References

Enzymes of sphingolipid metabolism as transducers of metabolic inputs

10.1042/bst20231442 · 2024 · External reference

Bioactive sphingolipids: metabolism and function

10.1194/jlr.r800080-jlr200 · 2009 · External reference

Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism

10.1016/s1388-1981(03)00059-3 · 2003 · External reference

Sphingolipids and their metabolism in physiology and disease

10.1038/nrm.2017.107 · 2018 · External reference

Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy

10.1056/nejmoa1815111 · 2019 · External reference

Novel HSAN1 mutation in serine palmitoyltransferase resides at a putative phosphorylation site that is involved in regulating substrate specificity

10.1007/s12017-014-8339-1 · 2015 · External reference

Hereditary sensory neuropathy type 1-associated deoxysphingolipids cause neurotoxicity, acute calcium handling abnormalities and mitochondrial dysfunction in vitro

10.1016/j.nbd.2018.05.008 · 2018 · External reference

Hereditary sensory neuropathy type 1 is caused by the accumulation of two neurotoxic sphingolipids

10.1074/jbc.m109.092973 · 2010 · External reference

Localization of 1-deoxysphingolipids to mitochondria induces mitochondrial dysfunction

10.1194/jlr.m068676 · 2017 · External reference

Very long-chain fatty acids drive 1-deoxySphingolipid toxicity

10.1038/s41467-025-66687-8 · 2025 · External reference

1-Deoxysphingolipid synthesis compromises anchorage-independent growth and plasma membrane endocytosis in cancer cells

10.1016/j.jlr.2022.100281 · 2022 · External reference

Serine restriction alters sphingolipid diversity to constrain tumour growth

10.1038/s41586-020-2609-x · 2020 · External reference

The cGAS-STING pathway as a therapeutic target in inflammatory diseases

10.1038/s41577-021-00524-z · 2021 · External reference

cGAS in action: Expanding roles in immunity and inflammation

10.1126/science.aat8657 · 2019 · External reference

New frontiers in the cGAS-STING intracellular DNA-sensing pathway

10.1016/j.immuni.2024.02.019 · 2024 · External reference

Mitochondrial DNA stress primes the antiviral innate immune response

10.1038/nature14156 · 2015 · External reference

Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway

10.1038/s12276-023-00965-7 · 2023 · External reference

Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA

10.1016/j.cell.2014.11.037 · 2014 · External reference

Mitochondrial DNA in inflammation and immunity

10.15252/embr.201949799 · 2020 · External reference

Serine Depletion Promotes Antitumor Immunity by Activating Mitochondrial DNA-Mediated cGAS-STING Signaling

10.1158/0008-5472.can-23-1788 · 2024 · External reference

Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy

10.1038/s41590-020-0751-0 · 2020 · External reference

Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury

10.1016/j.celrep.2019.09.050 · 2019 · External reference

Mitochondrial dysfunction acts as a modulator of the immunometabolic route for activating the cytosolic DNA sensor pathway in triggering innate immunosurveillance

10.1186/s12967-025-07392-4 · 2025 · External reference

Mitochondrial DNA: leakage, recognition and associated human diseases

10.1093/jb/mvaf037 · 2025 · External reference

1-Deoxysphinganine initiates adaptive responses to serine and glycine starvation in cancer cells via proteolysis of sphingosine kinase

10.1016/j.jlr.2021.100154 · 2022 · External reference

L-Serine Deficiency Elicits Intracellular Accumulation of Cytotoxic Deoxysphingolipids and Lipid Body Formation

10.1074/jbc.m114.603860 · 2015 · External reference

Serine Supports Epithelial and Immune Cell Function in Colitis

10.1016/j.ajpath.2024.01.021 · 2024 · External reference

A disease-causing mutation in the active site of serine palmitoyltransferase causes catalytic promiscuity

10.1074/jbc.m110.122259 · 2010 · External reference

HSAN1 mutations in serine palmitoyltransferase reveal a close structure-function-phenotype relationship

