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References from Progressive remodeling of global protein interaction networks in a mouse model of tauopathy. Local targets link to admitted publications; unresolved targets remain external evidence.
Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression
10.1016/j.neuron.2019.12.015 · 2020 · External reference
Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia
10.1038/s41591-018-0223-3 · 2019 · External reference
Tau interactome and RNA binding proteins in neurodegenerative diseases
10.1186/s13024-022-00572-6 · 2022 · External reference
Phosphorylated tau interactome in the human Alzheimer's disease brain
10.1093/brain/awaa223 · 2020 · External reference
Decreased synthesis of ribosomal proteins in tauopathy revealed by non-canonical amino acid labelling
10.15252/embj.2018101174 · 2019 · External reference
Proteomic landscape of Alzheimer's Disease: novel insights into pathogenesis and biomarker discovery
10.1186/s13024-021-00474-z · 2021 · External reference
Efficient proximity labeling in living cells and organisms with TurboID
10.1038/nbt.4201 · 2018 · External reference
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain
10.1016/j.cels.2020.08.006 · 2020 · External reference
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model
10.1016/j.neuron.2007.01.010 · 2007 · External reference
Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo
10.1038/s41593-017-0022-z · 2018 · External reference
Dendritic Tau in Alzheimer's Disease
10.1016/j.neuron.2018.06.003 · 2018 · External reference
Neurodegenerative Disease Tauopathies
10.1146/annurev-pathmechdis-051222-120750 · 2024 · External reference
Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model
10.1016/j.neuron.2016.09.022 · 2016 · External reference
Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease
10.1186/s40478-016-0333-4 · 2016 · External reference
Functional variants identify sex-specific genes and pathways in Alzheimer's Disease
10.1038/s41467-023-38374-z · 2023 · External reference
Computational and functional prioritization identifies genes that rescue behavior and reduce tau protein in fly and human cell models of Alzheimer disease
10.1016/j.ajhg.2025.03.012 · 2025 · External reference
Tau association with synaptic mitochondria coincides with energetic dysfunction and excitatory synapse loss in the P301S tauopathy mouse model
10.1016/j.neurobiolaging.2024.12.006 · 2025 · External reference
Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's disease mouse models
10.1038/s43587-022-00281-1 · 2022 · External reference
Bassoon contributes to tau-seed propagation and neurotoxicity
10.1038/s41593-022-01191-6 · 2022 · External reference
Molecular Signatures of Neurodegenerative Diseases Identified by Proteomic and Phosphoproteomic Analyses in Aging Mouse Brain
10.1016/j.mcpro.2024.100819 · 2024 · External reference
Human and mouse proteomics reveals the shared pathways in Alzheimer's disease and delayed protein turnover in the amyloidome
10.1038/s41467-025-56853-3 · 2025 · External reference
Brain phosphoproteomic analysis identifies diabetes-related substrates in Alzheimer's disease pathology in older adults
10.1002/alz.14460 · 2025 · External reference
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery
10.1038/s41467-022-31809-z · 2022 · External reference
EPIC: software toolkit for elution profile-based inference of protein complexes
10.1038/s41592-019-0461-4 · 2019 · External reference
Revisiting the relation between species diversity and information theory
10.1007/s10441-008-9053-x · 2008 · External reference
Acute Fluid Biomarkers for Diagnosis and Prognosis in Children with Mild Traumatic Brain Injury: A Systematic Review
10.1007/s40291-023-00685-8 · 2024 · External reference
The role of peroxiredoxin 1 in redox sensing and transducing
10.1016/j.abb.2016.10.009 · 2017 · External reference
ACO2 deficiency increases vulnerability to Parkinson's disease via dysregulating mitochondrial function and histone acetylation-mediated transcription of autophagy genes
10.1038/s42003-023-05570-y · 2023 · External reference
mRNA transport, translation, and decay in adult mammalian central nervous system axons
10.1016/j.neuron.2022.12.015 · 2023 · External reference
CAV1-CAVIN1-LC3B-mediated autophagy regulates high glucose-stimulated LDL transcytosis
