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References from A non-canonical function of glutathione to suppress ferroptosis via FSP1. Local targets link to admitted publications; unresolved targets remain external evidence.
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
10.1016/j.cell.2012.03.042 · 2012 · External reference
The chemical basis of ferroptosis
10.1038/s41589-019-0408-1 · 2019 · External reference
ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway
10.1038/s41556-019-0305-6 · 2019 · External reference
iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4
2021 · External reference
Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis
10.1016/j.cell.2024.01.030 · 2024 · External reference
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
10.1038/nchembio.2239 · 2017 · External reference
PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis
10.1038/s41556-021-00818-3 · 2022 · External reference
LPCAT3 Inhibitors Remodel the Polyunsaturated Phospholipid Content of Human Cells and Protect from Ferroptosis
10.1021/acschembio.2c00317 · 2022 · External reference
Plasticity of ether lipids promotes ferroptosis susceptibility and evasion
10.1038/s41586-020-2732-8 · 2020 · External reference
Lymph protects metastasizing melanoma cells from ferroptosis
10.1038/s41586-020-2623-z · 2020 · External reference
Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State
10.1016/j.chembiol.2018.11.016 · 2019 · External reference
Peroxisome-driven ether-linked phospholipids biosynthesis is essential for ferroptosis
10.1038/s41418-021-00769-0 · 2021 · External reference
LPCAT1-mediated membrane phospholipid remodelling promotes ferroptosis evasion and tumour growth
10.1038/s41556-024-01405-y · 2024 · External reference
Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition
10.1038/nature24297 · 2017 · External reference
FSP1 is a glutathione-independent ferroptosis suppressor
10.1038/s41586-019-1707-0 · 2019 · External reference
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
10.1038/s41586-019-1705-2 · 2019 · External reference
Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers
10.1038/s41589-020-0613-y · 2020 · External reference
DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer
10.1038/s41586-021-03539-7 · 2021 · External reference
Tryptophan Metabolism Acts as a New Anti-Ferroptotic Pathway to Mediate Tumor Growth
2023 · External reference
7-Dehydrocholesterol dictates ferroptosis sensitivity
10.1038/s41586-023-06983-9 · 2024 · External reference
7-Dehydrocholesterol is an endogenous suppressor of ferroptosis
10.1038/s41586-023-06878-9 · 2024 · External reference
Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer
2021 · External reference
Cholesterol mediated ferroptosis suppression reveals essential roles of Coenzyme Q and squalene
10.1038/s42003-023-05477-8 · 2023 · External reference
Regulation of Ferroptotic Cancer Cell Death by GPX4
10.1016/j.cell.2013.12.010 · 2014 · External reference
A non-canonical vitamin K cycle is a potent ferroptosis suppressor
10.1038/s41586-022-05022-3 · 2022 · External reference
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
10.1038/ncb3064 · 2014 · External reference
Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway
10.1038/s41467-020-20154-8 · 2020 · External reference
Intermittent dietary methionine deprivation facilitates tumoral ferroptosis and synergizes with checkpoint blockade
10.1038/s41467-023-40518-0 · 2023 · External reference
Selenium–GPX4 axis protects follicular helper T cells from ferroptosis
10.1038/s41590-021-00996-0 · 2021 · External reference
T cell lipid peroxidation induces ferroptosis and prevents immunity to infection
10.1084/jem.20140857 · 2015 · External reference
Fenton reaction-independent ferroptosis therapy via glutathione and iron redox couple sequentially triggered lipid peroxide generator
10.1016/j.biomaterials.2020.119911 · 2020 · External reference
Beyond DPPH: Use of Fluorescence-Enabled Inhibited Autoxidation to Predict Oxidative Cell Death Rescue
10.1016/j.chembiol.2019.09.007 · 2019 · External reference
Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals
10.1038/s41589-022-01145-w · 2023 · External reference
Hydrogen sulfide-mediated persulfidation regulates homocysteine metabolism and enhances ferroptosis in non-small cell lung cancer
10.1016/j.molcel.2024.08.035 · 2024 · External reference
Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation
10.1016/j.cmet.2019.09.009 · 2019 · External reference
Adipocyte-derived glutathione promotes obesity-related breast cancer by regulating the SCARB2-ARF1-mTORC1 complex
10.1016/j.cmet.2024.09.013 · 2024 · External reference
Role of glutathione transport processes in kidney function
10.1016/j.taap.2004.10.004 · 2005 · External reference
Glutathione uptake and protection against oxidative injury in isolated kidney cells
10.1038/ki.1988.147 · 1988 · External reference
Heme Oxygenase-1-Modified BMMSCs Activate AMPK-Nrf2-FTH1 to Reduce Severe Steatotic Liver Ischemia-Reperfusion Injury
10.1007/s10620-023-08102-0 · 2023 · External reference
Salvia miltiorrhiza Bge. processed with porcine cardiac blood inhibited GLRX5-mediated ferroptosis alleviating cerebral ischemia-reperfusion injury
10.1016/j.phymed.2024.155622 · 2024 · External reference
Structural insights into FSP1 catalysis and ferroptosis inhibition
10.1038/s41467-023-41626-7 · 2023 · External reference
The crystal structure of human ferroptosis suppressive protein 1 in complex with flavin adenine dinucleotide and nicotinamide adenine nucleotide
10.1002/mco2.479 · 2024 · External reference
Structural insight into 6-OH-FAD-dependent activation of hFSP1 for ferroptosis suppression
10.1038/s41421-024-00723-7 · 2024 · External reference
FSP1 oxidizes NADPH to suppress ferroptosis
10.1038/s41422-023-00879-z · 2023 · External reference
Activation of lysosomal iron triggers ferroptosis in cancer
10.1038/s41586-025-08974-4 · 2025 · External reference
Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes
10.1126/science.aan6298 · 2017 · External reference
Lymph node environment drives FSP1 targetability in metastasizing melanoma
10.1038/s41586-025-09709-1 · 2025 · External reference
Riboflavin metabolism shapes FSP1-driven ferroptosis resistance
10.1038/s41556-025-01856-x · 2026 · External reference
Vitamin B2 metabolism promotes FSP1 stability to prevent ferroptosis
10.1038/s41594-026-01759-x · 2026 · External reference
Glutathione-dependent redox balance characterizes the distinct metabolic properties of follicular and marginal zone B cells
10.1038/s41467-022-29426-x · 2022 · External reference
Glutathione Primes T Cell Metabolism for Inflammation
10.1016/j.immuni.2017.06.009 · 2017 · External reference
Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition
10.1038/s41556-023-01314-6 · 2024 · External reference
NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus
10.1016/j.cmet.2015.05.023 · 2015 · External reference
Glutathione Metabolism and Its Selective Modification
10.1016/s0021-9258(19)77815-6 · 1988 · External reference
Regulation of genes encoding NAD(P)H:quinone oxidoreductases
10.1016/s0891-5849(00)00306-3 · 2000 · External reference
Mitochondrial ubiquinol oxidation is necessary for tumour growth
10.1038/s41586-020-2475-6 · 2020 · External reference
Mutation of a Nuclear Succinate Dehydrogenase Gene Results in Mitochondrial Respiratory Chain Deficiency
10.1038/ng1095-144 · 1995 · External reference
Sensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury
10.1016/j.cmet.2024.09.007 · 2024 · External reference
The diverse functionality of NQO1 and its roles in redox control
10.1016/j.redox.2021.101950 · 2021 · External reference
Phase separation of FSP1 promotes ferroptosis
10.1038/s41586-023-06255-6 · 2023 · External reference
