Research graph
References from A single residue in the Gc protein dictates neutralization sensitivity and virulence in SFTSV. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
External reference
Severe fever with thrombocytopenia syndrome virus: emerging novel phlebovirus and their control strategy
10.1038/s12276-021-00610-1 · 2021 · External reference
Phylogenetic and Geographic Relationships of Severe Fever With Thrombocytopenia Syndrome Virus in China, South Korea, and Japan
10.1093/infdis/jiv144 · 2015 · External reference
Severe fever with thrombocytopenia syndrome, an emerging tick-borne zoonosis
10.1016/s1473-3099(14)70718-2 · 2014 · External reference
Fever with thrombocytopenia associated with a novel bunyavirus in China
10.1056/nejmoa1010095 · 2011 · External reference
Structure of severe fever with thrombocytopenia syndrome virus L protein elucidates the mechanisms of viral transcription initiation
10.1038/s41564-020-0712-2 · 2020 · External reference
Cryo-EM structure of severe fever with thrombocytopenia syndrome virus
10.1038/s41467-023-41804-7 · 2023 · External reference
The Role of Non-Structural Protein NSs in the Pathogenesis of Severe Fever with Thrombocytopenia Syndrome
10.3390/v13050876 · 2021 · External reference
Multiple Genotypes and Reassortants of Severe Fever With Thrombocytopenia Syndrome Virus Co-Circulating in Hangzhou in Southeastern China, 2013-2023
10.1002/jmv.70029 · 2024 · External reference
Molecular genomic characterization of tick- and human-derived severe fever with thrombocytopenia syndrome virus isolates from South Korea
10.1371/journal.pntd.0005893 · 2017 · External reference
A new phlebovirus associated with severe febrile illness in Missouri
10.1056/nejmoa1203378 · 2012 · External reference
Notes from the field: Heartland virus disease - United States, 2012-2013
2014 · External reference
A novel tick-borne phlebovirus, closely related to severe fever with thrombocytopenia syndrome virus and Heartland virus, is a potential pathogen
10.1038/s41426-018-0093-2 · 2018 · External reference
Entry of severe fever with thrombocytopenia syndrome virus
10.1007/s12250-016-3858-6 · 2017 · External reference
Bispecific antibodies targeting two glycoproteins on SFTSV exhibit synergistic neutralization and protection in a mouse model
10.1073/pnas.2400163121 · 2024 · External reference
Molecular mechanism of potently neutralizing human monoclonal antibodies against severe fever with thrombocytopenia virus infection
10.1128/jvi.00533-25 · 2025 · External reference
A broadly protective antibody targeting glycoprotein Gn inhibits severe fever with thrombocytopenia syndrome virus infection
10.1038/s41467-024-51108-z · 2024 · External reference
Neutralizing mAbs against SFTS Virus Gn Protein Show Strong Therapeutic Effects in an SFTS Animal Model
10.3390/v14081665 · 2022 · External reference
A single-domain antibody inhibits SFTSV and mitigates virus-induced pathogenesis in vivo
10.1172/jci.insight.136855 · 2020 · External reference
Identification and characterization of three monoclonal antibodies targeting the SFTSV glycoprotein and displaying a broad spectrum recognition of SFTSV-related viruses
10.1371/journal.pntd.0012216 · 2024 · External reference
A rationally designed cocktail of nanobodies elicited by heterologous vaccination confers protection against SFTSV in preclinical models
10.1126/scitranslmed.ady9025 · 2025 · External reference
Discovery and characterization of potent broadly neutralizing antibodies from human survivors of severe fever with thrombocytopenia syndrome
10.1016/j.ebiom.2024.105481 · 2025 · External reference
A natural variation in the RNA polymerase of severe fever with thrombocytopenia syndrome virus enhances viral replication and in vivo virulence
10.1002/jmv.29099 · 2023 · External reference
N-glycosylation of viral glycoprotein is a novel determinant for the tropism and virulence of highly pathogenic tick-borne bunyaviruses
10.1371/journal.ppat.1012348 · 2024 · External reference
Two amino acid pairs in the Gc glycoprotein of severe fever with thrombocytopenia syndrome virus responsible for the enhanced virulence
10.1016/j.virol.2024.110294 · 2025 · External reference
Cross-genotype protection of live-attenuated vaccine candidate for severe fever with thrombocytopenia syndrome virus in a ferret model
10.1073/pnas.1914704116 · 2019 · External reference
The mRNA vaccine encoding Gc protein confers complete protection against severe fever with thrombocytopaenia syndrome virus
10.1016/j.vaccine.2025.127631 · 2025 · External reference
Comparative analysis of the efficacy of vaccines using structural protein subunits of the severe fever with thrombocytopenia syndrome virus
10.3389/fmicb.2024.1348276 · 2024 · External reference
Adenovirus type 5-expressing Gn induces better protective immunity than Gc against SFTSV infection in mice
10.1038/s41541-024-00993-y · 2024 · External reference
Recent Advances in Therapeutics for Severe Fever with Thrombocytopenia Syndrome Virus. Viruses 17
10.3390/v17091174 · 2025 · External reference
A potent Gc neutralizing antibody reveals architecture-dependent bispecific protection against SFTSV
10.1080/22221751.2026.2645854 · 2026 · External reference
Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes
10.1038/nature22365 · 2017 · External reference
A Zika virus envelope mutation preceding the 2015 epidemic enhances virulence and fitness for transmission
10.1073/pnas.2005722117 · 2020 · External reference
A single mutation in the prM protein of Zika virus contributes to fetal microcephaly
10.1126/science.aam7120 · 2017 · External reference
Viral warriors: Unlocking the immune system's potential with oncolytic viruses in cancer immunotherapy. Molecular therapy
2025 · External reference
RNA Helicase A/DHX9 Forms Unique Cytoplasmic Antiviral Granules That Restrict Oncolytic Myxoma Virus Replication in Human Cancer Cells
10.1128/jvi.00151-21 · 2021 · External reference
Severe fever with thrombocytopenia syndrome virus NSs: a multifaceted viral protein in host-virus interactions
10.1016/j.coviro.2025.101495 · 2025 · External reference
Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures
10.1099/vir.0.83391-0 · 2008 · External reference
Interaction of Newcastle disease virus V protein with EFTUD2 modulates MDA5 pathway to suppress viral replication
10.1016/j.psj.2025.105470 · 2025 · External reference
EFTUD2 Is a Novel Innate Immune Regulator Restricting Hepatitis C Virus Infection through the RIG-I/MDA5 Pathway
10.1128/jvi.00364-15 · 2015 · External reference
NF-κB pathway and the Goldilocks principle: Lessons from human disorders of immunity and inflammation
10.1016/j.jaci.2019.03.016 · 2019 · External reference
Isolation, characterization, and phylogenic analysis of three new severe fever with thrombocytopenia syndrome bunyavirus strains derived from Hubei Province, China
10.1007/s12250-017-3953-3 · 2017 · External reference
Novel SFTSV Phylogeny Reveals New Reassortment Events and Migration Routes
10.1007/s12250-020-00289-0 · 2021 · External reference
A nanoluciferase SFTSV for rapid screening antivirals and real-time visualization of virus infection in mice
10.1016/j.ebiom.2023.104944 · 2024 · External reference
