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References from Cancer competition for vitamin B2 creates metabolic checkpoint for T cell ferroptosis. Local targets link to admitted publications; unresolved targets remain external evidence.
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Metabolic pathway analysis using stable isotopes in patients with cancer
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Metabolic barriers to cancer immunotherapy
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10.1016/j.ccell.2023.01.009 · 2023 · External reference
Metabolism of immune cells in cancer
10.1038/s41568-020-0273-y · 2020 · External reference
Immunometabolic Interplay in the Tumor Microenvironment
10.1016/j.ccell.2020.09.004 · 2021 · External reference
Metabolic communication in the tumour–immune microenvironment
10.1038/s41556-022-01002-x · 2022 · External reference
Solute carrier transporters: the metabolic gatekeepers of immune cells
10.1016/j.apsb.2019.12.006 · 2020 · External reference
A guide to plasma membrane solute carrier proteins
10.1111/febs.15531 · 2021 · External reference
A structure and evolutionary-based classification of solute carriers
10.1016/j.isci.2022.105096 · 2022 · External reference
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
10.1016/j.cell.2015.08.016 · 2015 · External reference
Tumor aerobic glycolysis confers immune evasion through modulating sensitivity to T cell-mediated bystander killing via TNF-α
10.1016/j.cmet.2023.07.001 · 2023 · External reference
Cancer SLC43A2 alters T cell methionine metabolism and histone methylation
10.1038/s41586-020-2682-1 · 2020 · External reference
SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity
10.1038/s41586-023-06299-8 · 2023 · External reference
Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8+ T cells
10.1016/j.cell.2024.03.011 · 2024 · External reference
Monocarboxylate transporter 1 blockade with AZD3965 inhibits lipid biosynthesis and increases tumour immune cell infiltration
10.1038/s41416-019-0717-x · 2020 · External reference
Riboflavin (vitamin B-2) and health
10.1093/ajcn/77.6.1352 · 2003 · External reference
Riboflavin (vitamin B2) and oxidative stress: a review
10.1017/s0007114514000178 · 2014 · External reference
Identification and functional characterization of a novel human and rat riboflavin transporter, RFT1
10.1152/ajpcell.00019.2008 · 2008 · External reference
Identification and Functional Characterization of Rat Riboflavin Transporter 2
10.1093/jb/mvn181 · 2009 · External reference
Identification and Comparative Functional Characterization of a New Human Riboflavin Transporter hRFT3 Expressed in the Brain
10.3945/jn.110.122911 · 2010 · External reference
SLC52A3, A Brown-Vialetto-van Laere syndrome candidate gene is essential for mouse development, but dispensable for motor neuron differentiation
10.1093/hmg/ddw053 · 2016 · External reference
The Expression of Riboflavin Transporters in Human Colorectal Cancer
2018 · External reference
Evaluation of Riboflavin Transporters as Targets for Drug Delivery and Theranostics
10.3389/fphar.2019.00079 · 2019 · External reference
Systematic analysis of the role of SLC52A2 in multiple human cancers
2022 · External reference
Riboflavin transport and metabolism in humans
10.1007/s10545-016-9950-0 · 2016 · External reference
Riboflavin drives nucleotide biosynthesis and iron-sulfur metabolism to promote acute myeloid leukemia
2025 · External reference
The assembly of succinate dehydrogenase: a key enzyme in bioenergetics
10.1007/s00018-019-03200-7 · 2019 · External reference
Succinate dehydrogenase and human diseases: new insights into a well-known enzyme
10.1038/sj.ejhg.5200793 · 2002 · External reference
Role of Mitochondria in Ferroptosis
10.1016/j.molcel.2018.10.042 · 2019 · External reference
Mitochondria and ferroptosis
2022 · External reference
The diversified role of mitochondria in ferroptosis in cancer
2023 · External reference
Mitochondrial superoxide mediates labile iron level: evidence from Mn-SOD-transgenic mice and heterozygous knockout mice and isolated rat liver mitochondria
10.1016/j.freeradbiomed.2013.06.026 · 2013 · External reference
The significance, trafficking and determination of labile iron in cytosol, mitochondria and lysosomes
10.1039/c8mt00048d · 2018 · External reference
Pulling back the mitochondria’s iron curtain
10.1038/s44324-024-00045-y · 2025 · External reference
Myoferlin targeting triggers mitophagy and primes ferroptosis in pancreatic cancer cells
10.1016/j.redox.2022.102324 · 2022 · External reference
Mdivi-1 alleviates ferroptosis induced by hypoxia combined with propofol in HT22 cells by inhibiting excessive mitophagy
10.1007/s11033-024-09812-y · 2024 · External reference
Iron chelators as mitophagy agents: Potential and limitations
10.1016/j.biopha.2024.117407 · 2024 · External reference
Mitophagy-related regulated cell death: molecular mechanisms and disease implications
