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References from Single-cell transcriptomic reference map of human peripheral blood γδ T cells from 1 year to 90 years reveals major changes before adulthood. Local targets link to admitted publications; unresolved targets remain external evidence.
Human T Cell Development, Localization, and Function throughout Life
10.1016/j.immuni.2018.01.007 · 2018 · External reference
Immune-microbe interactions early in life: A determinant of health and disease long term
10.1126/science.abk2189 · 2022 · External reference
A Prime Time for Trained Immunity: Innate Immune Memory in Newborns and Infants
10.1159/000356035 · 2014 · External reference
Hallmarks of T cell aging
10.1038/s41590-021-00927-z · 2021 · External reference
Surfing on the waves of the human γδ T cell ontogenic sea
10.1111/imr.13184 · 2023 · External reference
A Cell for the Ages: Human γδ T Cells across the Lifespan
10.3390/ijms21238903 · 2020 · External reference
The Aging of γδ T Cells
10.3390/cells9051181 · 2020 · External reference
Aging unconventionally: γδ T cells, iNKT cells, and MAIT cells in aging
10.1016/j.smim.2023.101816 · 2023 · External reference
Immune recognition of phosphoantigen-butyrophilin molecular complexes by γδ T cells
10.1111/imr.12923 · 2020 · External reference
Extrathymic origin of human gamma delta T cells during fetal development
10.4049/jimmunol.157.7.2873 · 1996 · External reference
Regulated expression and structure of T cell receptor gamma/delta transcripts in human thymic ontogeny
10.1002/j.1460-2075.1991.tb07923.x · 1991 · External reference
A distinct wave of human T cell receptor gamma/delta lymphocytes in the early fetal thymus: evidence for controlled gene rearrangement and cytokine production
10.1084/jem.172.3.847 · 1990 · External reference
Identification of distinct functional thymic programming of fetal and pediatric human γδ thymocytes via single-cell analysis
10.1038/s41467-022-33488-2 · 2022 · External reference
A three-stage developmental pathway for human Vγ9Vδ2 T cells within the postnatal thymus
10.1126/sciimmunol.abo4365 · 2023 · External reference
Fetal public Vγ9Vδ2 T cells expand and gain potent cytotoxic functions early after birth
10.1073/pnas.1922595117 · 2020 · External reference
Microbial exposure drives polyclonal expansion of innate γδ T cells immediately after birth
10.1073/pnas.1922588117 · 2020 · External reference
Evidence for extrathymic changes in the T cell receptor gamma/delta repertoire
10.1084/jem.171.5.1597 · 1990 · External reference
A high-dimensional cytometry atlas of peripheral blood over the human life span
10.1111/imcb.12594 · 2022 · External reference
Ageing and latent CMV infection impact on maturation, differentiation and exhaustion profiles of T-cell receptor gammadelta T-cells
10.1038/s41598-017-05849-1 · 2017 · External reference
Age-associated alteration of γδ T-cell repertoire and different profiles of activation-induced death of Vδ1 and Vδ2 T cells
10.1007/s12185-011-0907-7 · 2011 · External reference
Human γδ T cells in diverse tissues exhibit site-specific maturation dynamics across the life span
10.1126/sciimmunol.adn3954 · 2024 · External reference
Tissue distribution of human gamma delta T cells: no evidence for general epithelial tropism
10.1136/jcp.44.12.1012 · 1991 · External reference
Recasting Human Vδ1 Lymphocytes in an Adaptive Role
10.1016/j.it.2018.03.003 · 2018 · External reference
Mapping of γ/δ T cells reveals Vδ2+ T cells resistance to senescence
10.1016/j.ebiom.2018.11.053 · 2019 · External reference
Effector Vγ9Vδ2 T cells dominate the human fetal γδ T-cell repertoire
10.1073/pnas.1412058112 · 2015 · External reference
Functional spectrum of γδ T cells in perinatal infectious diseases
10.1016/j.imlet.2026.107167 · 2026 · External reference
γδ T cell profiling in a cohort of preterm infants reveals elevated frequencies of CD83+ γδ T cells in sepsis
10.1084/jem.20231987 · 2024 · External reference
Robust γδ+ T cell expansion in infants immunized at birth with BCG vaccine
10.1016/j.vaccine.2007.06.039 · 2007 · External reference
Sepsis shapes the human γδ TCR repertoire in an age- and pathogen-dependent manner
10.1002/eji.202451190 · 2024 · External reference
Single-cell atlas of healthy human blood unveils age-related loss of NKG2C+GZMB−CD8+ memory T cells and accumulation of type 2 memory T cells
10.1016/j.immuni.2023.10.013 · 2023 · External reference
Single-cell map of the healthy human immune system across the lifespan reveals unique infant immune signatures
10.1038/s41467-026-73729-2 · 2026 · External reference
Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age
10.1038/s41590-025-02241-4 · 2025 · External reference
Immune ageing at single-cell resolution
10.1038/s41577-021-00646-4 · 2022 · External reference
Multi-omic profiling reveals age-related immune dynamics in healthy adults
