Research graph
References from Lysophospholipase PNPLA7 is a critical checkpoint of phosphatidylcholine catabolism and turnover for skeletal muscle homeostasis. Local targets link to admitted publications; unresolved targets remain external evidence.
Asian working group for sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment
10.1016/j.jamda.2019.12.012 · 2020 · External reference
Sarcopenia is associated with mortality in adults: a systematic review and meta-analysis
10.1159/000517099 · 2022 · External reference
The function of cytidine coenzymes in the biosynthesis of phospholipides
10.1016/s0021-9258(19)50785-2 · 1956 · External reference
Phosphatidylcholine and choline homeostasis
10.1194/jlr.r700019-jlr200 · 2008 · External reference
The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease
10.1016/j.bbamem.2017.04.006 · 2017 · External reference
Nutritional genomics: defining the dietary requirement and effects of choline
10.3945/jn.110.130369 · 2011 · External reference
Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals
10.1016/j.cmet.2023.04.003 · 2023 · External reference
Flvcr1a deficiency promotes heme-based energy metabolism dysfunction in skeletal muscle
10.1016/j.celrep.2024.113854 · 2024 · External reference
Mutations in FLVCR1 cause posterior column ataxia and retinitis pigmentosa
10.1016/j.ajhg.2010.10.013 · 2010 · External reference
Molecular mechanism of choline and ethanolamine transport in humans
10.1038/s41586-024-07444-7 · 2024 · External reference
Differential expression of choline kinase isoforms in skeletal muscle explains the phenotypic variability in the rostrocaudal muscular dystrophy mouse
10.1016/j.bbalip.2009.12.003 · 2010 · External reference
CHKB-related muscular dystrophy
1993 · External reference
Megaconial congenital muscular dystrophy due to loss-of-function mutations in choline kinase β
10.1097/wco.0b013e328364c82d · 2013 · External reference
A rostrocaudal muscular dystrophy caused by a defect in choline kinase beta, the first enzyme in phosphatidylcholine biosynthesis
10.1074/jbc.m512578200 · 2006 · External reference
Understanding the muscular dystrophy caused by deletion of choline kinase beta in mice
10.1016/j.bbalip.2009.02.006 · 2009 · External reference
Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns
10.1074/jbc.m610745200 · 2007 · External reference
Mammalian lipin phosphatidic acid phosphatases in lipid synthesis and beyond: metabolic and inflammatory disorders
10.1194/jlr.s091769 · 2019 · External reference
Lipin-1 regulates autophagy clearance and intersects with statin drug effects in skeletal muscle
10.1016/j.cmet.2014.05.003 · 2014 · External reference
The phospholipase A2 superfamily as a central hub of bioactive lipids and beyond
10.1016/j.pharmthera.2023.108382 · 2023 · External reference
The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy
10.1038/ng1951 · 2007 · External reference
Increased intramyocellular lipids but unaltered in vivo mitochondrial oxidative phosphorylation in skeletal muscle of adipose triglyceride lipase-deficient mice
10.1152/ajpendo.00597.2011 · 2012 · External reference
10.1074/jbc.m502358200
10.1074/jbc.m502358200 · 2005 · External reference
Loss of function variants in human PNPLA8 encoding calcium-independent phospholipase A2 gamma recapitulate the mitochondriopathy of the homologous null mouse
10.1002/humu.22743 · 2015 · External reference
Mitochondrial dysfunction and reduced prostaglandin synthesis in skeletal muscle of Group VIB Ca2+-independent phospholipase A2γ-deficient mice
10.1194/jlr.m008060 · 2010 · External reference
Genetic deletion of skeletal muscle iPLA2γ results in mitochondrial dysfunction, muscle atrophy and alterations in whole-body energy metabolism
10.1016/j.isci.2023.106895 · 2023 · External reference
GDE5/Gpcpd1 activity determines phosphatidylcholine composition in skeletal muscle and regulates contractile force in mice
10.1038/s42003-024-06298-z · 2024 · External reference
Gpcpd1-GPC metabolic pathway is dysfunctional in aging and its deficiency severely perturbs glucose metabolism
10.1038/s43587-023-00551-6 · 2024 · External reference
The phospholipase PNPLA7 functions as a lysophosphatidylcholine hydrolase and interacts with lipid droplets through its catalytic domain
10.1074/jbc.m117.792978 · 2017 · External reference
Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups
10.1016/j.celrep.2022.111940 · 2023 · External reference
Evidence that mouse brain neuropathy target esterase is a lysophospholipase
10.1073/pnas.1232473100 · 2003 · External reference
