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References from Curcumin scaffold to dual NF-κB/STAT3 modulators: advancing strategies against chemotherapy-resistant colorectal cancer. Local targets link to admitted publications; unresolved targets remain external evidence.
The impact of cancer stem cells in colorectal cancer
10.3390/ijms25084140 · 2024 · External reference
Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN
10.1136/gutjnl-2022-327736 · 2023 · External reference
An examination of colorectal cancer burden by socioeconomic status: evidence from GLOBOCAN 2018
10.1007/s13167-019-00185-y · 2020 · External reference
Cancer of colon, rectum and anus: the rising burden of disease worldwide from 1990 to 2019
10.1093/pubmed/fdad197 · 2024 · External reference
Anti-EGFR-resistant clones decay exponentially after progression: implications for anti-EGFR re-challenge
10.1093/annonc/mdy509 · 2019 · External reference
Intratumor CMS heterogeneity impacts patient prognosis in localized colon cancer
10.1158/1078-0432.ccr-21-0529 · 2021 · External reference
Intratumor heterogeneity and cell secretome promote chemotherapy resistance and progression of colorectal cancer
10.1038/s41419-023-05806-z · 2023 · External reference
The role of p53 dysfunction in colorectal cancer and its implication for therapy
10.3390/cancers13102296 · 2021 · External reference
The role of KRAS mutations in colorectal cancer: biological insights, clinical implications, and future therapeutic perspectives
10.3390/cancers17030428 · 2025 · External reference
Molecular mechanisms targeting drug-resistance and metastasis in colorectal cancer: updates and beyond
10.3748/wjg.v29.i9.1395 · 2023 · External reference
Comprehensive review of targeted therapy for colorectal cancer
10.1038/s41392-020-0116-z · 2020 · External reference
Long-term resistance to 5-fluorouracil promotes epithelial-mesenchymal transition, apoptosis evasion, autophagy, and reduced proliferation rate in colon cancer cells
10.1016/j.ejphar.2022.175253 · 2022 · External reference
Association of the epithelial-mesenchymal transition (EMT) with cisplatin resistance
10.3390/ijms21114002 · 2020 · External reference
The effect and mechanism of erianin on the reversal of oxaliplatin resistance in human colon cancer cells
10.1002/cbin.11684 · 2021 · External reference
Colorectal cancer cell-derived CCL20 recruits regulatory T cells to promote chemoresistance via FOXO1/CEBPB/NF-κB signaling
10.1186/s40425-019-0701-2 · 2019 · External reference
Enalapril overcomes chemoresistance and potentiates antitumor efficacy of 5-FU in colorectal cancer by suppressing proliferation, angiogenesis, and NF-κb/STAT3-regulated proteins
10.1038/s41419-020-2675-x · 2020 · External reference
Pharmacological NF-κb inhibition decreases cisplatin chemoresistance in muscle-invasive bladder cancer and reduces cisplatin-induced toxicities
10.1002/1878-0261.13504 · 2023 · External reference
STAT3 regulates 5-Fu resistance in human colorectal cancer cells by promoting Mcl-1-dependent cytoprotective autophagy
10.1111/cas.15761 · 2023 · External reference
NF-κb in biology and targeted therapy: new insights and translational implications
10.1038/s41392-024-01757-9 · 2024 · External reference
Targeting STAT3 in cancer immunotherapy
10.1186/s12943-020-01258-7 · 2020 · External reference
NF-κb in inflammation and cancer
10.1038/s41423-025-01310-w · 2025 · External reference
Modulating multidrug resistance to drug-based antitumor therapies through NF-κb signaling pathway: mechanisms and perspectives
10.1080/14728222.2023.2225767 · 2023 · External reference
The bright side of Curcumin: a narrative review of its therapeutic potential in cancer management
10.3390/cancers16142580 · 2024 · External reference
A review of curcumin and its derivatives as anticancer agents
10.3390/ijms20051033 · 2019 · External reference
Antitumoral activities of curcumin and recent advances to ImProve its oral bioavailability
10.3390/biomedicines9101476 · 2021 · External reference
Developments in the anticancer activity of structurally modified curcumin: an up-to-date review
10.1016/j.ejmech.2019.04.058 · 2019 · External reference
The potency of heterocyclic curcumin analogues: an evidence-based review
10.1016/j.phrs.2021.105489 · 2021 · External reference
Molecular mechanisms of curcumin and its analogs in colon cancer prevention and treatment
10.1016/j.lfs.2019.117032 · 2019 · External reference
Unraveling the complexity of STAT3 in cancer: molecular understanding and drug discovery
10.1186/s13046-024-02949-5 · 2024 · External reference
Targeted therapies of curcumin focus on its therapeutic benefits in cancers and human health: molecular signaling pathway-based approaches and future perspectives
10.1016/j.biopha.2023.116034 · 2024 · External reference
Systematic elucidation of the mechanism of action of Curcumin against colorectal cancer via network pharmacology approach
2021 · External reference
Curcumin delivery systems: how far from clinical application in tumor therapy?
