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References from SMURF1 alleviates preeclampsia by suppressing ferroptosis in trophoblast cells via mediating ubiquitination of FLT1. Local targets link to admitted publications; unresolved targets remain external evidence.
A narrative review on the pathophysiology of preeclampsia
10.3390/ijms25147569 · 2024 · External reference
Preeclampsia epidemiology(ies) and pathophysiology(ies)
10.1016/j.bpobgyn.2024.102480 · 2024 · External reference
Overexpressed trophoblast glycoprotein contributes to preeclampsia development by inducing abnormal trophoblast migration and invasion toward the uterine spiral artery
10.1161/hypertensionaha.124.22923 · 2024 · External reference
Understanding preeclampsia: cardiovascular pathophysiology, histopathological insights and molecular biomarkers
10.3390/medsci13030154 · 2025 · External reference
Nano-enabled therapeutics: novel strategies for preeclampsia treatment
10.2147/ijn.s578148 · 2026 · External reference
Ferroptosis: an iron-dependent form of nonapoptotic cell death
10.1016/j.cell.2012.03.042 · 2012 · External reference
Ferroptosis: mechanisms and therapeutic targets
2024 · External reference
Ferroptosis, a therapeutic target for cardiovascular diseases, neurodegenerative diseases and cancer
10.1186/s12967-024-05881-6 · 2024 · External reference
Ferroptosis and apoptosis crosstalk in early-onset preeclampsia: redefining placental cell death and maternal survival pathways
10.4103/mgmj.mgmj_188_25 · 2025 · External reference
Iron overload-induced Ferroptosis drives placental dysfunction in preeclampsia
10.1161/hypertensionaha.125.26344 · 2026 · External reference
Vitamin D may alleviate pre-eclampsia by modulating the ferroptosis signalling pathway: a hypothesis based on recent literature
10.1111/jcmm.17754 · 2023 · External reference
Comprehensive identification of immune-related biomarkers and therapeutic targets in preeclampsia: integrative bioinformatics and experimental validation
10.1186/s12884-025-08169-9 · 2025 · External reference
Soluble FMS-like tyrosine kinase-1: an overview
2023 · External reference
Vascular endothelial growth factor signaling in health and disease: from molecular mechanisms to therapeutic perspectives
2025 · External reference
Preeclampsia is a double-hit vascular disorder: the VEGF-HO-1-CSE axis
10.3390/biom16030436 · 2026 · External reference
Preeclampsia, a disease of the maternal endothelium
10.1161/circulationaha.109.853127 · 2011 · External reference
Placental origins of preeclampsia: insights from multi-omic studies
10.3390/ijms25179343 · 2024 · External reference
Targeting ubiquitination in disease and therapy
2025 · External reference
Editorial: the role of ubiquitination in disease development, progression, and prognosis
10.3389/fimmu.2025.1595755 · 2025 · External reference
USP7 represses ferroptosis in trophoblasts in pre-eclampsia by mediating the xCT/GPX4 axis via deubiquitination of NRF2
10.1016/j.tice.2025.103050 · 2025 · External reference
USP17 regulates preeclampsia by modulating the NF-κB signaling pathway via deubiquitinating HDAC2
10.1016/j.placenta.2023.11.010 · 2024 · External reference
Regulation of placental development and function by ubiquitination
10.1186/s10020-025-01268-5 · 2025 · External reference
Evaluation of blood vessel injury, oxidative stress and circulating inflammatory factors in an L-NAME-induced preeclampsia-like rat model
2018 · External reference
ARIH1 promotes preeclampsia by inducing MFN2-dependent hypoxia-triggered mitophagy and endoplasmic reticulum stress in trophoblasts
10.1096/fj.202500821r · 2025 · External reference
Unresolved reference
1988 · External reference
How to calculate sample size in animal studies?
