Research graph
References from p62-Keap1-Nrf2 positive feedback loop protects against inorganic arsenic-induced senescence and EMT in alveolar type II cells. Local targets link to admitted publications; unresolved targets remain external evidence.
Arsenic inorganic exposure, metabolism, genetic biomarkers and its impact on human health: a mini-review
10.1016/j.toxlet.2024.06.008 · 2024 · External reference
Arsenic in drinking water and lung cancer: a systematic review of 35 years of evidence
10.1016/j.taap.2024.116808 · 2024 · External reference
Arsenic trioxide promotes ERK1/2-mediated phosphorylation and degradation of BIMEL to attenuate apoptosis in BEAS-2B cells
10.1016/j.cbi.2022.110304 · 2023 · External reference
Arsenite-induced downregulation of occludin in mouse lungs and BEAS-2B cells via the ROS/ERK/ELK1/MLCK and ROS/p38 MAPK signaling pathways
10.1016/j.toxlet.2020.07.010 · 2020 · External reference
Arsenic exposure and amyloid precursor protein processing: a focus on Alzheimer’s disease
10.2174/0118761429272806231020045840 · 2024 · External reference
Impact of climate change on arsenic concentrations in paddy rice and the associated dietary health risks in Asia: an experimental and modelling study
10.1016/s2542-5196(25)00055-5 · 2025 · External reference
Arsenic exposure associated with lung interstitial changes in non-smoking individuals living near a petrochemical complex: a repeated cross-sectional study
10.1016/j.envpol.2023.121844 · 2023 · External reference
Urea cycle promotion via ammonia-upregulated CPS1 is involved in arsenite-induced pulmonary fibrosis through enhancing collagen synthesis
10.1016/j.cbi.2024.111029 · 2024 · External reference
Abnormal mitochondrial iron metabolism damages alveolar type II epithelial cells involved in bleomycin-induced pulmonary fibrosis
10.7150/thno.94072 · 2024 · External reference
Alveolar epithelial type 2 cell dysfunction in idiopathic pulmonary fibrosis
10.1007/s00408-022-00571-w · 2022 · External reference
Promoting epithelial regeneration in chemically induced acute lung injury through Sox9-positive alveolar type 2 epithelial cells
10.1186/s13287-024-04124-1 · 2025 · External reference
Arsenic up-regulates PD-L1 and enhances lung tumorigenesis through activation of STAT3 in alveolar epithelial type 2 cells
10.1016/j.taap.2023.116787 · 2024 · External reference
Autocrine TGF-β-positive feedback in profibrotic AT2-lineage cells plays a crucial role in non-inflammatory lung fibrogenesis
10.1038/s41467-023-40617-y · 2023 · External reference
WNT/β-catenin signaling induces IL-1β expression by alveolar epithelial cells in pulmonary fibrosis
10.1165/rcmb.2012-0524oc · 2013 · External reference
Transcriptional intermediary factor 1 gamma prevents lung inflammation and fibrosis via AT2 cells, fibroblasts, and macrophages
10.1016/j.ymthe.2025.08.035 · 2025 · External reference
Hydrogen sulfide inhibits alveolar type II cell senescence and limits pulmonary fibrosis via promoting MDM2-mediated p53 degradation
10.1111/apha.14059 · 2024 · External reference
LCN2-positive alveolar type II cells promote silica-induced pulmonary fibrosis via STAT3-TGF-β1-Smad3-mediated signaling
10.1016/j.taap.2025.117579 · 2025 · External reference
Synergistic effects of diammonium glycyrrhizinate and vitamin D3 against EMT in pulmonary fibrosis through modulating the crosstalk of STAT3/HSP90AA1 and HIF-1α pathway
10.1016/j.jep.2025.120649 · 2026 · External reference
Arsenic induces M2 macrophage polarization and shifts M1/M2 cytokine production via mitophagy
10.3390/ijms232213879 · 2022 · External reference
Epithelial mesenchymal transition (EMT): a universal process in lung diseases with implications for cystic fibrosis pathophysiology
10.1186/s12931-018-0834-8 · 2018 · External reference
Mangiferin prevents hepatocyte epithelial-mesenchymal transition in liver fibrosis via targeting HSP27 -mediated JAK2 / STAT3 and TGF -β1/Smad pathway
10.1002/ptr.7549 · 2022 · External reference
Arsenic exposure and lung fibrotic changes-evidence from a longitudinal cohort study and experimental models
2023 · External reference
HER2 overexpression triggers the IL-8 to promote arsenic-induced EMT and stem cell-like phenotypes in human bladder epithelial cells
10.1016/j.ecoenv.2020.111693 · 2021 · External reference
Mitochondria in cell senescence: is mitophagy the weakest link?
