Research graph
References from USP-48 enables insulin-mediated longevity and modulates the mitochondrial stress response. Local targets link to admitted publications; unresolved targets remain external evidence.
Mitochondrial and metabolic dysfunction in ageing and age-related diseases
10.1038/s41574-021-00626-7 · 2022 · External reference
Folding the Mitochondrial UPR into the Integrated Stress Response
10.1016/j.tcb.2020.03.001 · 2020 · External reference
Prohibitins act as a membrane-bound chaperone for the stabilization of mitochondrial proteins
10.1093/emboj/19.11.2444 · 2000 · External reference
Prohibitins
10.1016/j.cub.2017.04.030 · 2017 · External reference
A structure for the yeast prohibitin complex: Structure prediction and evidence from chemical crosslinking and mass spectrometry
10.1110/ps.0212602 · 2002 · External reference
Prohibitin depletion extends lifespan of a TORC2/SGK-1 mutant through autophagy and the mitochondrial UPR
10.1111/acel.13359 · 2021 · External reference
The Mitochondrial PHB Complex Determines Lipid Composition and Interacts With the Endoplasmic Reticulum to Regulate Ageing
10.3389/fphys.2021.696275 · 2021 · External reference
DNAJC19, a mitochondrial cochaperone associated with cardiomyopathy, forms a complex with prohibitins to regulate cardiolipin remodeling
10.1016/j.cmet.2014.04.016 · 2014 · External reference
Prohibitins and the functional compartmentalization of mitochondrial membranes
10.1242/jcs.037655 · 2009 · External reference
Prohibitin and mitochondrial biology
10.1016/j.tem.2009.04.004 · 2009 · External reference
Mitochondrial Quality Control Mechanisms and the PHB (Prohibitin) Complex
10.3390/cells7120238 · 2018 · External reference
Prohibitin couples diapause signalling to mitochondrial metabolism during ageing in C. elegans
10.1038/nature08466 · 2009 · External reference
Prohibitin-mediated lifespan and mitochondrial stress implicate SGK-1, insulin/IGF and mTORC2 in C. elegans
10.1371/journal.pone.0107671 · 2014 · External reference
Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure
10.15252/emmm.201404916 · 2015 · External reference
Molecular mechanisms underlying genotype-dependent responses to dietary restriction
10.1111/acel.12130 · 2013 · External reference
Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans
10.1038/ncomms4483 · 2014 · External reference
Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation
10.1126/science.1223560 · 2012 · External reference
Mitochondrial genome recovery by ATFS-1 is essential for development after starvation
10.1016/j.celrep.2022.111875 · 2022 · External reference
OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes
10.1534/genetics.118.301307 · 2018 · External reference
REVIGO summarizes and visualizes long lists of gene ontology terms
10.1371/journal.pone.0021800 · 2011 · External reference
Improved scoring of functional groups from gene expression data by decorrelating GO graph structure
10.1093/bioinformatics/btl140 · 2006 · External reference
The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans
10.1016/j.molcel.2010.01.015 · 2010 · External reference
Combined flow cytometry and high-throughput image analysis for the study of essential genes in Caenorhabditis elegans
10.1186/s12915-018-0496-5 · 2018 · External reference
Mitonuclear protein imbalance as a conserved longevity mechanism
10.1038/nature12188 · 2013 · External reference
Surveillance-activated defenses block the ROS-induced mitochondrial unfolded protein response
10.1371/journal.pgen.1003346 · 2013 · External reference
Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways
10.1371/journal.pgen.1002792 · 2012 · External reference
Basic culture methods
10.1016/s0091-679x(08)61381-3 · 1995 · External reference
Genetic and environmental conditions that increase longevity in Caenorhabditis elegans decrease metabolic rate
10.1073/pnas.96.20.11399 · 1999 · External reference
Effects of liquid cultivation on gene expression and phenotype of C. elegans