10.1093/hmg/ddv611 · 2016 · External reference

Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism

10.1016/j.celrep.2018.03.017 · 2018 · External reference

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

10.1038/ng.890 · 2011 · External reference

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

10.1038/nature11743 · 2013 · External reference

Exogenous and Endogenous Sources of Serine Contribute to Colon Cancer Metabolism, Growth, and Resistance to 5-Fluorouracil

10.1158/0008-5472.can-20-1541 · 2021 · External reference

Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

10.1158/2159-8290.cd-19-1228 · 2020 · External reference

Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting

10.1016/j.cmet.2019.02.015 · 2019 · External reference

Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells

10.1016/j.celrep.2014.04.045 · 2014 · External reference

Modulating the therapeutic response of tumours to dietary serine and glycine starvation

10.1038/nature22056 · 2017 · External reference

ASCT2 is a major contributor to serine uptake in cancer cells

10.1016/j.celrep.2024.114552 · 2024 · External reference

Lineage-specific silencing of PSAT1 induces serine auxotrophy and sensitivity to dietary serine starvation in luminal breast tumors

10.1016/j.celrep.2021.110278 · 2022 · External reference

PHGDH supports liver ceramide synthesis and sustains lipid homeostasis

10.1186/s40170-020-00212-x · 2020 · External reference

Novel synthesis and biological evaluation of enigmols as therapeutic agents for treating prostate cancer

10.1021/ml2000164 · 2011 · External reference

Enigmol: a novel sphingolipid analogue with anticancer activity against cancer cell lines and in vivo models for intestinal and prostate cancer

10.1158/1535-7163.mct-10-0754 · 2011 · External reference

Kahalalide F and ES285: potent anticancer agents from marine molluscs

10.1007/978-3-540-30880-5_16 · 2006 · External reference

Homospisulosine induced apoptosis in cervical carcinoma cells is associated with phosphorylation of Bcl-2 and up-regulation of p27/Kip1

10.32725/jab.2023.019 · 2023 · External reference

1-deoxysphingolipids dysregulate membrane properties and cargo trafficking in the early secretory pathway

10.1016/j.chembiol.2025.12.006 · 2026 · External reference

1-Deoxysphingolipids Require Very-Long-Chain Ceramide Synthesis to Induce ER Stress and cytotoxicity

10.1016/j.jbc.2026.113281 · 2026 · External reference

Mitochondria-Associated Endoplasmic Reticulum Membranes in Human Health and Diseases

10.1002/mco2.70259 · 2025 · External reference

ER Stress-Sensor Proteins and ER-Mitochondrial Crosstalk-Signaling Beyond (ER) Stress Response

10.3390/biom11020173 · 2021 · External reference

Endoplasmic reticulum stress-induced complex I defect: Central role of calcium overload

10.1016/j.abb.2020.108299 · 2020 · External reference

Structural and functional link between the mitochondrial network and the endoplasmic reticulum

10.1016/j.biocel.2009.04.010 · 2009 · External reference

Insulin-regulated serine and lipid metabolism drive peripheral neuropathy

10.1038/s41586-022-05637-6 · 2023 · External reference

Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1

10.1172/jci57549 · 2011 · External reference

Phase I safety, pharmacokinetic, and pharmacogenomic trial of ES-285, a novel marine cytotoxic agent, administered to adult patients with advanced solid tumors

10.1158/1535-7163.mct-08-1167 · 2009 · External reference

Spisulosine (ES-285) given as a weekly three-hour intravenous infusion: results of a phase I dose-escalating study in patients with advanced solid malignancies

10.1007/s00280-011-1612-1 · 2011 · External reference

Bloom syndrome protein restrains innate immune sensing of micronuclei by cGAS

10.1084/jem.20181329 · 2019 · External reference

Sphingolipid analysis by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS)

10.1007/978-1-4419-6741-1_3 · 2010 · External reference

Comprehensive quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry

10.1007/978-1-60761-322-0_22 · 2009 · External reference

Quantifying 1-deoxydihydroceramides and 1-deoxyceramides in mouse nervous system tissue

10.1016/j.prostaglandins.2019.02.005 · 2019 · External reference