic and clinical characteristics
10.1186/s12967-025-06387-5 · 2025 · External reference
Development and validation of an explainable machine learning model using routine laboratory biomarkers for identifying prevalent MASLD: evidence from two observational studies
10.1007/s10238-026-02163-x · 2026 · External reference
Machine-learning algorithm for predicting fatty liver disease in a Taiwanese population
10.3390/jpm12071026 · 2022 · External reference
Use of machine learning to predict onset of NAFLD in an all-comers cohort-development and validation in 2 large Asian cohorts
10.1016/j.gastha.2024.06.007 · 2024 · External reference
Application of quantitative ultrasonography and artificial intelligence for assessing severity of fatty liver: A pilot study
2024 · External reference
Noninvasive diagnosis of nonalcoholic fatty liver disease and quantification of liver fat with radiofrequency ultrasound data using one-dimensional convolutional neural networks
10.1148/radiol.2020191160 · 2020 · External reference
Image-based AI diagnostic performance for fatty liver: a systematic review and meta-analysis
10.1186/s12880-023-01172-6 · 2023 · External reference
Advancing AI-assisted US screening for fatty liver
10.1148/radiol.232442 · 2023 · External reference
Physics-aware imaging AI for quantitative MASLD biomarker mapping: a systematic review of deep learning and radiomics across ultrasound, CT, and MRI
10.1007/s00261-025-05317-9 · 2026 · External reference
Artificial intelligence in nonalcoholic fatty liver disease: A new frontier in diagnosis and treatment
10.1002/cld.1071 · 2021 · External reference
Clinical validation of an AI-based pathology tool for scoring of metabolic dysfunction-associated steatohepatitis
10.1038/s41591-024-03301-2 · 2025 · External reference
Artificial intelligence in precision medicine in hepatology
10.1111/jgh.15415 · 2021 · External reference
Machine learning survival models for non-alcoholic fatty liver disease based on a health checkup cohort
10.1186/s12876-025-04120-6 · 2025 · External reference
Diagnostic of fatty liver using radiomics and deep learning models on non-contrast abdominal CT
2025 · External reference
Transfer learning with pre-trained deep convolutional neural networks for the automatic assessment of liver steatosis in ultrasound images
2021 · External reference
A machine learning-based predictive model discriminates nonalcoholic steatohepatitis from nonalcoholic fatty liver disease
10.1016/j.heliyon.2024.e38848 · 2024 · External reference
Biological and clinical role of TREM2 in liver diseases
10.1097/hc9.0000000000000578 · 2024 · External reference
Effect of curcumin on attenuation of liver cirrhosis via genes/proteins and pathways: A system pharmacology study
10.3390/nu14204344 · 2022 · External reference
Target deconvolution of fenofibrate in nonalcoholic fatty liver disease using bioinformatics analysis
10.1155/2021/3654660 · 2021 · External reference
Effect of calebin-A on critical genes related to NAFLD: A protein-protein interaction network and molecular docking study
10.2174/0113892029280454240214072212 · 2024 · External reference
Statins as a potential treatment for non-alcoholic fatty liver disease: target deconvolution using protein-protein interaction network analysis
10.2174/0929867331666230829164832 · 2025 · External reference
AZD2693, a PNPLA3 antisense oligonucleotide, for the treatment of MASH in 148M homozygous participants: two randomized phase I trials
10.1016/j.jhep.2024.12.046 · 2025 · External reference
Phase I randomized double-blind study of an RNA interference therapeutic targeting HSD17B13 for metabolic dysfunction-associated steatohepatitis
10.1016/j.jhep.2025.05.031 · 2025 · External reference
A phase 3, randomized, controlled trial of Resmetirom in NASH with liver fibrosis
10.1056/nejmoa2309000 · 2024 · External reference
Phase 3 trial of Semaglutide in metabolic dysfunction-associated steatohepatitis
10.1056/nejmoa2413258 · 2025 · External reference
PNPLA3 gene polymorphism and response to lifestyle modification in patients with nonalcoholic fatty liver disease
10.1111/jgh.12656 · 2015 · External reference
Design and rationale of the WELCOME trial: a randomised, placebo controlled study to test the efficacy of purified long chainomega-3 fatty acid treatment in non-alcoholic fatty liver disease [corrected]
10.1016/j.cct.2014.02.002 · 2014 · External reference
Treating liver fat and serum triglyceride levels in NAFLD, effects of PNPLA3 and TM6SF2 genotypes: results from the WELCOME trial
10.1016/j.jhep.2015.07.036 · 2015 · External reference
Statin use and non-alcoholic steatohepatitis in at risk individuals
10.1016/j.jhep.2015.05.006 · 2015 · External reference
EASL–EASD–EASO clinical practice guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD)
10.1016/j.jhep.2024.04.031 · 2024 · External reference
Pharmaco-economic assessment of screening strategies for high-risk MASLD in primary care
10.1111/liv.16119 · 2025 · External reference
Cost-effectiveness of MASH diagnosis and management approaches among those with type 2 diabetes
10.1001/jamanetworkopen.2025.42750 · 2025 · External reference
Utility and cost-effectiveness of LiverMultiScan for MASLD diagnosis: a real-world multi-national randomised clinical trial
10.1038/s43856-025-00796-9 · 2025 · External reference
Non-alcoholic fatty liver and liver fibrosis predictive analytics: risk prediction and machine learning techniques for improved preventive medicine
10.1007/s10916-020-01693-5 · 2021 · External reference
Omics, big data and machine learning as tools to propel understanding of biological mechanisms and to discover novel diagnostics and therapeutics
10.1016/j.metabol.2018.08.002 · 2018 · External reference
Application of artificial intelligence for the diagnosis and treatment of liver diseases
10.1002/hep.31603 · 2021 · External reference