Research graph
References from Bioelectric regulation of stem cell fate: From the plasma membrane to organelles. Local targets link to admitted publications; unresolved targets remain external evidence.
Bioelectric signaling: reprogrammable circuits underlying embryogenesis, regeneration, and cancer
10.1016/j.cell.2021.02.034 · 2021 · External reference
Membrane potential controls adipogenic and osteogenic differentiation of mesenchymal stem cells
10.1371/journal.pone.0003737 · 2008 · External reference
Progenitor hyperpolarization regulates the sequential generation of neuronal subtypes in the developing neocortex
10.1016/j.cell.2018.06.036 · 2018 · External reference
The ion channels of endomembranes
10.1152/physrev.00025.2023 · 2024 · External reference
Bioenergetic mechanisms of seizure control
10.3389/fncel.2018.00335 · 2018 · External reference
Monitoring and modulating cardiac bioelectricity: from Einthoven to end-user
10.1093/europace/euae300 · 2024 · External reference
Balancing ER-Mitochondrial Ca(2+) fluxes in health and disease
10.1016/j.tcb.2021.02.003 · 2021 · External reference
Endosomal pH is an evolutionarily conserved driver of phenotypic plasticity in colorectal cancer
10.1038/s41540-024-00463-0 · 2024 · External reference
Sensing the squeeze: nuclear mechanotransduction in health and disease
10.1080/19491034.2024.2374854 · 2024 · External reference
Remodeling of calcium signaling and store operated calcium entry as a consequence of human neural progenitor cell differentiation
10.1038/s41598-025-22675-y · 2025 · External reference
The responsive nucleus: morphological signatures of cellular state
10.1080/19491034.2026.2630145 · 2026 · External reference
PIEZO-dependent mechanosensing is essential for intestinal stem cell fate decision and maintenance
10.1126/science.adj7615 · 2024 · External reference
PIEZO1-mediated calcium signaling reinforces mechanical properties of hair follicle stem cells to promote quiescence
10.4028/b-xdtcg5 · 2025 · External reference
Transient mechanical activation of the Piezo1 channel facilitates ex vivo expansion of hematopoietic stem cells
10.1038/s41422-025-01209-1 · 2026 · External reference
Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry
10.1016/j.neuron.2025.11.009 · 2026 · External reference
Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels
10.1038/s41556-024-01353-7 · 2024 · External reference
Piezo1 regulates colon stem cells to maintain epithelial homeostasis through SCD1-Wnt-β-catenin and programming fatty acid metabolism
10.1016/j.celrep.2025.115400 · 2025 · External reference
Notch as a molecular switch in neural stem cells
10.1002/iub.362 · 2010 · External reference
Wnt-Notch signaling interactions during neural and astroglial patterning of human stem cells
10.1089/ten.tea.2019.0202 · 2020 · External reference
Opposing activities of Notch and Wnt signaling regulate intestinal stem cells and gut homeostasis
10.1016/j.celrep.2015.03.007 · 2015 · External reference
Cation channel TMEM63A autonomously facilitates oligodendrocyte differentiation at an early stage
10.1007/s12264-024-01338-4 · 2025 · External reference
TMEM63A, associated with hypomyelinating leukodystrophies, is an evolutionarily conserved regulator of myelination
10.1073/pnas.2507354122 · 2025 · External reference
Measuring absolute membrane potential across space and time
10.1146/annurev-biophys-062920-063555 · 2021 · External reference
Lysosomes as dynamic regulators of cell and organismal homeostasis
10.1038/s41580-019-0185-4 · 2020 · External reference
The endosomal-lysosomal system: from acidification and cargo sorting to neurodegeneration
10.1186/s40035-015-0041-1 · 2015 · External reference
Amino acids and mTORC1: from lysosomes to disease
10.1016/j.molmed.2012.05.007 · 2012 · External reference
The lysosome as a command-and-control center for cellular metabolism
10.1083/jcb.201607005 · 2016 · External reference
The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis
10.1126/scisignal.2002790 · 2012 · External reference
New developments in AMPK and mTORC1 cross-talk
10.1042/ebc20240007 · 2024 · External reference
The lysosomal v-ATPase-Ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism
10.1016/j.cmet.2014.06.014 · 2014 · External reference
Metabolic reprogramming from glycolysis to fatty acid uptake and beta-oxidation in platinum-resistant cancer cells
10.1038/s41467-022-32101-w · 2022 · External reference
Metabolic regulation in pluripotent stem cells during reprogramming and self-renewal
10.1016/j.stem.2012.10.005 · 2012 · External reference
Metabolic regulation of the hallmarks of stem cell biology
10.1016/j.stem.2024.01.003 · 2024 · External reference
AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes
10.1101/gad.274142.115 · 2016 · External reference
Restraining lysosomal activity preserves Hematopoietic stem cell quiescence and potency
10.1016/j.stem.2020.01.013 · 2020 · External reference
Reversing lysosomal dysfunction restores youthful state in aged hematopoietic stem cells