2024 · External reference
Unresolved reference
2020 · External reference
Curcumin’s potential as A drug delivery method and anticancer treatment
10.37021/ijper.v5i2.04 · 2023 · External reference
Curcumin and its anti-colorectal cancer potential: from mechanisms of action to autophagy
10.1002/ptr.8220 · 2024 · External reference
The inflammatory pathogenesis of colorectal cancer
10.1038/s41577-021-00534-x · 2021 · External reference
TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells
10.1038/s41419-021-04151-3 · 2021 · External reference
STAT3 as a newly emerging target in colorectal cancer therapy: tumorigenesis, therapy response, and pharmacological/nanoplatform strategies
10.1016/j.envres.2023.116458 · 2023 · External reference
Data from cytokine Induction of Tumor Necrosis factor receptor 2 Is mediated by STAT3 in colon
2023 · External reference
NF-κb signaling in inflammation and cancer
10.1002/mco2.104 · 2021 · External reference
Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer
10.1038/s41392-021-00670-9 · 2021 · External reference
Aspirin suppresses chemoresistance and enhances antitumor activity of 5-fu in 5-Fu-resistant colorectal cancer by abolishing 5-Fu-induced NF-\\u03baB activation
10.1038/s41598-019-53276-1 · 2019 · External reference
Preclinical efficacy of carfilzomib in BRAF-mutant colorectal cancer models
10.1002/1878-0261.13595 · 2024 · External reference
IL-6 promotes drug resistance through formation of polyploid giant cancer cells and stromal fibroblast reprogramming
10.1038/s41389-021-00349-4 · 2021 · External reference
IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation
10.1038/s41467-021-23923-1 · 2021 · External reference
STAT3 and the STAT3-regulated inhibitor of apoptosis protein survivin as potential therapeutic targets in colorectal cancer (Review)
10.3892/br.2024.1863 · 2024 · External reference
Progress in understanding the IL-6/STAT3 pathway in colorectal cancer
10.2147/ott.s278013 · 2020 · External reference
Overcoming acquired drug resistance to cancer therapies through targeted STAT3 inhibition
10.3390/ijms24054722 · 2023 · External reference
Small molecular inhibitors and degraders targeting STAT3 for cancer therapy: an updated review (from 2022 to 2024)
10.1016/j.cclet.2024.110447 · 2025 · External reference
Interleukins in cancer: from biology to therapy
10.1038/s41568-021-00363-z · 2021 · External reference
Curcumin nicotinate selectively induces cancer cell apoptosis and cycle arrest through a P53-mediated mechanism
10.3390/molecules24224179 · 2019 · External reference
Rafoxanide negatively modulates STAT3 and NF-κb activity and inflammation-associated colon tumorigenesis
10.1111/cas.16317 · 2024 · External reference
Unresolved reference
2023 · External reference
Anti-obesity drug orlistat alleviates western-diet-driven colitis-associated colon cancer via inhibition of STAT3 and NF-κb-mediated signaling
10.3390/cells10082060 · 2021 · External reference
Important chemical structural features of curcumin and its derivatives: how do they influence their anticancer activity?
