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References from ESCAPE enables receptor-specific chemogenetic dissection of GPCR signaling. Local targets link to admitted publications; unresolved targets remain external evidence.
Efficient, Complete Deletion of Synaptic Proteins using CRISPR
10.1016/j.neuron.2014.07.043 · 2014 · External reference
Polypharmacology - Foe or friend?
10.1021/jm400856t · 2013 · External reference
A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs
10.1038/s41467-023-40064-9 · 2023 · External reference
The structure and function of G-protein-coupled receptors
10.1038/nature08144 · 2009 · External reference
Trends in GPCR drug discovery: New agents, targets and indications
10.1038/nrd.2017.178 · 2017 · External reference
Adenosine receptors as therapeutic targets
10.1038/nrd1983 · 2006 · External reference
Adenosine A2A receptor as a drug discovery target
10.1021/jm4011669 · 2014 · External reference
Optochemical control of slow-wave sleep in the nucleus accumbens of male mice by a photoactivatable allosteric modulator of adenosine A2A receptors
10.1038/s41467-024-47964-4 · 2024 · External reference
The role of the D2 dopamine receptor (D2R) in A2A adenosine receptor (A2AR)-mediated behavioral and cellular responses as revealed by A2A and D2 receptor knockout mice
10.1073/pnas.98.4.1970 · 2001 · External reference
A2A adenosine receptor protects tumors from antitumor T cells
10.1073/pnas.0605251103 · 2006 · External reference
Adenosine promotes wound healing and mediates angiogenesis in response to tissue injury via occupancy of A2A receptors
10.1016/s0002-9440(10)61151-0 · 2002 · External reference
Adenosine 2A receptor availability in dyskinetic and nondyskinetic patients with Parkinson disease
10.1212/wnl.0b013e31821ccce4 · 2011 · External reference
Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory
10.1038/nn.3930 · 2015 · External reference
Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation
10.1038/nature10136 · 2011 · External reference
The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist
10.1126/science.1164772 · 2008 · External reference
Chemogenetic Approach Using Ni(II) Complex-Agonist Conjugates Allows Selective Activation of Class A G-Protein-Coupled Receptors
10.1021/acscentsci.8b00390 · 2018 · External reference
Novel adenosine A2A receptor ligands: A synthetic, functional and computational investigation of selected literature adenosine A2A receptor antagonists for extending into extracellular space
10.1016/j.bmcl.2013.03.070 · 2013 · External reference
Small molecule AZD4635 inhibitor of A2AR signaling rescues immune cell function including CD103+ dendritic cells enhancing anti-tumor immunity
10.1136/jitc-2019-000417 · 2020 · External reference
Towards high throughput GPCR crystallography: In Meso soaking of Adenosine A2A Receptor crystals
10.1038/s41598-017-18570-w · 2018 · External reference
Crystal structure of adenosine A2A receptor in complex with clinical candidate Etrumadenant reveals unprecedented antagonist interaction
10.1038/s42004-023-00894-6 · 2023 · External reference
The genetic design of signaling cascades to record receptor activation
10.1073/pnas.0710487105 · 2008 · External reference
PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome
10.1038/nsmb.3014 · 2015 · External reference
The role of serotonin 5-HT2A receptors in memory and cognition
10.3389/fphar.2015.00225 · 2015 · External reference
The 5-HT2A serotonin receptor in executive function: Implications for neuropsychiatric and neurodegenerative diseases
10.1016/j.neubiorev.2016.02.008 · 2016 · External reference
Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity
10.1038/s41586-022-05258-z · 2022 · External reference
Structure-based discovery of nonhallucinogenic psychedelic analogs
10.1126/science.abl8615 · 2022 · External reference
Signaling pathways for PC12 cell differentiation: Making the right connections
10.1126/science.1071552 · 2002 · External reference
Hypoxia induces neurite outgrowth in PC12 cells that is mediated through adenosine A2A receptors
10.1016/j.neuroscience.2004.11.015 · 2005 · External reference
Chronic hypoxia leads to a glycolytic phenotype and suppressed HIF-2 signaling in PC12 cells
