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References from Separation of phosphodiester impurities from fully phosphorothioate-modified oligonucleotides by ion-pair reversed-phase liquid chromatography. Local targets link to admitted publications; unresolved targets remain external evidence.
Antisense technology: an overview and prospectus
10.1038/s41573-021-00162-z · 2021 · External reference
The chemical evolution of oligonucleotide therapies of clinical utility
10.1038/nbt.3765 · 2017 · External reference
The current landscape of nucleic acid therapeutics
2021 · External reference
Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs
10.1093/nar/gkx1239 · 2018 · External reference
Advances in analysis of therapeutic oligonucleotides with chromatography coupled to mass spectrometry
10.1021/acs.analchem.5c06656 · 2026 · External reference
Guideline on the development and manufacture of oligonucleotides
2024 · External reference
Phosphorothioates, essential components of therapeutic oligonucleotides
10.1089/nat.2014.0506 · 2014 · External reference
Impurities in oligonucleotide drug substances and drug products
10.1089/nat.2017.0691 · 2017 · External reference
10.1002/mas.21615
10.1002/mas.21615 · 2021 · External reference
31P NMR study of the desulfurization of oligonucleoside phosphorothioates effected by "aged" trichloroacetic acid solutions
10.1021/jo050035n · 2005 · External reference
THF peroxide as a factor in generating desulphurised products from the solid-phase synthesis of phosphorothioate-modified oligonucleotides
10.1039/d4ra03592e · 2024 · External reference
Separation of phosphorothioate oligonucleotide impurities by WAX HPLC under high organic content elution conditions
10.1016/j.ab.2022.114956 · 2022 · External reference
Comparing ion-pairing reagents and counter anions for ion-pair reversed-phase liquid chromatography/electrospray ionization mass spectrometry analysis of synthetic oligonucleotides
10.1002/rcm.7409 · 2015 · External reference
Characterization of therapeutic oligonucleotides by liquid chromatography
10.1016/j.jpba.2020.113105 · 2020 · External reference
The role of fluorinated alcohols as mobile phase modifiers for LC-MS analysis of oligonucleotides
10.1007/s13361-016-1500-3 · 2017 · External reference
The critical role of mobile phase pH in the performance of oligonucleotide ion-pair liquid chromatography-mass spectrometry methods
10.2144/fsoa-2021-0084 · 2021 · External reference
Impact of ion-pairing systems choice on diastereomeric selectivity of phosphorothioated oligonucleotides in reversed-phase liquid chromatography
2024 · External reference
Selectivity limits of and opportunities for ion pair chromatographic separation of oligonucleotides
2021 · External reference
Oligonucleotide analysis by hydrophilic interaction liquid chromatography-mass spectrometry in the absence of ion-pair reagents
10.1016/j.chroma.2019.02.016 · 2019 · External reference
Ion-pair reversed-phase and hydrophilic interaction chromatography methods for analysis of phosphorothioate oligonucleotides
2023 · External reference
pH effects on the separation of oligonucleotides by ion-pair reserved phase liquid chromatography mass spectrometry
2026 · External reference
Improving the chromatographic separation of phosphorothioate oligonucleotide from impurities by optimizing selectivity through mobile-phase conditions in Ion-pair reversed-phase high-performance liquid chromatography
2025 · External reference
Phosphorothioate oligonucleotides separation in ion-pairing reversed-phase liquid chromatography: Effect of ion-pairing system
2022 · External reference
Effect of ion-pairing reagent hydrophobicity on liquid chromatography and mass spectrometry analysis of oligonucleotides
2022 · External reference
Investigation of factors influencing the separation of diastereomers of phosphorothioated oligonucleotides
10.1007/s00216-019-01813-2 · 2019 · External reference