2020 · External reference
Curcumin induces apoptosis in human hepatocellular carcinoma cells by decreasing the expression of STAT3/VEGF/HIF-1α signaling
2023 · External reference
Curcumin in prostate cancer: a systematic review of molecular mechanisms and nanoformulated therapeutic strategies
10.1186/s12885-025-15152-2 · 2025 · External reference
Curcumin activates a ROS/KEAP1/NRF2/miR-34a/b/c cascade to suppress colorectal cancer metastasis
10.1038/s41418-023-01178-1 · 2023 · External reference
Natural products as chemo-radiation therapy sensitizers in cancers
10.1016/j.biopha.2022.113610 · 2022 · External reference
A review of different approaches for improving curcumin bioavailability
10.22270/jddt.v13i12.6267 · 2023 · External reference
Assessment of enhancing curcumin’s solubility versus uptake on its anti-cancer efficacy
10.1016/j.colsurfb.2024.114090 · 2024 · External reference
Review of Curcumin and its different formulations: pharmacokinetics, pharmacodynamics and pharmacokinetic-pharmacodynamic interactions
10.21926/obm.icm.2204057 · 2022 · External reference
Enhancing the bioavailability and bioactivity of curcumin for disease prevention and treatment
10.3390/antiox13030331 · 2024 · External reference
Enhancing therapeutic impact of curcumins, through development of monocarbonyl analogues of curcumin for improved bioavailability and activity in healthcare
10.2174/0122103155307922241022143752 · 2026 · External reference
Curcumin-based nanoparticles: advancements and challenges in tumor therapy
10.3390/pharmaceutics17010114 · 2025 · External reference
Enhancing therapeutic efficacy of Curcumin: advances in delivery systems and clinical applications
10.3390/gels9080596 · 2023 · External reference
Curcumin nanoformulations for colorectal cancer: a review
10.3389/fphar.2019.00152 · 2019 · External reference
Herbal approach for treatment of cancer using curcumin as an anticancer agent: a review on novel drug delivery systems
10.1016/j.molliq.2023.123037 · 2023 · External reference
Trends in advanced oral drug delivery systems for curcumin: a systematic review
10.1016/j.jconrel.2022.05.048 · 2022 · External reference
Utility of intravenous curcumin nanodelivery systems for improving in vivo pharmacokinetics and anticancer pharmacodynamics
10.1021/acs.molpharmaceut.2c00455 · 2022 · External reference
Gut microbiota in phytopharmacology: a comprehensive overview of concepts, reciprocal interactions, biotransformations and mode of actions
10.1016/j.phrs.2019.104367 · 2019 · External reference
Curcumin β-D-glucuronide exhibits anti-tumor effects on oxaliplatin-resistant colon cancer with less toxicity in vivo
10.1111/cas.14383 · 2020 · External reference
Recent advances of analogues of curcumin for treatment of cancer
10.1016/j.ejmech.2019.07.034 · 2019 · External reference
Preparation and anti-colon cancer effect of a novel curcumin analogue (CA8): in vivo and in vitro evaluation
10.3389/fphar.2024.1464626 · 2024 · External reference
Tumour-suppressive effects of curcumin analogs CCA-1.1 and pentagamavunone-1 in colon cancer: in vivo and in vitro studies
10.4103/japtr.japtr_315_23 · 2023 · External reference
Preparation and cytotoxic evaluation of PGV-1 derivative, CCA-1.1, as a new curcumin analog with improved-physicochemical and pharmacological properties
10.34172/apb.2022.063 · 2022 · External reference
An old spice with new tricks: curcumin targets adenoma and colorectal cancer stem-like cells associated with poor survival outcomes
10.1016/j.canlet.2025.217885 · 2025 · External reference
The curcumin analogue, MS13 (1,5-Bis(4-hydroxy-3- methoxyphenyl)-1,4-pentadiene-3-one), inhibits cell proliferation and induces apoptosis in primary and metastatic Human colon cancer cells
