Research graph
References from Genome-wide CRISPR screening identified hemojuvelin as a non-neuronal receptor for the botulinum neurotoxin serotypes A and C. Local targets link to admitted publications; unresolved targets remain external evidence.
Discovery of Dipeptides as Potent Botulinum Neurotoxin A Light-Chain Inhibitors
10.1021/acsmedchemlett.0c00674 · 2021 · External reference
Botulinum and Tetanus Neurotoxins
10.1146/annurev-biochem-013118-111654 · 2019 · External reference
Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons
10.1091/mbc.e08-07-0765 · 2008 · External reference
Association of botulinum neurotoxin serotypes a and B with synaptic vesicle protein complexes
10.1021/bi602396x · 2007 · External reference
Delivery of single-domain antibodies into neurons using a chimeric toxin-based platform is therapeutic in mouse models of botulism
10.1126/scitranslmed.aaz4197 · 2021 · External reference
Structural basis of the pH-dependent assembly of a botulinum neurotoxin complex
10.1016/j.jmb.2014.09.009 · 2014 · External reference
Identification and characterization of a novel botulinum neurotoxin
2017 · External reference
Cytotoxicity of botulinum neurotoxins reveals a direct role of syntaxin 1 and SNAP-25 in neuron survival
10.1038/ncomms2462 · 2013 · External reference
Gangliosides interact with synaptotagmin to form the high-affinity receptor complex for botulinum neurotoxin B
10.1073/pnas.1908051116 · 2019 · External reference
Ganglioside GT1b as a complementary receptor component for Clostridium botulinum neurotoxins
10.1006/mpat.1998.0214 · 1998 · External reference
Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor
10.1111/j.1471-4159.2009.06298.x · 2009 · External reference
SV2 is the protein receptor for botulinum neurotoxin A
10.1126/science.1123654 · 2006 · External reference
Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors
10.1371/journal.ppat.1002008 · 2011 · External reference
Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells
10.1083/jcb.200305098 · 2003 · External reference
Mechanism of botulinum neurotoxin B and G entry into hippocampal neurons
10.1083/jcb.200707184 · 2007 · External reference
Synaptotagmins I and II act as nerve cell receptors for botulinum neurotoxin G
10.1074/jbc.m403945200 · 2004 · External reference
The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sites
10.1111/j.1365-2958.2011.07682.x · 2011 · External reference
Unique ganglioside binding by botulinum neurotoxins C and D-SA
10.1111/j.1742-4658.2011.08166.x · 2011 · External reference
Cell internalization and traffic pathway of Clostridium botulinum type C neurotoxin in HT-29 cells
10.1016/j.bbamcr.2005.11.014 · 2006 · External reference
Clinical uses of botulinum neurotoxins: current indications, limitations and future developments
10.3390/toxins4100913 · 2012 · External reference
TFPI is a colonic crypt receptor for TcdB from hypervirulent clade 2 C. difficile
10.1016/j.cell.2022.02.010 · 2022 · External reference
Binding of Clostridium botulinum type C and D neurotoxins to ganglioside and phospholipid. Novel insights into the receptor for clostridial neurotoxins
10.1074/jbc.m507596200 · 2005 · External reference
A Cell Line for Detection of Botulinum Neurotoxin Type B
10.3389/fphar.2017.00796 · 2017 · External reference
Transferrin receptors
10.1038/s12276-025-01436-x · 2025 · External reference
Hemojuvelin regulates the innate immune response to peritoneal bacterial infection in mice
10.1038/celldisc.2017.28 · 2017 · External reference
Hemojuvelin is a novel suppressor for Duchenne muscular dystrophy and age-related muscle wasting
10.1002/jcsm.12414 · 2019 · External reference
Plasminogen Receptors Promote Lipoprotein(a) Uptake by Enhancing Surface Binding and Facilitating Macropinocytosis
10.1161/atvbaha.123.319344 · 2023 · External reference
Cholesterol-induced LRP3 downregulation promotes cartilage degeneration in osteoarthritis by targeting Syndecan-4
10.1038/s41467-022-34830-4 · 2022 · External reference
Low-density lipoprotein receptor family: endocytosis and signal transduction
10.1385/mn:23:1:53 · 2001 · External reference
Botulinum neurotoxin serotype C associates with dual ganglioside receptors to facilitate cell entry
10.1074/jbc.m112.404244 · 2012 · External reference
The liver and muscle secreted HFE2-protein maintains central nervous system blood vessel integrity
10.1038/s41467-024-45303-1 · 2024 · External reference
Skeletal muscle hemojuvelin is dispensable for systemic iron homeostasis
10.1182/blood-2010-12-327957 · 2011 · External reference
Interaction of hemojuvelin with neogenin results in iron accumulation in human embryonic kidney 293 cells
10.1074/jbc.m506207200 · 2005 · External reference
Recent progress in the synthesis of glycosphingolipids
10.1016/j.cbpa.2023.102423 · 2024 · External reference
Two Feet on the Membrane: Uptake of Clostridial Neurotoxins
2017 · External reference
Negative chronotropic effect of botulinum toxin on neonatal rat cardiac myocytes
10.1006/bbrc.1998.8188 · 1998 · External reference
Cellular electrophysiological effects of botulinum toxin A on neonatal rat cardiomyocytes and on cardiomyocytes derived from human-induced pluripotent stem cells
10.1007/s00210-022-02332-1 · 2023 · External reference
Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD
10.1007/s00109-009-0447-2 · 2009 · External reference
Hepatic and extrahepatic expression of the new iron regulatory protein hemojuvelin
2004 · External reference
Complex biosynthesis of the muscle-enriched iron regulator RGMc
10.1242/jcs.03074 · 2006 · External reference
Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin
10.1182/blood-2005-05-1845 · 2005 · External reference
Transmembrane serine protease 6, a novel target for inhibition of neuronal tumor growth
10.1038/s41419-024-06442-x · 2024 · External reference
EGFP/RFP-based FRET sensors for botulinum neurotoxin A biological activity detection and methodological validation
10.1016/j.aca.2024.343546 · 2025 · External reference
