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References from Salicylic acid engages central metabolic regulators SnRK1 and TOR to govern immunity by differential phosphorylation of NPR1. Local targets link to admitted publications; unresolved targets remain external evidence.
A renaissance of elicitors: perception of microbe-associated molecular patterns and danger signals by pattern-recognition receptors
10.1146/annurev.arplant.57.032905.105346 · 2009 · External reference
Molecular mechanisms of early plant pattern-triggered immune signaling
10.1016/j.molcel.2021.09.028 · 2021 · External reference
Effector-triggered immunity: from pathogen perception to robust defense
10.1146/annurev-arplant-050213-040012 · 2015 · External reference
The plant immune system
10.1038/nature05286 · 2006 · External reference
Salicylic Acid: a likely endogenous signal in the resistance response of tobacco to viral infection
10.1126/science.250.4983.1002 · 1990 · External reference
H2O2 sulfenylates CHE, linking local infection to the establishment of systemic acquired resistance
10.1126/science.adj7249 · 2024 · External reference
Systemic acquired resistance: turning local infection into global defense
10.1146/annurev-arplant-042811-105606 · 2013 · External reference
Characterization of an Arabidopsis Mutant That Is Nonresponsive to Inducers of Systemic Acquired Resistance
10.2307/3869945 · 1994 · External reference
The Arabidopsis NPR1 gene that controls systemic acquired resistance encodes a novel protein containing ankyrin repeats
10.1016/s0092-8674(00)81858-9 · 1997 · External reference
Induction of protein secretory pathway is required for systemic acquired resistance
10.1126/science.1108791 · 2005 · External reference
Increase in salicylic Acid at the onset of systemic acquired resistance in cucumber
10.1126/science.250.4983.1004 · 1990 · External reference
Requirement of salicylic Acid for the induction of systemic acquired resistance
10.1126/science.261.5122.754 · 1993 · External reference
Arabidopsis signal transduction mutant defective in chemically and biologically induced disease resistance
10.1073/pnas.92.14.6602 · 1995 · External reference
Characterization of a salicylic acid-insensitive mutant (sai1) of Arabidopsis thaliana, identified in a selective screen utilizing the SA-inducible expression of the tms2 gene
10.1094/mpmi.1997.10.1.69 · 1997 · External reference
The Arabidopsis NIM1 protein shows homology to the mammalian transcription factor inhibitor I kappa B
1997 · External reference
Seeing is believing: Understanding functions of NPR1 and its paralogs in plant immunity through cellular and structural analyses
10.1016/j.pbi.2023.102352 · 2023 · External reference
In vivo interaction between NPR1 and transcription factor TGA2 leads to salicylic acid-mediated gene activation in Arabidopsis
10.1105/tpc.001628 · 2002 · External reference
Interaction of NPR1 with basic leucine zipper protein transcription factors that bind sequences required for salicylic acid induction of the PR-1 gene
10.1073/pnas.96.11.6523 · 1999 · External reference
Next-generation mapping of the salicylic acid signaling hub and transcriptional cascade
10.1016/j.molp.2024.08.008 · 2024 · External reference
The Arabidopsis NPR1/NIM1 protein enhances the DNA binding activity of a subgroup of the TGA family of bZIP transcription factors
10.1105/tpc.12.2.279 · 2000 · External reference
NPR1 differentially interacts with members of the TGA/OBF family of transcription factors that bind an element of the PR-1 gene required for induction by salicylic acid
10.1094/mpmi.2000.13.2.191 · 2000 · External reference
Posttranslational Modifications of NPR1: A Single Protein Playing Multiple Roles in Plant Immunity and Physiology
10.1371/journal.ppat.1005707 · 2016 · External reference
Posttranslational Modifications of the Master Transcriptional Regulator NPR1 Enable Dynamic but Tight Control of Plant Immune Responses
10.1016/j.chom.2015.07.005 · 2015 · External reference
Inducers of plant systemic acquired resistance regulate NPR1 function through redox changes
10.1016/s0092-8674(03)00429-x · 2003 · External reference
Plant immunity requires conformational changes of NPR1 via S-nitrosylation and thioredoxins
10.1126/science.1156970 · 2008 · External reference
Proteasome-mediated turnover of the transcription coactivator NPR1 plays dual roles in regulating plant immunity
