Research graph
References from Arginine methylation in immunoregulation: Mechanisms and therapeutic targeting. Local targets link to admitted publications; unresolved targets remain external evidence.
Unconventional post-translational modifications in immunological signaling
10.1038/ni.2873 · 2014 · External reference
Arginine Methylation: The Coming of Age
10.1016/j.molcel.2016.11.003 · 2017 · External reference
The Influence of Arginine Methylation in Immunity and Inflammation
10.2147/jir.s364190 · 2022 · External reference
Proteome-wide analysis of arginine monomethylation reveals widespread occurrence in human cells
10.1126/scisignal.aaf7329 · 2016 · External reference
Protein arginine methylation in mammals: who, what, and why
10.1016/j.molcel.2008.12.013 · 2009 · External reference
PRMT9 is a type II methyltransferase that methylates the splicing factor SAP145
10.1038/ncomms7428 · 2015 · External reference
Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets RXR sites in lysine- and arginine-rich regions
10.1074/jbc.m113.525345 · 2013 · External reference
Histone arginine methylation
10.1016/j.febslet.2010.11.010 · 2011 · External reference
The role of arginine methylation in the DNA damage response
10.1016/j.dnarep.2013.04.006 · 2013 · External reference
Protein arginine methyltransferases and cancer
10.1038/nrc3409 · 2013 · External reference
Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt
10.1016/j.molcel.2008.09.013 · 2008 · External reference
Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt
10.1073/pnas.1015328108 · 2011 · External reference
Protein arginine methyltransferases in cancer: mechanisms, functions, and therapeutic opportunities
10.1186/s12929-026-01240-3 · 2026 · External reference
Arginine N-methyltransferase 1 is required for early postimplantation mouse development, but cells deficient in the enzyme are viable
10.1128/mcb.20.13.4859-4869.2000 · 2000 · External reference
Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice
10.1073/pnas.1232272100 · 2003 · External reference
Prmt5 is essential for early mouse development and acts in the cytoplasm to maintain ES cell pluripotency
10.1101/gad.606110 · 2010 · External reference
Loss-of-function mutation in PRMT9 causes abnormal synapse development by dysregulation of RNA alternative splicing
10.1038/s41467-024-47107-9 · 2024 · External reference
Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor
10.1093/nar/gks764 · 2012 · External reference
PRMT7 Preserves Satellite Cell Regenerative Capacity
10.1016/j.celrep.2016.01.022 · 2016 · External reference
PRMT8 as a phospholipase regulates Purkinje cell dendritic arborization and motor coordination
10.1126/sciadv.1500615 · 2015 · External reference
The protein arginine methyltransferase PRMT1 promotes TBK1 activation through asymmetric arginine methylation
10.1016/j.celrep.2021.109731 · 2021 · External reference
Protein arginine methyltransferase 1 modulates innate immune responses through regulation of peroxisome proliferator-activated receptor gamma-dependent macrophage differentiation
10.1074/jbc.m117.778761 · 2017 · External reference
Protein arginine methyltransferase 2 controls inflammatory signaling in acute myeloid leukemia
10.1038/s42003-024-06453-6 · 2024 · External reference
The CARM1 epigenetic enzyme inhibits cross-presenting dendritic cell function in cancer immunity
10.1126/science.aea1200 · 2026 · External reference
PRMT5 Is Required for T Cell Survival and Proliferation by Maintaining Cytokine Signaling
10.3389/fimmu.2020.00621 · 2020 · External reference
Prmt5 deficiency inhibits CD4+ T-cell Klf2/S1pr1 expression and ameliorates EAE disease
10.1186/s12974-023-02854-2 · 2023 · External reference