10.1186/s12864-018-4948-7 · 2018 · External reference
miR-24-mediated knockdown of H2AX damages mitochondria and the insulin signaling pathway
10.1038/emm.2016.174 · 2017 · External reference
Histone H2AX promotes neuronal health by controlling mitochondrial homeostasis
10.1073/pnas.1820245116 · 2019 · External reference
Breaking the chains: structure and function of the deubiquitinases
10.1038/nrm2731 · 2009 · External reference
Restriction of Cellular Plasticity of Differentiated Cells Mediated by Chromatin Modifiers, Transcription Factors and Protein Kinases
10.1534/g3.119.400328 · 2019 · External reference
Novel imaging tools to study mitochondrial morphology in Caenorhabditis elegans
10.26508/lsa.202402918 · 2024 · External reference
The mitochondrial prohibitin complex is essential for embryonic viability and germline function in Caenorhabditis elegans
10.1074/jbc.m304877200 · 2003 · External reference
Increased mitochondrial fusion allows the survival of older animals in diverse C. elegans longevity pathways
10.1038/s41467-017-00274-4 · 2017 · External reference
WormCat: An Online Tool for Annotation and Visualization of Caenorhabditis elegans Genome-Scale Data
10.1534/genetics.119.302919 · 2020 · External reference
High confidence ATFS-1 target genes for quantifying activation of the mitochondrial unfolded protein response
2021 · External reference
USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A
10.1038/s41467-017-02653-3 · 2018 · External reference
Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt)
10.1016/j.molcel.2015.02.008 · 2015 · External reference
Mitochondrial Stress Induces Chromatin Reorganization to Promote Longevity and UPR(mt)
10.1016/j.cell.2016.04.011 · 2016 · External reference
The homeodomain transcriptional regulator DVE-1 directs a program for synapse elimination during circuit remodeling
10.1038/s41467-023-43281-4 · 2023 · External reference
ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans
10.1016/j.devcel.2007.07.016 · 2007 · External reference
NuRD mediates mitochondrial stress-induced longevity via chromatin remodeling in response to acetyl-CoA level
10.1126/sciadv.abb2529 · 2020 · External reference
An integrated encyclopedia of DNA elements in the human genome
10.1038/nature11247 · 2012 · External reference
The ENCODE Uniform Analysis Pipelines
2023 · External reference
New developments on the Encyclopedia of DNA Elements (ENCODE) data portal
10.1093/nar/gkz1062 · 2020 · External reference
Autophagy compensates for defects in mitochondrial dynamics
10.1371/journal.pgen.1008638 · 2020 · External reference
Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones
10.1242/jcs.01275 · 2004 · External reference
Methods to Study the Mitochondrial Unfolded Protein Response (UPR(mt)) in Caenorhabditis elegans
10.1007/978-1-0716-1732-8_16 · 2022 · External reference
C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span
10.1016/s1534-5807(04)00095-4 · 2004 · External reference
Mitochondrial Perturbations Couple mTORC2 to Autophagy in C. elegans
10.1016/j.celrep.2019.09.072 · 2019 · External reference
A chromatin modifier integrates insulin/IGF-1 signalling and dietary restriction to regulate longevity
10.1111/acel.12477 · 2016 · External reference
Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans
10.1016/j.cell.2008.01.030 · 2008 · External reference
USP28 regulates deubiquitination of histone H2A and cell proliferation
10.1016/j.yexcr.2019.03.026 · 2019 · External reference
Ubiquitin-dependent regulation of transcription in development and disease
10.15252/embr.202051078 · 2021 · External reference
The ZFP-1(AF10)/DOT-1 complex opposes H2B ubiquitination to reduce Pol II transcription
10.1016/j.molcel.2013.06.002 · 2013 · External reference
The conserved PHD1-PHD2 domain of ZFP-1/AF10 is a discrete functional module essential for viability in Caenorhabditis elegans
10.1128/mcb.01462-12 · 2013 · External reference
Proteins that bind regulatory regions identified by histone modification chromatin immunoprecipitations and mass spectrometry