10.1016/j.stem.2025.10.012 · 2025 · External reference
Early, H+-V-ATPase-dependent proton flux is necessary for consistent left-right patterning of non-mammalian vertebrates
10.1242/dev.02341 · 2006 · External reference
V-ATPase-dependent ectodermal voltage and pH regionalization are required for craniofacial morphogenesis
10.1002/dvdy.22685 · 2011 · External reference
Time-resolved transcriptomics in neural stem cells identifies a v-ATPase/Notch regulatory loop
10.1083/jcb.201711167 · 2018 · External reference
Mitochondrial dynamics and signaling in stem cell differentiation
10.1242/jcs.263847 · 2026 · External reference
New insights into mitophagy and stem cells
10.1186/s13287-021-02520-5 · 2021 · External reference
Mitochondrial quality control in hematopoietic stem cells: mechanisms, implications, and therapeutic opportunities
10.1186/s13287-025-04304-7 · 2025 · External reference
Selection of mitochondria in female germline cells: is Balbiani body implicated in this process?
10.1007/s10815-017-1006-3 · 2017 · External reference
Exclusion of dysfunctional mitochondria from Balbiani body during early oogenesis of Thermobia
10.1007/s00441-016-2414-x · 2016 · External reference
Unresolved reference
2026 · External reference
Unequal mitochondrial segregation promotes asymmetric fates during neurogenesis
10.1038/s41467-025-66932-0 · 2025 · External reference
Metabolic determination of cell fate through selective inheritance of mitochondria
10.1038/s41556-021-00837-0 · 2022 · External reference
Metabolic patterns predispose human pluripotent stem cells to spatial organization of cell fate
2025 · External reference
Mitochondrial-activity-driven hematopoietic stem cell fate and lineage choice is first established in the aorta-gonad-mesonephros
10.1016/j.celrep.2025.116296 · 2025 · External reference
Calcium signaling
10.1101/cshperspect.a011171 · 2012 · External reference
Fundamentals of cellular calcium signaling: a primer
10.1101/cshperspect.a038802 · 2020 · External reference
Mitochondria-associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease
10.1002/2211-5463.70121 · 2026 · External reference
Restoring calcium crosstalk between ER and mitochondria promotes intestinal stem cell rejuvenation through autophagy in aged Drosophila
10.1038/s41467-025-60196-4 · 2025 · External reference
ER-mitochondria contacts and mitochondrial fusion correlate with increased mitochondrial activity during vertebrate embryogenesis
10.1016/j.celrep.2026.117615 · 2026 · External reference
How the chromatin landscape influences nuclear morphology
10.3389/fcell.2025.1634252 · 2025 · External reference
The nuclear lamina couples mechanical forces to cell fate in the preimplantation embryo via actin organization
10.1038/s41467-023-38770-5 · 2023 · External reference
Mechanical signal-chromatin interactions: molecular networks from nuclear membrane force transmission to epigenetic regulation
2025 · External reference
Physical Nature of chromatin in the nucleus
10.1101/cshperspect.a040675 · 2021 · External reference
Condensed chromatin behaves like a solid on the mesoscale in vitro and in living cells
10.1016/j.cell.2020.11.027 · 2020 · External reference
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells
10.1038/s41556-025-01767-x · 2025 · External reference
Calcium ions function as a booster of chromosome condensation
10.1038/srep38281 · 2016 · External reference
Chromatin condensation modulates access and binding of nuclear proteins
10.1096/fj.08-128959 · 2010 · External reference
Lysosomal regulation of metabolism in quiescent hematopoietic stem cells: more than just autophagy
10.1016/j.stem.2021.02.017 · 2021 · External reference
Intracellular pH dynamics regulates intestinal stem cell lineage specification
10.1038/s41467-023-39312-9 · 2023 · External reference
Organelles harbour pH gradients
2026 · External reference
Lipids at membrane contact sites: cell signaling and ion transport
10.15252/embr.201744331 · 2017 · External reference
Liquid-Liquid phase separation: mechanisms, roles, and implications in cellular function and disease
10.1096/fba.2025-00140 · 2025 · External reference
Biomolecular condensates sustain pH gradients at equilibrium through charge neutralization
10.1038/s41557-025-02039-9 · 2026 · External reference
Liquid-liquid phase separation in neuronal development and synaptic signaling
10.1016/j.devcel.2020.06.012 · 2020 · External reference
Nanotechnology and cancer bioelectricity: bridging the gap between biology and translational medicine
2024 · External reference
Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics
10.3389/fnmol.2013.00002 · 2013 · External reference
Genetically encoded probes for measurement of intracellular calcium
10.1016/b978-0-12-374841-6.00006-2 · 2010 · External reference
Calcium oscillations in mesenchymal stem cells, a control on cell cycle progression to influence cell fate towards proliferation or differentiation?