PRMT5 Associates With the FOXP3 Homomer and When Disabled Enhances Targeted p185(erbB2/neu) Tumor Immunotherapy
10.3389/fimmu.2019.00174 · 2019 · External reference
Prmt5 deficient mouse B cells display RNA processing complexity and slower colorectal tumor progression
10.1002/eji.202250226 · 2023 · External reference
Macrophage PRMT9 Ameliorates Acute Myocardial Infarction by Promoting Symmetric Dimethylation and Degradation of STAT1
10.1161/circulationaha.125.076101 · 2026 · External reference
Protein arginine methylation in transcription and epigenetic regulation
10.3389/freae.2023.1245832 · 2023 · External reference
Methylation of histone H3 by coactivator-associated arginine methyltransferase 1
10.1021/bi002631b · 2001 · External reference
PRMT1 Plays a Critical Role in Th17 Differentiation by Regulating Reciprocal Recruitment of STAT3 and STAT5
10.4049/jimmunol.1701654 · 2018 · External reference
PRMT2 promotes tumorigenic phenotypes through the Wnt signaling pathway and drives immune suppression in Colorectal cancer
10.1016/j.canlet.2025.217967 · 2025 · External reference
Hypoxia-inducible PRMT2 addiction in glioblastomas
10.1016/j.cellsig.2024.111094 · 2024 · External reference
Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17
10.1210/me.2005-0365 · 2006 · External reference
Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression
10.1038/sj.emboj.7600500 · 2005 · External reference
Nuclear carbonic anhydrase 6B associates with PRMT5 to epigenetically promote IL-12 expression in innate response
10.1073/pnas.1700917114 · 2017 · External reference
PRMT5 regulates epigenetic changes in suppressive Th1-like iTregs in response to IL-12 treatment
10.3389/fimmu.2023.1292049 · 2024 · External reference
PRMT5 Deficiency Enforces the Transcriptional and Epigenetic Programs of Klrg1(+)CD8(+) Terminal Effector T Cells and Promotes Cancer Development
10.4049/jimmunol.2100523 · 2022 · External reference
Myelocytomatosis-Protein Arginine N-Methyltransferase 5 Axis Defines the Tumorigenesis and Immune Response in Hepatocellular Carcinoma
10.1002/hep.31864 · 2021 · External reference
A gain-of-function mouse model identifies PRMT6 as a NF-kappaB coactivator
10.1093/nar/gku530 · 2014 · External reference
The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD
10.1038/s41467-022-28809-4 · 2022 · External reference
PRMT7 ablation stimulates anti-tumor immunity and sensitizes melanoma to immune checkpoint blockade
10.1016/j.celrep.2022.110582 · 2022 · External reference
BAF155 methylation drives metastasis by hijacking super-enhancers and subverting anti-tumor immunity
10.1093/nar/gkab1122 · 2021 · External reference
Inhibiting Type I Arginine Methyltransferase Activity Promotes T Cell-Mediated Antitumor Immune Responses
10.1158/2326-6066.cir-21-0614 · 2022 · External reference
Integrating genome-wide CRISPR immune screen with multi-omic clinical data reveals distinct classes of tumor intrinsic immune regulators
10.1136/jitc-2020-001819 · 2021 · External reference
Protein arginine methyltransferase 1 is a therapeutic vulnerability in multiple myeloma
2023 · External reference
PRMT1 acts as a suppressor of MHC-I and anti-tumor immunity
10.1016/j.celrep.2024.113831 · 2024 · External reference
PRMT3-mediated arginine methylation of IGF2BP1 promotes oxaliplatin resistance in liver cancer
10.1038/s41467-023-37542-5 · 2023 · External reference
PRMT5-Mediated ALKBH5 Methylation Promotes Colorectal Cancer Immune Evasion via Increasing CD276 Expression
10.34133/research.0549 · 2025 · External reference
PRMT5 Promotes Symmetric Dimethylation of RNA Processing Proteins and Modulates Activated T Cell Alternative Splicing and Ca(2+)/NFAT Signaling
10.4049/immunohorizons.2100076 · 2021 · External reference
