Research graph
References from The RNA-binding protein EIF3B promotes necroptosis and subsequent metabolic acidosis in acute pancreatitis through stabilization of RIPK3 mRNA. Local targets link to admitted publications; unresolved targets remain external evidence.
Diagnosis and management of acute pancreatitis
10.1053/j.gastro.2024.02.052 · 2024 · External reference
Acute pancreatitis: a review
10.1001/jama.2020.20317 · 2021 · External reference
The role of Interleukin-22 in severe acute pancreatitis
10.1186/s10020-024-00826-7 · 2024 · External reference
Comprehensive mechanism, novel markers and multidisciplinary treatment of severe acute pancreatitis-associated cardiac injury - a narrative review
10.2147/jir.s310990 · 2021 · External reference
Predictors of severity of acute pancreatitis
10.5009/gnl230235 · 2023 · External reference
Identification of key biomarkers associated with immunogenic cell death and their regulatory mechanisms in severe acute pancreatitis based on WGCNA and machine learning
10.3390/ijms24033033 · 2023 · External reference
Using acidosis as a surrogate for or supplement to the bedside index of severity in acute pancreatitis scoring prediction system has a nonsignificant effect
2024 · External reference
Acute pancreatitis: current clinical approaches, molecular pathophysiology, and potential therapeutics
10.1097/mpa.0000000000002259 · 2023 · External reference
Current trends in acute pancreatitis: diagnostic and therapeutic challenges
10.3748/wjg.v29.i18.2747 · 2023 · External reference
Cell death and its interaction with mitochondrial dysfunction in pathogenesis of acute pancreatitis: a comprehensive review
10.1007/s10495-026-02288-0 · 2026 · External reference
A Glimpse of necroptosis and diseases
10.1016/j.biopha.2022.113925 · 2022 · External reference
Necroptosis inhibitors: mechanisms of action and therapeutic potential
10.1007/s10495-023-01905-6 · 2024 · External reference
The regulation of necroptosis by ubiquitylation
10.1007/s10495-022-01755-8 · 2022 · External reference
Understanding necroptosis in pancreatic diseases
10.3390/biom12060828 · 2022 · External reference
Targeting multiple regulated cell death pathways in acute pancreatitis: the multi-target potential of natural products from traditional Chinese medicine
10.1016/j.prp.2026.156449 · 2026 · External reference
MLKL signaling regulates macrophage polarization in acute pancreatitis through CXCL10
10.1038/s41419-023-05655-w · 2023 · External reference
E3 ubiquitin ligase Pellino1 suppresses acinar cell necroptosis and alleviates severe acute pancreatitis by promoting ubiquitin-dependent receptor-interacting protein kinase 3 (RIP3) degradation
10.1111/bph.70175 · 2025 · External reference
Investigating the role of salidroside in alleviating acute pancreatitis by inhibiting the RIPK1/RIPK3/MLKL pathway-mediated necroptosis in pancreatic acinar cells in rats
10.2147/jir.s545785 · 2025 · External reference
Curcumol alleviates acute pancreatitis by inhibiting RIPK1/RIPK3/MLKL pathway-mediated necroptosis: integrated bioinformatics, network pharmacology, molecular docking and dynamics simulations, and experimental validation
10.1016/j.intimp.2026.116632 · 2026 · External reference
Understanding RNA-binding proteins
2022 · External reference
Research progress in RNA-binding proteins
10.3390/ijms24010058 · 2022 · External reference
Targeting RNA-binding proteins with small molecules: perspectives, pitfalls and bifunctional molecules
10.1002/1873-3468.14710 · 2023 · External reference
RNA-binding proteins: underestimated contributors in tumorigenesis
10.1016/j.semcancer.2022.01.010 · 2022 · External reference
Alternative splicing and related RNA binding proteins in human health and disease
10.1038/s41392-024-01734-2 · 2024 · External reference
A cardiovascular, craniofacial, and neurodevelopmental disorder caused by loss-of-function variants in the eIF3 complex component genes EIF3A and EIF3B
10.1016/j.ajhg.2025.09.008 · 2025 · External reference
