Research graph
References from Rational design of protease-resistant lipopeptides for combating antibiotic-resistant bacteria. Local targets link to admitted publications; unresolved targets remain external evidence.
Probing key elements of teixobactin-lipid II interactions in membranes
10.1039/c8sc02616e · 2018 · External reference
Will 10 Million People Die a Year due to Antimicrobial Resistance by 2050?
10.1371/journal.pmed.1002184 · 2016 · External reference
Antimicrobial Peptides: Amphibian Host Defense Peptides
10.2174/0929867325666180713125314 · 2019 · External reference
Bioinspired Designs, Molecular Premise and Tools for Evaluating the Ecological Importance of Antimicrobial Peptides
10.3390/ph11030068 · 2018 · External reference
Design of Heptad Repeat Amphiphiles Based on Database Filtering and Structure-Function Relationships to Combat Drug-Resistant Fungi and Biofilms
10.1021/acsami.9b19927 · 2020 · External reference
From Antimicrobial Peptides to Antimicrobial Poly(alpha-amino acid)s
10.1002/adhm.201800354 · 2018 · External reference
Mechanistic Landscape of Membrane-Permeabilizing Peptides
10.1021/acs.chemrev.8b00520 · 2019 · External reference
Host Defense Peptide Mimicking Peptide Polymer Exerting Fast, Broad Spectrum, and Potent Activities toward Clinically Isolated Multidrug-Resistant Bacteria
10.1021/acsinfecdis.9b00410 · 2020 · External reference
Host defense peptide mimicking poly-β-peptides with fast, potent and broad spectrum antibacterial activities
10.1039/c9bm00248k · 2019 · External reference
Cathelicidin-HG Alleviates Sepsis-Induced Platelet Dysfunction by Inhibiting GPVI-Mediated Platelet Activation
10.34133/research.0381 · 2024 · External reference
Susceptibility of Colistin-Resistant, Gram-Negative Bacteria to Antimicrobial Peptides and Ceragenins
10.1128/aac.00292-17 · 2017 · External reference
Degradation of human antimicrobial peptide LL-37 by Staphylococcus aureus-derived proteinases
10.1128/aac.48.12.4673-4679.2004 · 2004 · External reference
Cathelicidin family of antimicrobial peptides: proteolytic processing and protease resistance
10.1016/s0045-2068(03)00080-4 · 2003 · External reference
Towards Robust Delivery of Antimicrobial Peptides to Combat Bacterial Resistance
10.3390/molecules25133048 · 2020 · External reference
Antimicrobial Peptides: Diversity, Mechanism of Action and Strategies to Improve the Activity and Biocompatibility In Vivo
10.3390/biom8010004 · 2018 · External reference
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria
10.1021/acs.jmedchem.8b01348 · 2019 · External reference
Antimicrobial potency and selectivity of simplified symmetric-end peptides
10.1016/j.biomaterials.2014.06.005 · 2014 · External reference
Unresolved reference
1992 · External reference
Unnatural Amino Acid Side Chains as S1, S1 ', and S2 ' Probes Yield Cationic Antimicrobial Peptides with Stability toward Chymotryptic Degradation
10.1021/jm1006337 · 2010 · External reference
Serine protease mechanism and specificity
10.1021/cr000033x · 2002 · External reference
Evolutionary divergence of substrate specificity within the chymotrypsin-like serine protease fold
10.1074/jbc.272.48.29987 · 1997 · External reference
N-terminal fatty acylation of peptides spanning the cationic C-terminal segment of bovine beta-defensin-2 results in salt-resistant antibacterial activity
10.1016/j.bpc.2015.02.005 · 2015 · External reference
Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide
10.1042/bj20041270 · 2005 · External reference
The increased bactericidal activity of a fatty acid-modified synthetic antimicrobial peptide of human cathepsin G correlates with its enhanced capacity to interact with model membranes
10.1016/s0924-8579(02)00245-5 · 2003 · External reference
Enhancement of antibacterial and lipopolysaccharide binding activities of a human lactoferrin peptide fragment by the addition of acyl chain
10.1093/jac/dkg219 · 2003 · External reference
Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity
10.1016/j.ejmech.2019.111636 · 2019 · External reference
Lipidation of Antimicrobial Peptides as a Design Strategy for Future Alternatives to Antibiotics
10.3390/ijms21249692 · 2020 · External reference
Lipidated Analogs of the LL-37-Derived Peptide Fragment KR12 Structural Analysis, Surface-Active Properties and Antimicrobial Activity