10.1080/15548627.2019.1659613 · 2020 · External reference
Autophagy-lysosomal-associated neuronal death in neurodegenerative disease
10.1007/s00401-024-02799-7 · 2024 · External reference
Impact of RTN3 deficiency on expression of BACE1 and amyloid deposition
10.1523/jneurosci.1588-14.2014 · 2014 · External reference
RTN1 and RTN3 protein are differentially associated with senile plaques in Alzheimer's brains
10.1038/s41598-017-05504-9 · 2017 · External reference
Widespread distribution of reticulon-3 in various neurodegenerative diseases
10.1111/j.1440-1789.2010.01107.x · 2010 · External reference
Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
10.1186/s13024-022-00526-y · 2022 · External reference
Pyk2 Signaling through Graf1 and RhoA GTPase Is Required for Amyloid-beta Oligomer-Triggered Synapse Loss
10.1523/jneurosci.2983-18.2018 · 2019 · External reference
Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-beta-Induced Synaptic Dysfunction and Loss
10.1523/jneurosci.1873-18.2018 · 2019 · External reference
Enhanced phagocytosis associated with multinucleated microglia via Pyk2 inhibition in an acute beta-amyloid infusion model
10.1186/s12974-024-03192-7 · 2024 · External reference
[WHO has to beg for more funds]
1991 · External reference
Pyk2 regulates cell-edge protrusion dynamics by interacting with Crk
10.1091/mbc.e20-10-0640 · 2021 · External reference
Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites
10.1242/jcs.01148 · 2004 · External reference
Epimerase Deficiency Galactosemia
1993 · External reference
FAK and PYK2/CAKbeta in the nervous system: a link between neuronal activity, plasticity and survival?
10.1016/s0166-2236(98)01358-7 · 1999 · External reference
PTK2B/Pyk2 overexpression improves a mouse model of Alzheimer's disease
10.1016/j.expneurol.2018.05.020 · 2018 · External reference
The Landscape of m6A Regulators in Multiple Brain Regions of Alzheimer's Disease
10.1007/s12035-023-03409-5 · 2023 · External reference
m6A and YTHDF proteins contribute to the localization of select neuronal mRNAs
10.1093/nar/gkac251 · 2022 · External reference
RNA methylation influences TDP43 binding and disease pathogenesis in models of amyotrophic lateral sclerosis and frontotemporal dementia
10.1016/j.molcel.2022.12.019 · 2023 · External reference
Universal tight correlation of codon bias and pool of RNA codons (codonome): The genome is optimized to allow any distribution of gene expression values in the transcriptome from bacteria to humans
10.1016/j.ygeno.2013.02.009 · 2013 · External reference
Multiscale proteomic modeling reveals protein networks driving Alzheimer's disease pathogenesis
10.1016/j.cell.2025.08.038 · 2025 · External reference
Ezrin Expression is Increased During Disease Progression in a Tauopathy Mouse Model and Alzheimer's Disease
10.2174/1567205015666180813152043 · 2018 · External reference
IFNgamma: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy
10.1038/s41577-018-0029-z · 2018 · External reference
Unique aspects of IFN-gamma/STAT1 signaling in neurons
10.1111/imr.13092 · 2022 · External reference
Stress granules and neurodegeneration
10.1038/s41583-019-0222-5 · 2019 · External reference
RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction
10.1038/s41467-020-18022-6 · 2020 · External reference
Increased G3BP2-Tau interaction in tauopathies is a natural defense against Tau aggregation
10.1016/j.neuron.2023.05.033 · 2023 · External reference
Loss of age-associated increase in m6A-modified RNA contributes to GABAergic dysregulation in Alzheimer’s disease
2025 · External reference
Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level
10.1038/s41593-021-00999-y · 2022 · External reference
Compilation of reported protein changes in the brain in Alzheimer's disease
10.1038/s41467-023-40208-x · 2023 · External reference
The MaxQuant computational platform for mass spectrometry-based shotgun proteomics
10.1038/nprot.2016.136 · 2016 · External reference
Omics Notebook: robust, reproducible and flexible automated multiomics exploratory analysis and reporting
10.1093/bioadv/vbab024 · 2021 · External reference
The Gene Ontology resource: enriching a GOld mine
10.1093/nar/gkaa1113 · 2021 · External reference
Reconstructing targetable pathways in lung cancer by integrating diverse omics data
10.1038/ncomms3617 · 2013 · External reference