EIF3 engages with 3'-UTR termini of highly translated mRNAs
10.7554/elife.102977.3 · 2025 · External reference
Eukaryotic initiation factor 3b regulates the development and progression of breast cancer
2023 · External reference
EIF3B stabilizes MAP2K2 to activate the ERK pathway and promote the progression of laryngeal squamous cell carcinoma
10.1038/s41420-025-02634-2 · 2025 · External reference
EIF3B regulates the cell cycle of lung adenocarcinoma cells by activating the GTSE1 mediated ERK/MAPK pathway
10.1186/s12931-026-03559-9 · 2026 · External reference
CIRP contributes to multiple organ damage in acute pancreatitis by increasing endothelial permeability
10.1038/s42003-025-07772-y · 2025 · External reference
Blocking TRPM4 alleviates pancreatic acinar cell damage via an NMDA receptor-dependent pathway in acute pancreatitis
10.7150/thno.116520 · 2025 · External reference
Long non-coding RNA FENDRR modulates autophagy through epigenetic suppression of ATG7 via binding PRC2 in acute pancreatitis
10.1007/s10753-020-01395-7 · 2021 · External reference
Effects of tRNA-derived fragments and microRNAs regulatory network on pancreatic acinar intracellular trypsinogen activation
10.1080/21655979.2021.2018880 · 2022 · External reference
CNOT3 suppression promotes necroptosis by stabilizing mRNAs for cell death-inducing proteins
10.1038/srep14779 · 2015 · External reference
Expression of HIF1α in intestinal epithelium restricts arthritis inflammation by inhibiting RIPK3-induced cell death machinery
10.1136/ard-2023-224491 · 2024 · External reference
Dissecting the stress activating signaling pathways in acute pancreatitis
2010 · External reference
Oxidative stress and inflammatory signaling in cerulein pancreatitis
10.3748/wjg.v20.i46.17324 · 2014 · External reference
Endoplasmic reticulum stress promoted acinar cell necroptosis in acute pancreatitis through cathepsinB-mediated AP-1 activation
10.3389/fimmu.2022.968639 · 2022 · External reference
Roles of RIPK3 in necroptosis, cell signaling, and disease
10.1038/s12276-022-00868-z · 2022 · External reference
RIPK3 in necroptosis and cancer
2025 · External reference
Oxidative cell death in cancer: mechanisms and therapeutic opportunities
10.1038/s41419-024-06939-5 · 2024 · External reference
Mediators of necroptosis: from cell death to metabolic regulation
10.1038/s44321-023-00011-z · 2024 · External reference
Mitochondria as multifaceted regulators of cell death
10.1038/s41580-019-0173-8 · 2020 · External reference
Mitochondria and cell death
10.1038/s41556-024-01429-4 · 2024 · External reference
HMGB1: key mediator in digestive system diseases
10.1007/s00011-025-02002-x · 2025 · External reference
Ac2-26 alleviates hepatic ischemia-reperfusion injury based on inhibiting the positive feedback loop of HMGB1/TLR4/NF-κB/neutrophils
10.3892/etm.2022.11609 · 2022 · External reference
RAGE interacts with the necroptotic protein RIPK3 and mediates transfusion-induced danger signal release
10.1111/vox.12946 · 2020 · External reference
Roles of RAGE/ROCK1 pathway in HMGB1-induced early changes in barrier permeability of human pulmonary microvascular endothelial cell
10.3389/fimmu.2021.697071 · 2021 · External reference
Platelet HMGB1 steers intravascular immunity and thrombosis
10.1016/j.jtha.2024.07.030 · 2024 · External reference
Involvement of role of HMGB1-NLRP3 pathway in systemic disorders
10.3389/fcell.2025.1600596 · 2025 · External reference
Involvement of IL-1β-mediated necroptosis in neurodevelopment impairment after neonatal sepsis in rats
10.3390/ijms241914693 · 2023 · External reference
Endoplasmic reticulum stress in acute pancreatitis: exploring the molecular mechanisms and therapeutic targets
10.1016/j.cstres.2025.03.001 · 2025 · External reference
Involvement of phosphorylation of ULK1 in alternative autophagy
10.1080/15548627.2020.1776476 · 2020 · External reference
Mitochondrial dysfunction in pancreatic acinar cells: mechanisms and therapeutic strategies in acute pancreatitis
10.3389/fimmu.2024.1503087 · 2024 · External reference
