Research graph
References from NSD2 drives triple-negative breast cancer progression via ATAD3A-dependent senescence. Local targets link to admitted publications; unresolved targets remain external evidence.
Breast cancer: pathogenesis and treatments
2025 · External reference
Ferroptotic neutrophils induce immunosuppression and Chemoresistance in breast Cancer
10.1158/0008-5472.can-24-1941 · 2025 · External reference
Recent advances in targeted strategies for triple-negative breast cancer
10.1186/s13045-023-01497-3 · 2023 · External reference
Final results from the randomized phase III ASCENT clinical trial in metastatic triple-negative breast Cancer and Association of Outcomes by human epidermal growth factor receptor 2 and trophoblast cell surface antigen 2 expression
10.1200/jco.23.01409 · 2024 · External reference
Selective elimination of breast surgery for invasive breast Cancer: a nonrandomized clinical trial
10.1001/jamaoncol.2025.0207 · 2025 · External reference
Triple-negative breast cancer: epidemiology, molecular mechanisms, and modern vaccine-based treatment strategies
10.1016/j.bcp.2023.115545 · 2023 · External reference
Epigenetic modulations in triple-negative breast cancer: therapeutic implications for tumor microenvironment
10.1016/j.phrs.2024.107205 · 2024 · External reference
HEBP2-governed glutamine competition between tumor and macrophages dictates immunotherapy efficacy in triple-negative breast cancer
10.1016/j.cmet.2025.08.009 · 2025 · External reference
piR-1170 drives brain metastasis and immune evasion via WTAP-mediated m6A methylation reprogramming in triple-negative breast cancer
10.1186/s12943-026-02568-y · 2026 · External reference
Precision targeted therapy and immunotherapy in breast cancer: advances and clinical frontiers
10.1097/cm9.0000000000004168 · 2026 · External reference
Copper orchestrates triple-negative breast cancer progression via the STEAP3-dependent CDK16-JAK1 activation
10.1016/j.canlet.2025.218192 · 2026 · External reference
Single-cell transcriptomic analysis identifies senescent osteocytes that trigger bone destruction in breast Cancer metastasis
10.1158/0008-5472.can-24-0857 · 2024 · External reference
Combined targeting of senescent cells and senescent macrophages: a new idea for integrated treatment of lung cancer
10.1016/j.semcancer.2024.08.006 · 2024 · External reference
Cellular senescence and SASP in tumor progression and therapeutic opportunities
10.1186/s12943-024-02096-7 · 2024 · External reference
The senescence-associated secretory phenotype and its physiological and pathological implications
10.1038/s41580-024-00727-x · 2024 · External reference
The SASP factor IL-6 sustains cell-autonomous senescent cells via a cGAS-STING-NFκB intracrine senescent noncanonical pathway
10.1111/acel.14258 · 2024 · External reference
Senescent cells promote breast cancer cells motility by secreting GM-CSF and bFGF that activate the JNK signaling pathway
10.1186/s12964-024-01861-x · 2024 · External reference
Multi-dimensional targeting of the tumor microenvironment to inhibit the invasion and metastasis of breast cancer
10.1016/j.prp.2025.156309 · 2026 · External reference
Inhibition of the FEN1-PBX1 axis elicits cellular senescence in breast cancer via the increased intracellular reactive oxygen species levels
10.1186/s12967-025-06216-9 · 2025 · External reference
NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers
10.1038/s41586-025-09299-y · 2026 · External reference
H3K36me2 methyltransferase NSD2/WHSC1 promotes triple-negative breast cancer metastasis via activation of ULK1-dependent autophagy
10.1080/15548627.2025.2479995 · 2025 · External reference
Discovery of a potent and selective targeted NSD2 degrader for the reduction of H3K36me2
10.1021/jacs.3c01421 · 2023 · External reference
Overexpression of EZH2/NSD2 histone methyltransferase Axis predicts poor prognosis and accelerates tumor progression in triple-negative breast Cancer
2020 · External reference
CircWHSC1 regulates malignancy and glycolysis by the miR-212-5p/AKT3 pathway in triple-negative breast cancer
10.1016/j.yexmp.2021.104704 · 2021 · External reference
NSD2-mediated H3K36me2 exacerbates osteoporosis via activation of hoxa2 in bone marrow mesenchymal stem cells
10.1016/j.cellsig.2024.111294 · 2024 · External reference
Histone methyltransferase NSD2 mediates the survival and invasion of triple-negative breast cancer cells via stimulating ADAM9-EGFR-AKT signaling
10.1038/s41401-018-0199-z · 2019 · External reference
Kdm2a inhibition in skeletal muscle improves metabolic flexibility in obesity
10.1038/s42255-024-01210-9 · 2025 · External reference
Mitochondrial DNA breaks activate an integrated stress response to reestablish homeostasis
10.1016/j.molcel.2023.09.026 · 2023 · External reference
The SIRT3-ATAD3A axis regulates MAM dynamics and mitochondrial calcium homeostasis in cardiac hypertrophy
10.7150/ijbs.89253 · 2024 · External reference
Thymoquinone alleviates myocardial ischemia/reperfusion injury by stabilizing mitochondria-associated membrane homeostasis via targeting ATAD3A
