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References from A Gata4–Loxl2 axis controls ECM remodeling to enable scar-free spinal cord regeneration in zebrafish. Local targets link to admitted publications; unresolved targets remain external evidence.
Moving beyond the glial scar for spinal cord repair
10.1038/s41467-019-11707-7 · 2019 · External reference
The Biology of Regeneration Failure and Success After Spinal Cord Injury
10.1152/physrev.00017.2017 · 2018 · External reference
Perivascular fibroblasts form the fibrotic scar after contusive spinal cord injury
10.1523/jneurosci.2524-13.2013 · 2013 · External reference
A pericyte origin of spinal cord scar tissue
10.1126/science.1203165 · 2011 · External reference
Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury
10.1016/j.cell.2018.02.004 · 2018 · External reference
Glial scar borders are formed by newly proliferated, elongated astrocytes that interact to corral inflammatory and fibrotic cells via STAT3-dependent mechanisms after spinal cord injury
10.1523/jneurosci.2121-13.2013 · 2013 · External reference
Molecular dissection of reactive astrogliosis and glial scar formation
10.1016/j.tins.2009.08.002 · 2009 · External reference
Reactive gliosis in traumatic brain injury: a comprehensive review
10.3389/fncel.2024.1335849 · 2024 · External reference
Suppression of fibrous scarring in spinal cord injury of rat promotes long-distance regeneration of corticospinal tract axons, rescue of primary motoneurons in somatosensory cortex and significant functional recovery
10.1111/j.1460-9568.2005.04495.x · 2005 · External reference
Inhibition of collagen IV deposition promotes regeneration of injured CNS axons
10.1046/j.1460-9568.1999.00466.x · 1999 · External reference
Axonal regrowth after spinal cord transection in adult zebrafish
10.1002/(sici)1096-9861(19970127)377:4<577::aid-cne8>3.0.co;2-# · 1997 · External reference
Motor neuron regeneration in adult zebrafish
10.1523/jneurosci.1189-08.2008 · 2008 · External reference
Injury-induced ctgfa directs glial bridging and spinal cord regeneration in zebrafish
10.1126/science.aaf2679 · 2016 · External reference
Spinal cord repair is modulated by the neurogenic factor Hb-egf under direction of a regeneration-associated enhancer
10.1038/s41467-023-40486-5 · 2023 · External reference
Building bridges, not walls: spinal cord regeneration in zebrafish
10.1242/dmm.044131 · 2020 · External reference
Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment
10.1038/s41467-023-42339-7 · 2023 · External reference
Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish
10.1038/s41467-017-00143-0 · 2017 · External reference
A switch in pdgfrb+ cell-derived ECM composition prevents inhibitory scarring and promotes axon regeneration in the zebrafish spinal cord
10.1016/j.devcel.2020.12.009 · 2021 · External reference
Biphasic inflammation control by fibroblasts enables spinal cord regeneration in zebrafish
10.1016/j.celrep.2025.116469 · 2025 · External reference
Fgf-dependent glial cell bridges facilitate spinal cord regeneration in zebrafish
10.1523/jneurosci.0758-12.2012 · 2012 · External reference
Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes
10.1038/nature08804 · 2010 · External reference
The transcription factor GATA4 promotes myocardial regeneration in neonatal mice
10.15252/emmm.201606602 · 2017 · External reference
GATA4 regulates Fgf16 to promote heart repair after injury
2016 · External reference
GATA4 induces liver fibrosis regression by deactivating hepatic stellate cells
10.1172/jci.insight.150059 · 2021 · External reference
GATA4 loss in the septum transversum mesenchyme promotes liver fibrosis in mice
10.1002/hep.27005 · 2014 · External reference
Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling
10.1016/j.jhep.2020.08.033 · 2021 · External reference
Induction of Senescence by Loss of Gata4 in Cardiac Fibroblasts
10.3390/cells12121652 · 2023 · External reference
GATA4 is a regulator of astrocyte cell proliferation and apoptosis in the human and murine central nervous system
10.1038/onc.2009.159 · 2009 · External reference
A GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomas
10.1084/jem.20102099 · 2011 · External reference
T-box binding sites are required for activity of a cardiac GATA-4 enhancer
10.1016/j.ydbio.2003.09.042 · 2004 · External reference
Progenitor-derived glia are required for spinal cord regeneration in zebrafish
10.1242/dev.201162 · 2023 · External reference
Localized EMT reprograms glial progenitors to promote spinal cord repair
10.1016/j.devcel.2021.01.017 · 2021 · External reference
Specificity, redundancy and dosage thresholds among gata4/5/6 genes during zebrafish cardiogenesis
10.1242/bio.053611 · 2020 · External reference
Functional trajectories during innate spinal cord repair
10.3389/fnmol.2023.1155754 · 2023 · External reference
Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment
10.1038/ncomms13710 · 2016 · External reference
Lysine post-translational modifications of collagen
10.1042/bse0520113 · 2012 · External reference
Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury
10.1038/s41392-022-00885-4 · 2022 · External reference
Vimentin coordinates fibroblast proliferation and keratinocyte differentiation in wound healing via TGF-beta-Slug signaling
10.1073/pnas.1519197113 · 2016 · External reference
LOXL2 Is Highly Expressed in Cancer-Associated Fibroblasts and Associates to Poor Colon Cancer Survival
10.1158/1078-0432.ccr-14-3096 · 2015 · External reference
Comparative analysis of lysyl oxidase (like) family members in pulmonary fibrosis
10.1038/s41598-017-00270-0 · 2017 · External reference
Single-cell sequencing dissects the transcriptional identity of activated fibroblasts and identifies novel persistent distal tubular injury patterns in kidney fibrosis
10.1038/s41598-023-50195-0 · 2024 · External reference
Collagen XVIII, containing an endogenous inhibitor of angiogenesis and tumor growth, plays a critical role in the maintenance of retinal structure and in neural tube closure (Knobloch syndrome)
10.1093/hmg/9.13.2051 · 2000 · External reference
Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming
10.1038/s42003-020-0922-4 · 2020 · External reference
Heterogeneous fibroblasts contribute to fibrotic scar formation after spinal cord injury in mice and monkeys
10.1038/s41467-024-50564-x · 2024 · External reference
MCF-7 cells expressing nuclear associated lysyl oxidase-like 2 (LOXL2) exhibit an epithelial-to-mesenchymal transition (EMT) phenotype and are highly invasive in vitro
10.1074/jbc.c113.502310 · 2013 · External reference
Cross-linking in collagen and elastin
10.1146/annurev.bi.53.070184.003441 · 1984 · External reference
Dynamics of collagen oxidation and cross linking in regenerating and irreversibly infarcted myocardium
10.1038/s41467-024-48604-7 · 2024 · External reference
Collagen Pyridinoline Cross-Links Are Absent in Reversible Myocardial Fibrosis
10.1161/circresaha.124.325406 · 2025 · External reference
Time-dependent adaptations of damaged neurons and their microenvironment in the regenerating adult zebrafish spinal cord
10.1126/sciadv.aea2882 · 2026 · External reference
Softening of the chronic hemi-section spinal cord injury scar parallels dysregulation of cellular and extracellular matrix content
10.1016/j.jmbbm.2020.103953 · 2020 · External reference
The soft mechanical signature of glial scars in the central nervous system
10.1038/ncomms14787 · 2017 · External reference
Zebrafish Spinal Cord Repair Is Accompanied by Transient Tissue Stiffening
10.1016/j.bpj.2019.10.044 · 2020 · External reference
Modulation of lysyl oxidase-like 2 enzymatic activity by an allosteric antibody inhibitor
10.1074/jbc.m109.094136 · 2010 · External reference
Collagen fibers provide guidance cues for capillary regrowth during regenerative angiogenesis in zebrafish
10.1038/s41598-021-98852-6 · 2021 · External reference
Inducing aortic aneurysm/dissection in zebrafish: evaluating the efficacy of beta-Aminopropionic Nitrile as a model
10.1080/19768354.2024.2322055 · 2024 · External reference
Unique advantages of zebrafish larvae as a model for spinal cord regeneration
10.3389/fnmol.2022.983336 · 2022 · External reference