Long non-coding RNA-derived peptides are immunogenic and drive a potent anti-tumour response
10.1038/s41467-023-36826-0 · 2023 · External reference
Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity
10.1038/s43018-024-00736-x · 2024 · External reference
CD28 costimulatory signal induces protein arginine methylation in T cells
10.1084/jem.20050176 · 2005 · External reference
Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription
10.1016/s0092-8674(01)00269-0 · 2001 · External reference
Methylation of STAT6 modulates STAT6 phosphorylation, nuclear translocation, and DNA-binding activity
10.4049/jimmunol.172.11.6744 · 2004 · External reference
Asymmetric arginine dimethylation of RelA provides a repressive mark to modulate TNFα/NF-κB response
10.1073/pnas.1522372113 · 2016 · External reference
Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity
10.1101/gad.1632608 · 2008 · External reference
Protein arginine methyltransferase 1 (PRMT1) represses MHC II transcription in macrophages by methylating CIITA
2017 · External reference
Arginine methylation of FOXP3 is crucial for the suppressive function of regulatory T cells
10.1016/j.jaut.2018.09.011 · 2019 · External reference
Arginine methylation of NIP45 modulates cytokine gene expression in effector T lymphocytes
10.1016/j.molcel.2004.06.042 · 2004 · External reference
NIP45 controls the magnitude of the type 2 T helper cell response
10.1073/pnas.0914700107 · 2010 · External reference
Methylation of dual-specificity phosphatase 4 controls cell differentiation
10.1016/j.celrep.2021.109421 · 2021 · External reference
PRMT1 mediated methylation of cGAS suppresses anti-tumor immunity
10.1038/s41467-023-38443-3 · 2023 · External reference
Arginine methylation of the B cell antigen receptor promotes differentiation
10.1084/jem.20091303 · 2010 · External reference
The BTG2-PRMT1 module limits pre-B cell expansion by regulating the CDK4-Cyclin-D3 complex
10.1038/ni.3774 · 2017 · External reference
PRMT2 silencing regulates macrophage polarization through activation of STAT1 or inhibition of STAT6
10.1186/s12865-023-00593-w · 2024 · External reference
Disruption of protein arginine N-methyltransferase 2 regulates leptin signaling and produces leanness in vivo through loss of STAT3 methylation
10.1161/circresaha.110.225326 · 2010 · External reference
PRMT3 Drives IDO1-Dependent Radioresistance and Immunosuppression by Promoting Kynurenine Metabolism in Non-Small Cell Lung Cancer
10.1158/0008-5472.can-24-4162 · 2026 · External reference
Targeting PRMT3 impairs methylation and oligomerization of HSP60 to boost anti-tumor immunity by activating cGAS/STING signaling
10.1038/s41467-024-52170-3 · 2024 · External reference
PRMT4 blocks myeloid differentiation by assembling a methyl-RUNX1-dependent repressor complex
10.1016/j.celrep.2013.11.025 · 2013 · External reference
Loss of CARM1 results in hypomethylation of thymocyte cyclic AMP-regulated phosphoprotein and deregulated early T cell development
10.1074/jbc.m402544200 · 2004 · External reference
PRMT5 dimethylates R30 of the p65 subunit to activate NF-κB
10.1073/pnas.1311784110 · 2013 · External reference
Arginine methyltransferase PRMT5 negatively regulates cGAS-mediated antiviral immune response
10.1126/sciadv.abc1834 · 2021 · External reference
Targeting PRMT7-mediated monomethylation of MAVS enhances antiviral innate immune responses and inhibits RNA virus replication
10.1073/pnas.2408117121 · 2024 · External reference
The protein arginine methyltransferase PRMT9 attenuates MAVS activation through arginine methylation
10.1038/s41467-022-32628-y · 2022 · External reference
Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation
10.1038/s41467-017-01009-1 · 2017 · External reference
