Research graph
References from Acanthamoeba ATP synthase structure reveals the TCA cycle is tethered to OXPHOS. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
2025 · External reference
Mitochondrial OXPHOS biogenesis: co-regulation of protein synthesis, import, and assembly pathways
10.3390/ijms21113820 · 2020 · External reference
Structure and Mechanisms of F-Type ATP Synthases
10.1146/annurev-biochem-013118-110903 · 2019 · External reference
Mitochondrial TCA cycle metabolites control physiology and disease
10.1038/s41467-019-13668-3 · 2020 · External reference
An evolving view of complex II—noncanonical complexes, megacomplexes, respiration, signaling, and beyond
10.1016/j.jbc.2023.104761 · 2023 · External reference
Mitochondrial ATP synthase: architecture, function and pathology
10.1007/s10545-011-9382-9 · 2012 · External reference
The ATP synthase: the understood, the uncertain and the unknown
10.1042/bst20110773 · 2013 · External reference
Cryo-EM of ATP synthases
10.1016/j.sbi.2018.08.005 · 2018 · External reference
THE ATP SYNTHASE—A SPLENDID MOLECULAR MACHINE
10.1146/annurev.biochem.66.1.717 · 1997 · External reference
Direct observation of the rotation of F1-ATPase
10.1038/386299a0 · 1997 · External reference
Cryo-EM structure of the entire mammalian F-type ATP synthase
10.1038/s41594-020-0503-8 · 2020 · External reference
Bioenergetic cost of making an adenosine triphosphate molecule in animal mitochondria
10.1073/pnas.1011099107 · 2010 · External reference
High-resolution structure of the rotor ring of a proton-dependent ATP synthase
10.1038/nsmb.1678 · 2009 · External reference
Structure of the c10 ring of the yeast mitochondrial ATP synthase in the open conformation
10.1038/nsmb.2284 · 2012 · External reference
CryoEM Reveals the Complexity and Diversity of ATP Synthases
10.3389/fmicb.2022.864006 · 2022 · External reference
Helical arrays of U-shaped ATP synthase dimers form tubular cristae in ciliate mitochondria
10.1073/pnas.1525430113 · 2016 · External reference
Structural basis of proton translocation and force generation in mitochondrial ATP synthase
10.7554/elife.33274 · 2017 · External reference
In situ structure of trypanosomal ATP synthase dimer reveals a unique arrangement of catalytic subunits
10.1073/pnas.1612386114 · 2017 · External reference
The consequence of ATP synthase dimer angle on mitochondrial morphology studied by cryo-electron tomography
10.1042/bcj20230450 · 2024 · External reference
Macromolecular organization of ATP synthase and complex I in whole mitochondria
10.1073/pnas.1103621108 · 2011 · External reference
Interface mobility between monomers in dimeric bovine ATP synthase participates in the ultrastructure of inner mitochondrial membranes
10.1073/pnas.2021012118 · 2021 · External reference
Cryo-EM structure of the mammalian ATP synthase tetramer bound with inhibitory protein IF1
10.1126/science.aaw4852 · 2019 · External reference
Dimers of mitochondrial ATP synthase induce membrane curvature and self-assemble into rows
10.1073/pnas.1816556116 · 2019 · External reference
An ancestral interaction module promotes oligomerization in divergent mitochondrial ATP synthases
10.1038/s41467-022-33588-z · 2022 · External reference
In situ structure and rotary states of mitochondrial ATP synthase in whole Polytomella cells
10.1126/science.adp4640 · 2024 · External reference
ATP synthase hexamer assemblies shape cristae of Toxoplasma mitochondria
10.1038/s41467-020-20381-z · 2021 · External reference
Structural dynamics of mitochondrial ATP synthase in Chlamydomonas reinhardtii revealed by in situ CryoET
2025 · External reference
Structure of a mitochondrial ATP synthase with bound native cardiolipin
10.7554/elife.51179 · 2019 · External reference
Rotary substates of mitochondrial ATP synthase reveal the basis of flexible F1 -Fo coupling
10.1126/science.aaw9128 · 2019 · External reference
10.1016/j.cell.2026.08.056 · 2026 · Admitted local publication
Composition of the mitochondrial electron transport chain in Acanthamoeba castellanii: Structural and evolutionary insights
10.1016/j.bbabio.2012.06.005 · 2012 · External reference
Between a Pod and a Hard Test: The Deep Evolution of Amoebae
10.1093/molbev/msx162 · 2017 · External reference
The phagotrophic origin of eukaryotes and phylogenetic classification of Protozoa
10.1099/00207713-52-2-297 · 2002 · External reference
Revisions to the Classification, Nomenclature, and Diversity of Eukaryotes