10.1016/j.cell.2009.03.038 · 2009 · External reference
Dynamic ubiquitination determines transcriptional activity of the plant immune coactivator NPR1
10.7554/elife.47005 · 2019 · External reference
PKS5, a SNF1-related kinase, interacts with and phosphorylates NPR1, and modulates expression of WRKY38 and WRKY62
10.1016/s1673-8527(09)60054-0 · 2010 · External reference
Systemic Immunity Requires SnRK2.8-Mediated Nuclear Import of NPR1 in Arabidopsis
10.1105/tpc.15.00371 · 2015 · External reference
Salicylic Acid Regulation of Respiration in Higher Plants: Alternative Oxidase Expression
10.2307/3869481 · 1992 · External reference
Regulation of heat production in the inflorescences of an Arum lily by endogenous salicylic acid
10.1073/pnas.86.7.2214 · 1989 · External reference
Importance of the alternative oxidase (AOX) pathway in regulating cellular redox and ROS homeostasis to optimize photosynthesis during restriction of the cytochrome oxidase pathway in Arabidopsis thaliana
10.1093/aob/mcv122 · 2015 · External reference
Identification of a soluble salicylic acid-binding protein that may function in signal transduction in the plant disease-resistance response
10.1073/pnas.88.18.8179 · 1991 · External reference
Active oxygen species in the induction of plant systemic acquired resistance by salicylic acid
10.1126/science.8266079 · 1993 · External reference
Rapamycin and glucose-target of rapamycin (TOR) protein signaling in plants
10.1074/jbc.m111.300749 · 2012 · External reference
Glucose-TOR signalling reprograms the transcriptome and activates meristems
10.1038/nature12030 · 2013 · External reference
Target of Rapamycin (TOR): A Master Regulator in Plant Growth, Development, and Stress Responses
10.1146/annurev-arplant-083123-050311 · 2025 · External reference
Shaping plant development through the SnRK1-TOR metabolic regulators
10.1016/j.pbi.2016.12.004 · 2017 · External reference
A central integrator of transcription networks in plant stress and energy signalling
10.1038/nature06069 · 2007 · External reference
SNF1-related protein kinase 1: the many-faced signaling hub regulating developmental plasticity in plants
10.1093/jxb/erab079 · 2021 · External reference
TOR kinase, a GPS in the complex nutrient and hormonal signaling networks to guide plant growth and development
10.1093/jxb/erac282 · 2022 · External reference
TOR and S6K1 promote translation reinitiation of uORF-containing mRNAs via phosphorylation of eIF3h
10.1038/emboj.2013.61 · 2013 · External reference
Inhibition of SnRK1 by metabolites: tissue-dependent effects and cooperative inhibition by glucose 1-phosphate in combination with trehalose 6-phosphate
10.1016/j.plaphy.2012.11.011 · 2013 · External reference
In vivo protein kinase activity of SnRK1 fluctuates in Arabidopsis rosettes during light-dark cycles
10.1093/plphys/kiad066 · 2023 · External reference
Mechanisms of regulation of SNF1/AMPK/SnRK1 protein kinases
10.3389/fpls.2014.00190 · 2014 · External reference
Quantitative phosphoproteomics of protein kinase SnRK1 regulated protein phosphorylation in Arabidopsis under submergence
10.1093/jxb/erw107 · 2016 · External reference
ABI1 and PP2CA phosphatases are negative regulators of Snf1-related protein kinase1 signaling in Arabidopsis
10.1105/tpc.113.114066 · 2013 · External reference
SnRK1 and TOR: modulating growth-defense trade-offs in plant stress responses
10.1093/jxb/erz066 · 2019 · External reference
The SnRK1 Energy Sensor in Plant Biotic Interactions
10.1016/j.tplants.2016.04.008 · 2016 · External reference
Geminivirus AL2 and L2 proteins interact with and inactivate SNF1 kinase
10.1105/tpc.009530 · 2003 · External reference
SnRK1 phosphorylation of AL2 delays Cabbage leaf curl virus infection in Arabidopsis
10.1128/jvi.00761-14 · 2014 · External reference
Viral factor TAV recruits TOR/S6K1 signalling to activate reinitiation after long ORF translation
10.1038/emboj.2011.39 · 2011 · External reference
The energy sensor OsSnRK1a confers broad-spectrum disease resistance in rice
10.1038/s41598-018-22101-6 · 2018 · External reference
Target of rapamycin signaling orchestrates growth-defense trade-offs in plants
10.1111/nph.14785 · 2018 · External reference
Translatome analysis of an NB-LRR immune response identifies important contributors to plant immunity in Arabidopsis
10.1093/jxb/erx078 · 2017 · External reference