Defining the RGG/RG motif
10.1016/j.molcel.2013.05.021 · 2013 · External reference
Chemical biology of protein arginine modifications in epigenetic regulation
10.1021/acs.chemrev.5b00003 · 2015 · External reference
Arginine methylation in cancer: mechanisms and therapeutic implications
10.1186/s40364-025-00860-5 · 2025 · External reference
Inhibition of HIF-1α ameliorates pulmonary fibrosis by suppressing M2 macrophage polarization through PRMT1/STAT6 signals
10.1016/j.intimp.2024.113931 · 2025 · External reference
The circular RNA circHMGB2 drives immunosuppression and anti-PD-1 resistance in lung adenocarcinomas and squamous cell carcinomas via the miR-181a-5p/CARM1 axis
10.1186/s12943-022-01586-w · 2022 · External reference
Inflammaging: a new immune-metabolic viewpoint for age-related diseases
10.1038/s41574-018-0059-4 · 2018 · External reference
Abnormal Epigenetic Regulation of Immune System during Aging
10.3389/fimmu.2018.00197 · 2018 · External reference
Asymmetric arginine dimethylation determines life span in C. elegans by regulating forkhead transcription factor DAF-16
10.1016/j.cmet.2011.03.017 · 2011 · External reference
Functional Implications of Protein Arginine Methyltransferases (PRMTs) in Neurodegenerative Diseases
10.3390/biology12091257 · 2023 · External reference
Protein Arginine Methyltransferases: Emerging Targets in Cardiovascular and Metabolic Disease
10.4093/dmj.2023.0362 · 2024 · External reference
Autonomic nervous system imbalance during aging contributes to impair endogenous anti-inflammaging strategies
10.1007/s11357-023-00947-7 · 2024 · External reference
The antidepressant effects of protein arginine methyltransferase 2 involve neuroinflammation
10.1016/j.neuint.2024.105728 · 2024 · External reference
The Protein Arginine Methyltransferase PRMT8 and Substrate G3BP1 Control Rac1-PAK1 Signaling and Actin Cytoskeleton for Dendritic Spine Maturation
10.1016/j.celrep.2020.107744 · 2020 · External reference
Arginine Methyltransferase PRMT8 Provides Cellular Stress Tolerance in Aging Motoneurons
10.1523/jneurosci.3389-17.2018 · 2018 · External reference
Protein arginine methylation regulates anti-inflammatory programming in response to aging stress
10.1016/j.isci.2025.113095 · 2025 · External reference
Cellular Senescence and Inflammaging in Age-Related Diseases
10.1155/2018/9076485 · 2018 · External reference
Arginine hypomethylation-mediated proteasomal degradation of histone H4-an early biomarker of cellular senescence
10.1038/s41418-020-0562-8 · 2020 · External reference
The dual function of PRMT1 in modulating epithelial-mesenchymal transition and cellular senescence in breast cancer cells through regulation of ZEB1
2016 · External reference
PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin
10.1016/j.celrep.2019.12.061 · 2020 · External reference
Loss of CARM1 is linked to reduced HuR function in replicative senescence
10.1186/1471-2199-14-15 · 2013 · External reference
PRMT5-PTEN molecular pathway regulates senescence and self-renewal of primary glioblastoma neurosphere cells
10.1038/onc.2016.199 · 2017 · External reference
Global analysis of protein arginine methylation
2021 · External reference
New horizons in arginine metabolism, ageing and chronic disease states
10.1093/ageing/afz083 · 2019 · External reference
Methylarginine levels and their impact on vascular aging: a systematic review
2025 · External reference
Toxic Dimethylarginines: Asymmetric Dimethylarginine (ADMA) and Symmetric Dimethylarginine (SDMA)
10.3390/toxins9030092 · 2017 · External reference
Inflammation and tumor immune escape in response to DNA damage
10.1016/j.semcancer.2025.02.005 · 2025 · External reference
RIP kinases and necroptosis in aging and aging-related diseases
