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References from Lysosomal multi-omics reveals altered sphingolipid catabolism associated with lysosomal dysfunction in the aging brain. Local targets link to admitted publications; unresolved targets remain external evidence.
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PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma
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Spatial Neurolipidomics at the Single Amyloid-beta Plaque Level in Postmortem Human Alzheimer's Disease Brain
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Early plasma ceramide and sphingomyelin levels reflect APOE genotype but not familial Alzheimer's disease gene mutations in female 5xFAD mice, with brain-region specific sphingolipid alterations
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Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes
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CLN3 is required for the clearance of glycerophosphodiesters from lysosomes
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The Bis(monoacylglycero)-phosphate Hypothesis: From Lysosomal Function to Therapeutic Avenues
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Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons
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Secretome translation shaped by lysosomes and lunapark-marked ER junctions
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Targeting phospholipase PLAG-15 promotes healthy aging in C. elegans via lysosomal-related genes
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PLA2G15 is a BMP hydrolase and its targeting ameliorates lysosomal disease
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Early life changes in histone landscape protect against age-associated amyloid toxicities through HSF-1-dependent regulation of lipid metabolism
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PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid degradation in lysosomes
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Regulation of the lysosome by sphingolipids: Potential role in aging
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Lysosomal Ceramide Metabolism Disorders: Implications in Parkinson's Disease
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Elevated glucosylsphingosine in Gaucher disease induced pluripotent stem cell neurons deregulates lysosomal compartment through mammalian target of rapamycin complex 1
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Cln1 gene disruption in mice reveals a common pathogenic link between two of the most lethal childhood neurodegenerative lysosomal storage disorders
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Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
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Expanding our understanding of Guillain-Barre syndrome: Recent advances and clinical implications
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Acid sphingomyelinase activity is regulated by membrane lipids and facilitates cholesterol transfer by NPC2
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Saposin D: a sphingomyelinase activator
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Lysosomal ceramides regulate cathepsin B-mediated processing of saposin C and glucocerebrosidase activity
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Autophagic degradation of CNS myelin maintains axon integrity
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