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References from CAR-engineered microglia harness phagocytosis to target brain tumor in organoid models. Local targets link to admitted publications; unresolved targets remain external evidence.
CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2017-2021
10.1093/neuonc/noae145 · 2024 · External reference
Advances in Glioblastoma Therapy: An Update on Current Approaches
10.3390/brainsci13111536 · 2023 · External reference
Survival prediction in glioblastoma: 10-year follow-up from the Dutch Neurosurgery Quality Registry
10.1007/s11060-025-05080-3 · 2025 · External reference
Radiotherapy plus concomitant adjuvant temozolomide for glioblastoma: Japanese mono-institutional results
10.1371/journal.pone.0078943 · 2013 · External reference
Emerging Cellular Therapies for Cancer
10.1146/annurev-immunol-042718-041407 · 2019 · External reference
CAR T cell immunotherapy for human cancer
10.1126/science.aar6711 · 2018 · External reference
Global research trends in CAR-T cell therapy for solid tumors: A comprehensive visualization and bibliometric study (2012-2023)
10.1080/21645515.2024.2338984 · 2024 · External reference
HER2-Specific Chimeric Antigen Receptor-Modified Virus-Specific T Cells for Progressive Glioblastoma: A Phase 1 Dose-Escalation Trial
10.1001/jamaoncol.2017.0184 · 2017 · External reference
Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy
10.1056/nejmoa1610497 · 2016 · External reference
A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma
2017 · External reference
Intraventricular CARv3-TEAM-E T Cells in Recurrent Glioblastoma
10.1056/nejmoa2314390 · 2024 · External reference
Intrathecal bivalent CAR T cells targeting EGFR and IL13Ralpha2 in recurrent glioblastoma: phase 1 trial interim results
10.1038/s41591-024-02893-z · 2024 · External reference
Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors (vol 24, pg 1459, 2018)
10.1038/s41591-019-0355-0 · 2019 · External reference
T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma
10.1158/1078-0432.ccr-17-1846 · 2018 · External reference
Immune profiling of human tumors identifies CD73 as a combinatorial target in glioblastoma
10.1038/s41591-019-0694-x · 2020 · External reference
The complex role of tumor-infiltrating macrophages
10.1038/s41590-022-01267-2 · 2022 · External reference
Depletion of tristetraprolin in breast cancer cells increases interleukin-16 expression and promotes tumor infiltration with monocytes/macrophages
10.1093/carcin/bgs387 · 2013 · External reference
The degree of macrophage infiltration into the cancer cell nest is a significant predictor of survival in gastric cancer patients
2003 · External reference
Targeting inflammation with chimeric antigen receptor macrophages using a signal switch
10.1038/s41551-025-01387-8 · 2025 · External reference
Engineered CD147-CAR macrophages for enhanced phagocytosis of cancers
10.1007/s00262-024-03759-6 · 2024 · External reference
Human chimeric antigen receptor macrophages for cancer immunotherapy
10.1038/s41587-020-0462-y · 2020 · External reference
A second-generation M1-polarized CAR macrophage with antitumor efficacy
10.1038/s41590-023-01687-8 · 2024 · External reference
Role of microglia in glioma biology
10.1002/jemt.1125 · 2001 · External reference
Microglia function in brain tumors
10.1002/jnr.20485 · 2005 · External reference
Review: Molecular mechanism of microglia stimulated glioblastoma invasion
10.1016/j.matbio.2013.07.008 · 2013 · External reference
Microglia phagocytic mechanisms: Development informing disease
10.1016/j.conb.2024.102877 · 2024 · External reference
Phagocytosis of microglia in the central nervous system diseases
10.1007/s12035-013-8620-6 · 2014 · External reference
The Role of Microglia in Glioblastoma
2020 · External reference
Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids
10.1038/s41467-022-28043-y · 2022 · External reference
Brain organoids for the study of human neurobiology at the interface of in vitro and in vivo