10.1016/j.phymed.2025.156914 · 2025 · External reference
Elevated FBXL6 activates ATAD3A through K63-linked polyubiquitination and promotes the malignant progression of TNBC via metabolic reprogramming
10.1016/j.ijbiomac.2025.147713 · 2025 · External reference
The oncoprotein MUC1 facilitates breast cancer progression by promoting Pink1-dependent mitophagy via ATAD3A destabilization
10.1038/s41419-022-05345-z · 2022 · External reference
Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation
10.1016/j.cmet.2024.05.016 · 2024 · External reference
Aldehyde dehydrogenase 2 lactylation aggravates mitochondrial dysfunction by disrupting PHB2 mediated mitophagy in acute kidney injury
2025 · External reference
TRAP1 drives smooth muscle cell senescence and promotes atherosclerosis via HDAC3-primed histone H4 lysine 12 lactylation
10.1093/eurheartj/ehae379 · 2024 · External reference
AhR-mediated histone lactylation drives cellular senescence during benzo[a]pyrene-evoked chronic obstructive pulmonary disease
10.1016/j.jhazmat.2025.139083 · 2025 · External reference
HK2-driven histone H3K18 lactylation promotes stromal cell senescence and decidualization deficiency in URSA via CUX1-mediated SASP factor transcription
10.1186/s11658-026-00879-y · 2026 · External reference
Histone lactylation antagonizes senescence and skeletal muscle aging by modulating aging-related pathways
2025 · External reference
Histone lactylation-induced premature senescence contributes to 1-nitropyrene-induced chronic obstructive pulmonary disease
10.1016/j.redox.2025.103703 · 2025 · External reference
Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases
10.1038/s41586-020-03069-8 · 2021 · External reference
High-risk MCL: recognition and treatment
10.1182/blood.2023022354 · 2025 · External reference
Emerging links between control of mitochondrial protein ATAD3A and Cancer
10.3390/ijms21217917 · 2020 · External reference
Tiam1 methylation by NSD2 promotes Rac1 signaling activation and colon cancer metastasis
10.1073/pnas.2305684120 · 2023 · External reference
Mitochondrial nucleoid trafficking regulated by the inner-membrane AAA-ATPase ATAD3A modulates respiratory complex formation
10.1073/pnas.2210730119 · 2022 · External reference
Targeting ATAD3A-PINK1-mitophagy axis overcomes chemoimmunotherapy resistance by redirecting PD-L1 to mitochondria
10.1038/s41422-022-00766-z · 2023 · External reference
Exploring the communication of the SASP: dynamic, interactive, and adaptive effects on the microenvironment
10.3390/ijms241310788 · 2023 · External reference
Senescent cells: a new Achilles' heel to exploit for cancer medicine?
10.1111/acel.12875 · 2019 · External reference
Non-canonical senescence phenotype in resistance to CDK4/6 inhibitors in ER-positive breast Cancer
10.3390/biom16010093 · 2026 · External reference
Decoding tumor microenvironment: EMT modulation in breast cancer metastasis and therapeutic resistance, and implications of novel immune checkpoint blockers
10.1016/j.biopha.2024.117714 · 2024 · External reference
The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis
10.1186/s13045-022-01347-8 · 2022 · External reference
DEK deficiency suppresses mitophagy to protect against house dust mite-induced asthma
2023 · External reference
ATAD3A: a key regulator of mitochondria-associated diseases
2023 · External reference
Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites
10.1002/cac2.12510 · 2024 · External reference
TIMP2-mediated mitochondrial fragmentation and glycolytic reprogramming drive renal fibrogenesis following ischemia-reperfusion injury
10.1016/j.freeradbiomed.2025.02.020 · 2025 · External reference
Inhibition of ERK downregulates autophagy via mitigating mitochondrial fragmentation to protect SH-SY5Y cells from OGD/R injury
10.1186/s12964-023-01211-3 · 2023 · External reference
Mitochondrial dynamics and colorectal cancer biology: mechanisms and potential targets
10.1186/s12964-024-01490-4 · 2024 · External reference
Perspectives on mitochondrial dysfunction in the regeneration of aging skeletal muscle
10.1186/s11658-025-00771-1 · 2025 · External reference
Self-assembling imidazolium nanoaggregates trigger a unique dynamin-dependent cell death via cytoplasmic vacuolization and mitochondrial dysfunction in human lung adenocarcinoma
10.1021/acs.jmedchem.5c00651 · 2025 · External reference
Integration of vascular smooth muscle cell phenotypic switching and senescence
10.1097/fjc.0000000000001752 · 2025 · External reference
PDP1 drives hepatocellular carcinoma progression by regulating senescence through the cAMP/Ca2+ signaling pathway
10.1016/j.bcp.2026.117772 · 2026 · External reference
NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis
10.1016/j.molcel.2021.08.034 · 2021 · External reference
Characterization of the activity of KTX-1001, a small molecule inhibitor of multiple myeloma SET domain using surface plasmon resonance
10.1016/j.jbc.2025.110382 · 2025 · External reference
Drug discovery targeting nuclear receptor binding SET domain protein 2 (NSD2)
10.1021/acs.jmedchem.3c00948 · 2023 · External reference