10.1038/s41419-024-06804-5 · 2024 · External reference
Role of nrf2 in oxidative stress and toxicity
10.1146/annurev-pharmtox-011112-140320 · 2013 · External reference
Regulation of SLC7A11 as an unconventional checkpoint in tumorigenesis through ferroptosis
2025 · External reference
HBx facilitates ferroptosis in acute liver failure via EZH2 mediated SLC7A11 suppression
10.1186/s12929-021-00762-2 · 2021 · External reference
Targeting SLC7A11-mediated cysteine metabolism for the treatment of trastuzumab-resistant HER2-positive breast cancer
10.7554/elife.103953 · 2025 · External reference
Orchestration of H3K27 methylation: mechanisms and therapeutic implication
10.1007/s00018-017-2596-8 · 2018 · External reference
KDM6 Demethylases and Their Roles in Human Cancers
10.3389/fonc.2021.779918 · 2021 · External reference
FAD-binding site of glutathione reductase
10.1016/0022-2836(82)90177-2 · 1982 · External reference
Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes
10.1016/j.bbagen.2012.09.018 · 2013 · External reference
Vitamin B2 metabolism promotes FSP1 stability to prevent ferroptosis
10.1038/s41594-026-01759-x · 2026 · External reference
Riboflavin metabolism shapes FSP1-driven ferroptosis resistance
10.1038/s41556-025-01856-x · 2026 · External reference
CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4
10.1016/j.ccell.2022.02.003 · 2022 · External reference
Comprehensive profiling of lipid metabolic reprogramming expands precision medicine for HCC
10.1097/hep.0000000000000962 · 2025 · External reference
Nutrient transporters: connecting cancer metabolism to therapeutic opportunities
10.1038/s41388-023-02593-x · 2023 · External reference
Solute Carrier Transporters as Potential Targets for the Treatment of Metabolic Disease
10.1124/pr.118.015735 · 2020 · External reference
SLC transporters as therapeutic targets: emerging opportunities
10.1038/nrd4626 · 2015 · External reference
A Call for Systematic Research on Solute Carriers
10.1016/j.cell.2015.07.022 · 2015 · External reference
Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation
10.1126/sciimmunol.abm8161 · 2022 · External reference
Sulfur partitioning from cysteine controls T cell proliferation and effector function
10.1016/j.cell.2026.03.012 · 2026 · External reference
Riboflavin: The Health Benefits of a Forgotten Natural Vitamin
10.3390/ijms21030950 · 2020 · External reference
B Vitamins, Glucoronolactone and the Immune System: Bioavailability, Doses and Efficiency
10.3390/nu16010024 · 2023 · External reference
Dietary vitamin B2 intake and breast cancer risk: a systematic review and meta-analysis
10.1007/s00404-016-4278-4 · 2017 · External reference
Vitamin B2 intake reduces the risk for colorectal cancer: a dose–response analysis
10.1007/s00394-018-1702-5 · 2019 · External reference
Riboflavin intake, MTRR genetic polymorphism (rs1532268) and gastric cancer risk in a Korean population: a case–control study
10.1017/s0007114521001811 · 2022 · External reference
Structure and transport mechanism of human riboflavin transporters
2025 · External reference
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle
10.1016/j.molcel.2025.10.002 · 2025 · External reference
Genome-wide identification of differentially methylated promoters and enhancers associated with response to anti-PD-1 therapy in non-small cell lung cancer
10.1038/s12276-020-00493-8 · 2020 · External reference
Phenotype molding of stromal cells in the lung tumor microenvironment
10.1038/s41591-018-0096-5 · 2018 · External reference
Skewer: a fast and accurate adapter trimmer for next-generation sequencing paired-end reads
10.1186/1471-2105-15-182 · 2014 · External reference
Fast gapped-read alignment with Bowtie 2
10.1038/nmeth.1923 · 2012 · External reference
The Sequence Alignment/Map format and SAMtools
10.1093/bioinformatics/btp352 · 2009 · External reference
Model-based analysis of ChIP-Seq (MACS)
10.1186/gb-2008-9-9-r137 · 2008 · External reference
Differential oestrogen receptor binding is associated with clinical outcome in breast cancer
10.1038/nature10730 · 2012 · External reference
ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization
10.1093/bioinformatics/btv145 · 2015 · External reference
clusterProfiler 4.0: A universal enrichment tool for interpreting omics data
2021 · External reference
Extending support for mouse data in the Molecular Signatures Database (MSigDB)
10.1038/s41592-023-02014-7 · 2023 · External reference
Dictionary learning for integrative, multimodal and scalable single-cell analysis
10.1038/s41587-023-01767-y · 2024 · External reference
GSVA: gene set variation analysis for microarray and RNA-seq data
10.1186/1471-2105-14-7 · 2013 · External reference
limma powers differential expression analyses for RNA-sequencing and microarray studies
10.1093/nar/gkv007 · 2015 · External reference
Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening
10.1038/nprot.2017.016 · 2017 · External reference
