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References from Histone lactylation-upregulated CEBPB transcriptionally activates CXCL12 and p21 to modulate vascular smooth muscle cell senescence and macrophage polarization. Local targets link to admitted publications; unresolved targets remain external evidence.
Pathogenesis and management of abdominal aortic aneurysm
10.1093/eurheartj/ehad386 · 2023 · External reference
Abdominal aortic aneurysm
2022 · External reference
Inflammation in abdominal aortic aneurysm: cause or comorbidity?
2024 · External reference
Abdominal aortic aneurysm formation with a focus on vascular smooth muscle cells
10.3390/life12020191 · 2022 · External reference
Prenyl diphosphate synthase subunit 2 is downregulated in abdominal aortic aneurysm and retards the progression of abdominal aortic aneurysm
10.25259/cytojournal_70_2024 · 2024 · External reference
Cellular senescence and abdominal aortic aneurysm: from pathogenesis to therapeutics
2022 · External reference
A preliminary study of sirtuin-1 on angiotensin II-induced senescence and inflammation in abdominal aortic aneurysms
10.25259/cytojournal_80_2024 · 2024 · External reference
Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype
10.3389/fcell.2021.645593 · 2021 · External reference
The role of p21 in cellular senescence and aging-related diseases
2024 · External reference
The roles and mechanisms of senescence-associated secretory phenotype (SASP): can it be controlled by senolysis?
10.1186/s41232-022-00197-8 · 2022 · External reference
PDK4-dependent hypercatabolism and lactate production of senescent cells promotes cancer malignancy
10.1038/s42255-023-00912-w · 2023 · External reference
Hallmarks of aging: an expanding universe
10.1016/j.cell.2022.11.001 · 2023 · External reference
Lactate, histone lactylation and cancer hallmarks
10.1017/erm.2022.42 · 2023 · External reference
H3K18 lactylation marks tissue-specific active enhancers
10.1186/s13059-022-02775-y · 2022 · External reference
p21 produces a bioactive secretome that places stressed cells under immunosurveillance
10.1126/science.abb3420 · 2021 · External reference
Distinct functions of senescence-associated immune responses in liver tumor surveillance and tumor progression
10.1016/j.ccell.2016.09.003 · 2016 · External reference
Crosstalk between CXCL12/CXCR4/ACKR3 and the STAT3 pathway
10.3390/cells13121027 · 2024 · External reference
Inhibition of abdominal aortic aneurysm progression through the CXCL12/CXCR4 axis via MiR206-3p sponge
10.1111/jcmm.70328 · 2025 · External reference
Neutralization of CXCL12 attenuates established pulmonary hypertension in rats
10.1093/cvr/cvz153 · 2020 · External reference
Metformin suppresses vascular smooth muscle cell senescence by promoting autophagic flux
10.1016/j.jare.2021.12.009 · 2022 · External reference
Vascular smooth muscle cells in aortic aneurysm: from genetics to mechanisms
10.1161/jaha.121.023601 · 2021 · External reference
High-energy phosphate metabolism in vascular smooth muscle
10.1146/annurev.ph.47.030185.003213 · 1985 · External reference
Regulative roles of metabolic plasticity caused by mitochondrial oxidative phosphorylation and glycolysis on the initiation and progression of tumorigenesis
10.3390/ijms24087076 · 2023 · External reference
Oxidative stress-induced DNA damage response pathways in aortic disease: implications for inflammation and vascular degeneration
10.3390/ijms27041855 · 2026 · External reference
Enhanced expression and activation of pro-inflammatory transcription factors distinguish aneurysmal from atherosclerotic aorta: IL-6- and IL-8-dominated inflammatory responses prevail in the human aneurysm
10.1042/cs20070352 · 2008 · External reference
Regulation of vascular smooth muscle cell differentiation
10.1016/j.jvs.2007.03.001 · 2007 · External reference
Metabolism of vascular smooth muscle cells in vascular diseases
10.1152/ajpheart.00220.2020 · 2020 · External reference
PHB2 maintains the contractile phenotype of VSMCs by counteracting PKM2 splicing
10.1161/circresaha.122.321005 · 2022 · External reference
Immune and inflammatory mechanisms of abdominal aortic aneurysm
10.3389/fimmu.2022.989933 · 2022 · External reference
T cells in abdominal aortic aneurysm: immunomodulation and clinical application
10.3389/fimmu.2023.1240132 · 2023 · External reference
Monocytes and macrophages in abdominal aortic aneurysm
10.1038/nrcardio.2017.52 · 2017 · External reference
TREM-1 orchestrates angiotensin II-induced monocyte trafficking and promotes experimental abdominal aortic aneurysm
10.1172/jci142468 · 2021 · External reference
Histone lactylation: from tumor lactate metabolism to epigenetic regulation
10.7150/ijbs.91492 · 2024 · External reference
CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentials
10.1073/pnas.90.17.8219 · 1993 · External reference
A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA
10.1016/0092-8674(91)90531-3 · 1991 · External reference
H4K79 and H4K91 histone lactylation, newly identified lactylation sites enriched in breast cancer
10.1186/s13046-025-03512-6 · 2025 · External reference
Generic diagramming platform (GDP): a comprehensive database of high-quality biomedical graphics
10.1093/nar/gkae973 · 2025 · External reference
