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References from Paralogous mutations in the Plasmodium falciparum surface anion channel associate with reduced protection due to sickle hemoglobin. Local targets link to admitted publications; unresolved targets remain external evidence.
Human genetics and malaria resistance
10.1007/s00439-020-02142-6 · 2020 · External reference
Malaria protection due to sickle haemoglobin depends on parasite genotype
10.1038/s41586-021-04288-3 · 2022 · External reference
A fourth locus in the Plasmodium falciparum genome associated with sickle haemoglobin
2023 · External reference
Sickle cell status skews malaria parasite genotype at infection
2025 · External reference
Geographical variation drives adaptive equilibrium of the P. falciparum sickle-associated mutations
2025 · External reference
Common West African Hla Antigens Are Associated with Protection from Severe Malaria
10.1038/352595a0 · 1991 · External reference
Pf7: an open dataset of Plasmodium falciparum genome variation in 20,000 worldwide samples
10.12688/wellcomeopenres.18681.1 · 2023 · External reference
Indels, structural variation, and recombination drive genomic diversity in Plasmodium falciparum
10.1101/gr.203711.115 · 2016 · External reference
Impact of Sickle Cell Trait Hemoglobin on the Intraerythrocytic Transcriptional Program of Plasmodium falciparum
10.1128/msphere.00755-21 · 2021 · External reference
Insights into malaria susceptibility using genome-wide data on 17,000 individuals from Africa, Asia and Oceania
2019 · External reference
New insights on malaria parasite adaptation yielded by samples archived for more than 50 years
2026 · External reference
Genomes of all known members of a Plasmodium subgenus reveal paths to virulent human malaria
10.1038/s41564-018-0162-2 · 2018 · External reference
Malaria Parasite clag3 Genes Determine Channel-Mediated Nutrient Uptake by Infected Red Blood Cells
10.1016/j.cell.2011.05.002 · 2011 · External reference
Expression of the Plasmodium falciparum Clonally Variant clag3 Genes in Human Infections
10.1093/infdis/jix053 · 2017 · External reference
Epigenetic Silencing of Plasmodium falciparum Genes Linked to Erythrocyte Invasion
10.1371/journal.ppat.0030107 · 2007 · External reference
Diversity and evolution of the rhoph1/clag multigene family of Plasmodium falciparum
10.1016/j.molbiopara.2007.11.004 · 2008 · External reference
Long read assemblies of geographically dispersed Plasmodium falciparum isolates reveal highly structured subtelomeres
10.12688/wellcomeopenres.14571.1 · 2018 · External reference
Gene Conversion as a Source of Nucleotide Diversity in Plasmodium falciparum
10.1093/molbev/msg076 · 2003 · External reference
Role for gene conversion in the evolution of cell-surface antigens of the malaria parasite Plasmodium falciparum
10.1371/journal.pbio.3002507 · 2024 · External reference
Generation of Antigenic Diversity in Plasmodium falciparum by Structured Rearrangement of Var Genes During Mitosis
10.1371/journal.pgen.1004812 · 2014 · External reference
Deciphering the principles that govern mutually exclusive expression of Plasmodium falciparum clag3genes
10.1093/nar/gkv730 · 2015 · External reference
Accurate structure prediction of biomolecular interactions with AlphaFold 3
10.1038/s41586-024-07487-w · 2024 · External reference
A voltage-dependent channel involved in nutrient uptake by red blood cells infected with the malaria parasite
10.1038/35023000 · 2000 · External reference
Plasmodium falciparum CLAG Paralogs All Traffic to the Host Membrane but Knockouts Have Distinct Phenotypes
10.3390/microorganisms12061172 · 2024 · External reference
The critical role of PSAC channel in malaria parasite survival is driven home by phenotypic screening under relevant nutrient levels
10.1016/j.chembiol.2025.05.001 · 2025 · External reference
A CLAG3 Mutation in an Amphipathic Transmembrane Domain Alters Malaria Parasite Nutrient Channels and Confers Leupeptin Resistance
10.1128/iai.02966-14 · 2015 · External reference
Native structure of the RhopH complex, a key determinant of malaria parasite nutrient acquisition
10.1073/pnas.2100514118 · 2021 · External reference
The fast-evolving FIKK kinase family of Plasmodium falciparum can be inhibited by a single compound
10.1038/s41564-025-02017-4 · 2025 · External reference
An exported kinase family mediates species-specific erythrocyte remodelling and virulence in human malaria
10.1038/s41564-020-0702-4 · 2020 · External reference
An exported kinase (FIKK4.2) that mediates virulence-associated changes in Plasmodium falciparum-infected red blood cells
10.1016/j.ijpara.2014.01.003 · 2014 · External reference
Identification of essential exported Plasmodium falciparum protein kinases in malaria-infected red blood cells
10.1111/bjh.16219 · 2020 · External reference
A Cluster of Ring Stage–specific Genes Linked to a Locus Implicated in Cytoadherence in Plasmodium falciparum Codes for PEXEL-negative and PEXEL-positive Proteins Exported into the Host Cell