10.1016/j.ebiom.2017.03.020 · 2017 · External reference
Research progress on the regulatory mechanism of cell senescence in arsenic toxicity: a systematic review
10.1093/toxres/tfae136 · 2024 · External reference
Cellular senescence in liver diseases: from mechanisms to therapies
10.1016/j.intimp.2023.110522 · 2023 · External reference
Senescence and aging: causes, consequences, and therapeutic avenues
10.1083/jcb.201708092 · 2018 · External reference
Nicotine triggers islet β cell senescence to facilitate the progression of type 2 diabetes
10.1016/j.tox.2020.152502 · 2020 · External reference
p21 produces a bioactive secretome that places stressed cells under immunosurveillance
10.1126/science.abb3420 · 2021 · External reference
p16-expressing microglia and endothelial cells promote tauopathy and neurovascular abnormalities in PS19 mice
10.1016/j.neuron.2025.04.020 · 2025 · External reference
Cellular senescence: from mechanisms to current biomarkers and senotherapies
10.1124/pharmrev.122.000622 · 2023 · External reference
Pursuing healthy aging and longevity through natural product and stem cell-driven rejuvenation
10.1016/j.bcp.2025.117359 · 2025 · External reference
SIRT1-mediated tunnelling nanotubes may be a potential intervention target for arsenic-induced hepatocyte senescence and liver damage
10.1016/j.scitotenv.2024.174502 · 2024 · External reference
METTL3-regulated m6A modification of lncRNA E230001N04Rik is involved in myofibroblast differentiation in arsenic-induced pulmonary fibrosis through promoting senescence of lung epithelial cells
10.1016/j.jhazmat.2024.136094 · 2024 · External reference
The Nrf2-HO-1 system and inflammaging
10.3389/fimmu.2024.1457010 · 2024 · External reference
Uridine alleviates the aging of alveolar epithelial cells in idiopathic pulmonary fibrosis through the Keap1-Nrf2 signaling pathway
10.1038/s41598-025-04053-w · 2025 · External reference
Nrf2 inhibits epithelial-mesenchymal transition by suppressing snail expression during pulmonary fibrosis
10.1038/srep38646 · 2016 · External reference
The involvement of p62–Keap1–Nrf2 antioxidative signaling pathway and JNK in the protection of natural flavonoid quercetin against hepatotoxicity
10.1016/j.freeradbiomed.2015.03.035 · 2015 · External reference
Sequestered SQSTM1/p62 crosstalk with Keap1/NRF2 axis in hPDLCs promotes oxidative stress injury induced by periodontitis
10.1016/j.freeradbiomed.2022.08.001 · 2022 · External reference
The Keap1-Nrf2 system: a mediator between oxidative stress and aging
10.1155/2021/6635460 · 2021 · External reference
Proteostasis decline and redox imbalance in age-related diseases: the therapeutic potential of NRF2
10.3390/biom15010113 · 2025 · External reference
Inhibition of p62 and/or NFE2L2 induced autophagy impaires esophageal squamous cell cancer metastasis by reversing EMT
10.1016/j.gene.2023.147194 · 2023 · External reference
Tissue-specific distributions of inorganic arsenic and its methylated metabolites, especially in cerebral cortex, cerebellum and hippocampus of mice after a single oral administration of arsenite
10.1016/j.jtemb.2016.10.002 · 2017 · External reference
Imbalanced immune responses involving inflammatory molecules and immune-related pathways in the lung of acute and subchronic arsenic-exposed mice
10.1016/j.envres.2017.08.036 · 2017 · External reference
p62 links autophagy and Nrf2 signaling
10.1016/j.freeradbiomed.2015.06.014 · 2015 · External reference
p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming
10.1038/ncomms12030 · 2016 · External reference
Arsenic exposure and respiratory outcomes during childhood in the INMA study
10.1371/journal.pone.0274215 · 2022 · External reference
Positive association of cardiovascular disease (CVD) with chronic exposure to drinking water arsenic (As) at concentrations below the WHO provisional guideline value: a systematic review and meta-analysis
2020 · External reference
Proteomic study on the mechanism of arsenic neurotoxicity in the rat cerebral cortex and the protective mechanism of dictyophora polysaccharides against arsenic neurotoxicity
10.1021/acschemneuro.3c00009 · 2023 · External reference
Shared and context-specific mechanisms of EMT and cellular plasticity in cancer and fibrotic diseases
10.3390/ijms26199476 · 2025 · External reference
Inorganic arsenic exposure-induced premature senescence and senescence-associated secretory phenotype (SASP) in human hepatic stellate cells
10.1016/j.taap.2022.116231 · 2022 · External reference
Arsenic exposure induces neural cells senescence and abnormal lipid droplet accumulation leading to social memory impairment in mice
10.1016/j.envpol.2025.125779 · 2025 · External reference
Mitochondrial metabolism reprogramming-mediated cardiomyocyte senescence involved in arsenic stress-evoked heart failure
10.1016/j.envint.2025.109686 · 2025 · External reference
Therapy-induced cellular senescence induces epithelial-to-mesenchymal transition and increases invasiveness in rectal cancer
2016 · External reference
Ferroptosis in pneumoconiosis: from molecular and cellular mechanisms to therapeutic strategies
2025 · External reference
Ganoderic acid D prevents oxidative stress-induced senescence by targeting 14-3-3ε to activate CaM/CaMKII/NRF2 signaling pathway in mesenchymal stem cells
10.1111/acel.13686 · 2022 · External reference
Lowering endogenous cathepsin D abundance results in reactive oxygen species accumulation and cell senescence
10.1074/mcp.m115.050179 · 2017 · External reference
Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma
10.1038/s41388-019-0956-6 · 2019 · External reference
Autophagy regulates cellular senescence by mediating the degradation of CDKN1A/p21 and CDKN2A/p16 through SQSTM1/p62-mediated selective autophagy in myxomatous mitral valve degeneration
10.1080/15548627.2025.2469315 · 2026 · External reference
SLC15A3 plays a crucial role in pulmonary fibrosis by regulating macrophage oxidative stress
10.1038/s41418-024-01266-w · 2024 · External reference
Spermidine confers liver protection by enhancing NRF2 signaling through a MAP1S-mediated non-canonical mechanism
10.1002/hep.30616 · 2019 · External reference
Unresolved reference
2022 · External reference
p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription
10.1074/jbc.m110.118976 · 2010 · External reference
The crosstalk between autophagy and Nrf2 signaling in cancer: from biology to clinical applications
10.7150/ijbs.103187 · 2024 · External reference
