Research graph
References from P4-ATPase BbCrpa2 detoxifies cyclosporine a via AP2-clathrin-dependent endocytic pathway in Beauveria bassiana. Local targets link to admitted publications; unresolved targets remain external evidence.
Cyclosporin A and C: new metabolites from Trichoderma polysporum (Link ex Pers
1976 · External reference
Cyclosporin A, ein immunsuppressiv wirksamer Peptidmetabolit aus Trichoderma polysporum (Link ex Pers.) Rifai
10.1002/hlca.19760590412 · 1976 · External reference
Biological effects of cyclosporin A: a new antilymphocytic agent
10.1007/bf01973261 · 1976 · External reference
Effects of the new anti-lymphocytic peptide cyclosporin A in animals
1977 · External reference
The Use of Cyclosporine A in Rheumatology: a 2016 Comprehensive Review
10.1007/s12016-016-8582-3 · 2017 · External reference
Cyclosporine-associated leukoencephalopathy in a case of sympathetic ophthalmitis
10.1159/000443826 · 2016 · External reference
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
10.1016/0092-8674(91)90124-h · 1991 · External reference
Mechanisms of action of cyclosporine
10.1016/s0162-3109(00)00192-2 · 2000 · External reference
Isolation of the cyclosporin-sensitive T cell transcription factor NFATp
10.1126/science.8235597 · 1993 · External reference
The mechanism of action of cyclosporin A and FK506
10.1016/0167-5699(92)90111-j · 1992 · External reference
Cyclosporin A as a source for a novel insecticidal product for controlling spodoptera frugiperda
10.3390/toxins14100721 · 2022 · External reference
Neurological complications following liver transplantation
10.1016/s0140-6736(87)90294-7 · 1987 · External reference
Cyclosporine-associated central-nervous-system toxicity after allogeneic bone-marrow transplantation
10.1056/nejm198402233100814 · 1984 · External reference
Cyclosporin A associated nephrotoxicity in the first 100 d after allogeneic bone marrow transplantation: three distinct syndromes
10.1111/j.1365-2141.1983.tb02067.x · 1983 · External reference
The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun
10.1038/365352a0 · 1993 · External reference
Immunosuppressant neurotoxicity in rat brain models: oxidative stress and cellular metabolism
10.1021/tx900351q · 2010 · External reference
Biochemical mechanisms of cyclosporine neurotoxicity
10.1124/mi.4.2.7 · 2004 · External reference
Efflux-mediated antifungal drug resistance
10.1128/cmr.00051-08 · 2009 · External reference
Cell detoxification of secondary metabolites by P4-ATPase-mediated vesicle transport
10.7554/elife.79179 · 2023 · External reference
Reversal of ABC drug transporter-mediated multidrug resistance in cancer cells: evaluation of current strategies
10.2174/1874467210801020093 · 2008 · External reference
Structural basis of the P4B ATPase lipid flippase activity
10.1038/s41467-021-26273-0 · 2021 · External reference
Role for Drs2p, a P-type ATPase and potential aminophospholipid translocase, in yeast late Golgi function
10.1083/jcb.147.6.1223 · 1999 · External reference
Pseudohyphal growth in Saccharomyces cerevisiae involves protein kinase-regulated lipid flippases
10.1242/jcs.235994 · 2020 · External reference
An essential subfamily of Drs2p-related P-type ATPases is required for protein trafficking between Golgi complex and endosomal/vacuolar system
10.1091/mbc.e02-03-0172 · 2002 · External reference
P4-ATPase endosomal recycling relies on multiple retromer-dependent localization signals
10.1091/mbc.e24-05-0209 · 2024 · External reference
P4-ATPases: lipid flippases in cell membranes
10.1007/s00424-013-1363-4 · 2014 · External reference
Flipping the script: Advances in understanding how and why P4-ATPases flip lipid across membranes
10.1016/j.bbamcr.2024.119700 · 2024 · External reference
Cdc50p, a protein required for polarized growth, associates with the Drs2p P-type ATPase implicated in phospholipid translocation in Saccharomyces cerevisiae
10.1091/mbc.e03-11-0829 · 2004 · External reference
Phosphatidylserine flipping by the P4-ATPase ATP8A2 is electrogenic
10.1073/pnas.1910211116 · 2019 · External reference
The essential Neo1 protein from budding yeast plays a role in establishing aminophospholipid asymmetry of the plasma membrane
10.1074/jbc.m115.686253 · 2016 · External reference
Toxoplasma gondii phosphatidylserine flippase complex ATP2B-CDC50.4 critically participates in microneme exocytosis
10.1371/journal.ppat.1010438 · 2022 · External reference
Lipid asymmetry and membrane trafficking: Transbilayer distribution of structural phospholipids as regulators of exocytosis and endocytosis
10.1016/j.jbc.2025.110441 · 2025 · External reference
Consensus, controversies, and conundrums of P4-ATPases: The emerging face of eukaryotic lipid flippases
10.1016/j.jbc.2024.107387 · 2024 · External reference
ATP9A deficiency causes ADHD and aberrant endosomal recycling via modulating RAB5 and RAB11 activity
10.1038/s41380-022-01940-w · 2023 · External reference
Transport Cycle of Plasma Membrane Flippase ATP11C by Cryo-EM
10.1016/j.celrep.2020.108208 · 2020 · External reference
Substrates, regulation, cellular functions, and disease associations of P4-ATPases
10.1038/s42003-025-07549-3 · 2025 · External reference
Arl1p regulates spatial membrane organization at the trans-Golgi network through interaction with Arf-GEF Gea2p and flippase Drs2p
10.1073/pnas.1221484110 · 2013 · External reference