10.3390/ijms21030887 · 2020 · External reference
Inhibition of fungal and bacterial plant pathogens in vitro and in planta with ultrashort cationic lipopeptides
10.1128/aem.01334-07 · 2007 · External reference
Peptide antibiotics
10.1016/s0140-6736(97)80051-7 · 1997 · External reference
Combating bacterial infections with host defense peptides: Shifting focus from bacteria to host immunity
10.1016/j.drup.2023.101030 · 2024 · External reference
Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice
10.1038/s41587-019-0222-z · 2019 · External reference
Comparing pH-responsive nanogel swelling in dispersion and inside a polyacrylamide gel using photoluminescence spectroscopy and small-angle neutron scattering
10.1016/j.jcis.2021.09.163 · 2022 · External reference
Optimized proteolytic resistance motif (DabW)-based U1-2WD: A membrane-induced self-aggregating peptide to trigger bacterial agglutination and death
10.1016/j.actbio.2022.09.038 · 2022 · External reference
Antimicrobial Peptides: An Overview of their Structure, Function and Mechanism of Action
10.2174/0929866529666220613102145 · 2022 · External reference
Strategies in Translating the Therapeutic Potentials of Host Defense Peptides
10.3389/fimmu.2020.00983 · 2020 · External reference
Antimicrobial peptides with protease stability: progress and perspective
10.4155/fmc-2019-0167 · 2019 · External reference
Effects of PEGylation on membrane and lipopolysaccharide interactions of host defense peptides
10.1021/bm401884e · 2014 · External reference
Cyclization increases the antimicrobial activity and selectivity of arginine- and tryptophan-containing hexapeptides
10.1021/bi035948v · 2004 · External reference
Proline-rich antimicrobial peptides: converging to a non-lytic mechanism of action
10.1007/s00018-011-0721-7 · 2011 · External reference
Proline-rich antimicrobial peptides targeting protein synthesis
10.1039/c7np00020k · 2017 · External reference
Effects of Lipidation on a Proline-Rich Antibacterial Peptide
10.3390/ijms22157959 · 2021 · External reference
Antimicrobial Activity of Cationic Antimicrobial Peptides against Gram-Positives: Current Progress Made in Understanding the Mode of Action and the Response of Bacteria
10.3389/fcell.2016.00111 · 2016 · External reference
Antimicrobial activity of short, synthetic cationic lipopeptides
10.1111/j.1747-0285.2010.00973.x · 2010 · External reference
Promotion of peptide antimicrobial activity by fatty acid conjugation
10.1021/bc0341573 · 2004 · External reference
Chemically modified and conjugated antimicrobial peptides against superbugs
10.1039/d0cs01026j · 2021 · External reference
Antibacterial activity of ultrashort cationic Lipo-β-peptides
10.1128/aac.01100-08 · 2009 · External reference
Immobilization Studies of an Engineered Arginine-Tryptophan Rich Peptide on a Silicone Surface with Antimicrobial and Antibiofilm Activity
10.1021/am401629p · 2013 · External reference
Interaction between amphiphilic peptides and phospholipid membranes
10.1016/j.cocis.2010.05.006 · 2010 · External reference
Effects of topology, length, and charge on the activity of a kininogen-derived peptide on lipid membranes and bacteria
10.1016/j.bbamem.2006.11.016 · 2007 · External reference
Effect of peptide length on the interaction between consensus peptides and DOPC/DOPA bilayers
10.1021/la060317y · 2006 · External reference
COLL 136-Composition effect on peptide interaction with lipids and bacteria: Variants of the C3a peptide CNY21. Abstr. Pap
2006 · External reference
Effects of pH and salinity on the antimicrobial properties of clavanins
10.1128/iai.65.7.2898-2903.1997 · 1997 · External reference
Synthetic lipopeptides: a novel class of anti-infectives
10.1517/13543784.16.8.1159 · 2007 · External reference
Conjugation of a magainin analogue with lipophilic acids controls hydrophobicity, solution assembly, and cell selectivity
10.1021/bi011549t · 2002 · External reference
A Comparative Study of the Antimicrobial and Structural Properties of Short Peptides and Lipopeptides Containing a Repetitive Motif KLFK. Protein Pept
2019 · External reference
The role of fatty acid unsaturation in minimizing biophysical changes on the structure and local effects of bilayer membranes