10.1038/s41586-025-09686-5 · 2025 · External reference
Human PBMC scRNA-seq–based aging clocks reveal ribosome to inflammation balance as a single-cell aging hallmark and super longevity
10.1126/sciadv.abq7599 · 2023 · External reference
Trimodal single-cell profiling reveals a novel pediatric CD8αα+ T cell subset and broad age-related molecular reprogramming across the T cell compartment
10.1038/s41590-023-01641-8 · 2023 · External reference
Integrating single-cell RNA and T cell/B cell receptor sequencing with mass cytometry reveals dynamic trajectories of human peripheral immune cells from birth to old age
10.1038/s41590-024-02059-6 · 2025 · External reference
Early-life thymectomy leads to an increase of granzyme-producing γδ T cells in children with congenital heart disease
10.1038/s41467-024-51673-3 · 2024 · External reference
Single-cell multi-omics analysis of the immune response in COVID-19
10.1038/s41591-021-01329-2 · 2021 · External reference
Multidimensional single-cell analysis of human peripheral blood reveals characteristic features of the immune system landscape in aging and frailty
10.1038/s43587-022-00198-9 · 2022 · External reference
Interpretable inflammation landscape of circulating immune cells
10.1038/s41591-025-04126-3 · 2026 · External reference
Single-cell transcriptional and epigenomic landscape of human blood immune cells across the lifespan
10.1016/j.celrep.2026.117072 · 2026 · External reference
Single-cell eQTL mapping identifies cell type–specific genetic control of autoimmune disease
10.1126/science.abf3041 · 2022 · External reference
Genetic ancestry effects on the response to viral infection are pervasive but cell type specific
10.1126/science.abg0928 · 2021 · External reference
SARS-CoV-2 induced immune perturbations in infants vary with disease severity and differ from adults’ responses
10.1038/s41467-025-59411-z · 2025 · External reference
Multi-omics analysis of mucosal and systemic immunity to SARS-CoV-2 after birth
10.1016/j.cell.2023.08.044 · 2023 · External reference
Population-level single-cell genomics reveals conserved gene programs in systemic juvenile idiopathic arthritis
10.1172/jci166741 · 2023 · External reference
Local and systemic responses to SARS-CoV-2 infection in children and adults
10.1038/s41586-021-04345-x · 2022 · External reference
Single-cell RNA-seq uncovers cellular heterogeneity and provides a signature for paediatric sleep apnoea
10.1183/13993003.01465-2022 · 2023 · External reference
Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children
10.1016/j.immuni.2021.04.003 · 2021 · External reference
Young infants display heterogeneous serological responses and extensive but reversible transcriptional changes following initial immunizations
10.1038/s41467-023-43758-2 · 2023 · External reference
Fast, sensitive and accurate integration of single-cell data with Harmony
10.1038/s41592-019-0619-0 · 2019 · External reference
A fetal wave of human type 3 effector γδ cells with restricted TCR diversity persists into adulthood
10.1126/sciimmunol.abf0125 · 2021 · External reference
Single-cell RNA sequencing unveils the shared and the distinct cytotoxic hallmarks of human TCRVδ1 and TCRVδ2 γδ T lymphocytes
10.1073/pnas.1818488116 · 2019 · External reference
Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor
10.1038/ni.1689 · 2009 · External reference
The single-cell transcriptional landscape of mammalian organogenesis
10.1038/s41586-019-0969-x · 2019 · External reference
Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics
10.1186/s12864-018-4772-0 · 2018 · External reference
Death by a Thousand Cuts: Granzyme Pathways of Programmed Cell Death
10.1146/annurev.immunol.26.021607.090404 · 2008 · External reference
Mitochondrial and metabolic dysfunction in ageing and age-related diseases
10.1038/s41574-021-00626-7 · 2022 · External reference
Mitochondria during T cell aging
10.1016/j.smim.2023.101808 · 2023 · External reference
Hallmarks of aging: An expanding universe
10.1016/j.cell.2022.11.001 · 2023 · External reference
Mitochondrial dysfunction in cell senescence and aging
10.1172/jci158447 · 2022 · External reference
The RESIST Senior Individuals Cohort: Design, participant characteristics and aims
10.1007/s11357-024-01299-6 · 2025 · External reference
Souporcell: robust clustering of single-cell RNA-seq data by genotype without reference genotypes
10.1038/s41592-020-0820-1 · 2020 · External reference
Dictionary learning for integrative, multimodal and scalable single-cell analysis
10.1038/s41587-023-01767-y · 2024 · External reference
Human γδ T cell identification from single-cell RNA sequencing datasets by modular TCR expression
10.1093/jleuko/qiad069 · 2023 · External reference
clusterProfiler: an R package for comparing biological themes among gene clusters
10.1089/omi.2011.0118 · 2012 · External reference