10.1016/j.bbagen.2013.02.016 · 2013 · External reference
8-(3-Chlorostyryl) caffeine may attenuate MPTP neurotoxicity through dual actions of monoamine oxidase inhibition and A2A receptor antagonism
10.1074/jbc.m206830200 · 2002 · External reference
Release of dopamine and norepinephrine by hypoxia from PC-12 cells
10.1152/ajpcell.1998.274.6.c1592 · 1998 · External reference
Psychedelics Promote Structural and Functional Neural Plasticity
10.1016/j.celrep.2018.05.022 · 2018 · External reference
Serotonin induces the increase in intracellular Ca2+ that enhances neurite outgrowth in PC12 cells via activation of 5-HT3 receptors and voltage-gated calcium channels
10.1002/jnr.20894 · 2006 · External reference
Bioactivation of sitaxentan in liver microsomes, hepatocytes, and expressed human P450s with characterization of the glutathione conjugate by liquid chromatography tandem mass spectrometry
10.1021/tx4001144 · 2013 · External reference
Chemogenetics of cell surface receptors: Beyond genetic and pharmacological approaches
10.1039/d1cb00195g · 2022 · External reference
Controlling signaling with a specifically designed Gi-coupled receptor
10.1073/pnas.95.1.352 · 1998 · External reference
Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand
10.1073/pnas.0700293104 · 2007 · External reference
Chemical and genetic engineering of selective ion channel-ligand interactions
10.1126/science.1206606 · 2011 · External reference
Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys
10.1038/s41593-020-0661-3 · 2020 · External reference
Synthetic GPCRs for programmable sensing and control of cell behaviour
10.1038/s41586-024-08282-3 · 2025 · External reference
Deconstructing behavioral neuropharmacology with cellular specificity
10.1126/science.aaj2161 · 2017 · External reference
Coordination chemogenetics for activation of GPCR-type glutamate receptors in brain tissue
10.1038/s41467-022-30828-0 · 2022 · External reference
10.1021/jm501065t
10.1021/jm501065t · 2014 · External reference
Ultra-large virtual screening unveils potent agonists of the neuromodulatory orphan receptor GPR139
10.1038/s41467-025-66845-y · 2025 · External reference
ADORA2A promotes proliferation and inhibits apoptosis through PI3K/AKT pathway activation in colorectal carcinoma
10.1038/s41598-023-46521-1 · 2023 · External reference
The measurement of adenosine and estrogen receptor expression in rat brains following ovariectomy using quantitative PCR analysis
10.1016/s1385-299x(02)00219-2 · 2003 · External reference
In Vitro Evolution of the Adenosine A2A Receptor Based on an Antagonist Binding Using a Ribosome Display
10.1021/jacs.6c02372 · 2026 · External reference
Photoresponsive Adenosine Derivatives for the Optical Control of Adenosine A2A Receptors in Living Cells
10.1021/acschembio.4c00583 · 2024 · External reference
Single Stabilizing Point Mutation Enables High-Resolution Co-Crystal Structures of the Adenosine A2A Receptor with Preladenant Conjugates
2022 · External reference
Avogadro: an advanced semantic chemical editor, visualization, and analysis platform
10.1186/1758-2946-4-17 · 2012 · External reference
Unresolved reference
External reference
Comparative protein modelling by satisfaction of spatial restraints
10.1006/jmbi.1993.1626 · 1993 · External reference
UCSF ChimeraX: Tools for structure building and analysis
10.1002/pro.4792 · 2023 · External reference
Ff19SB: Amino-Acid-Specific Protein Backbone Parameters Trained against Quantum Mechanics Energy Surfaces in Solution
10.1021/acs.jctc.9b00591 · 2020 · External reference
Development and testing of a general Amber force field
10.1002/jcc.20035 · 2004 · External reference
AmberTools
10.1021/acs.jcim.3c01153 · 2023 · External reference
Fast, efficient generation of high-quality atomic charges. AM1-BCC model: I. Method
10.1002/(sici)1096-987x(20000130)21:2<132::aid-jcc5>3.0.co;2-p · 2000 · External reference
Fast, efficient generation of high-quality atomic charges. AM1-BCC model: II. Parameterization and validation
10.1002/jcc.10128 · 2002 · External reference
Zygote Microinjection for Creating Gene Cassette Knock-in and Flox Alleles in Mice
2022 · External reference