10.4103/0976-500x.119726 · 2013 · External reference
PPARγ alleviates preeclampsia development by regulating lipid metabolism and ferroptosis
10.1038/s42003-024-06063-2 · 2024 · External reference
Microplastic exposure induces preeclampsia-like symptoms via HIF-1α/TFRC-mediated ferroptosis in placental trophoblast cells
10.1016/j.tox.2025.154197 · 2025 · External reference
The degradation of TGR5 mediated by Smurf1 contributes to diabetic nephropathy
10.1016/j.celrep.2023.112851 · 2023 · External reference
Novel molecular strategies for preeclampsia management: a pathophysiological and therapeutic perspective
10.1080/10641955.2025.2540285 · 2025 · External reference
The role of Ferroptosis in placental-related diseases
10.1007/s43032-023-01193-0 · 2023 · External reference
Per2 deficiency in microglia alleviates motor dysfunction by inhibiting ferroptosis in spinal cord injury
10.1038/s42003-025-08664-x · 2025 · External reference
Two decades of advances in preeclampsia research: molecular mechanisms and translational studies
10.1172/jci184052 · 2024 · External reference
One step closer to a cure for preeclampsia?: boosting the natural affinity of VEGF (vascular endothelial growth factor) to sFlt (soluble fms-like tyrosine kinase)-1
10.1161/hypertensionaha.120.15112 · 2020 · External reference
SOD3 regulates FLT1 to affect bone metabolism by promoting osteogenesis and inhibiting adipogenesis through PI3K/AKT and MAPK pathways
10.1016/j.freeradbiomed.2023.12.021 · 2024 · External reference
Zinc induces iron uptake and DMT1 expression in Caco-2 cells via a PI3K/IRP2 dependent mechanism
10.1042/bcj20180939 · 2019 · External reference
Transferrin receptor promotes endometrial Cancer proliferation by activating the Iron-dependent PI3K/AKT/mTOR signaling pathway
10.1111/cas.70015 · 2025 · External reference
Ferritinophagy-mediated apoptosis and paraptosis induction involved MAPK and PI3K/AKT pathway in mechanism of an iron chelator
10.1016/j.bcp.2023.115874 · 2023 · External reference
Osteosarcoma cells-derived exosomal YES1 promote tumor progression via MAPK pathway
10.1002/inmd.20240072 · 2025 · External reference
Advances in protein ubiquitination modification and immune evasion of breast cancer
2026 · External reference
Opposing regulation of the K63-linked polyubiquitination of RIPK3 by SMURF1 and USP5 in necroptosis
10.1038/s41467-025-62723-9 · 2025 · External reference
Uncovering new insights into the role of the ubiquitin ligase Smurf1 on the regulation of innate immune signaling and resistance to infection
10.3389/fimmu.2023.1185741 · 2023 · External reference
TRIB3 mediates vascular calcification by facilitating self-ubiquitination and dissociation of Smurf1 in chronic kidney disease
10.1172/jci175972 · 2025 · External reference
Aberrant TGFβ signaling contributes to altered trophoblast differentiation in preeclampsia
10.1210/en.2015-1696 · 2016 · External reference
H19 long noncoding RNA alters trophoblast cell migration and invasion by regulating TβR3 in placentae with fetal growth restriction
10.18632/oncotarget.9534 · 2016 · External reference
Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation
10.1038/srep04965 · 2014 · External reference
Antiangiogenic and anti-invasive effects of sunitinib on experimental human glioblastoma
10.1215/15228517-2007-024 · 2007 · External reference
Methionine induced placental angiogenesis through activating WNT3A/CTNNB1-PIGF-VEGFR1 pathway
10.1186/s12964-025-02488-2 · 2025 · External reference
Smurf1 regulates neural patterning and folding in Xenopus embryos by antagonizing the BMP/Smad1 pathway
10.1016/j.ydbio.2006.08.009 · 2006 · External reference
Trophoblast-targeted nanomedicine modulates placental sFLT1 for preeclampsia treatment
2020 · External reference
VEGFR1 as a target for cardiovascular gene therapy
10.1007/s12265-025-10672-5 · 2025 · External reference
Soluble FLT-1 in angiogenesis: pathophysiological roles and therapeutic implications
10.1007/s10456-024-09942-8 · 2024 · External reference
Pivotal role of the C2 domain of the Smurf1 ubiquitin ligase in substrate selection
10.1074/jbc.m110.211979 · 2011 · External reference
Binding of RhoA by the C2 domain of E3 ligase Smurf1 is essential for Smurf1-regulated RhoA ubiquitination and cell protrusive activity
10.1016/j.febslet.2011.06.016 · 2011 · External reference
Heparin elevates circulating soluble fms-like tyrosine Kinase-1 immunoreactivity in pregnant women receiving anticoagulation therapy
10.1161/circulationaha.111.046821 · 2011 · External reference
Full-length human placental sFlt-1-e15a isoform induces distinct maternal phenotypes of preeclampsia in mice
10.1371/journal.pone.0119547 · 2015 · External reference