SnRK1.1 Coordinates Organ-Specific Growth–Defense Programs via Transcriptomic Rewiring in Arabidopsis thaliana
2025 · External reference
Formation of NPR1 Condensates Promotes Cell Survival during the Plant Immune Response
10.1016/j.cell.2020.07.016 · 2020 · External reference
Structural basis of NPR1 in activating plant immunity
10.1038/s41586-022-04699-w · 2022 · External reference
NPR1 Promotes Its Own and Target Gene Expression in Plant Defense by Recruiting CDK8
10.1104/pp.19.00124 · 2019 · External reference
The Arabidopsis CDPK-SnRK superfamily of protein kinases
10.1104/pp.102.011999 · 2003 · External reference
SnRK2 protein kinases--key regulators of plant response to abiotic stresses
10.1089/omi.2011.0091 · 2011 · External reference
The CBL-CIPK Calcium Signaling Network: Unified Paradigm from 20 Years of Discoveries
10.1016/j.tplants.2020.01.009 · 2020 · External reference
Plant SnRK1 Kinases: Structure, Regulation, and Function
2016 · External reference
Role and Regulation of Sucrose-Phosphate Synthase in Higher Plants
10.1146/annurev.arplant.47.1.431 · 1996 · External reference
Two SNF1-related protein kinases from spinach leaf phosphorylate and inactivate 3-hydroxy-3-methylglutaryl-coenzyme A reductase, nitrate reductase, and sucrose phosphate synthase in vitro
10.1104/pp.120.1.257 · 1999 · External reference
Regulation of spinach SNF1-related (SnRK1) kinases by protein kinases and phosphatases is associated with phosphorylation of the T loop and is regulated by 5′-AMP
10.1046/j.1365-313x.1999.00532.x · 1999 · External reference
Review: How do SnRK1 protein kinases truly work?
10.1016/j.plantsci.2019.110330 · 2020 · External reference
A dual function of SnRK2 kinases in the regulation of SnRK1 and plant growth
10.1038/s41477-020-00778-w · 2020 · External reference
Impact of the SnRK1 protein kinase on sucrose homeostasis and the transcriptome during the diel cycle
10.1093/plphys/kiab350 · 2021 · External reference
Perturbations in plant energy homeostasis prime lateral root initiation via SnRK1-bZIP63-ARF19 signaling
10.1073/pnas.2106961118 · 2021 · External reference
Molecular mechanism of trehalose 6-phosphate inhibition of the plant metabolic sensor kinase SnRK1
10.1126/sciadv.adn0895 · 2024 · External reference
Phosphorylation of AMPK by upstream kinases is required for activity in mammalian cells
10.1042/bcj20170458 · 2017 · External reference
The regulation of AMP-activated protein kinase by phosphorylation
10.1042/bj3450437 · 2000 · External reference
The hybrid four-CBS-domain KINβγ subunit functions as the canonical γ subunit of the plant energy sensor SnRK1
10.1111/tpj.12192 · 2013 · External reference
SnRK1 from Arabidopsis thaliana is an atypical AMPK
10.1111/tpj.12813 · 2015 · External reference
SnRK1 and trehalose 6-phosphate - two ancient pathways converge to regulate plant metabolism and growth
10.1016/j.pbi.2020.01.010 · 2020 · External reference
Functional Features of TREHALOSE-6-PHOSPHATE SYNTHASE1, an Essential Enzyme in Arabidopsis
10.1105/tpc.19.00837 · 2020 · External reference
TPS Proteins coordinate plant growth with sugar availability via the SnRK1 Kinase
2025 · External reference
Phase separation-based visualization of protein-protein interactions and kinase activities in plants
10.1093/plcell/koad188 · 2023 · External reference
SUnSET, a nonradioactive method to monitor protein synthesis
10.1038/nmeth.1314 · 2009 · External reference
Global translational induction during NLR-mediated immunity in plants is dynamically regulated by CDC123, an ATP-sensitive protein
10.1016/j.chom.2023.01.014 · 2023 · External reference
Arabidopsis TARGET OF RAPAMYCIN interacts with RAPTOR, which regulates the activity of S6 kinase in response to osmotic stress signals
10.1105/tpc.105.035931 · 2006 · External reference
Capturing the phosphorylation and protein interaction landscape of the plant TOR kinase
10.1038/s41477-019-0378-z · 2019 · External reference
mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin
10.1126/science.1236566 · 2013 · External reference
AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity
10.1158/0008-5472.can-09-1751 · 2010 · External reference
Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells
10.1053/j.gastro.2012.02.050 · 2012 · External reference
AMPK protects endothelial cells against HSV-1 replication via inhibition of mTORC1 and ACC1
10.1128/spectrum.00417-23 · 2023 · External reference