10.1186/s13287-025-04454-8 · 2025 · External reference
Nanobodies as negative allosteric modulators for human calcium sensing receptor
10.1016/j.bbrc.2023.149401 · 2024 · External reference
Progress in pH-Sensitive sensors: essential tools for organelle pH detection, spotlighting mitochondrion and diverse applications
2023 · External reference
RpH-ILV: probe for lysosomal pH and acute LLOMe-induced membrane permeabilization in cell lines and Drosophila
10.1126/sciadv.adr7325 · 2025 · External reference
Sensing mechanism and excited-state dynamics of a widely used intracellular fluorescent pH probe: phrodo
10.1021/acs.jpclett.3c02653 · 2023 · External reference
Genetically encoded voltage indicators in circulation research
10.3390/ijms160921626 · 2015 · External reference
Genetically encoded voltage indicators: opportunities and challenges
10.1523/jneurosci.1095-16.2016 · 2016 · External reference
An ultrasensitive genetically encoded voltage indicator uncovers the electrical activity of non-excitable cells
2024 · External reference
Mitochondria-associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease
10.1002/2211-5463.70121 · ExternalCitation · doi-reference
V-ATPase-dependent ectodermal voltage and pH regionalization are required for craniofacial morphogenesis
10.1002/dvdy.22685 · ExternalCitation · doi-reference
Notch as a molecular switch in neural stem cells
10.1002/iub.362 · ExternalCitation · doi-reference
Exclusion of dysfunctional mitochondria from Balbiani body during early oogenesis of Thermobia
10.1007/s00441-016-2414-x · ExternalCitation · doi-reference
Selection of mitochondria in female germline cells: is Balbiani body implicated in this process?
10.1007/s10815-017-1006-3 · ExternalCitation · doi-reference
Cation channel TMEM63A autonomously facilitates oligodendrocyte differentiation at an early stage
10.1007/s12264-024-01338-4 · ExternalCitation · doi-reference
Genetically encoded probes for measurement of intracellular calcium
10.1016/b978-0-12-374841-6.00006-2 · ExternalCitation · doi-reference
Nanobodies as negative allosteric modulators for human calcium sensing receptor
10.1016/j.bbrc.2023.149401 · ExternalCitation · doi-reference
Progenitor hyperpolarization regulates the sequential generation of neuronal subtypes in the developing neocortex
10.1016/j.cell.2018.06.036 · ExternalCitation · doi-reference
Condensed chromatin behaves like a solid on the mesoscale in vitro and in living cells
10.1016/j.cell.2020.11.027 · ExternalCitation · doi-reference
Bioelectric signaling: reprogrammable circuits underlying embryogenesis, regeneration, and cancer
10.1016/j.cell.2021.02.034 · ExternalCitation · doi-reference
Opposing activities of Notch and Wnt signaling regulate intestinal stem cells and gut homeostasis
10.1016/j.celrep.2015.03.007 · ExternalCitation · doi-reference
Piezo1 regulates colon stem cells to maintain epithelial homeostasis through SCD1-Wnt-β-catenin and programming fatty acid metabolism
10.1016/j.celrep.2025.115400 · ExternalCitation · doi-reference
Mitochondrial-activity-driven hematopoietic stem cell fate and lineage choice is first established in the aorta-gonad-mesonephros
10.1016/j.celrep.2025.116296 · ExternalCitation · doi-reference
ER-mitochondria contacts and mitochondrial fusion correlate with increased mitochondrial activity during vertebrate embryogenesis
10.1016/j.celrep.2026.117615 · ExternalCitation · doi-reference
The lysosomal v-ATPase-Ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism
10.1016/j.cmet.2014.06.014 · ExternalCitation · doi-reference
Liquid-liquid phase separation in neuronal development and synaptic signaling
10.1016/j.devcel.2020.06.012 · ExternalCitation · doi-reference
Amino acids and mTORC1: from lysosomes to disease
10.1016/j.molmed.2012.05.007 · ExternalCitation · doi-reference
Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry
10.1016/j.neuron.2025.11.009 · ExternalCitation · doi-reference
Metabolic regulation in pluripotent stem cells during reprogramming and self-renewal
10.1016/j.stem.2012.10.005 · ExternalCitation · doi-reference
Restraining lysosomal activity preserves Hematopoietic stem cell quiescence and potency
10.1016/j.stem.2020.01.013 · ExternalCitation · doi-reference
Lysosomal regulation of metabolism in quiescent hematopoietic stem cells: more than just autophagy
10.1016/j.stem.2021.02.017 · ExternalCitation · doi-reference
Metabolic regulation of the hallmarks of stem cell biology
10.1016/j.stem.2024.01.003 · ExternalCitation · doi-reference
Reversing lysosomal dysfunction restores youthful state in aged hematopoietic stem cells
10.1016/j.stem.2025.10.012 · ExternalCitation · doi-reference
Balancing ER-Mitochondrial Ca(2+) fluxes in health and disease
10.1016/j.tcb.2021.02.003 · ExternalCitation · doi-reference
Sensing mechanism and excited-state dynamics of a widely used intracellular fluorescent pH probe: phrodo
10.1021/acs.jpclett.3c02653 · ExternalCitation · doi-reference
Transient mechanical activation of the Piezo1 channel facilitates ex vivo expansion of hematopoietic stem cells
10.1038/s41422-025-01209-1 · ExternalCitation · doi-reference
Metabolic reprogramming from glycolysis to fatty acid uptake and beta-oxidation in platinum-resistant cancer cells
10.1038/s41467-022-32101-w · ExternalCitation · doi-reference
The nuclear lamina couples mechanical forces to cell fate in the preimplantation embryo via actin organization
10.1038/s41467-023-38770-5 · ExternalCitation · doi-reference
Intracellular pH dynamics regulates intestinal stem cell lineage specification
10.1038/s41467-023-39312-9 · ExternalCitation · doi-reference
Restoring calcium crosstalk between ER and mitochondria promotes intestinal stem cell rejuvenation through autophagy in aged Drosophila
10.1038/s41467-025-60196-4 · ExternalCitation · doi-reference
Unequal mitochondrial segregation promotes asymmetric fates during neurogenesis
10.1038/s41467-025-66932-0 · ExternalCitation · doi-reference
Endosomal pH is an evolutionarily conserved driver of phenotypic plasticity in colorectal cancer
10.1038/s41540-024-00463-0 · ExternalCitation · doi-reference
Metabolic determination of cell fate through selective inheritance of mitochondria
10.1038/s41556-021-00837-0 · ExternalCitation · doi-reference
Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels
10.1038/s41556-024-01353-7 · ExternalCitation · doi-reference
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells
10.1038/s41556-025-01767-x · ExternalCitation · doi-reference
Biomolecular condensates sustain pH gradients at equilibrium through charge neutralization
10.1038/s41557-025-02039-9 · ExternalCitation · doi-reference
Lysosomes as dynamic regulators of cell and organismal homeostasis
10.1038/s41580-019-0185-4 · ExternalCitation · doi-reference
Remodeling of calcium signaling and store operated calcium entry as a consequence of human neural progenitor cell differentiation
10.1038/s41598-025-22675-y · ExternalCitation · doi-reference
Calcium ions function as a booster of chromosome condensation
10.1038/srep38281 · ExternalCitation · doi-reference
New developments in AMPK and mTORC1 cross-talk
10.1042/ebc20240007 · ExternalCitation · doi-reference
TMEM63A, associated with hypomyelinating leukodystrophies, is an evolutionarily conserved regulator of myelination
10.1073/pnas.2507354122 · ExternalCitation · doi-reference
Sensing the squeeze: nuclear mechanotransduction in health and disease
10.1080/19491034.2024.2374854 · ExternalCitation · doi-reference
The responsive nucleus: morphological signatures of cellular state
10.1080/19491034.2026.2630145 · ExternalCitation · doi-reference
The lysosome as a command-and-control center for cellular metabolism