10.1038/ncomms8155 · 2015 · External reference
Chromatin proteomic profiling reveals novel proteins associated with histone-marked genomic regions
10.1073/pnas.1502971112 · 2015 · External reference
Two sensory neurons coordinate the systemic mitochondrial stress response via GPCR signaling in C. elegans
10.1016/j.devcel.2022.10.001 · 2022 · External reference
The glyoxylate shunt protein ICL-1 protects from mitochondrial superoxide stress through activation of the mitochondrial unfolded protein response
10.1016/j.freeradbiomed.2023.09.029 · 2023 · External reference
Protein disulfide isomerase PDI-6 regulates Wnt secretion to coordinate inter-tissue UPR(mt) activation and lifespan extension in C. elegans
10.1016/j.celrep.2022.110931 · 2022 · External reference
Characterization of C. elegans RING finger protein 1, a binding partner of ubiquitin-conjugating enzyme 1
10.1016/j.ydbio.2003.09.037 · 2004 · External reference
A conserved PHD finger protein and endogenous RNAi modulate insulin signaling in Caenorhabditis elegans
10.1371/journal.pgen.1002299 · 2011 · External reference
Lysosomes signal through the epigenome to regulate longevity across generations
10.1126/science.adn8754 · 2025 · External reference
An altered method of feeding RNAi that knocks down multiple genes simultaneously in the nematode Caenorhabditis elegans
10.1271/bbb.100579 · 2010 · External reference
The CONJUDOR pipeline for multiplexed knockdown of gene pairs identifies RBBP-5 as a germ cell reprogramming barrier in C. elegans
10.1093/nar/gkaa1171 · 2021 · External reference
Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways
10.1186/s12915-018-0615-3 · 2018 · External reference
A genomic and functional inventory of deubiquitinating enzymes
10.1016/j.cell.2005.11.007 · 2005 · External reference
The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation
10.1038/s43587-025-00943-w · 2025 · External reference
SLP-2 is required for stress-induced mitochondrial hyperfusion
10.1038/emboj.2009.89 · 2009 · External reference
Mitochondrial fission surveillance is coupled to Caenorhabditis elegans DNA and chromosome segregation integrity
10.1371/journal.pgen.1011678 · 2025 · External reference
A novel mitochondrial outer membrane protein, MOMA-1, that affects cristae morphology in Caenorhabditis elegans
10.1091/mbc.e10-07-0600 · 2011 · External reference
A feedback loop engaging propionate catabolism intermediates controls mitochondrial morphology
10.1038/s41556-022-00883-2 · 2022 · External reference
Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity
10.1038/s41467-020-18501-w · 2020 · External reference
Gli1-induced deubiquitinase USP48 aids glioblastoma tumorigenesis by stabilizing Gli1
10.15252/embr.201643124 · 2017 · External reference
CSN-associated USP48 confers stability to nuclear NF-kappaB/RelA by trimming K48-linked Ub-chains
10.1016/j.bbamcr.2014.11.028 · 2015 · External reference
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi
10.1038/nature01278 · 2003 · External reference
OrthoList: a compendium of C. elegans genes with human orthologs
10.1371/journal.pone.0020085 · 2011 · External reference
The genetics of Caenorhabditis elegans
10.1093/genetics/77.1.71 · 1974 · External reference
CellProfiler: image analysis software for identifying and quantifying cell phenotypes
10.1186/gb-2006-7-10-r100 · 2006 · External reference
A pair of new statistical parameters for quality control in RNA interference high-throughput screening assays
10.1016/j.ygeno.2006.12.014 · 2007 · External reference
More powerful procedures for multiple significance testing
10.1002/sim.4780090710 · 1990 · External reference
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
10.1006/meth.2001.1262 · 2001 · External reference
A new mathematical model for relative quantification in real-time RT-PCR
10.1093/nar/29.9.e45 · 2001 · External reference
Adapting the Smart-seq2 Protocol for Robust Single Worm RNA-seq
10.21769/bioprotoc.2729 · 2018 · External reference