10.1091/mbc.e06-04-0291 · 2006 · External reference
Deletion of the Plasmodium falciparum exported protein PTP7 leads to Maurer’s clefts vesiculation, host cell remodeling defects, and loss of surface presentation of EMP1
10.1371/journal.ppat.1009882 · 2022 · External reference
Resistance to Plasmodium falciparum in sickle cell trait erythrocytes is driven by oxygen-dependent growth inhibition
10.1073/pnas.1804388115 · 2018 · External reference
Hemoglobins S and C Interfere with Actin Remodeling in Plasmodium falciparum –Infected Erythrocytes
10.1126/science.1213775 · 2011 · External reference
Sickle-trait hemoglobin reduces adhesion to both CD36 and EPCR by Plasmodium falciparum-infected erythrocytes
10.1371/journal.ppat.1009659 · 2021 · External reference
Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes
10.1038/ncomms13401 · 2016 · External reference
An Immune Basis for Malaria Protection by the Sickle Cell Trait
10.1371/journal.pmed.0020128 · 2005 · External reference
Whole genome sequencing of Plasmodium falciparum from dried blood spots using selective whole genome amplification
10.1186/s12936-016-1641-7 · 2016 · External reference
Genomes of cryptic chimpanzee Plasmodium species reveal key evolutionary events leading to human malaria
10.1038/ncomms11078 · 2016 · External reference
Snakemake—a scalable bioinformatics workflow engine
10.1093/bioinformatics/bts480 · 2012 · External reference
The Sequence Alignment/Map format and SAMtools
10.1093/bioinformatics/btp352 · 2009 · External reference
Twelve years of SAMtools and BCFtools
10.1093/gigascience/giab008 · 2021 · External reference
Fast and accurate short read alignment with Burrows–Wheeler transform
10.1093/bioinformatics/btp324 · 2009 · External reference
The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
10.1101/gr.107524.110 · 2010 · External reference
A framework for variation discovery and genotyping using next-generation DNA sequencing data
10.1038/ng.806 · 2011 · External reference
From FastQ Data to High-Confidence Variant Calls: The Genome Analysis Toolkit Best Practices Pipeline
10.1002/0471250953.bi1110s43 · 2013 · External reference
A spectrum of free software tools for processing the VCF variant call format: vcflib, bio-vcf, cyvcf2, hts-nim and slivar
10.1371/journal.pcbi.1009123 · 2022 · External reference
STAR: ultrafast universal RNA-seq aligner
10.1093/bioinformatics/bts635 · 2013 · External reference
BEDTools: a flexible suite of utilities for comparing genomic features
10.1093/bioinformatics/btq033 · 2010 · External reference
MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability
10.1093/molbev/mst010 · 2013 · External reference
Unresolved reference
External reference
Rapid genotype imputation from sequence with reference panels
10.1038/s41588-021-00877-0 · 2021 · External reference
Unified representation of genetic variants
10.1093/bioinformatics/btv112 · 2015 · External reference
Unresolved reference
External reference
Optimization of whole-genome sequencing of Plasmodium falciparum from low-density dried blood spot samples
10.1186/s12936-021-03630-4 · 2021 · External reference
Improved workflows for high throughput library preparation using the transposome-based Nextera system
10.1186/1472-6750-13-104 · 2013 · External reference
Genome sequence of the human malaria parasite Plasmodium falciparum
10.1038/nature01097 · 2002 · External reference
FastUniq: A Fast De Novo Duplicates Removal Tool for Paired Short Reads
10.1371/journal.pone.0052249 · 2012 · External reference
Trimmomatic: a flexible trimmer for Illumina sequence data
10.1093/bioinformatics/btu170 · 2014 · External reference
MultiQC: summarize analysis results for multiple tools and samples in a single report
10.1093/bioinformatics/btw354 · 2016 · External reference
BAM-matcher: a tool for rapid NGS sample matching
10.1093/bioinformatics/btw239 · 2016 · External reference
Haplotype-resolved de novo assembly using phased assembly graphs with hifiasm
10.1038/s41592-020-01056-5 · 2021 · External reference
Liftoff: accurate mapping of gene annotations
10.1093/bioinformatics/btaa1016 · 2021 · External reference
BLAT —The BLAST-Like Alignment Tool
2002 · External reference
Reappraisal of known malaria resistance loci in a large multicenter study
10.1038/ng.3107 · 2014 · External reference
A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff
10.4161/fly.19695 · 2012 · External reference
GENCODE 2025: reference gene annotation for human and mouse
10.1093/nar/gkae1078 · 2025 · External reference
PlasmoDB: a functional genomic database for malaria parasites
10.1093/nar/gkn814 · 2009 · External reference
Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing
10.1038/nature11174 · 2012 · External reference
TMB: Automatic Differentiation and Laplace Approximation
10.18637/jss.v070.i05 · 2016 · External reference
