Research graph
References from FPGS drives breast cancer proliferation via CDK9-mediated mitophagy through the mTOR signaling pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
Breast cancer statistics 2024
2024 · External reference
Cancer treatment and survivorship statistics, 2025
2025 · External reference
Extending the duration of endocrine treatment for early breast cancer: patient-level meta-analysis of 12 randomised trials of aromatase inhibitors in 22,031 postmenopausal women already treated with at least 5 years of endocrine therapy
10.1016/s0140-6736(25)01013-x · 2025 · External reference
Metabolomic rewiring promotes endocrine therapy resistance in breast cancer
10.1158/0008-5472.can-23-0184 · 2024 · External reference
Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways
10.1073/pnas.1816391116 · 2019 · External reference
Mechanisms of genome instability from cellular folate stress
10.1083/jcb.202502205 · 2025 · External reference
Toward a better understanding of folate metabolism in health and disease
10.1084/jem.20181965 · 2019 · External reference
Folic acid modulates VPO1 DNA methylation levels and alleviates oxidative stress-induced apoptosis in vivo and in vitro
10.1016/j.redox.2018.08.005 · 2018 · External reference
Beyond the Warburg effect: how do cancer cells regulate one-carbon metabolism?
10.3389/fcell.2018.00090 · 2018 · External reference
The role of nutrients in protecting mitochondrial function and neurotransmitter signaling: implications for the treatment of depression, PTSD, and suicidal behaviors
10.1080/10408398.2013.876960 · 2016 · External reference
Serine and one-carbon metabolism in cancer
10.1038/nrc.2016.81 · 2016 · External reference
Inactivation of folylpolyglutamate synthetase Met7 results in genome instability driven by an increased dUTP/dTTP ratio
2020 · External reference
Functionalizing of magnetic nanoparticles as nano-architecture towards bioimaging and colorimetric recognition of MCF-7 cells: dual opto-sensing and fluorescence monitoring for early-stage diagnosis of breast cancer
10.1007/s00604-024-06826-y · 2024 · External reference
A phase II trial to evaluate the safety and immunogenicity of two doses of a folate receptor alpha vaccine in patients with triple negative breast cancer
2025 · External reference
Antibody drug conjugate targets are highly differentially expressed across the major types of ovarian cancer
10.1016/j.ejca.2025.115522 · 2025 · External reference
Folate intake, tissue levels, and colorectal cancer deaths in a national cohort established before folic acid fortification
10.1007/s00394-025-03720-y · 2025 · External reference
Association of folate intake and plasma folate level with the risk of breast cancer: a dose-response meta-analysis of observational studies
10.18632/aging.103881 · 2020 · External reference
Folate and breast cancer: the role of polymorphisms in methylenetetrahydrofolate reductase (MTHFR)
10.1016/s0304-3835(02)00030-7 · 2002 · External reference
Regulation of folate and one-carbon metabolism in mammalian cells. I. Folate metabolism in Chinese hamster ovary cells expressing Escherichia coli or human folylpoly-gamma-glutamate synthetase activity
10.1016/s0021-9258(20)80592-4 · 1993 · External reference
Effects of overexpression of gamma-Glutamyl hydrolase on methotrexate metabolism and resistance
2001 · External reference
Identification and characterization of genetic variation in the folylpolyglutamate synthase gene
10.1158/0008-5472.can-07-0156 · 2007 · External reference
Folylpolyglutamate synthetase inactivation in relapsed ALL induces a druggable folate metabolic vulnerability
10.1016/j.drup.2024.101141 · 2024 · External reference
Effects of folylpolyglutamate synthetase modulation on chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate
10.1136/gut.2004.042713 · 2004 · External reference
Associations between TS, TTF-1, FR-α, FPGS, and overall survival in patients with advanced non-small-cell lung cancer receiving pemetrexed plus carboplatin or gemcitabine plus carboplatin as first-line chemotherapy
10.1097/jto.0b013e3182a406a3 · 2013 · External reference
Folylpoly-glutamate synthetase expression is associated with tumor response and outcome from pemetrexed-based chemotherapy in malignant pleural mesothelioma
10.1097/jto.0b013e318260deaa · 2012 · External reference
Effects of folylpolyglutamate synthase modulation on global and gene-specific DNA methylation and gene expression in human colon and breast cancer cells
10.1016/j.jnutbio.2015.10.019 · 2016 · External reference
The role of B12 deficiency and methionine synthase in methionine-dependent cancer cells
10.1186/s40170-025-00405-2 · 2025 · External reference