In toto imaging of glial JNK signaling during larval zebrafish spinal cord regeneration
10.1242/dev.202076 · 2023 · External reference
Stabilization of Hypoxia Inducible Factor-1alpha by Dimethyloxalylglycine Promotes Recovery from Acute Spinal Cord Injury by Inhibiting Neural Apoptosis and Enhancing Axon Regeneration
10.1089/neu.2018.6364 · 2019 · External reference
Hif-1alpha regulates macrophage-endothelial interactions during blood vessel development in zebrafish
10.1038/ncomms15492 · 2017 · External reference
On the mechanism of phenylhydrazine-induced hemolytic anemia
10.1016/0006-291x(78)90332-7 · 1978 · External reference
Hypoxia induces myocardial regeneration in zebrafish
10.1161/circulationaha.112.107888 · 2012 · External reference
Oxidative stress induced by hydrogen peroxide disrupts zebrafish visual development by altering apoptosis, antioxidant and estrogen related genes
2024 · External reference
Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1alpha
10.1158/1535-7163.mct-07-0463 · 2008 · External reference
FIMO: scanning for occurrences of a given motif
10.1093/bioinformatics/btr064 · 2011 · External reference
Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development
10.1136/gutjnl-2013-306596 · 2015 · External reference
GATA4 regulates ANF expression synergistically with Sp1 in a cardiac hypertrophy model
10.1111/j.1582-4934.2010.01182.x · 2011 · External reference
GATA-dependent recruitment of MEF2 proteins to target promoters
10.1093/emboj/19.9.2046 · 2000 · External reference
Cardiac reprogramming factor Gata4 reduces postinfarct cardiac fibrosis through direct repression of the profibrotic mediator snail
10.1016/j.jtcvs.2017.06.035 · 2017 · External reference
Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration
10.1126/science.adw8526 · 2026 · External reference
Beta-aminopropionitrile treatment can accelerate recovery of mice after spinal cord injury
10.1016/s0014-2999(01)01354-1 · 2001 · External reference
Characterization of a nap1l1 transgenic reporter in zebrafish
10.1016/j.gene.2020.144388 · 2020 · External reference
GFAP transgenic zebrafish
10.1016/j.modgep.2006.04.006 · 2006 · External reference
Notch signaling regulates cardiomyocyte proliferation during zebrafish heart regeneration
10.1073/pnas.1311705111 · 2014 · External reference
Neural cell fate analysis in zebrafish using olig2 BAC transgenics
10.1023/b:mics.0000006847.09037.3a · 2003 · External reference
Clarification of mural cell coverage of vascular endothelial cells by live imaging of zebrafish
2016 · External reference
NIH Image to ImageJ: 25 years of image analysis
10.1038/nmeth.2089 · 2012 · External reference
Dictionary learning for integrative, multimodal and scalable single-cell analysis
10.1038/s41587-023-01767-y · 2024 · External reference
WebGestalt 2024: faster gene set analysis and new support for metabolomics and multi-omics
10.1093/nar/gkae456 · 2024 · External reference
The MEME Suite
10.1093/nar/gkv416 · 2015 · External reference
A surgery protocol for adult zebrafish spinal cord injury
10.1016/j.jgg.2012.07.010 · 2012 · External reference
Regenerating descending axons preferentially reroute to the gray matter in the presence of a general macrophage/microglial reaction caudal to a spinal transection in adult zebrafish
10.1002/cne.1131 · 2001 · External reference
L1.1 is involved in spinal cord regeneration in adult zebrafish
10.1523/jneurosci.2420-04.2004 · 2004 · External reference
GATA4 regulates angiogenesis and persistence of inflammation in rheumatoid arthritis
10.1038/s41419-018-0570-5 · 2018 · External reference
The Expression Patterns and Roles of Lysyl Oxidases in Aortic Dissection
10.3389/fcvm.2021.692856 · 2021 · External reference
GATA4 as a novel regulator involved in the development of the neural crest and craniofacial skeleton via Barx1
10.1038/s41418-018-0083-x · 2018 · External reference
Genetic Pathways of Neuroregeneration in a Novel Mild Traumatic Brain Injury Model in Adult Zebrafish
10.1523/eneuro.0208-17.2017 · 2018 · External reference
Unresolved reference
External reference