Conformational changes of a phosphatidylcholine flippase in lipid membranes
10.1016/j.celrep.2022.110518 · 2022 · External reference
Activation and substrate specificity of the human P4-ATPase ATP8B1
10.1038/s41467-023-42828-9 · 2023 · External reference
Structural insight into an Arl1-ArfGEF complex involved in Golgi recruitment of a GRIP-domain golgin
10.1038/s41467-024-46304-w · 2024 · External reference
Cryo-EM structures capture the transport cycle of the P4-ATPase flippase
10.1126/science.aay3353 · 2019 · External reference
Structure and autoregulation of a P4-ATPase lipid flippase
10.1038/s41586-019-1344-7 · 2019 · External reference
N terminus and C terminus of Arabidopsis P4-ATPase AtALA1 facilitate the detoxification of the mycotoxin deoxynivalenol in wheat
2025 · External reference
Substrate specificity controlled by the exit site of human P4-ATPases, revealed by de novo point mutations in neurological disorders
10.1073/pnas.2415755121 · 2024 · External reference
Butyrolactol a potentiates caspofungin efficacy against resistant fungi via phospholipid flippase inhibition
2025 · External reference
Lipid flippase subunit cdc50 mediates drug resistance and virulence in Cryptococcus neoformans
10.1128/mbio.00478-16 · 2016 · External reference
Arabidopsis flippase ALA3 is required for adjustment of early subcellular trafficking in plant response to osmotic stress
10.1093/jxb/erad234 · 2023 · External reference
Human type IV P-type ATPases that work as plasma membrane phospholipid flippases and their regulation by caspase and calcium
10.1074/jbc.m115.690727 · 2016 · External reference
Cryptococcus flips its lid - membrane phospholipid asymmetry modulates antifungal drug resistance and virulence
10.15698/mic2016.08.521 · 2016 · External reference
Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure
10.1126/science.1252809 · 2014 · External reference
P4-ATPases control phosphoinositide membrane asymmetry and neomycin resistance
10.1038/s41556-025-01692-z · 2025 · External reference
Arabidopsis P4 ATPase-mediated cell detoxification confers resistance to Fusarium graminearum and Verticillium dahliae
10.1038/s41467-021-26727-5 · 2021 · External reference
Arabidopsis P4-ATPases ALA1 and ALA7 enhance resistance to Verticillium dahliae via detoxifying Vd-toxins
10.3390/biology14060595 · 2025 · External reference
FM-dyes as experimental probes for dissecting vesicle trafficking in living plant cells
10.1111/j.0022-2720.2004.01348.x · 2004 · External reference
Confocal microscopy of FM4-64 as a tool for analysing endocytosis and vesicle trafficking in living fungal hyphae
10.1046/j.1365-2818.2000.00708.x · 2000 · External reference
The endosomal recycling of FgSnc1 by FgSnx41-FgSnx4 heterodimer is essential for polarized growth and pathogenicity in Fusarium graminearum
10.1111/nph.15178 · 2018 · External reference
Tyrphostin A23 inhibits internalization of the transferrin receptor by perturbing the interaction between tyrosine motifs and the medium chain subunit of the AP-2 adaptor complex
10.1074/jbc.m211966200 · 2003 · External reference
CesA6 and PGIP2 endocytosis involves different subpopulations of TGN-related endosomes
10.3389/fpls.2020.00350 · 2020 · External reference
Clathrin-mediated constitutive endocytosis of PIN auxin efflux carriers in Arabidopsis
10.1016/j.cub.2007.01.052 · 2007 · External reference
Regulation and pH-dependent expression of a bilaterally truncated yeast plasma membrane H+-ATPase
10.1016/s0005-2736(98)00065-0 · 1998 · External reference
Structural and functional properties of the N- and C-terminal segments of the P4-ATPase phospholipid flippase ATP8A2
10.1016/j.jbc.2024.108065 · 2025 · External reference
The N- or C-terminal cytoplasmic regions of P4-ATPases determine their cellular localization
10.1091/mbc.e20-04-0225 · 2020 · External reference
The P4-ATPase Drs2 interacts with and stabilizes the multisubunit tethering complex TRAPPIII in yeast
10.15252/embr.202256134 · 2023 · External reference
TRAPPIII requires Drs2 binding to transport Atg9 vesicles at cold temperatures
10.1080/15548627.2023.2233365 · 2023 · External reference
Regulatory roles of N- and C-terminal cytoplasmic regions of P4-ATPases
10.1248/cpb.c22-00042 · 2022 · External reference
ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner
10.1074/jbc.m111.281006 · 2011 · External reference
Phospholipid flippase activities and substrate specificities of human type IV P-type ATPases localized to the plasma membrane
10.1074/jbc.a114.593012 · 2016 · External reference
Auto-inhibition of Drs2p, a yeast phospholipid flippase, by its carboxyl-terminal tail
10.1074/jbc.m113.481986 · 2013 · External reference
Governance of endocytic trafficking and signaling by reversible ubiquitylation
10.1016/j.devcel.2012.08.011 · 2012 · External reference
In vitro assessment of fluconazole and Cyclosporine A antifungal activities: a promising drug combination against different candida species
10.3390/jof11020133 · 2025 · External reference
Multicenter Evaluation of a new disk agar diffusion method for susceptibility testing of filamentous fungi with voriconazole, posaconazole, itraconazole, amphotericin b, and caspofungin
10.1128/jcm.00134-07 · 2007 · External reference
Loss of function of VdDrs2, a P4-ATPase, impairs the toxin secretion and microsclerotia formation, and decreases the pathogenicity of Verticillium dahliae
10.3389/fpls.2022.944364 · 2022 · External reference