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References from Molecular stratification of SPOP-mutant prostate cancer demonstrates Wnt signaling and replication stress signatures in diverse patient populations. Local targets link to admitted publications; unresolved targets remain external evidence.
Cancer statistics, 2025
2025 · External reference
Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer
10.1038/ng.2279 · 2012 · External reference
SPOP mutations in prostate cancer across demographically diverse patient cohorts
10.1593/neo.131704 · 2014 · External reference
The emerging role of speckle-type POZ protein (SPOP) in cancer development
10.1016/j.drudis.2014.07.009 · 2014 · External reference
The ubiquitin ligase adaptor SPOP in cancer
10.1111/febs.15056 · 2019 · External reference
Androgen receptor is the key transcriptional mediator of the tumor suppressor SPOP in prostate cancer
10.1158/0008-5472.can-14-0476 · 2014 · External reference
Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover
10.1073/pnas.1304502110 · 2013 · External reference
SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein
10.1038/onc.2017.80 · 2017 · External reference
SPOP Mutations Target STING1 Signaling in Prostate Cancer and Create Therapeutic Vulnerabilities to PARP Inhibitor-Induced Growth Suppression
10.1158/1078-0432.ccr-23-1439 · 2023 · External reference
TRIM24 Is an Oncogenic Transcriptional Activator in Prostate Cancer
10.1016/j.ccell.2016.04.012 · 2016 · External reference
Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer
10.1126/science.1250255 · 2014 · External reference
SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression
10.1016/j.molcel.2015.07.026 · 2015 · External reference
SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase
10.1016/j.celrep.2015.09.083 · 2015 · External reference
Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4
10.1038/nm.4378 · 2017 · External reference
Association of SPOP Mutations with Outcomes in Men with De Novo Metastatic Castration-sensitive Prostate Cancer
10.1016/j.eururo.2020.06.033 · 2020 · External reference
Molecular features of exceptional response to neoadjuvant anti-androgen therapy in high-risk localized prostate cancer
10.1016/j.celrep.2021.109665 · 2021 · External reference
SPOP mutation leads to genomic instability in prostate cancer
10.7554/elife.09207 · 2015 · External reference
SPOP mutations increase PARP inhibitor sensitivity via CK2/PIAS1/SPOP axis in prostate cancer
10.1172/jci.insight.186871 · 2025 · External reference
Molecular features and race-associated outcomes of SPOP-mutant metastatic castration-resistant prostate cancer
10.1002/pros.24481 · 2023 · External reference
Clinical and genomic features of SPOP-mutant prostate cancer
10.1002/pros.24269 · 2022 · External reference
Integrative comparison of the genomic and transcriptomic landscape between prostate cancer patients of predominantly African or European genetic ancestry
10.1371/journal.pgen.1008641 · 2020 · External reference
Racial Differences in Genomic Profiling of Prostate Cancer
10.1056/nejmc2000069 · 2020 · External reference
The Molecular Taxonomy of Primary Prostate Cancer
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Differences in Prostate Cancer Genomes by Self-reported Race: Contributions of Genetic Ancestry, Modifiable Cancer Risk Factors, and Clinical Factors
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Cell-of-origin patterns dominate the molecular classification of 10,000 tumors from 33 types of cancer
10.1016/j.cell.2018.03.022 · 2018 · External reference
Scalable open science approach for mutation calling of tumor exomes using multiple genomic pipelines
10.1016/j.cels.2018.03.002 · 2018 · External reference
The Impact of PIK3R1 Mutations and Insulin-PI3K-Glycolytic Pathway Regulation in Prostate Cancer
10.1158/1078-0432.ccr-21-4272 · 2022 · External reference
Microsatellite instability, tumor mutational burden, and response to immune checkpoint blockade in patients with prostate cancer
10.1158/1078-0432.ccr-23-3403 · 2024 · External reference
Race and Genetic Alterations in Prostate Cancer
2021 · External reference
Genomic correlates of clinical outcome in advanced prostate cancer
10.1073/pnas.1902651116 · 2019 · External reference
Cancer statistics for African American and Black people, 2025
2025 · External reference