10.3390/molecules25173798 · 2020 · External reference
Curcumin may reverse 5-fluorouracil resistance on colonic cancer cells by regulating TET1-NKD-wnt signal pathway to inhibit the EMT progress
10.1016/j.biopha.2020.110381 · 2020 · External reference
AI-guided design of leucopelargonidin-derived ligands targeting glucokinase regulatory protein: quantum descriptors, binding dynamics, and network pharmacology
10.1016/j.chphi.2026.101102 · 2026 · External reference
Proteomic analysis of the chemosensitizing effect of curcumin on CRC cells treated with 5-FU
10.3389/fmed.2022.1032256 · 2022 · External reference
Curcumin against gastrointestinal cancer: a review of the pharmacological mechanisms underlying its antitumor activity
10.3389/fphar.2022.990475 · 2022 · External reference
Curcumin in colorectal cancer: mechanistic insights, pharmacological limitations, and translational perspectives
2025 · External reference
Cancer stem cells: advances in knowledge and implications for cancer therapy
10.1038/s41392-024-01851-y · 2024 · External reference
Low curcumin concentration enhances the anticancer effect of 5-fluorouracil against colorectal cancer
10.1016/j.phymed.2021.153547 · 2021 · External reference
Curcumin and derivatives in nanoformulations with therapeutic potential on colorectal cancer
2022 · External reference
Curcumin combined with FOLFOX chemotherapy is safe and tolerable in patients with metastatic colorectal cancer in a randomized phase IIa trial
10.1093/jn/nxz029 · 2019 · External reference
Synthesis and biological evaluations of monocarbonyl analogs of curcumin with improved stability and pharmacological properties
10.2147/dddt.s244865 · 2020 · External reference
The therapeutic potential of curcumin: a review of clinical trials
10.1016/j.ejmech.2018.12.016 · 2019 · External reference
Smart polymer-based delivery systems for curcumin in colon cancer therapy: a review
10.1002/ptr.8394 · 2025 · External reference
Curcumin loaded eudragit S100/PLGA nanoparticles in treatment of colon cancer: formulation, optimization, and in-vitro cytotoxicity study
10.5530/ijper.55.2s.114 · 2021 · External reference
Folate-modified curcumin-loaded nanoparticles for overcoming delivery challenges in cancer treatment: a narrative review
10.2174/0113892010299290240531101441 · 2025 · External reference
Fabrication of targeted and pH responsive lysozyme-hyaluronan nanoparticles for 5-fluorouracil and curcumin co-delivery in colorectal cancer therapy
10.1016/j.ijbiomac.2023.127836 · 2024 · External reference
Co-administration of curcumin with other phytochemicals improves anticancer activity by regulating multiple molecular targets
10.1002/ptr.7794 · 2023 · External reference
Curcuma as an adjuvant in colorectal cancer treatment
10.1016/j.lfs.2021.120043 · 2021 · External reference
Is curcumin at the threshold of therapeutic effectiveness on patients with colon cancer?-A systematic review
2021 · External reference
Curcumin and colorectal cancer: from basic to clinical evidences
10.3390/ijms21072364 · 2020 · External reference
Review on regulation of herbal products used as a medicine across the globe: a case study on turmeric - golden medicine
10.13005/bpj/2458 · 2022 · External reference
Curcumin reverses oxaliplatin resistance in human colorectal cancer via regulation of TGF-β/Smad2/3 signaling pathway
10.2147/ott.s199601 · 2019 · External reference
Curcumin-loaded porous particles functionalized with pH-responsive cell-penetrating peptide for colorectal cancer targeted drug delivery
10.1039/d3ra06270h · 2023 · External reference
Curcumin formulations for better bioavailability: what we learned from clinical trials thus far?
10.1021/acsomega.2c07326 · 2023 · External reference