10.1083/jcb.201607005 · ExternalCitation · doi-reference
Time-resolved transcriptomics in neural stem cells identifies a v-ATPase/Notch regulatory loop
10.1083/jcb.201711167 · ExternalCitation · doi-reference
Wnt-Notch signaling interactions during neural and astroglial patterning of human stem cells
10.1089/ten.tea.2019.0202 · ExternalCitation · doi-reference
Monitoring and modulating cardiac bioelectricity: from Einthoven to end-user
10.1093/europace/euae300 · ExternalCitation · doi-reference
Liquid-Liquid phase separation: mechanisms, roles, and implications in cellular function and disease
10.1096/fba.2025-00140 · ExternalCitation · doi-reference
Chromatin condensation modulates access and binding of nuclear proteins
10.1096/fj.08-128959 · ExternalCitation · doi-reference
Calcium signaling
10.1101/cshperspect.a011171 · ExternalCitation · doi-reference
Fundamentals of cellular calcium signaling: a primer
10.1101/cshperspect.a038802 · ExternalCitation · doi-reference
Physical Nature of chromatin in the nucleus
10.1101/cshperspect.a040675 · ExternalCitation · doi-reference
AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes
10.1101/gad.274142.115 · ExternalCitation · doi-reference
RpH-ILV: probe for lysosomal pH and acute LLOMe-induced membrane permeabilization in cell lines and Drosophila
10.1126/sciadv.adr7325 · ExternalCitation · doi-reference
PIEZO-dependent mechanosensing is essential for intestinal stem cell fate decision and maintenance
10.1126/science.adj7615 · ExternalCitation · doi-reference
The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis
10.1126/scisignal.2002790 · ExternalCitation · doi-reference
Measuring absolute membrane potential across space and time
10.1146/annurev-biophys-062920-063555 · ExternalCitation · doi-reference
The ion channels of endomembranes
10.1152/physrev.00025.2023 · ExternalCitation · doi-reference
New insights into mitophagy and stem cells
10.1186/s13287-021-02520-5 · ExternalCitation · doi-reference
Mitochondrial quality control in hematopoietic stem cells: mechanisms, implications, and therapeutic opportunities
10.1186/s13287-025-04304-7 · ExternalCitation · doi-reference
Calcium oscillations in mesenchymal stem cells, a control on cell cycle progression to influence cell fate towards proliferation or differentiation?
10.1186/s13287-025-04454-8 · ExternalCitation · doi-reference
The endosomal-lysosomal system: from acidification and cargo sorting to neurodegeneration
10.1186/s40035-015-0041-1 · ExternalCitation · doi-reference
Early, H+-V-ATPase-dependent proton flux is necessary for consistent left-right patterning of non-mammalian vertebrates
10.1242/dev.02341 · ExternalCitation · doi-reference
Mitochondrial dynamics and signaling in stem cell differentiation
10.1242/jcs.263847 · ExternalCitation · doi-reference
Membrane potential controls adipogenic and osteogenic differentiation of mesenchymal stem cells
10.1371/journal.pone.0003737 · ExternalCitation · doi-reference
Genetically encoded voltage indicators: opportunities and challenges
10.1523/jneurosci.1095-16.2016 · ExternalCitation · doi-reference
Lipids at membrane contact sites: cell signaling and ion transport
10.15252/embr.201744331 · ExternalCitation · doi-reference
How the chromatin landscape influences nuclear morphology
10.3389/fcell.2025.1634252 · ExternalCitation · doi-reference
Bioenergetic mechanisms of seizure control
10.3389/fncel.2018.00335 · ExternalCitation · doi-reference
Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics
10.3389/fnmol.2013.00002 · ExternalCitation · doi-reference
Genetically encoded voltage indicators in circulation research
10.3390/ijms160921626 · ExternalCitation · doi-reference
PIEZO1-mediated calcium signaling reinforces mechanical properties of hair follicle stem cells to promote quiescence
10.4028/b-xdtcg5 · ExternalCitation · doi-reference