Neuropathy target esterase gene mutations cause motor neuron disease
10.1016/j.ajhg.2007.12.018 · 2008 · External reference
Brain-specific deletion of neuropathy target esterase/swisscheese results in neurodegeneration
10.1073/pnas.0401030101 · 2004 · External reference
PNPLA6 regulates retinal homeostasis by choline through phospholipid turnover
10.1038/s41467-025-57402-8 · 2025 · External reference
Histopathology is required to identify and characterize myopathies in high-throughput phenotype screening of genetically engineered mice
10.1177/03009858211030541 · 2021 · External reference
Abnormal splicing of NEDD4 in myotonic dystrophy type 2: possible link to statin adverse reactions
10.1016/j.ajpath.2014.04.013 · 2014 · External reference
Nuclear positioning in muscle development and disease
10.3389/fphys.2013.00363 · 2013 · External reference
Melittin - A bee venom component - Enhances muscle regeneration factors expression in a mouse model of skeletal muscle contusion
10.1016/j.jphs.2019.03.009 · 2019 · External reference
Macrophages and skeletal muscle regeneration: a clodronate-containing liposome depletion study
10.1152/ajpregu.00465.2005 · 2006 · External reference
Bach1 promotes muscle regeneration through repressing Smad-mediated inhibition of myoblast differentiation
10.1371/journal.pone.0236781 · 2020 · External reference
Skeletal muscle hypertrophy and atrophy signaling pathways
10.1016/j.biocel.2005.04.018 · 2005 · External reference
Inflammation during skeletal muscle regeneration and tissue remodeling: application to exercise-induced muscle damage management
10.1038/icb.2015.97 · 2016 · External reference
Macrophages in inflammation, repair and regeneration
10.1093/intimm/dxy054 · 2018 · External reference
Fusogenic micropeptide Myomixer is essential for satellite cell fusion and muscle regeneration
10.1073/pnas.1800052115 · 2018 · External reference
The regulatory role of Myomaker and Myomixer-Myomerger-Minion in muscle development and regeneration
10.1007/s00018-019-03341-9 · 2020 · External reference
Myomaker is essential for muscle regeneration
10.1101/gad.247205.114 · 2014 · External reference
Pro-apoptotic complexes of BAX and BAK on the outer mitochondrial membrane
10.1016/j.bbamcr.2022.119317 · 2022 · External reference
Transcriptional regulation of metabolism
10.1152/physrev.00025.2005 · 2006 · External reference
Regulation of phospholipid biosynthesis in isolated rat hepatocytes. Effect of different substrates
10.1016/s0021-9258(19)41523-8 · 1975 · External reference
Lysophosphatidylcholine and 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine inhibit the CDP-choline pathway of phosphatidylcholine synthesis at the CTP:phosphocholine cytidylyltransferase step
10.1074/jbc.270.13.7757 · 1995 · External reference
NADPH Oxidase 4 contributes to myoblast fusion and skeletal muscle regeneration
10.1155/2019/3585390 · 2019 · External reference
PRDX5 regulates mitochondrial function and nuclear spreading in myogenesis and acts with PRDX3 to delay muscle aging
10.1002/jcsm.70098 · 2025 · External reference
Mechanism of action and therapeutic route for a muscular dystrophy caused by a genetic defect in lipid metabolism
10.1038/s41467-022-29270-z · 2022 · External reference
The patatin-like phospholipase domain containing protein 7 facilitates VLDL secretion by modulating ApoE stability
10.1002/hep.31161 · 2020 · External reference
Lysophospholipid acyltransferases mediate phosphatidylcholine diversification to achieve the physical properties required in vivo
10.1016/j.cmet.2014.05.019 · 2014 · External reference
Update and nomenclature proposal for mammalian lysophospholipid acyltransferases, which create membrane phospholipid diversity
10.1016/j.jbc.2021.101470 · 2022 · External reference
LPAAT3 incorporates docosahexaenoic acid into skeletal muscle cell membranes and is upregulated by PPARδ activation
10.1194/jlr.m077321 · 2018 · External reference
Role of cardiolipin alterations in mitochondrial dysfunction and disease
10.1152/ajpcell.00243.2006 · 2007 · External reference
Placental failure and impaired vasculogenesis result in embryonic lethality for neuropathy target esterase-deficient mice
10.1128/mcb.24.4.1667-1679.2004 · 2004 · External reference
Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans
10.1073/pnas.0504285102 · 2005 · External reference
Low intake of choline is associated with diminished strength and lean mass gains in older adults
10.14283/jfa.2022.50 · 2023 · External reference