10.1038/s41593-020-00730-3 · 2020 · External reference
An in vivo neuroimmune organoid model to study human microglia phenotypes
10.1016/j.cell.2023.04.022 · 2023 · External reference
Genetic mutation patterns among glioblastoma patients in the Taiwanese population - insights from a single institution retrospective study
10.1038/s41417-024-00746-y · 2024 · External reference
Epidermal Growth Factor Receptor Variant III (EGFRvIII) Positivity in -Amplified Glioblastomas: Prognostic Role and Comparison between Primary and Recurrent Tumors
10.1158/1078-0432.ccr-17-0890 · 2017 · External reference
Microglia in the cerebral wall of the human telencephalon at second trimester
10.1093/cercor/bhh194 · 2005 · External reference
ATP mediates rapid microglial response to local brain injury in vivo
10.1038/nn1472 · 2005 · External reference
Fcγ receptor signaling in primary human microglia:: differential roles of PI-3K and Ras/ERK MAPK pathways in phagocytosis and chemokine induction
10.1189/jlb.0403128 · 2004 · External reference
Chimeric antigen receptors that trigger phagocytosis
10.7554/elife.36688 · 2018 · External reference
EGFRVIII and EGFR targeted chimeric antigen receptor T cell therapy in glioblastoma
10.3389/fonc.2024.1434495 · 2024 · External reference
Apoptotic Signaling Pathways in Glioblastoma and Therapeutic Implications
10.1155/2017/7403747 · 2017 · External reference
Biomimetic GBM-targeted drug delivery system boosting ferroptosis for immunotherapy of orthotopic drug-resistant GBM
2022 · External reference
Microglia in Glioblastomas: Molecular Insight and Immunotherapeutic Potential
10.3390/cancers16111972 · 2024 · External reference
Tumor microenvironment in glioblastoma: Current and emerging concepts
2023 · External reference
Molecular Pathways: Activating T Cells after Cancer Cell Phagocytosis from Blockade of CD47 “Don't Eat Me” Signals
10.1158/1078-0432.ccr-14-2520 · 2015 · External reference
The MHC class I-LILRB1 signalling axis as a promising target in cancer therapy
10.1111/sji.12804 · 2019 · External reference
Immunogenic chemotherapy: Dose and schedule dependence and combination with immunotherapy
10.1016/j.canlet.2018.01.050 · 2018 · External reference
Outlook for New CAR-Based Therapies with a Focus on CAR NK Cells: What Lies Beyond CAR-Engineered T Cells in the Race against Cancer
10.1158/2159-8290.cd-20-0556 · 2021 · External reference
CAR-T cell therapy: current limitations and potential strategies
10.1038/s41408-021-00459-7 · 2021 · External reference
CAR-T cell therapy in multiple myeloma: Current limitations and potential strategies
2023 · External reference
Signaling pathways in phagocytosis
10.1002/(sici)1521-1878(199905)21:5<422::aid-bies9>3.0.co;2-# · 1999 · External reference
Information processing during phagocytosis
10.1038/nri3244 · 2012 · External reference
Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma
10.1038/s41467-020-20599-x · 2021 · External reference
IL15 modification enables CAR T cells to act as a dual targeting agent against tumor cells and myeloid-derived suppressor cells in GBM
10.1136/jitc-2022-006239 · 2023 · External reference
Armored bicistronic CAR T cells with dominant-negative TGF-beta receptor II to overcome resistance in glioblastoma
10.1016/j.ymthe.2024.07.020 · 2024 · External reference
CAR T cells, CAR NK cells, and CAR macrophages exhibit distinct traits in glioma models but are similarly enhanced when combined with cytokines
2025 · External reference
Repeated peripheral infusions of anti-EGFRvIII CAR T cells in combination with pembrolizumab show no efficacy in glioblastoma: a phase 1 trial
10.1038/s43018-023-00709-6 · 2024 · External reference
Integrated analysis of multimodal single-cell data
10.1016/j.cell.2021.04.048 · 2021 · External reference
The single-cell transcriptional landscape of mammalian organogenesis
10.1038/s41586-019-0969-x · 2019 · External reference
A simple metastatic brain cancer model using human embryonic stem cell-derived cerebral organoids
10.1096/fj.202000372r · 2020 · External reference