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References from Hepatic FoxO1 loss leads to pancreatic β cell deficiency via liver-derived C18/22/24 ceramides. Local targets link to admitted publications; unresolved targets remain external evidence.
Targeting hepatic glucose metabolism in the treatment of type 2 diabetes
10.1038/nrd.2016.151 · 2016 · External reference
Let-7 underlies metformin-induced inhibition of hepatic glucose production
10.1073/pnas.2122217119 · 2022 · External reference
Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors
10.1038/ncomms6190 · 2014 · External reference
FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression
10.1074/jbc.m600272200 · 2006 · External reference
Novel FoxO1 inhibitor, JY-2, ameliorates palmitic acid-induced lipotoxicity and gluconeogenesis in a murine model
10.1016/j.ejphar.2021.174011 · 2021 · External reference
A review of FoxO1-regulated metabolic diseases and related drug discoveries
10.3390/cells9010184 · 2020 · External reference
Ginsenoside Rg1 inhibits glucagon-induced hepatic gluconeogenesis through Akt-FoxO1 interaction
10.7150/thno.18788 · 2017 · External reference
TRB1 negatively regulates gluconeogenesis by suppressing the transcriptional activity of FOXO1
10.1002/1873-3468.13314 · 2019 · External reference
Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism
2006 · External reference
Phytochemicals targeting NAFLD through modulating the dual function of forkhead box O1 (FOXO1) transcription factor signaling pathways
10.1007/s00210-022-02234-2 · 2022 · External reference
FoxO1 knockdown promotes fatty acid synthesis via modulating SREBP1 activities in the dairy goat mammary epithelial cells
10.1021/acs.jafc.0c05237 · 2020 · External reference
Inter-organ crosstalk during development and progression of type 2 diabetes mellitus
10.1038/s41574-023-00898-1 · 2024 · External reference
Enhanced dynorphin expression and secretion in pancreatic beta-cells under hyperglycemic conditions
10.1016/j.molmet.2024.102088 · 2025 · External reference
RACking up ceramide-induced islet β-cell dysfunction
10.1016/j.bcp.2018.04.026 · 2018 · External reference
Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity
10.1186/s12864-020-07003-0 · 2020 · External reference
Low-grade elevation of palmitate and lipopolysaccharide synergistically induced β-cell damage via inhibition of neutral ceramidase
10.1016/j.mce.2021.111473 · 2022 · External reference
A primary role for α-cells as amino acid sensors
10.2337/dbi19-0021 · 2020 · External reference
Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal
10.1016/j.stem.2022.08.008 · 2022 · External reference
Cardiovascular risk in fatty liver disease: the liver-heart axis-literature review
10.3389/fmed.2019.00202 · 2019 · External reference
Therapeutic strategies targeting FOXO transcription factors
10.1038/s41573-020-0088-2 · 2020 · External reference
Legacy effect of Foxo1 in pancreatic endocrine progenitors on adult β-cell mass and function
10.2337/db14-1696 · 2015 · External reference
Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure
10.1016/j.cell.2012.07.029 · 2012 · External reference
Forkhead factor FoxO1 is essential for placental morphogenesis in the developing embryo
10.1073/pnas.1107341108 · 2011 · External reference
Different roles of insulin receptor a and b in maintaining blood glucose homeostasis in zebrafish
10.1016/j.ygcen.2018.08.012 · 2018 · External reference
Generation of targeted mutations in zebrafish using the CRISPR/Cas system
10.1007/978-1-4939-2917-7_16 · 2015 · External reference
Discovery of novel forkhead box O1 inhibitors for treating type 2 diabetes: improvement of fasting glycemia in diabetic db/db mice
10.1124/mol.110.065714 · 2010 · External reference
An insulin-independent mechanism for transcriptional regulation of Foxo1 in type 2 diabetic mice
10.1016/j.jbc.2021.100846 · 2021 · External reference
Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis
10.1038/cdd.2013.139 · 2014 · External reference
A global perspective on FOXO1 in lipid metabolism and lipid-related diseases
10.1016/j.plipres.2017.04.002 · 2017 · External reference
Fatty acid and lipopolysaccharide effect on beta cells proteostasis and its impact on insulin secretion
10.3390/cells8080884 · 2019 · External reference
Inhibition of ceramide synthesis ameliorates glucocorticoid-saturated-fat-and obesity-induced insulin resistance
10.1016/j.cmet.2007.01.002 · 2007 · External reference
Kicking off sphingolipid biosynthesis: structures of the serine palmitoyltransferase complex
10.1038/s41594-021-00562-0 · 2021 · External reference
Mammalian target of rapamycin (mTOR): pro- and anti-apoptotic
10.1038/sj.cdd.4400978 · 2002 · External reference
Ceramide-induced inhibition of Akt is mediated through protein kinase Czeta: implications for growth arrest
10.1074/jbc.m110541200 · 2002 · External reference
Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis
10.1073/pnas.2017152117 · 2020 · External reference
The role of mTOR signaling as a therapeutic target in cancer
10.3390/ijms22041743 · 2021 · External reference
Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism
10.1016/s1388-1981(03)00059-3 · 2003 · External reference
The ceramide synthase (CERS/LASS) family: functions involved in cancer progression
10.1007/s13402-023-00798-6 · 2023 · External reference
Emerging roles and therapeutic potentials of sphingolipids in pathophysiology: emphasis on fatty acyl heterogeneity
10.1016/j.jgg.2023.06.006 · 2024 · External reference
Role of FoxO proteins in pancreatic beta cells
10.1507/endocrj.kr-109 · 2007 · External reference
FoxO1 plays an important role in regulating beta-cell compensation for insulin resistance in male mice
10.1210/en.2015-1852 · 2016 · External reference
FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction
10.1016/j.cmet.2005.08.004 · 2005 · External reference
Interrupted glucagon signaling reveals hepatic α cell axis and role for L-glutamine in α cell proliferation
10.1016/j.cmet.2017.05.011 · 2017 · External reference
RIPK3-mediated inflammation is a conserved β cell response to ER stress
10.1126/sciadv.abd7272 · 2020 · External reference
Roles of ceramides and other sphingolipids in immune cell function and inflammation
10.1007/978-3-030-21735-8_15 · 2019 · External reference
Metabolic Messengers: ceramides
10.1038/s42255-019-0134-8 · 2019 · External reference
Sensing ceramides by CYSLTR2 and P2RY6 to aggravate atherosclerosis
10.1038/s41586-025-08792-8 · 2025 · External reference
Roles of ceramide and sphingolipids in pancreatic β-cell function and dysfunction
10.4161/isl.20102 · 2012 · External reference
Destabilization of β cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes
10.1073/pnas.2113074119 · 2022 · External reference
The role of ceramides in metabolic disorders: when size and localization matters
10.1038/s41574-020-0320-5 · 2020 · External reference
High-fat feeding drives the intestinal production and assembly of C16:0 ceramides in chylomicrons
10.1126/sciadv.adp2254 · 2024 · External reference
Localization, topology, and function of the LCB1 subunit of serine palmitoyltransferase in mammalian cells
10.1074/jbc.m209602200 · 2003 · External reference
Ceramide synthases are attractive drug targets for treating metabolic diseases
10.3389/fendo.2020.00483 · 2020 · External reference
Enzyme activities of the ceramide synthases CERS2-6 are regulated by phosphorylation in the c-terminal region
10.1074/jbc.m115.695858 · 2016 · External reference
Akt-dependent and -independent mechanisms of mTOR regulation in cancer
10.1016/j.cellsig.2009.01.004 · 2009 · External reference
Akt-dependent activation of mTORC1 complex involves phosphorylation of mTOR (mammalian target of rapamycin) by IκB kinase α (IKKα)
10.1074/jbc.m114.554881 · 2014 · External reference
Ceramide inhibits cell proliferation through Akt/PKB inactivation and decreases melanin synthesis in Mel-Ab cells
10.1034/j.1600-0749.2001.140206.x · 2001 · External reference
PP2A inhibitor SET promotes mTORC1 and Bmi1 signaling through Akt activation and maintains the colony-formation ability of cancer cells
10.1016/j.jbc.2023.105584 · 2024 · External reference
CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency
10.1126/science.aad5487 · 2016 · External reference
Metabolic signaling of ceramides through the FPR2 receptor inhibits adipocyte thermogenesis
10.1126/science.ado4188 · 2025 · External reference
Setdb2 restricts dorsal organizer territory and regulates left-right asymmetry through suppressing fgf8 activity
10.1073/pnas.0914396107 · 2010 · External reference
Requirement of vasculogenesis and blood circulation in late stages of liver growth in zebrafish
10.1186/1471-213x-8-84 · 2008 · External reference
Transgenesis in zebrafish with the tol2 transposon system
10.1007/978-1-60327-019-9_3 · 2009 · External reference
Isolation and culture of mouse hepatocytes and Kupffer cells (KCs)
10.1007/978-1-0716-2128-8_7 · 2022 · External reference
Third-generation in situ hybridization chain reaction: multiplexed, quantitative, sensitive, versatile, robust
10.1242/dev.165753 · 2018 · External reference
Talin-1 inhibits Smurf1-mediated Stat3 degradation to modulate β-cell proliferation and mass in mice
10.1038/s41419-023-06235-8 · 2023 · External reference
Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice
10.1038/s41467-019-14186-y · 2020 · External reference
A protocol for islet isolation from mouse pancreas
10.1038/nprot.2009.150 · 2009 · External reference
ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia
10.1101/gr.136184.111 · 2012 · External reference
Tissue-specific derepression of TCF/LEF controls the activity of the Wnt/β-catenin pathway
10.1038/ncomms6368 · 2014 · External reference