Systemic and metabolic signature of sarcopenia in community-dwelling older adults
2019 · External reference
Association between serum choline and betaine concentrations and longitudinal changes of body composition in community-dwelling middle-aged and older Chinese adults
10.1139/apnm-2019-0778 · 2020 · External reference
Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups
10.1096/fj.14-249557 · 2014 · External reference
An update on glycerophosphodiester phosphodiesterases; from bacteria to human
10.1007/s10930-024-10190-4 · 2024 · External reference
Animal models of Duchenne muscular dystrophy: from basic mechanisms to gene therapy
10.1242/dmm.018424 · 2015 · External reference
Muscle wasting in animal models of severe illness
10.1111/j.1365-2613.2012.00812.x · 2012 · External reference
Glycerophospholipid profile alterations are associated with murine muscle-wasting phenotype
10.1002/mus.26993 · 2020 · External reference
A congenital muscular dystrophy with mitochondrial structural abnormalities caused by defective de novo phosphatidylcholine biosynthesis
10.1016/j.ajhg.2011.05.010 · 2011 · External reference
Muscle choline kinase beta defect causes mitochondrial dysfunction and increased mitophagy
10.1093/hmg/ddr305 · 2011 · External reference
Skeletal muscle phospholipid metabolism regulates insulin sensitivity and contractile function
10.2337/db15-0659 · 2016 · External reference
PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing
10.1038/s42255-023-00766-2 · 2023 · External reference
Barth syndrome cardiomyopathy: an update
10.3390/genes13040656 · 2022 · External reference
Identification and characterization of human cardiolipin synthase
10.1016/j.febslet.2006.04.054 · 2006 · External reference
Age-dependent loss of Crls1 causes myopathy and skeletal muscle regeneration failure
10.1038/s12276-024-01199-x · 2024 · External reference
CDP-diacylglycerol synthases (CDS): gateway to phosphatidylinositol and cardiolipin synthesis
10.3389/fcell.2020.00063 · 2020 · External reference
Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production
10.1016/j.cmet.2019.03.011 · 2019 · External reference
Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria
10.1126/science.adh9351 · 2023 · External reference
Deficient endoplasmic reticulum-mitochondrial phosphatidylserine transfer causes liver disease
10.1016/j.cell.2019.04.010 · 2019 · External reference
PNPLA7 mediates Parkin-mitochondrial recruitment in adipose tissue for mitophagy and inhibits browning
10.1038/s41467-025-61904-w · 2025 · External reference
Evidence for osteocyte regulation of bone homeostasis through RANKL expression
10.1038/nm.2452 · 2011 · External reference
Gene targeting restricted to mouse striated muscle lineage
10.1093/nar/27.19.e27 · 1999 · External reference
Isolation, culturing, and differentiation of primary myoblasts from skeletal muscle of adult mice
10.21769/bioprotoc.2248 · 2017 · External reference
Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC
10.1073/pnas.1710366114 · 2017 · External reference
Metabolomic profiling of anionic metabolites by capillary electrophoresis mass spectrometry
10.1021/ac900675k · 2009 · External reference
A rapid method of total lipid extraction and purification
10.1139/y59-099 · 1959 · External reference
Method for preparing DNA from feces in guanidine thiocyanate solution affects 16S rRNA-based profiling of human microbiota diversity
10.1038/s41598-017-04511-0 · 2017 · External reference
Group IIA secreted phospholipase A2 controls skin carcinogenesis and psoriasis by shaping the gut microbiota
10.1172/jci.insight.152611 · 2022 · External reference
Group X phospholipase A2 links colonic lipid homeostasis to systemic metabolism via host-microbiota interaction
10.1016/j.celrep.2024.114752 · 2024 · External reference
Evaluation of general 16S ribosomal RNA gene PCR primers for classical and next-generation sequencing-based diversity studies
10.1093/nar/gks808 · 2013 · External reference
QIIME allows analysis of high-throughput community sequencing data
10.1038/nmeth.f.303 · 2010 · External reference
Impact of quality trimming on the efficiency of reads joining and diversity analysis of Illumina paired-end reads in the context of QIIME1 and QIIME2 microbiome analysis frameworks
10.1186/s12859-019-3187-5 · 2019 · External reference
UCHIME improves sensitivity and speed of chimera detection
10.1093/bioinformatics/btr381 · 2011 · External reference
The SILVA ribosomal RNA gene database project: improved data processing and web-based tools
10.1093/nar/gks1219 · 2013 · External reference