10.1111/jeu.12691 · 2019 · External reference
The evolution of gene functional repertoire in Amorphea: Divergent strategies across Amoebozoa, Fungi, and Metazoa
10.1093/molbev/msag071 · 2026 · External reference
The origin of animals: an ancestral reconstruction of the unicellular-to-multicellular transition
10.1098/rsob.200359 · 2021 · External reference
Acanthamoeba: biology and increasing importance in human health
10.1111/j.1574-6976.2006.00023.x · 2006 · External reference
Fungal respiration: a fusion of standard and alternative components
10.1016/s0005-2728(00)00251-6 · 2001 · External reference
Immunological identification of the alternative oxidase of Acanthamoeba castellanii mitochondria
10.1016/s0014-5793(97)00676-5 · 1997 · External reference
Alternative Oxidase: A Mitochondrial Respiratory Pathway to Maintain Metabolic and Signaling Homeostasis during Abiotic and Biotic Stress in Plants
10.3390/ijms14046805 · 2013 · External reference
Acanthamoeba alternative oxidase genes: Identification, characterisation and potential as antimicrobial targets
10.1016/j.ijpara.2009.04.011 · 2009 · External reference
Activation of alternative oxidase and uncoupling protein lowers hydrogen peroxide formation in amoeba Acanthamoeba castellanii mitochondria
10.1016/j.febslet.2005.04.081 · 2005 · External reference
Acanthamoeba castellanii genome reannotation and multi-omic encystation profiling reveals cyst wall proteins and carbohydrate-active enzymes
2026 · External reference
Malate dehydrogenase: A model for structure, evolution, and catalysis
10.1002/pro.5560031027 · 1994 · External reference
Catalytic mechanism and kinetics of malate dehydrogenase
10.1042/ebc20230086 · 2024 · External reference
Cryo-EM of native membranes reveals an intimate connection between the Krebs cycle and aerobic respiration in mycobacteria
10.1073/pnas.2423761122 · 2025 · External reference
High-resolution electron cryomicroscopy of V-ATPase in native synaptic vesicles
10.1126/science.adp5577 · 2024 · External reference
Cryo-EM snapshots of a native lysate provide structural insights into a metabolon-embedded transacetylase reaction
10.1038/s41467-021-27287-4 · 2021 · External reference
Native structure of the RhopH complex, a key determinant of malaria parasite nutrient acquisition
10.1073/pnas.2100514118 · 2021 · External reference
High-Resolution Structural Proteomics of Mitochondria Using the ‘Build and Retrieve’ Methodology
10.1016/j.mcpro.2023.100666 · 2023 · External reference
Capturing ribosomal structures in cellular extracts with cryoPRISM: A purification-free cryoEM approach reveals novel structural states
10.1073/pnas.2521210123 · 2026 · External reference
Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly
10.1038/s41594-024-01352-0 · 2024 · External reference
Structural basis for the structural dynamics of human mitochondrial chaperonin mHsp60
2021 · External reference
Retrospective on the early development of cryoelectron microscopy of macromolecules and a prospective on opportunities for the future
10.1016/j.jsb.2008.06.004 · 2008 · External reference
Structure of complex III with bound cytochrome c in reduced state and definition of a minimal core interface for electron transfer
10.1074/jbc.m710126200 · 2008 · External reference
Automated model building and protein identification in cryo-EM maps
10.1038/s41586-024-07215-4 · 2024 · External reference
HMMER web server: interactive sequence similarity searching
10.1093/nar/gkr367 · 2011 · External reference
Compositional complexity of the mitochondrial proteome of a unicellular eukaryote (Acanthamoeba castellanii, supergroup Amoebozoa) rivals that of animals, fungi, and plants
10.1016/j.jprot.2014.07.005 · 2014 · External reference
The persistent homology of mitochondrial ATP synthases
10.1016/j.isci.2023.106700 · 2023 · External reference
Accurate structure prediction of biomolecular interactions with AlphaFold 3
10.1038/s41586-024-07487-w · 2024 · External reference
Features and Development of Coot
10.1107/s0907444910007493 · 2010 · External reference
Structure of the human ATP synthase
10.1016/j.molcel.2023.04.029 · 2023 · External reference
Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex
10.1038/s41594-025-01531-7 · 2025 · External reference
Architecture of Human Mitochondrial Respiratory Megacomplex I2III2IV2
10.1016/j.cell.2017.07.050 · 2017 · External reference
10.1016/j.cell.2026.08.029 · 2026 · Admitted local publication