10.1093/lifemedi/lnac003 · 2022 · External reference
Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation
10.1126/science.aar2641 · 2018 · External reference
RIPK1 blocks T cell senescence mediated by RIPK3 and caspase-8
10.1126/sciadv.add6097 · 2023 · External reference
The protein arginine methyltransferase PRMT1 ameliorates cerebral ischemia-reperfusion injury by suppressing RIPK1-mediated necroptosis and apoptosis
10.1016/j.apsb.2025.06.005 · 2025 · External reference
Adenosine metabolic clearance maintains liver homeostasis by licensing arginine methylation of RIPK1
10.1084/jem.20250603 · 2026 · External reference
PRMT1 reverts the immune escape of necroptotic colon cancer through RIP3 methylation
10.1038/s41419-023-05752-w · 2023 · External reference
PRMT5-mediated regulatory arginine methylation of RIPK3
10.1038/s41420-023-01299-z · 2023 · External reference
Inflammation and aging: signaling pathways and intervention therapies
10.1038/s41392-023-01502-8 · 2023 · External reference
Type-I protein arginine methyltransferase inhibition primes anti-programmed cell death protein 1 immunotherapy in triple-negative breast cancer
10.1002/cncr.35142 · 2024 · External reference
Repression of PRMT activities sensitize human homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment
10.7554/elife.99225.4 · 2026 · External reference
Identification of hnRNP-A1 as a pharmacodynamic biomarker of type I PRMT inhibition in blood and tumor tissues
10.1038/s41598-020-78800-6 · 2020 · External reference
Dapagliflozin binds PRMT7 to inhibit p38 MAPK phosphorylation and macrophage foam cell formation in atherosclerosis
10.1016/j.isci.2026.116250 · 2026 · External reference
A novel 3-alkenylindol-2-one derivative selectively inhibits the growth of acute myeloid leukemia via modulation of the MYC-PRMT pathway
10.1016/j.bcp.2025.117111 · 2025 · External reference
Crystal structure of the conserved core of protein arginine methyltransferase PRMT3
10.1093/emboj/19.14.3509 · 2000 · External reference
Structural basis of arginine asymmetrical dimethylation by PRMT6
10.1042/bcj20160537 · 2016 · External reference
Insights into histone code syntax from structural and biochemical studies of CARM1 methyltransferase
10.1038/sj.emboj.7601856 · 2007 · External reference
Novel helical assembly in arginine methyltransferase 8
10.1016/j.jmb.2016.02.007 · 2016 · External reference
PRMT1 oligomerization regulates RNA-binding protein cascade to promote pancreatic cancer
10.26508/lsa.202503202 · 2025 · External reference
Oligomerization of protein arginine methyltransferase 1 and its functional impact on substrate arginine methylation
10.1016/j.jbc.2024.107947 · 2024 · External reference
Protein Arginine Methyltransferase 8: Tetrameric Structure and Protein Substrate Specificity
10.1021/acs.biochem.5b00995 · 2015 · External reference
The structure and oligomerization of the yeast arginine methyltransferase, Hmt1
10.1038/78941 · 2000 · External reference
Crystal structure of the human PRMT5:MEP50 complex
10.1073/pnas.1209814109 · 2012 · External reference
Structural insight into arginine methylation by the mouse protein arginine methyltransferase 7: a zinc finger freezes the mimic of the dimeric state into a single active site
10.1107/s1399004714014278 · 2014 · External reference
Protein arginine methylation: from enigmatic functions to therapeutic targeting
10.1038/s41573-021-00159-8 · 2021 · External reference
Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction
10.1021/acs.jmedchem.1c00507 · 2021 · External reference
Posttranscriptional regulation of PD-1 by PRMT5/WDR77 complex shapes T cell effector function and antitumor immunity
10.1172/jci191469 · 2026 · External reference