Prevalence and prognostic significance of TMPRSS2-ERG gene fusion in lymph node positive prostate cancers
10.1002/pros.22882 · 2014 · External reference
Characterizing the molecular features of ERG-positive tumors in primary and castration resistant prostate cancer
10.1002/pros.23171 · 2016 · External reference
TMPRSS2:ERG Gene Fusions in Prostate Cancer of West African Men and a Meta-Analysis of Racial Differences
10.1093/aje/kwx235 · 2017 · External reference
Integrative clinical genomics of advanced prostate cancer
10.1016/j.cell.2015.05.001 · 2015 · External reference
Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer
10.1056/nejmoa1603144 · 2016 · External reference
Regulation of Wnt signaling by the tumor suppressor adenomatous polyposis coli does not require the ability to enter the nucleus or a particular cytoplasmic localization
10.1091/mbc.e11-11-0965 · 2012 · External reference
Oncogenic KRAS signalling promotes the Wnt/beta-catenin pathway through LRP6 in colorectal cancer
10.1038/onc.2014.416 · 2015 · External reference
A novel Wilms tumor 1 (WT1) target gene negatively regulates the WNT signaling pathway
10.1074/jbc.m109.094334 · 2010 · External reference
The Role of Wnt Signalling in Angiogenesis
2017 · External reference
Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPrho/PTPRT)
10.1016/j.brainres.2006.07.122 · 2006 · External reference
Multiomics of Bohring-Opitz syndrome truncating ASXL1 mutations identify canonical and noncanonical Wnt signaling dysregulation
10.1172/jci.insight.167744 · 2023 · External reference
Cockayne syndrome group B protein regulates DNA double-strand break repair and checkpoint activation
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A Phase II Study of ERK Inhibition by Ulixertinib (BVD-523) in Metastatic Uveal Melanoma
10.1158/2767-9764.crc-24-0036 · 2024 · External reference
Elevated FOXG1 in glioblastoma stem cells cooperates with Wnt/beta-catenin to induce exit from quiescence
10.1016/j.celrep.2023.112561 · 2023 · External reference
Expression and immunotherapeutic targeting of the SSX family of cancer-testis antigens in prostate cancer
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Distinct TERB1 Domains Regulate Different Protein Interactions in Meiotic Telomere Movement
10.1016/j.celrep.2017.10.061 · 2017 · External reference
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MYH7 in cardiomyopathy and skeletal muscle myopathy
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Functions of myosin light chain-2 (MYL2) in cardiac muscle and disease
10.1016/j.gene.2015.06.027 · 2015 · External reference
XIRP2, an actin-binding protein essential for inner ear hair-cell stereocilia
10.1016/j.celrep.2015.02.042 · 2015 · External reference
The Evolutionary Landscape of Localized Prostate Cancers Drives Clinical Aggression
10.1016/j.cell.2018.03.029 · 2018 · External reference
SPOP Mutation Drives Prostate Tumorigenesis In Vivo through Coordinate Regulation of PI3K/mTOR and AR Signaling
10.1016/j.ccell.2017.02.004 · 2017 · External reference
The long tail of oncogenic drivers in prostate cancer
10.1038/s41588-018-0078-z · 2018 · External reference
Comparative analysis of p16 expression among African American and European American prostate cancer patients
10.1002/pros.23833 · 2019 · External reference
Identification of SPOP related metabolic pathways in prostate cancer
10.18632/oncotarget.21460 · 2017 · External reference
Clinical validation of the tempus xT next-generation targeted oncology sequencing assay
10.18632/oncotarget.26797 · 2019 · External reference
Integrative genomic profiling of human prostate cancer
10.1016/j.ccr.2010.05.026 · 2010 · External reference
Prospective Genomic Profiling of Prostate Cancer Across Disease States Reveals Germline and Somatic Alterations That May Affect Clinical Decision Making
2017 · External reference
Pan-cancer Analysis of CDK12 Alterations Identifies a Subset of Prostate Cancers with Distinct Genomic and Clinical Characteristics
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Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer
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Complex heatmaps reveal patterns and correlations in multidimensional genomic data
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Unresolved reference
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