How the regulatory protein, IF(1), inhibits F(1)-ATPase from bovine mitochondria
10.1073/pnas.0707326104 · 2007 · External reference
Modulation of the Oligomerization State of the Bovine F1-ATPase Inhibitor Protein, IF1, by pH
10.1074/jbc.m003859200 · 2000 · External reference
Homologous and Heterologous Inhibitory Effects of ATPase Inhibitor Proteins on F-ATPases
10.1074/jbc.m207169200 · 2002 · External reference
The role of the ATPase inhibitor factor 1 (IF1) in cancer cells adaptation to hypoxia and anoxia
10.1016/j.bbabio.2017.10.007 · 2018 · External reference
Structure of the mycobacterial ATP synthase Fo rotor ring in complex with the anti-TB drug bedaquiline
10.1126/sciadv.1500106 · 2015 · External reference
Inhibition of M. tuberculosis and human ATP synthase by BDQ and TBAJ-587
10.1038/s41586-024-07605-8 · 2024 · External reference
Atomic model for the dimeric FO region of mitochondrial ATP synthase
10.1126/science.aao4815 · 2017 · External reference
Oligomycin frames a common drug-binding site in the ATP synthase
10.1073/pnas.1207912109 · 2012 · External reference
FtsL, an essential cytoplasmic membrane protein involved in cell division in Escherichia coli
10.1128/jb.174.23.7717.1992 · 1992 · External reference
Structural Changes in Mitochondria of Acanthamoeba at Encystation
10.1038/188248a0 · 1960 · External reference
Functional and Structural Resilience of the Active Site Loop in the Evolution of Plasmodium Lactate Dehydrogenase
10.1021/acs.biochem.8b00913 · 2018 · External reference
Kinetic characterization and thermostability of C. elegans cytoplasmic and mitochondrial malate dehydrogenases
10.1016/j.bbapap.2021.140722 · 2022 · External reference
Mitochondrial malate dehydrogenase from the thermophilic, filamentous fungus Talaromyces emersonii
10.1111/j.1432-1033.2004.04230.x · 2004 · External reference
Unprecedented allosteric inhibition of E. coli malate dehydrogenase by silver(i) from atomic resolution analysis
10.1039/d5sc05183e · 2025 · External reference
A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity
10.1038/s42003-021-02442-1 · 2021 · External reference
Investigating the relationship between ATP synthase and the TCA cycle by crosslinking mass spectrometry
10.1038/s41467-026-74730-5 · 2026 · External reference
Presence of Glyoxylate Cycle Enzymes in the Mitochondria of Euglena gracilis
10.1111/j.1550-7408.2003.tb00239.x · 2003 · External reference
Redesigned and reversed: architectural and functional oddities of the trypanosomal ATP synthase
10.1017/s0031182021000202 · 2021 · External reference
Complex multicellularity in fungi: evolutionary convergence, single origin, or both?
10.1111/brv.12418 · 2018 · External reference
Phylogenomics demonstrates that breviate flagellates are related to opisthokonts and apusomonads
2013 · External reference
A revised six-kingdom system of life
1998 · External reference
cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
10.1038/nmeth.4169 · 2017 · External reference
Data-driven regularization lowers the size barrier of cryo-EM structure determination
10.1038/s41592-024-02304-8 · 2024 · External reference
UCSF ChimeraX: Tools for structure building and analysis
10.1002/pro.4792 · 2023 · External reference
Real-space refinement in PHENIX for cryo-EM and crystallography
10.1107/s2059798318006551 · 2018 · External reference
MolProbity: More and better reference data for improved all-atom structure validation
10.1002/pro.3330 · 2018 · External reference
Data processing and analysis with the autoPROC toolbox
10.1107/s0907444911007773 · 2011 · External reference
The CCP4 suite: integrative software for macromolecular crystallography
10.1107/s2059798323003595 · 2023 · External reference
Unresolved reference
External reference
XDS
10.1107/s0907444909047337 · 2010 · External reference
Scaling and assessment of data quality
10.1107/s0907444905036693 · 2006 · External reference
How good are my data and what is the resolution?
10.1107/s0907444913000061 · 2013 · External reference
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix
10.1107/s2059798319011471 · 2019 · External reference
SCEDS: protein fragments for molecular replacement in Phaser
10.1107/s0907444913021811 · 2013 · External reference
Improved crystallographic models through iterated local density-guided model deformation and reciprocal-space refinement
10.1107/s0907444912015636 · 2012 · External reference
Fiji: an open-source platform for biological-image analysis
10.1038/nmeth.2019 · 2012 · External reference