Feeding uninvited guests: mTOR and AMPK set the table for intracellular pathogens
10.1371/journal.ppat.1003552 · 2013 · External reference
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
10.1038/ncb2152 · 2011 · External reference
The plant unique ESCRT component FREE1 regulates autophagosome closure
2023 · External reference
Shedding Light on the Role of Phosphorylation in Plant Autophagy
10.1002/1873-3468.14352 · 2022 · External reference
AMPK: guardian of metabolism and mitochondrial homeostasis
10.1038/nrm.2017.95 · 2018 · External reference
Arabidopsis TGA256 Transcription Factors Suppress Salicylic-Acid-Induced Sucrose Starvation
2023 · External reference
Salicylic Acid Cooperates With Lignin and Sucrose Signals to Alleviate Waxy Maize Leaf Senescence Under Heat Stress
10.1111/pce.15437 · 2025 · External reference
SNF1/AMPK pathways in yeast
10.2741/2854 · 2008 · External reference
Cellular energy sensor SnRK1 suppresses salicylic acid-dependent and -independent defenses and bacterial resistance in Arabidopsis
10.1073/pnas.2527765122 · 2025 · External reference
Salicylic acid represses primary root growth through the Glucose-Target of Rapamycin-E2Fa pathway in Arabidopsis
2025 · External reference
Phenolic acid-induced phase separation and translation inhibition mediate plant interspecific competition
10.1038/s41477-023-01499-6 · 2023 · External reference
Chemical proteomics reveals an ISR-like response elicited by salicylic acid in Arabidopsis
10.1111/nph.18646 · 2023 · External reference
Salicylates trigger protein synthesis inhibition in a protein kinase R-like endoplasmic reticulum kinase-dependent manner
10.1074/jbc.m609996200 · 2007 · External reference
Salicylic Acid Binding Proteins (SABPs): The Hidden Forefront of Salicylic Acid Signalling
10.3390/ijms20184377 · 2019 · External reference
Structural basis of salicylic acid perception by Arabidopsis NPR proteins
10.1038/s41586-020-2596-y · 2020 · External reference
Opposite Roles of Salicylic Acid Receptors NPR1 and NPR3/NPR4 in Transcriptional Regulation of Plant Immunity
10.1016/j.cell.2018.03.044 · 2018 · External reference
The Arabidopsis NPR1 protein is a receptor for the plant defense hormone salicylic acid
10.1016/j.celrep.2012.05.008 · 2012 · External reference
Phosphorylation of Ribosomal Protein RPS6 Integrates Light Signals and Circadian Clock Signals
2017 · External reference
Induction of Arabidopsis defense genes by virulent and avirulent Pseudomonas syringae strains and by a cloned avirulence gene
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BAC-recombineering for studying plant gene regulation: developmental control and cellular localization of SnRK1 kinase subunits
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Three unique mutants of Arabidopsis identify eds loci required for limiting growth of a biotrophic fungal pathogen
10.1046/j.1365-313x.2000.00870.x · 2000 · External reference
Nuclear Pore Permeabilization Is a Convergent Signaling Event in Effector-Triggered Immunity
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The evolutionarily conserved kinase SnRK1 orchestrates resource mobilization during Arabidopsis seedling establishment
10.1093/plcell/koab270 · 2022 · External reference
Egg cell-specific promoter-controlled CRISPR/Cas9 efficiently generates homozygous mutants for multiple target genes in Arabidopsis in a single generation
10.1186/s13059-015-0715-0 · 2015 · External reference
ADP-ribosylation factor D1 modulates Golgi morphology, cell plate formation, and plant growth in Arabidopsis
10.1093/plphys/kiac329 · 2022 · External reference
The promoter of TL-DNA gene 5 controls the tissue-specific expression of chimaeric genes carried by a novel type of Agrobacterium binary vector
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10.1038/nprot.2007.199 · 2007 · External reference
Sugar-induced increases in trehalose 6-phosphate are correlated with redox activation of ADPglucose pyrophosphorylase and higher rates of starch synthesis in Arabidopsis thaliana
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10.1093/nar/gkae241 · 2024 · External reference
STAR: ultrafast universal RNA-seq aligner
10.1093/bioinformatics/bts635 · 2013 · External reference
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Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
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