Folic acid depletion as well as oversupplementation helps in the progression of hepatocarcinogenesis in HepG2 cells
10.1038/s41598-022-21084-9 · 2022 · External reference
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles
10.1080/15548627.2020.1725377 · 2021 · External reference
Mitophagy's impacts on cancer and neurodegenerative diseases: implications for future therapies
10.1186/s13045-025-01727-w · 2025 · External reference
Cyclin-dependent kinases
10.1186/gb4184 · 2014 · External reference
A precision medicine drug discovery pipeline identifies combined CDK2 and 9 inhibition as a novel therapeutic strategy in colorectal cancer
10.1158/1535-7163.mct-20-0454 · 2020 · External reference
One-carbon metabolism, MTHFR polymorphisms, and risk of breast cancer
10.1158/0008-5472.can-04-2630 · 2005 · External reference
Association of folate metabolism-related enzymes (MTHFR, MYD88, and TP53) and their single nucleotide polymorphisms with breast cancer susceptibility in women from Southwest China: a Bayesian network approach
2025 · External reference
Balancing the scales: folic acid and vitamin B12 in the aggressiveness of hepatocellular carcinoma
10.1007/s10238-025-01799-5 · 2025 · External reference
Compartmentalization of mammalian folate-mediated one-carbon metabolism
10.1146/annurev.nutr.012809.104810 · 2010 · External reference
Serine, glycine and one-carbon units: cancer metabolism in full circle
10.1038/nrc3557 · 2013 · External reference
A dual-targeting peptide-drug conjugate based on CXCR4 and FOLR1 inhibits triple-negative breast cancer
10.1016/j.apsb.2025.06.012 · 2025 · External reference
Dual-targeted Pt@Ce-MOF nanoplatform enhances radiotherapy efficacy via tumor-specific delivery and mitochondrial dysfunction in breast cancer
10.1002/bip.70054 · 2025 · External reference
Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer
10.1038/ncomms4128 · 2014 · External reference
Comparative oncogenomics identifies PSMB4 and SHMT2 as potential cancer driver genes
10.1158/0008-5472.can-13-2683 · 2014 · External reference
Molecular basis of antifolate resistance
10.1007/s10555-007-9049-z · 2007 · External reference
Role of mitochondrial and cytosolic folylpolyglutamate synthetase in one-carbon metabolism and antitumor efficacy of mitochondrial-targeted antifolates
10.1124/molpharm.124.000912 · 2024 · External reference
Increasing dosage of leucovorin results in pharmacokinetic and gene expression differences when administered as two-hour infusion or bolus injection to patients with colon cancer
10.3390/cancers15010258 · 2022 · External reference
Histone deacetylase inhibitors induce FPGS mRNA expression and intracellular accumulation of long-chain methotrexate polyglutamates in childhood acute lymphoblastic leukemia: implications for combination therapy
10.1038/leu.2009.282 · 2010 · External reference
P-TEFb: the master regulator of transcription elongation
10.1016/j.molcel.2022.12.006 · 2023 · External reference
CDK9 keeps RNA polymerase II on track
10.1007/s00018-021-03878-8 · 2021 · External reference
Novel agents and regimens in relapsed or refractory peripheral T-cell lymphoma: latest updates from 2023 ASH annual meeting
10.1186/s40164-024-00510-w · 2024 · External reference
CDK9 inhibition induces epigenetic reprogramming revealing strategies to circumvent resistance in lymphoma
10.1186/s12943-023-01762-6 · 2023 · External reference
CDK9: therapeutic perspective in HCC therapy
10.2174/1568009620666200212124357 · 2020 · External reference
Targeting processive transcription for Myc-driven circuitry in medulloblastoma
10.1093/neuonc/noaf121 · 2025 · External reference
CREPT promotes LUAD progression by enhancing the CDK9 and RNAPII assembly to promote ERK-driven gene transcription
10.7150/thno.115572 · 2025 · External reference
CircFUNDC1 interacts with CDK9 to promote mitophagy in nucleus pulposus cells under oxidative stress and ameliorates intervertebral disc degeneration
10.1038/s41419-025-07425-2 · 2025 · External reference
CDK9 inhibition blocks the initiation of PINK1-PRKN-mediated mitophagy by regulating the SIRT1-FOXO3-BNIP3 axis and enhances the therapeutic effects involving mitochondrial dysfunction in hepatocellular carcinoma
10.1080/15548627.2021.2007027 · 2022 · External reference
Clinical considerations for the design of PROTACs in cancer
10.1186/s12943-022-01535-7 · 2022 · External reference
CDK9 targeting PROTAC L055 inhibits ERα-positive breast cancer
10.1016/j.biopha.2024.116972 · 2024 · External reference
Discovery of a potent, selective and orally bioavailable CDK9 degrader for targeting transcription regulation in triple-negative breast cancer
10.1016/j.bioorg.2024.107876 · 2024 · External reference