10.1016/j.bbamem.2009.04.002 · 2009 · External reference
N-Lipidated Peptide Dimers: Effective Antibacterial Agents against Gram-Negative Pathogens through Lipopolysaccharide Permeabilization
10.1021/acs.jmedchem.5b00628 · 2015 · External reference
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action
10.1016/j.ejmech.2014.06.003 · 2014 · External reference
Effect of hydrophobic modifications in antimicrobial peptides
10.1016/j.cis.2013.06.009 · 2014 · External reference
Anti-tuberculosis activity of alpha-helical antimicrobial peptides: De novo designed L- and D-Enantiomers versus L- and D-LL37. Protein Pept
2011 · External reference
Colistin and its role in the Era of antibiotic resistance: an extended review (2000-2019)
10.1080/22221751.2020.1754133 · 2020 · External reference
Conjugation of fatty acids with different lengths modulates the antibacterial and antifungal activity of a cationic biologically inactive peptide
10.1042/bj20050520 · 2005 · External reference
Ultrashort Cationic Lipopeptides-Effect of N-Terminal Amino Acid and Fatty Acid Type on Antimicrobial Activity and Hemolysis
10.3390/molecules25020257 · 2020 · External reference
Dependence on size and shape of non-nature amino acids in the enhancement of lipopolysaccharide (LPS) neutralizing activities of antimicrobial peptides
10.1016/j.jcis.2018.08.042 · 2019 · External reference
Role of lipids in the interaction of antimicrobial peptides with membranes
10.1016/j.plipres.2011.12.005 · 2012 · External reference
Antibiotic efficacy is linked to bacterial cellular respiration
10.1073/pnas.1509743112 · 2015 · External reference
Ginsenoside Rg3 enriches SCFA-producing commensal bacteria to confer protection against enteric viral infection via the cGAS-STING-type I IFN axis
10.1038/s41396-023-01541-7 · 2023 · External reference
Growth of Prebiotically Plausible Fatty Acid Vesicles Proceeds in the Presence of Prebiotic Amino Acids, Dipeptides, Sugars, and Nucleic Acid Components
10.1021/acs.langmuir.2c02118 · 2022 · External reference
Nitric oxide and the immune response
10.1038/ni1001-907 · 2001 · External reference
Arginine-dependent immune responses
10.1007/s00018-021-03828-4 · 2021 · External reference
Immunomodulatory Function of the Tumor Suppressor p53 in Host Immune Response and the Tumor Microenvironment
10.3390/ijms17111942 · 2016 · External reference
Role of p53 in the Regulation of the Inflammatory Tumor Microenvironment and Tumor Suppression
10.3390/cancers10070219 · 2018 · External reference
Systematically Studying the Optimal Amino Acid Distribution Patterns of the Amphiphilic Structure by Using the Ultrashort Amphiphiles
10.3389/fmicb.2020.569118 · 2020 · External reference
A new class of synthetic retinoid antibiotics effective against bacterial persisters
10.1038/nature26157 · 2018 · External reference
Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides
10.1021/acs.jmedchem.9b00477 · 2019 · External reference
Pharmacokinetic and pharmacodynamic properties of polymyxin B in Escherichia coli and Klebsiella pneumoniae murine infection models
10.1093/jac/dkad022 · 2023 · External reference
Rational Design of Short Peptide Variants by Using Kunitzin-RE, an Amphibian-Derived Bioactivity Peptide, for Acquired Potent Broad-Spectrum Antimicrobial and Improved Therapeutic Potential of Commensalism Coinfection of Pathogens
10.1021/acs.jmedchem.9b00149 · 2019 · External reference
Characterization of cell selectivity, physiological stability and endotoxin neutralization capabilities of alpha-helix-based peptide amphiphiles
10.1016/j.biomaterials.2015.02.063 · 2015 · External reference
A selective membrane-targeting repurposed antibiotic with activity against persistent methicillin-resistant Staphylococcus aureus
10.1073/pnas.1904700116 · 2019 · External reference
Short Symmetric-End Antimicrobia Peptides Centered on beta-Turn Amino Acids Unit Improve Selectivity and Stability
10.3389/fmicb.2018.02832 · 2018 · External reference
Cross-Strand Interaction, Central Bending, and Sequence Pattern Act as Biomodulators of Simplified beta-Hairpin Antimicrobial Amphiphiles
2021 · External reference
Highly Stabilized alpha-Helical Coiled Coils Kill Gram-Negative Bacteria by Multicomplementary Mechanisms under Acidic Condition
10.1021/acsami.9b04654 · 2019 · External reference
